Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.4
USERS' SCORE
Good
Based on 20 Reviews
8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Saccharomyces boulardii(an S. cerevisiae Strain)
250 mg(5 Billion CFU)
†
MOS Yeast Fraction(Min. 35% Manno-oligosaccharides [MOS]) (S. cerevisiae)
200 mg
†
Top Medical Research Studies
9
We explored how the probiotic yeast, Saccharomyces boulardii, impacts ulcerative colitis in mice. Through a careful setup, C57BL/6 mice received the treatment for three weeks and were later exposed to a harmful substance to induce the condition.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
Read More
9
Saccharomyces boulardii reduces ulcer risk
We explored the effects of Saccharomyces boulardii on ulcerative colitis-related cancer in a mouse model.
Mice treated with a combination of azoxymethane and dextran sulfate sodium were given S. boulardii for 12 weeks.
Results showed that S. boulardii significantly lowered tumor load and reduced harmful substances TNF-α and IL-6 in the colon.
Additionally, it positively shifted the gut microbiota composition, suggesting a connection between the treatment and these beneficial outcomes.
Mice treated with a combination of azoxymethane and dextran sulfate sodium were given S. boulardii for 12 weeks.
Results showed that S. boulardii significantly lowered tumor load and reduced harmful substances TNF-α and IL-6 in the colon.
Additionally, it positively shifted the gut microbiota composition, suggesting a connection between the treatment and these beneficial outcomes.
Read More
9
We explored how the yeast strain QHNLD8L1 may help with ulcerative colitis. In our study, we looked at four different yeast strains and their effects on mice with induced colitis. Notably, QHNLD8L1 showed protective effects, improving body weight and colon length, while reducing inflammation. We also found that it decreased harmful bacteria and boosted beneficial ones, enhancing gut health overall. This indicates that QHNLD8L1 could be a promising approach to manage ulcerative colitis symptoms.
Read More
Most Useful Reviews
9
Diet and probiotics combo
20 people found this helpful
Just gentle diet with Saccharomyces boulardii has transformed my life. Having ulcerative colitis for about 8 years, this probiotic, coupled with a careful diet, has brought my symptoms under control. I meticulously adjusted my intake, and my symptoms improved significantly. I believe this product has been essential in protecting my colon from ulceration.
Read More
9
Rapid symptom relief
15 people found this helpful
An Amazing Probiotic! After a long round of strong antibiotics for an abscess, my stomach was in turmoil. Despite taking probiotics post-antibiotics, I still felt unwell. However, after just a few days of Saccharomyces Boulardii + MOS, I've noticed substantial improvement. My gut has settled, and I am seeing relief from symptoms associated with my ulcerative colitis.
Read More
9
Supports antibiotic treatment
10 people found this helpful
Saccharomyces Boulardii has numerous advantages. It is the only probiotic I can take alongside antibiotics, which is crucial for preserving my gut flora, especially post-COVID. These fungi don’t colonise our intestines but significantly help to maintain a healthy microflora. It is also effective for ulcers caused by pathogenic strains.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.4
- All Researches
We looked into how the probiotic Saccharomyces boulardii affects the treatment of Helicobacter pylori in Thai patients. In a double-blind study, participants received either a probiotic or placebo with a moxifloxacin-dexlansoprazole therapy.
While the treatment achieved high eradication rates of H. pylori, we found that the addition of the probiotic significantly reduced side effects like nausea and diarrhea compared to those on placebo. This suggests that Saccharomyces boulardii could enhance patient comfort during an effective antibiotic regimen.
While the treatment achieved high eradication rates of H. pylori, we found that the addition of the probiotic significantly reduced side effects like nausea and diarrhea compared to those on placebo. This suggests that Saccharomyces boulardii could enhance patient comfort during an effective antibiotic regimen.
Read More
9
Saccharomyces boulardii aids ulcer treatment
This study examined how Saccharomyces boulardii supernatant (SbS) impacts ulcerative colitis (UC) by activating the FXR-NLRP3 signaling pathway. We used a murine model to assess the effects of SbS compared to a control group.
Our findings showed that SbS not only activated FXR but also suppressed the NLRP3 inflammasome in colonic tissues. It reduced macrophage pyroptosis, a process linked to inflammation. However, the benefits were reversed by an FXR inhibitor, indicating that FXR’s activation is crucial for SbS's effects.
Our findings showed that SbS not only activated FXR but also suppressed the NLRP3 inflammasome in colonic tissues. It reduced macrophage pyroptosis, a process linked to inflammation. However, the benefits were reversed by an FXR inhibitor, indicating that FXR’s activation is crucial for SbS's effects.
Read More
9
Targeted Saccharomyces boulardii benefits ulcerative colitis
We investigated the impact of a targeted delivery system for Saccharomyces boulardii, a probiotic yeast, aimed at treating ulcerative colitis. In our preclinical studies on female mice, we found that this engineered strain significantly improved gut retention time, increasing it by an extra 24-48 hours.
This enhanced delivery led to a dramatic boost in the concentration of the probiotic in the colon, which resulted in notable improvements in colon health markers. Key indicators like colon length and inflammation scores returned to healthier levels, suggesting promising potential for this targeted treatment strategy in managing inflammatory bowel diseases.
This enhanced delivery led to a dramatic boost in the concentration of the probiotic in the colon, which resulted in notable improvements in colon health markers. Key indicators like colon length and inflammation scores returned to healthier levels, suggesting promising potential for this targeted treatment strategy in managing inflammatory bowel diseases.
Read More
9
We explored the effects of Saccharomyces boulardii (Sb) in mice with NSAID-induced enteropathy. Through various assessments, including clinical scores and intestinal analyses, we compared four groups: Control, Indomethacin, Sb, and Sb with Indomethacin.
Mice treated with Sb demonstrated significant improvements in their health compared to those only on indomethacin. Sb not only enhanced the intestinal barrier but also positively influenced gut bacteria, reducing inflammation and damage caused by NSAIDs.
Our findings suggest that Sb could serve as a protective agent against NSAID-related intestinal issues.
Mice treated with Sb demonstrated significant improvements in their health compared to those only on indomethacin. Sb not only enhanced the intestinal barrier but also positively influenced gut bacteria, reducing inflammation and damage caused by NSAIDs.
Our findings suggest that Sb could serve as a protective agent against NSAID-related intestinal issues.
Read More
9
We explored how the probiotic yeast, Saccharomyces boulardii, impacts ulcerative colitis in mice. Through a careful setup, C57BL/6 mice received the treatment for three weeks and were later exposed to a harmful substance to induce the condition.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
Read More
User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Diet and probiotics combo
20 people found this helpful
Just gentle diet with Saccharomyces boulardii has transformed my life. Having ulcerative colitis for about 8 years, this probiotic, coupled with a careful diet, has brought my symptoms under control. I meticulously adjusted my intake, and my symptoms improved significantly. I believe this product has been essential in protecting my colon from ulceration.
Read More
9
Rapid symptom relief
15 people found this helpful
An Amazing Probiotic! After a long round of strong antibiotics for an abscess, my stomach was in turmoil. Despite taking probiotics post-antibiotics, I still felt unwell. However, after just a few days of Saccharomyces Boulardii + MOS, I've noticed substantial improvement. My gut has settled, and I am seeing relief from symptoms associated with my ulcerative colitis.
Read More
9
Supports antibiotic treatment
10 people found this helpful
Saccharomyces Boulardii has numerous advantages. It is the only probiotic I can take alongside antibiotics, which is crucial for preserving my gut flora, especially post-COVID. These fungi don’t colonise our intestines but significantly help to maintain a healthy microflora. It is also effective for ulcers caused by pathogenic strains.
Read More
9
Effective for mouth ulcers
2 people found this helpful
I consistently order this product as it helps restore gut flora post-antibiotics and is indispensable in cases of poisoning. It helped my daughter with her stubborn mouth ulcers within days, making it a staple in our household.
Read More
7.5
Restores gut health
2 people found this helpful
This probiotic has remarkable benefits for the gastrointestinal tract. Saccharomyces Boulardii strengthens immunity and relieves acute diarrhoea. It efficiently tackles antibiotic-associated diarrhoea and aids in the treatment of ulcers caused by Helicobacter pylori.
Read More
Frequently Asked Questions
9
Effective for mouth ulcers
2 people found this helpful
I consistently order this product as it helps restore gut flora post-antibiotics and is indispensable in cases of poisoning. It helped my daughter with her stubborn mouth ulcers within days, making it a staple in our household.
7.5
Significant improvement
3 people found this helpful
I suffer from stomach ulcers, and within a fortnight of using this product, I noticed considerable improvement.
9
Supports antibiotic treatment
10 people found this helpful
Saccharomyces Boulardii has numerous advantages. It is the only probiotic I can take alongside antibiotics, which is crucial for preserving my gut flora, especially post-COVID. These fungi don’t colonise our intestines but significantly help to maintain a healthy microflora. It is also effective for ulcers caused by pathogenic strains.
7.5
Effective against ulcers
Always in my medicine cabinet! Saccharomyces boulardii helps with acute diarrhoea, ulcers, and even irritable bowel syndrome. It reduces spasm, bloating, and pain, while combatting Heliobacter pylori. This product aids in the healing of the intestinal wall, reduces inflammation, and enhances immune function, making it particularly useful after antibiotic use.
7.5
Restores gut health
2 people found this helpful
This probiotic has remarkable benefits for the gastrointestinal tract. Saccharomyces Boulardii strengthens immunity and relieves acute diarrhoea. It efficiently tackles antibiotic-associated diarrhoea and aids in the treatment of ulcers caused by Helicobacter pylori.
7.5
Helps with ulcer
Excellent Saccharomyces boulardii! I purchased it for my mother, who suffers from a stomach ulcer and poor digestion. She feels it helps her, so I have bought it a second time.
9
Improves ulcer recovery
I take this to aid recovery after my stomach ulcer. I've consumed four cans, and my well-being has improved.
7.5
Useful for ulcer
2 people found this helpful
This product is good for those suffering from colon ulcers or Crohn's disease. It is best taken on an empty stomach or before sleep.
9
We explored how the probiotic yeast, Saccharomyces boulardii, impacts ulcerative colitis in mice. Through a careful setup, C57BL/6 mice received the treatment for three weeks and were later exposed to a harmful substance to induce the condition.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
8
Saccharomyces boulardii reduces inflammatory response
We explored the effects of Saccharomyces boulardii on immune cells from patients with ulcerative colitis and Crohn's disease. In our study, we looked at how well this probiotic influences dendritic cells, which are important for immune responses.
Our findings showed that S. boulardii significantly reduced certain inflammatory markers and T cell activity linked to these conditions. It also encouraged mucosal healing, suggesting a potential therapeutic role for this probiotic in managing inflammation related to IBD.
Our findings showed that S. boulardii significantly reduced certain inflammatory markers and T cell activity linked to these conditions. It also encouraged mucosal healing, suggesting a potential therapeutic role for this probiotic in managing inflammation related to IBD.
7
We evaluated how Saccharomyces boulardii, combined with standard triple therapy, influences the eradication of Helicobacter pylori in patients with non-ulcer dyspepsia. In a controlled study of 144 patients, we measured eradication rates and symptom relief after treatment.
While the highest eradication rate was 93.18% in one group, those receiving Saccharomyces boulardii also reported fewer dyspepsia symptoms and experienced less gastrointestinal discomfort. This treatment shows promise in improving both effectiveness and patient comfort in H. pylori eradication.
While the highest eradication rate was 93.18% in one group, those receiving Saccharomyces boulardii also reported fewer dyspepsia symptoms and experienced less gastrointestinal discomfort. This treatment shows promise in improving both effectiveness and patient comfort in H. pylori eradication.
References
- Yang L, Li W, Zhao Q, Mo Q, Liu T, et al. Alleviates Colitis by Regulating FXR-NLRP3 Mediated Macrophage Pyroptosis. J Inflamm Res. 2025;18:3161. 10.2147/JIR.S504957
- Zhang Y, Lu B, Dong Y, Zhang Y, Du Q, et al. Saccharomyces boulardii combined with triple therapy alter the microbiota in the eradication of Helicobacter pylori infection. Sci Rep. 2024;14:13152. 10.1038/s41598-024-63894-z
- Heavey MK, Hazelton A, Wang Y, Garner M, Anselmo AC, et al. Targeted delivery of the probiotic Saccharomyces boulardii to the extracellular matrix enhances gut residence time and recovery in murine colitis. Nat Commun. 2024;15:3784. 10.1038/s41467-024-48128-0
- Simon O'Brien E, Robert A, Gauthier D, Le Cavorzin A, Planchais J, et al. Protective effects of Saccharomyces boulardii CNCM I-745 in an experimental model of NSAID-induced enteropathy. Benef Microbes. 2023;14:239. 10.3920/BM2023.0003
- Gao H, Li Y, Sun J, Xu H, Wang M, et al. Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Regulating NF-B and Nrf2 Signaling Pathways. Oxid Med Cell Longev. 2021;2021:1622375. 10.1155/2021/1622375
- Wang C, Li W, Wang H, Ma Y, Zhao X, et al. Saccharomyces boulardii alleviates ulcerative colitis carcinogenesis in mice by reducing TNF-α and IL-6 levels and functions and by rebalancing intestinal microbiota. BMC Microbiol. 2019;19:246. 10.1186/s12866-019-1610-8
- Lam S, Zuo T, Ho M, Chan FKL, Chan PKS, et al. Review article: fungal alterations in inflammatory bowel diseases. Aliment Pharmacol Ther. 2019;50:1159. 10.1111/apt.15523
- Chotivitayatarakorn P, Mahachai V, Vilaichone RK. Effectiveness of 7-Day and 14-Day Moxifloxacin-Dexlansoprazole Based Triple Therapy and Probiotic Supplement for Helicobacter Pylori Eradication in Thai Patients with Non-Ulcer Dyspepsia: A Double-Blind Randomized Placebo-Controlled Study. Asian Pac J Cancer Prev. 2017;18:2839.
- Ganji-Arjenaki M, Rafieian-Kopaei M. Probiotics are a good choice in remission of inflammatory bowel diseases: A meta analysis and systematic review. J Cell Physiol. 2018;233:2091. 10.1002/jcp.25911
- Thomas S, Metzke D, Schmitz J, Dörffel Y, Baumgart DC. Anti-inflammatory effects of Saccharomyces boulardii mediated by myeloid dendritic cells from patients with Crohn's disease and ulcerative colitis. Am J Physiol Gastrointest Liver Physiol. 2011;301:G1083. 10.1152/ajpgi.00217.2011
- Girard P, Coppé MC, Pansart Y, Gillardin JM. Gastroprotective effect of Saccharomyces boulardii in a rat model of ibuprofen-induced gastric ulcer. Pharmacology. 2010;85:188. 10.1159/000275146
- Duman DG, Bor S, Ozütemiz O, Sahin T, Oğuz D, et al. Efficacy and safety of Saccharomyces boulardii in prevention of antibiotic-associated diarrhoea due to Helicobacterpylori eradication. Eur J Gastroenterol Hepatol. 2005;17:1357.
- Guslandi M, Giollo P, Testoni PA. A pilot trial of Saccharomyces boulardii in ulcerative colitis. Eur J Gastroenterol Hepatol. 2003;15:697.
- Han X, Luo R, Qi S, Wang Y, Dai L, et al. "Dual sensitive supramolecular curcumin nanoparticles" in "advanced yeast particles" mediate macrophage reprogramming, ROS scavenging and inflammation resolution for ulcerative colitis treatment. J Nanobiotechnology. 2023;21:321. 10.1186/s12951-023-01976-2
- Hu Q, Yu L, Zhai Q, Zhao J, Tian F. Anti-Inflammatory, Barrier Maintenance, and Gut Microbiome Modulation Effects of QHNLD8L1 on DSS-Induced Ulcerative Colitis in Mice. Int J Mol Sci. 2023;24. 10.3390/ijms24076721
- Valibouze C, Speca S, Dubuquoy C, Mourey F, M'Ba L, et al. prevents postoperative recurrence of Crohn's disease modeled by ileocecal resection in HLA-B27 transgenic rats. World J Gastroenterol. 2023;29:851. 10.3748/wjg.v29.i5.851
- Magnoli AP, Parada J, de la Torre FC, Watson S, Poloni V, et al. Respiratory tract clinometry, fat thickness, haematology and productive parameters associated with direct-fed microbials used as growth promoter antibiotic alternative in weaned piglets. Vet Anim Sci. 2022;16:100246. 10.1016/j.vas.2022.100246
