Induces Two Types of Dendritic Cell Activation and Effectively Suppresses Onset of the Common Cold: A Randomized, Double-Blind, Placebo-Controlled Trial.
We looked into how GCL1815, a type of lactic acid bacterium, might aid in preventing the common cold. In our randomized, double-blind study with 200 participants, we found that those who took GCL1815 capsules for eight weeks had significantly lower symptoms of colds, like fatigue and nasal congestion, compared to those on placebo. We also observed key immune responses related to dendritic cell activation that were notably more enhanced in participants taking GCL1815. This suggests that GCL1815 is promising in boosting the body’s defenses against the cold.
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5
Lactobacillus impact on immunity
Supplementation with heat-sterilized Lactobacillus crispatus strain KT-11 stimulates the T cell-related immune function of healthy Japanese adults: A pilot randomized, placebo-controlled, double-blind, parallel-group study.
We conducted a pilot study to explore the effects of heat-sterilized Lactobacillus crispatus strain KT-11 on immune function in healthy adults. Over four weeks, 22 participants took either KT-11 or a placebo. We observed that those taking KT-11 had higher counts of certain immune cells and reported fewer cold-like symptoms, particularly fatigue. However, there were no significant increases in antibodies related to SARS-CoV-2. This indicates potential benefits of KT-11 for immune activity, suggesting further studies on its effectiveness are warranted.
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Most Useful Reviews
9
Balances pH levels
10 people found this helpful
Definitely give these a try! I was thrilled to discover these after my GYN suggested probiotic inserts due to my migraines making oral ones impossible. Suffering from chronic infections, this has been the only product that helped balance my pH levels almost immediately. After testing against a new body wash that usually induces infections, I inserted two capsules daily for three days, and my symptoms cleared up completely. They came well packed in cold packs, but just ensure you track your package as they don't mark it as needing refrigeration.
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10
Pain relief achieved
9 people found this helpful
As someone with chronic gynecological issues, I often faced painful secretions. After trying these probiotics, I began taking two pills daily. Remarkably, I felt pain relief the very next day, with no secretions to be found. This solution transformed my experience, allowing me to abandon previous treatments.
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9
Water intake helps
7 people found this helpful
Works! This product is effective. For others suffering from recurring yeast infections, reducing sugars and consuming light carbs has helped me. Drinking plenty of water flushes the bladder, which pairs well with this product. I recommend it to others, especially since ordering from the seller includes overnight shipping in a cold pack!
Induces Two Types of Dendritic Cell Activation and Effectively Suppresses Onset of the Common Cold: A Randomized, Double-Blind, Placebo-Controlled Trial.
We looked into how GCL1815, a type of lactic acid bacterium, might aid in preventing the common cold. In our randomized, double-blind study with 200 participants, we found that those who took GCL1815 capsules for eight weeks had significantly lower symptoms of colds, like fatigue and nasal congestion, compared to those on placebo. We also observed key immune responses related to dendritic cell activation that were notably more enhanced in participants taking GCL1815. This suggests that GCL1815 is promising in boosting the body’s defenses against the cold.
Read More
5
Lactobacillus impact on immunity
Supplementation with heat-sterilized Lactobacillus crispatus strain KT-11 stimulates the T cell-related immune function of healthy Japanese adults: A pilot randomized, placebo-controlled, double-blind, parallel-group study.
We conducted a pilot study to explore the effects of heat-sterilized Lactobacillus crispatus strain KT-11 on immune function in healthy adults. Over four weeks, 22 participants took either KT-11 or a placebo. We observed that those taking KT-11 had higher counts of certain immune cells and reported fewer cold-like symptoms, particularly fatigue. However, there were no significant increases in antibodies related to SARS-CoV-2. This indicates potential benefits of KT-11 for immune activity, suggesting further studies on its effectiveness are warranted.
Read More
User Reviews
USERS' SCORE
Good
Based on 74 Reviews
8.2
All Reviews
Positive Reviews
Negative Reviews
9
Balances pH levels
10 people found this helpful
Definitely give these a try! I was thrilled to discover these after my GYN suggested probiotic inserts due to my migraines making oral ones impossible. Suffering from chronic infections, this has been the only product that helped balance my pH levels almost immediately. After testing against a new body wash that usually induces infections, I inserted two capsules daily for three days, and my symptoms cleared up completely. They came well packed in cold packs, but just ensure you track your package as they don't mark it as needing refrigeration.
Read More
10
Pain relief achieved
9 people found this helpful
As someone with chronic gynecological issues, I often faced painful secretions. After trying these probiotics, I began taking two pills daily. Remarkably, I felt pain relief the very next day, with no secretions to be found. This solution transformed my experience, allowing me to abandon previous treatments.
Read More
9
Water intake helps
7 people found this helpful
Works! This product is effective. For others suffering from recurring yeast infections, reducing sugars and consuming light carbs has helped me. Drinking plenty of water flushes the bladder, which pairs well with this product. I recommend it to others, especially since ordering from the seller includes overnight shipping in a cold pack!
Read More
9
Immediate relief
6 people found this helpful
FINALLY! Something that works!!! I will admit to being a sceptic. Like many, I have tried countless prescriptions, herbal remedies, and cleanses. This is great, and it works almost immediately. The odour vanished within two days along with the other discomforts from BV and yeast. I highly recommend it. I did receive a shipment that was not refrigerated, but I found it can be okay for up to 7 days as long as it remains cold. Now that I've discovered this wonderful product, I never want to be without it again, although I'll purchase from a local shop since they keep it refrigerated.
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9
No more infections
6 people found this helpful
It works! I have dealt with recurrent yeast infections for six months, trying various prescriptions and home remedies without success. After using this product, despite it not being kept cold during shipping, I have had no further infections for over a month. I started taking 2-4 pills daily for the first week, then reduced to one daily. I only give it four stars as there was no option for ice packs during shipping, which could have enhanced potency. Regardless, it works without question!
Cold is a term that refers to a state of low temperature, often associated with a perceptibly chilly environment or the sensation of being cool to the touch. Scientifically, cold is relative to the presence and movement of heat, which is a measure of energy within matter. In everyday terms, we experience cold through weather changes, such as during winter months, and it can also be described in the context of specific temperature ranges – for example, temperatures below 32 degrees Fahrenheit (0 degrees Celsius) generally signify freezing conditions, which can impact outdoor activities, personal comfort, and various ecological systems.
Moreover, the sensation of cold is not solely dependent on temperature; factors like humidity and wind chill can enhance the feeling of coldness. When discussing cold in terms of human health, prolonged exposure to cold conditions can lead to hypothermia or frostbite if body heat is not effectively maintained. Hence, it's crucial to dress appropriately and take necessary precautions during colder months to prevent adverse effects. Understanding the concept of cold can help individuals better prepare for seasonal changes and ensure their comfort and safety.
Lactobacillus is a genus of bacteria that plays a crucial role in the fermentation of various foods and is found naturally in the human gut. Known for their probiotic properties, strains of Lactobacillus are commonly utilized in the production of yogurt, sauerkraut, and other fermented products. They are characterized by their rod-shaped structure and ability to convert sugars into lactic acid, which not only helps preserve food but also contributes to the tangy flavor of fermented foods.
In addition to their culinary uses, Lactobacillus bacteria can offer several health benefits. They are known to support gut health by enhancing the balance of beneficial bacteria in the microbiome, potentially aiding in digestion and alleviating symptoms of issues like irritable bowel syndrome (IBS). Regular consumption of Lactobacillus-containing foods or supplements may also bolster the immune system and improve overall digestive health. With a growing interest in gut health, Lactobacillus remains a key player in both dietary and therapeutic contexts.
Research suggests that certain strains of Lactobacillus, a type of beneficial bacteria found in probiotics, may have a role in supporting immune health and potentially reducing the severity and duration of cold symptoms. Probiotic supplementation, particularly with lactobacilli, has been studied for its ability to enhance the immune response and may help prevent respiratory infections. For instance, some studies indicate that regular intake of Lactobacillus strains could lead to a reduced incidence of upper respiratory tract infections, which are common during cold seasons.
However, it is important to note that while Lactobacillus can support gut health, which is linked to overall immune function, it should not be viewed as a cure or primary treatment for the common cold. It's always best to consult with a healthcare provider when considering probiotics for cold prevention or treatment, as individual responses can vary. Maintaining good hygiene practices, such as handwashing and getting adequate rest, remains essential in cold prevention.
Based on user reviews, many individuals report experiencing noticeable improvements in their cold symptoms within a relatively short time frame. For instance, one reviewer mentioned a significant decline in cold symptoms after just two days of consistent use Read Review. Another user indicated that they saw a marked reduction in their cold symptoms within four days Read Review. Additionally, reviews suggest that with regular intake, improvements can become even more pronounced over time, with one user noting significant reduction in symptoms after one month of consistent use Read Review.
The general consensus among users tends to emphasize the importance of consistent supplementation for the best results. Users have pointed out that maintaining a regular regimen is crucial; those who adhered to a routine reported better outcomes, with improved cold symptoms observed as they continued using the supplement over time Read Review. Overall, while early results may be felt within days, full benefits might take a few weeks to manifest.
Based on recent research, two supplements show promise in combating the common cold. The first, Lactobacillus crispatus KT-11, was tested in a pilot study involving 22 healthy adults over four weeks. Results indicated that participants taking KT-11 experienced fewer cold-like symptoms, particularly fatigue, alongside increased counts of certain immune cells. While the study does not conclude that KT-11 significantly boosts SARS-CoV-2 antibodies, its potential to enhance immune function is noteworthy, warranting further investigation [1].
Another supplement, GCL1815, a type of lactic acid bacterium, has been evaluated in a larger randomized, double-blind study with 200 participants. Those who took GCL1815 capsules for eight weeks exhibited notably reduced cold symptoms, including fatigue and nasal congestion, compared to the placebo group. The study also highlighted enhanced immune responses linked to dendritic cell activation in the GCL1815 group. This suggests that GCL1815 could play a significant role in strengthening the body's defenses against colds [2]. Overall, these findings underline the potential of both KT-11 and GCL1815 as supportive supplements in the fight against cold symptoms.
Based on user reviews, many individuals reported significant improvements in their symptoms after starting to use this product. For example, one user observed a remarkable pain relief and cessation of secretions just a day after beginning their regimen Read Review. Others noted reductions in cold sores and vaginitis cases, with one reviewer even mentioning substantial relief from menstrual cramps when shared with a sibling Read Review. The importance of consistent use is frequently highlighted, as another user shared that after just a month, they experienced a significant decline in their cold symptoms, which was previously accompanied by discoloration Read Review.
Additionally, several users expressed shorter timelines to see results, such as one individual who noticed a considerable reduction in their cold symptoms after only two days of daily consumption Read Review. While a majority reported positive outcomes, individual experiences may vary, with some stating that continuous and regular intake was key to maintaining their symptom relief Read Review. Overall, anecdotal evidence suggests that this product has transformed the experiences of many with various conditions, signifying its potential efficacy.
Users report a generally positive experience when combining this supplement with other probiotics or lactobacillus products for managing cold symptoms. Many individuals mentioned that taking the supplement regularly led to significant decreases in their cold sensations and related symptoms. For example, one user stated, "I feel less cold after consuming this lactobacillus," highlighting its effectiveness and their intention to repurchase Read Review. Another user who was unsure about the specific effects of this supplement mentioned they were also taking regular lactic acid bacteria but still felt a reduction in cold symptoms with consistent use of this product Read Review.
Additionally, users have pointed out that maintaining a regular intake plays a critical role in achieving symptom relief. One reviewer noted a noticeable reduction in their cold discharge, attributing it to consistent use of the product alongside other supplements Read Review. Another user emphasized the importance of sufficient lactobacillus for effective relief, suggesting that for some, combining supplements could enhance results Read Review. Overall, many users advocate for the product's efficacy, with several endorsing its continued use in conjunction with other probiotics for optimal outcomes.
Based on user reviews, the right dose of Lactobacillus for treating cold symptoms varies among individuals. Several users reported significant benefits from taking one to two pills daily. For instance, one user noted that they generally take a single pill each morning, leading to a notable reduction in their cold symptoms over time Read Review. Another user indicated that during periods of severe symptoms, taking two tablets was beneficial, but they usually found one pill sufficient Read Review.
Moreover, consistent use seems crucial, as multiple users emphasized improvement with regular consumption, often after a few weeks of steady intake Read Review. For some, the effects were felt quickly, while others noted that longer-term use yielded greater relief from cold symptoms Read Review. Overall, it appears that both the frequency and dosage greatly influence the results, making individual adjustments necessary based on personal experiences.
9
Immediate effects
The only downside is the scent reminiscent of old cosmetics. However, I've noticed a marked reduction in my cold just two days after starting it. I’ve been taking it consistently, and I believe it’s a commendable product for disease prevention.
9
Effective for cold
14 people found this helpful
The treatment for my yeast infection and cold was very effective. Within four days of taking the medicine, I noted improvements that lasted for about a month. I was pleased with the outcome. It's vital to ensure sufficient Lactobacillus; without it, I wouldn’t recommend buying it as it’s essential for relief.
7.5
Improved cold condition
4 people found this helpful
After a month of use, I have noticed a significant decline in my cold symptoms. I previously experienced discolouration in my cold, but now it improves quickly after consumption. Additionally, my urinary issues seem better, likely due to the probiotics. I intend to keep taking it.
9
Significant cold reduction
2 people found this helpful
After two years of consistent use, I find this product suits me well. I take a pill each morning on an empty stomach. Since starting this routine, my cold symptoms have significantly decreased, improving my overall wellbeing.
10
Pain relief achieved
9 people found this helpful
As someone with chronic gynecological issues, I often faced painful secretions. After trying these probiotics, I began taking two pills daily. Remarkably, I felt pain relief the very next day, with no secretions to be found. This solution transformed my experience, allowing me to abandon previous treatments.
9
Reduced cold sores
2 people found this helpful
By chance, I purchased this product and later ordered it from iHerb. I was pleasantly surprised by the substantial reduction in my cold sores and vaginitis cases. I even recommended it to my brother, who found it helpful for menstrual cramps.
9
Miraculous reduction
I feel less cold after consuming this lactobacillus. It has miraculously reduced my cold sensation. I plan to repurchase it.
9
Less cold feeling
I'm also taking regular lactic acid bacteria, so I'm uncertain if it's from this drug, but I feel I have less cold after consistent use.
9
Significant improvement
I've seen a noticeable reduction in cold discharge! I’ve always dealt with a lot of cold, but this product significantly decreases it. I initially took three pills consistently, and I've been recommending it to others. I am genuinely pleased with the results.
9
Relieved symptoms
1 people found this helpful
I've tried lactic acid bacteria before, but this is the first time I've bought female-specific strains. Depending on my condition, I often experience a lot of cold and some vaginitis symptoms (no itchiness), but since starting this, my cold has become clearer and the vaginitis symptoms have significantly improved. It's essential to take it regularly to prevent recurrence. Initially, I took two tablets when symptoms were severe, but usually, just one suffices. I wish I had discovered this product sooner! Highly recommended for women.
9
Works quickly
I purchased vaginal lactobacillus due to dryness and cold. It's small and easy to swallow, with meticulous packaging. It seems to take effect quickly after steady use for about two weeks.
5
Lactobacillus impact on immunity
Supplementation with heat-sterilized Lactobacillus crispatus strain KT-11 stimulates the T cell-related immune function of healthy Japanese adults: A pilot randomized, placebo-controlled, double-blind, parallel-group study.
We conducted a pilot study to explore the effects of heat-sterilized Lactobacillus crispatus strain KT-11 on immune function in healthy adults. Over four weeks, 22 participants took either KT-11 or a placebo. We observed that those taking KT-11 had higher counts of certain immune cells and reported fewer cold-like symptoms, particularly fatigue. However, there were no significant increases in antibodies related to SARS-CoV-2. This indicates potential benefits of KT-11 for immune activity, suggesting further studies on its effectiveness are warranted.
8
GCL1815 reduces cold symptoms
Induces Two Types of Dendritic Cell Activation and Effectively Suppresses Onset of the Common Cold: A Randomized, Double-Blind, Placebo-Controlled Trial.
We looked into how GCL1815, a type of lactic acid bacterium, might aid in preventing the common cold. In our randomized, double-blind study with 200 participants, we found that those who took GCL1815 capsules for eight weeks had significantly lower symptoms of colds, like fatigue and nasal congestion, compared to those on placebo. We also observed key immune responses related to dendritic cell activation that were notably more enhanced in participants taking GCL1815. This suggests that GCL1815 is promising in boosting the body’s defenses against the cold.
References
Watanabe I, Suzuki N, Takara T. Supplementation with heat-sterilized Lactobacillus crispatus strain KT-11 stimulates the T cell-related immune function of healthy Japanese adults: A pilot randomized, placebo-controlled, double-blind, parallel-group study. Nutr Res. 2025;134:99. 10.1016/j.nutres.2024.12.004
Wada H, Mawatari T, Saito Y, Azuma N, Iwama Y. Induces Two Types of Dendritic Cell Activation and Effectively Suppresses Onset of the Common Cold: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2024;17. 10.3390/nu17010101