Last update
3/15/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.9
USERS' SCORE
Good
Based on 158 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Saccharomyces boulardii(an S. cerevisiae Strain)
250 mg(5 Billion CFU)
†
MOS Yeast Fraction(Min. 35% Manno-oligosaccharides [MOS]) (S. cerevisiae)
200 mg
†
Top Medical Research Studies
9.5
Probiotic effectively reduces diarrhea
We investigated the effectiveness of the probiotic Saccharomyces boulardii CNCM I-745 in real-world settings for treating diarrhea. In a study involving over 30,000 patients, those treated with S. boulardii had a notable success rate of 77.8% in resolving their diarrhea, compared to just 15.8% in the control group.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
Read More
9
Probiotics mitigate antibiotic-related diarrhea
We looked into how probiotics, especially Saccharomyces boulardii CNCM I-745, can impact antibiotic-associated diarrhea. Through systematic reviews and clinical trials, we found that this yeast is effective in preventing and resolving diarrhea linked to antibiotic use. Since it isn't affected by antibiotics, S. boulardii can safely be administered at the start of treatment or within the first couple of days. This shows that using the right probiotics can help restore gut health after antibiotics, which is crucial for overall well-being.
Read More
9
We explored the effects of Saccharomyces boulardii on diarrhea caused by the cancer drug abemaciclib in a study involving thirty rats. The rats were divided into three groups: a control group, a group receiving only abemaciclib, and a group receiving both abemaciclib and Saccharomyces boulardii.
Our results indicated that the group treated with Saccharomyces boulardii showed a significant reduction in diarrhea severity and weight loss compared to the group that only received abemaciclib. Furthermore, histopathological evaluations revealed less inflammation in the Saccharomyces boulardii group. Overall, this suggests that Saccharomyces boulardii might be a beneficial treatment option to alleviate chemotherapy-induced diarrhea.
Our results indicated that the group treated with Saccharomyces boulardii showed a significant reduction in diarrhea severity and weight loss compared to the group that only received abemaciclib. Furthermore, histopathological evaluations revealed less inflammation in the Saccharomyces boulardii group. Overall, this suggests that Saccharomyces boulardii might be a beneficial treatment option to alleviate chemotherapy-induced diarrhea.
Read More
Most Useful Reviews
9
Vital for correction
556 people found this helpful
I have found Saccharomyces Boulardii essential for combatting Clostridium Difficile. This probiotic not only helps eliminate harmful microbes but also prevents them from attaching to the intestinal lining, crucial for restoring gut health.
Read More
9
Caught my attention
264 people found this helpful
When S. boulardii is the right one, it's the only one you need. My gut symptoms, including diarrhea and bloating, improved remarkably after switching to a targeted probiotic protocol.
Read More
9
Effective medication
94 people found this helpful
I take it for diarrhoea, and it’s an effective medication.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.9
- All Researches
9.5
Probiotic effectively reduces diarrhea
We investigated the effectiveness of the probiotic Saccharomyces boulardii CNCM I-745 in real-world settings for treating diarrhea. In a study involving over 30,000 patients, those treated with S. boulardii had a notable success rate of 77.8% in resolving their diarrhea, compared to just 15.8% in the control group.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
Read More
9
Probiotic reduces antibiotic-associated diarrhea
We examined how a high-dose, multistrain probiotic mix called Sinquanon helps prevent antibiotic-associated diarrhea (AAD) in adults taking broad-spectrum antibiotics. This well-structured clinical trial involved 564 participants, half receiving the probiotic and half a placebo.
Results showed that fewer people in the probiotic group experienced AAD—only 9.2% compared to 25.3% in the placebo group. This promising improvement suggests that Sinquanon may significantly enhance gastrointestinal health during antibiotic treatment without causing harmful side effects.
Results showed that fewer people in the probiotic group experienced AAD—only 9.2% compared to 25.3% in the placebo group. This promising improvement suggests that Sinquanon may significantly enhance gastrointestinal health during antibiotic treatment without causing harmful side effects.
Read More
9
Probiotics mitigate antibiotic-related diarrhea
We looked into how probiotics, especially Saccharomyces boulardii CNCM I-745, can impact antibiotic-associated diarrhea. Through systematic reviews and clinical trials, we found that this yeast is effective in preventing and resolving diarrhea linked to antibiotic use. Since it isn't affected by antibiotics, S. boulardii can safely be administered at the start of treatment or within the first couple of days. This shows that using the right probiotics can help restore gut health after antibiotics, which is crucial for overall well-being.
Read More
9
We looked into how probiotics might help manage antibiotic-associated diarrhea (AAD) in children through a review of systematic reviews. Our review considered various databases and included 20 studies, evaluating their reporting quality and overall evidence strength. While we found that higher doses of probiotics show promise in preventing AAD, caution is needed as many studies had significant quality gaps. Overall, probiotics could benefit kids facing AAD, but more robust research is essential for clearer recommendations.
Read More
9
We explored the effects of Saccharomyces boulardii on diarrhea caused by the cancer drug abemaciclib in a study involving thirty rats. The rats were divided into three groups: a control group, a group receiving only abemaciclib, and a group receiving both abemaciclib and Saccharomyces boulardii.
Our results indicated that the group treated with Saccharomyces boulardii showed a significant reduction in diarrhea severity and weight loss compared to the group that only received abemaciclib. Furthermore, histopathological evaluations revealed less inflammation in the Saccharomyces boulardii group. Overall, this suggests that Saccharomyces boulardii might be a beneficial treatment option to alleviate chemotherapy-induced diarrhea.
Our results indicated that the group treated with Saccharomyces boulardii showed a significant reduction in diarrhea severity and weight loss compared to the group that only received abemaciclib. Furthermore, histopathological evaluations revealed less inflammation in the Saccharomyces boulardii group. Overall, this suggests that Saccharomyces boulardii might be a beneficial treatment option to alleviate chemotherapy-induced diarrhea.
Read More
User Reviews
USERS' SCORE
Good
Based on 158 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Vital for correction
556 people found this helpful
I have found Saccharomyces Boulardii essential for combatting Clostridium Difficile. This probiotic not only helps eliminate harmful microbes but also prevents them from attaching to the intestinal lining, crucial for restoring gut health.
Read More
9
Caught my attention
264 people found this helpful
When S. boulardii is the right one, it's the only one you need. My gut symptoms, including diarrhea and bloating, improved remarkably after switching to a targeted probiotic protocol.
Read More
9
Effective medication
94 people found this helpful
I take it for diarrhoea, and it’s an effective medication.
Read More
9
Rapid recovery noted
89 people found this helpful
I experienced a rapid recovery of intestinal health despite battling probable C. Difficile. After implementing a protocol with Jarrow Formulas Saccharomyces Boulardii, within 48 hours, my loved one was eating comfortably and had no issues in the bathroom.
Read More
9
Life-saving product
89 people found this helpful
Miracle Pills, Life Saving. This product effectively addresses gas and diarrhoea symptoms associated with C-diff and colitis. After trying numerous probiotics, this one outperforms them all. It’s a staple in my life, providing immense relief and allowing me to maintain daily activities. Regular use fosters an environment that discourages harmful bacteria while supporting beneficial strains.
Read More
Frequently Asked Questions
9
Better than alternatives
51 people found this helpful
I bought this for stomach upsets. When my children had diarrhoea, I opened the capsule and gave it in powder form. It was more effective than smecta, with no resulting constipation. It worked very well.
9.5
Probiotic effectively reduces diarrhea
We investigated the effectiveness of the probiotic Saccharomyces boulardii CNCM I-745 in real-world settings for treating diarrhea. In a study involving over 30,000 patients, those treated with S. boulardii had a notable success rate of 77.8% in resolving their diarrhea, compared to just 15.8% in the control group.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
8
Saccharomyces boulardii aids IBS-D
We investigated the impact of Saccharomyces boulardii CNCM I-745 combined with dietary advice in patients suffering from diarrhea-predominant irritable bowel syndrome (IBS-D). This randomized open-label study showed that the treatment helped reduce bacterial overgrowth and improved digestive symptoms over 15 days.
Participants receiving S. boulardii noticed a decrease in diarrhea and better overall symptom scores compared to those who received dietary advice alone. Notably, a particular beneficial bacteria, F. prausnitzii, became more abundant in those receiving the treatment, signaling possible positive shifts in the gut microbiota.
Participants receiving S. boulardii noticed a decrease in diarrhea and better overall symptom scores compared to those who received dietary advice alone. Notably, a particular beneficial bacteria, F. prausnitzii, became more abundant in those receiving the treatment, signaling possible positive shifts in the gut microbiota.
8
We explored whether probiotics, particularly Saccharomyces boulardii, are effective for treating various digestive disorders in children. The findings suggest that S. boulardii is beneficial for acute gastroenteritis, antibiotic-associated diarrhea, and Clostridium difficile infections. However, its efficacy for conditions like functional constipation and gastroesophageal reflux disease remains questionable.
While S. boulardii shows promise for other conditions like infantile colic, evidence quality is inconsistent. The study emphasizes that while probiotics can aid in treatment, they should not replace core dietary management strategies.
While S. boulardii shows promise for other conditions like infantile colic, evidence quality is inconsistent. The study emphasizes that while probiotics can aid in treatment, they should not replace core dietary management strategies.
9
Probiotics mitigate antibiotic-related diarrhea
We looked into how probiotics, especially Saccharomyces boulardii CNCM I-745, can impact antibiotic-associated diarrhea. Through systematic reviews and clinical trials, we found that this yeast is effective in preventing and resolving diarrhea linked to antibiotic use. Since it isn't affected by antibiotics, S. boulardii can safely be administered at the start of treatment or within the first couple of days. This shows that using the right probiotics can help restore gut health after antibiotics, which is crucial for overall well-being.
References
- Li M, Xie Y. Efficacy and safety of as an adjuvant therapy for the eradication of : a meta-analysis. Front Cell Infect Microbiol. 2025;15:1441185. 10.3389/fcimb.2025.1441185
- Girard P, Verleye M, Castagné V. Serotoninergic Mechanisms of Action in the Relaxant Properties of Saccharomyces boulardii CNCM I-745 on the Intestine. Dig Dis Sci. 2025;70:191. 10.1007/s10620-024-08786-y
- Gwee KA, Lee WRW, Chua Q, Chiou FK, Aw MM, et al. The evidence for probiotics in the treatment of digestive disorders in the pediatric population. J Gastroenterol Hepatol. 2025;40:41. 10.1111/jgh.16809
- Hodzhev V, Dzhambazov K, Sapundziev N, Encheva M, Todorov S, et al. High-dose Probiotic Mix of spp., spp., , and to Prevent Antibiotic-associated Diarrhea in Adults: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial (SPAADA). Open Forum Infect Dis. 2024;11:ofae615. 10.1093/ofid/ofae615
- Chen Y, Teng T, Su Y, Chen WZ. The effect of supplementing with on bismuth quadruple therapy for eradicating : a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2024;11:1344702. 10.3389/fmed.2024.1344702
- Pal BB, Bandagi RV, Pebbili KK, Rathod R, Kotak B, et al. Effectiveness of Saccharomyces boulardii CNCM I-745 in Adult Indian Patients with Diarrhoea: A Real-world, Multicentre, Retrospective, Comparative Study. Drugs Real World Outcomes. 2024;11:309. 10.1007/s40801-024-00424-3
- Alharbi BF, Alateek AA. Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review. Travel Med Infect Dis. 2024;59:102703. 10.1016/j.tmaid.2024.102703
- Waitzberg D, Guarner F, Hojsak I, Ianiro G, Polk DB, et al. Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis?. Adv Ther. 2024;41:901. 10.1007/s12325-024-02783-3
- Liu LH, Han B, Tao J, Zhang K, Wang XK, et al. The effect of Saccharomyces boulardii supplementation on Helicobacter pylori eradication in children: a systematic review and meta-analysis of Randomized controlled trials. BMC Infect Dis. 2023;23:878. 10.1186/s12879-023-08896-4
- Sjomina O, Poļaka I, Suhorukova J, Vangravs R, Paršutins S, et al. Randomised clinical trial: efficacy and safety of H. pylori eradication treatment with and without Saccharomyces boulardii supplementation. Eur J Cancer Prev. 2024;33:217. 10.1097/CEJ.0000000000000858
- Gopalan S, Ganapathy S, Mitra M, Kumar Joshi D, Veligandla KC, et al. Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review. Cureus. 2023;15:e46314. 10.7759/cureus.46314
- Yang Q, Hu Z, Lei Y, Li X, Xu C, et al. Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children. Front Pharmacol. 2023;14:1153070. 10.3389/fphar.2023.1153070
- Salazar-Parra MA, Cruz-Neri RU, Trujillo-Trujillo XA, Dominguez-Mora JJ, Cruz-Neri HI, et al. Effectiveness of Saccharomyces Boulardii CNCM I-745 probiotic in acute inflammatory viral diarrhoea in adults: results from a single-centre randomized trial. BMC Gastroenterol. 2023;23:229. 10.1186/s12876-023-02863-8
- Cakcak İE, Aytın YE, Sayın S, Küçükarda A, Gökyer A, et al. An experimental study: the effect of S. boulardii on abemaciclibinduced diarrhea. Turk J Med Sci. 2023;53:51. 10.55730/1300-0144.5557
- He XJ, Wang XL, Sun DJ, Huang XY, Liu G, et al. The efficacy and safety of in addition to antofloxacin-based bismuth quadruple therapy for eradication: a single-center, prospective randomized-control study. Therap Adv Gastroenterol. 2023;16:17562848221147763. 10.1177/17562848221147763
- Bustos Fernández LM, Man F, Lasa JS. Impact of Saccharomyces boulardii CNCM I-745 on Bacterial Overgrowth and Composition of Intestinal Microbiota in Diarrhea-Predominant Irritable Bowel Syndrome Patients: Results of a Randomized Pilot Study. Dig Dis. 2023;41:798. 10.1159/000528954
- Dang X, Choi SY, Choi YJ, Lee JH, Castex M, et al. Probiotic, Paraprobiotic, and Hydrolyzed Yeast Mixture Supplementation Has Comparable Effects to Zinc Oxide in Improving Growth Performance and Ameliorating Post-weaning Diarrhea in Weaned Piglets. Probiotics Antimicrob Proteins. 2024;16:249. 10.1007/s12602-022-10008-8
- Duarte ME, Kim SW. Efficacy of Saccharomyces yeast postbiotics on cell turnover, immune responses, and oxidative stress in the jejunal mucosa of young pigs. Sci Rep. 2024;14:19235. 10.1038/s41598-024-70399-2
- Zhang H, Nuermaimaiti Y, Hao K, Qi Y, Xu Y, et al. Supplementation with Combined Additive Improved the Production of Dairy Cows and Their Offspring with Maintenance of Antioxidative Stability. Antioxidants (Basel). 2024;13. 10.3390/antiox13060650
- Siyal M, Abbas Z, Amir MR, Qadeer MA. Saccharomyces cerevisiae for abdominal pain and discomfort in irritable bowel syndrome patients. Pak J Med Sci. 2024;40:492. 10.12669/pjms.40.3.8349
- Middelkoop A, Kettunen H, Guan X, Vuorenmaa J, Tichelaar R, et al. Effect of dietary tall oil fatty acids and hydrolysed yeast in SNP2-positive and SNP2-negative piglets challenged with F4 enterotoxigenic Escherichia coli. Sci Rep. 2024;14:2060. 10.1038/s41598-024-52586-3
- Miranda-Yuquilema J, Taboada J, Once V, Coyago M, Briñez W. Effect of Agroindustrial Waste Substrate Fermented with Lactic Acid Bacteria and Yeast on Changes in the Gut Microbiota of Guinea Pigs. Microorganisms. 2024;12. 10.3390/microorganisms12010133
- Salah N, Legendre H, Nenov V, Briche M, Serieys F, et al. Does micro-granulated yeast probiotic () supplementation in milk replacer affect health, growth, feed efficiency and economic gain of calves?. Vet Anim Sci. 2024;23:100329. 10.1016/j.vas.2023.100329
- Yan H, Xing Q, Xiao X, Yu B, He J, et al. Effect of Saccharomyces cerevisiae Postbiotics and Essential Oil on Growth Performance and Intestinal Health of Weanling Pigs During K88 ETEC Infection. J Anim Sci. 2024;102. 10.1093/jas/skae007
- Xu S, Jia X, Liu Y, Pan X, Chang J, et al. Effects of yeast-derived postbiotic supplementation in late gestation and lactation diets on performance, milk quality, and immune function in lactating sows. J Anim Sci. 2023;101. 10.1093/jas/skad201
- Santana DAD, Machado MO, de Azevedo BZ, Weber SH, Sotomaior CS, et al. Influence of probiotic supplementation on parasitological parameters in lambs. Vet Parasitol. 2023;318:109934. 10.1016/j.vetpar.2023.109934
- Liu J, Ren H, Yuan F, Shao M, Luo H. The effects of on rat colonic hypermotility induced by repeated water avoidance stress and the potential mechanism. PeerJ. 2022;10:e14390. 10.7717/peerj.14390
- Conway E, O'Doherty JV, Mukhopadhya A, Dowley A, Vigors S, et al. Maternal and/or direct supplementation with a combination of a casein hydrolysate and yeast β-glucan on post-weaning performance and intestinal health in the pig. PLoS One. 2022;17:e0265051. 10.1371/journal.pone.0265051
Data last updated:
