5/12/2025
Last update
5/12/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.1
USERS' SCORE
Good
Based on 20 Reviews
8.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Proprietary Probiotic Blend
134 mg (1 Billion CFU§)
†
Lactobacillus rhamnosus (GR-1®)
Lactobacillus reuteri (RC-14®)
Top Medical Research Studies
8
Probiotics effectively prevent UTIs
We evaluated how probiotics could help prevent recurrent urinary tract infections (UTIs) in premenopausal women. In our study, 174 women were randomly assigned to different treatment groups, including a placebo and various probiotic combinations over four months. After tracking symptoms for a year, we found that using vaginal probiotics, alone or combined with oral ones, effectively reduced episodes of symptomatic UTIs. This suggests probiotics may be a promising non-antibiotic approach to managing recurrent UTIs.
Read More
8
We examined how the GAI98322 strain of Lactobacillus crispatus can help in preventing recurrent cystitis. Through tests on its cell-free culture supernatant, we found that it effectively reduces the growth and biofilm formation of various harmful bacteria, including E. coli and Pseudomonas aeruginosa.
This action is facilitated by specific factors, which work independently of traditional antibiotics. While our findings highlight the potential of Lactobacillus in managing recurrent infections, further studies are essential to confirm its effectiveness in clinical settings.
This action is facilitated by specific factors, which work independently of traditional antibiotics. While our findings highlight the potential of Lactobacillus in managing recurrent infections, further studies are essential to confirm its effectiveness in clinical settings.
Read More
8
We explored the use of 3D bioprinted catheters to deliver Lactobacillus rhamnosus as a potential preventative measure against catheter-associated urinary tract infections (CAUTIs). In our assessment, the bioprints successfully supported the growth and viability of L. rhamnosus under simulated urine flow conditions. Remarkably, this probiotic managed to colonize the bladder without causing tissue inflammation.
Our findings suggest that these bioprinted probiotic catheters could be a promising new approach to help combat CAUTIs, offering a safe and effective strategy to reduce pathogen colonization in urinary catheters.
Our findings suggest that these bioprinted probiotic catheters could be a promising new approach to help combat CAUTIs, offering a safe and effective strategy to reduce pathogen colonization in urinary catheters.
Read More
Most Useful Reviews
9
Fast relief
475 people found this helpful
I kicked a stubborn yeast infection after trying multiple treatments and failing. Instead of antifungals, I turned to probiotics, which worked wonders. I’ve been using Femdophilus and it has provided almost immediate relief. I plan to continue with this long-term. Additionally, I've discovered another probiotic that boosts immunity, which is an additional benefit!
Read More
10
No infections since use
163 people found this helpful
The capsules are small and easy to take. They are a legitimate lifesaver. This is the third bottle I have ordered in the past year. I have suffered from constant yeast and bacterial infections for the past six years, and nothing worked. After trying numerous treatments, I consulted a P.A. on 31st December 2015. She recommended this probiotic, claiming it effectively targets yeast infections, bacterial vaginosis, and urinary tract infections. I decided to give it a try, and since starting it, I have not experienced any infections. I take one daily, and even if I occasionally forget, it still proves effective. It’s been nearly a year, and I remain proactive with another purchase. These capsules are easy on my stomach, accommodating my food intolerances. They are absolutely worth it.
Read More
9
Natural support
9 people found this helpful
Fem-Dophilus® is excellent for supporting vaginal and urinary tract health. Its clinically proven probiotic strains promote beneficial bacteria survival in the intestine. I highly recommend it for maintaining vaginal and urinary tract health naturally and effectively.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.1
- All Researches
9
We investigated the effectiveness of probiotics sourced from Bulgarian cheese and shallot yogurt against common bacteria causing urinary tract infections (UTIs).
By isolating 100 strains from clinical samples and testing various probiotic strains, we found that certain probiotics showed encouraging antibacterial and antibiofilm activity.
Notably, strains M and B indicated strong antimicrobial effects without any harmful qualities. While these results are promising, we recognize that further research is essential to fully assess their therapeutic potential for UTIs.
By isolating 100 strains from clinical samples and testing various probiotic strains, we found that certain probiotics showed encouraging antibacterial and antibiofilm activity.
Notably, strains M and B indicated strong antimicrobial effects without any harmful qualities. While these results are promising, we recognize that further research is essential to fully assess their therapeutic potential for UTIs.
Read More
9
We investigated how by-products from Lactobacillus rhamnosus can affect uropathogenic Escherichia coli (UPEC), the bacteria commonly responsible for urinary tract infections (UTIs). Our findings revealed that lactic acid, hydrogen peroxide, and other compounds from these probiotics significantly inhibited the growth of UPEC.
Additionally, they reduced the production of proteins that help the bacteria cling to the urinary tract. This suggests that Lactobacillus rhamnosus and its by-products offer protective benefits against UTIs by combating harmful bacteria and reducing their ability to establish infections.
Additionally, they reduced the production of proteins that help the bacteria cling to the urinary tract. This suggests that Lactobacillus rhamnosus and its by-products offer protective benefits against UTIs by combating harmful bacteria and reducing their ability to establish infections.
Read More
8
Dietary supplement improves UTI outcomes
We examined the effects of a specific supplement, combining Lactobacillus strains with proanthocyanidin-rich extracts from cranberry and cinnamon, on recurrent urinary tract infections (UTIs) in women.
In our controlled study with 80 participants over six months, we compared those taking the supplement to a non-supplemented group.
The results were striking: 64.9% of women on the supplement didn't experience any cystitis episodes, versus just 31.6% of those without. Additionally, the supplement significantly improved symptom severity and quality of life.
In our controlled study with 80 participants over six months, we compared those taking the supplement to a non-supplemented group.
The results were striking: 64.9% of women on the supplement didn't experience any cystitis episodes, versus just 31.6% of those without. Additionally, the supplement significantly improved symptom severity and quality of life.
Read More
8
Probiotics effectively prevent UTIs
We evaluated how probiotics could help prevent recurrent urinary tract infections (UTIs) in premenopausal women. In our study, 174 women were randomly assigned to different treatment groups, including a placebo and various probiotic combinations over four months. After tracking symptoms for a year, we found that using vaginal probiotics, alone or combined with oral ones, effectively reduced episodes of symptomatic UTIs. This suggests probiotics may be a promising non-antibiotic approach to managing recurrent UTIs.
Read More
8
We examined how the GAI98322 strain of Lactobacillus crispatus can help in preventing recurrent cystitis. Through tests on its cell-free culture supernatant, we found that it effectively reduces the growth and biofilm formation of various harmful bacteria, including E. coli and Pseudomonas aeruginosa.
This action is facilitated by specific factors, which work independently of traditional antibiotics. While our findings highlight the potential of Lactobacillus in managing recurrent infections, further studies are essential to confirm its effectiveness in clinical settings.
This action is facilitated by specific factors, which work independently of traditional antibiotics. While our findings highlight the potential of Lactobacillus in managing recurrent infections, further studies are essential to confirm its effectiveness in clinical settings.
Read More
User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Fast relief
475 people found this helpful
I kicked a stubborn yeast infection after trying multiple treatments and failing. Instead of antifungals, I turned to probiotics, which worked wonders. I’ve been using Femdophilus and it has provided almost immediate relief. I plan to continue with this long-term. Additionally, I've discovered another probiotic that boosts immunity, which is an additional benefit!
Read More
10
No infections since use
163 people found this helpful
The capsules are small and easy to take. They are a legitimate lifesaver. This is the third bottle I have ordered in the past year. I have suffered from constant yeast and bacterial infections for the past six years, and nothing worked. After trying numerous treatments, I consulted a P.A. on 31st December 2015. She recommended this probiotic, claiming it effectively targets yeast infections, bacterial vaginosis, and urinary tract infections. I decided to give it a try, and since starting it, I have not experienced any infections. I take one daily, and even if I occasionally forget, it still proves effective. It’s been nearly a year, and I remain proactive with another purchase. These capsules are easy on my stomach, accommodating my food intolerances. They are absolutely worth it.
Read More
9
Natural support
9 people found this helpful
Fem-Dophilus® is excellent for supporting vaginal and urinary tract health. Its clinically proven probiotic strains promote beneficial bacteria survival in the intestine. I highly recommend it for maintaining vaginal and urinary tract health naturally and effectively.
Read More
10
Enhances vaginal flora
2 people found this helpful
Fem-Dophilus® is backed by over 25 years of clinical studies and is free of major allergens. In a clinical trial, 75% of women taking GR-1® and RC-14® probiotics had a significant improvement in vaginal microflora compared to only 34% in the placebo group. This product effectively repopulates the vagina with beneficial microflora and improves urinary tract health.
Read More
8
Supports urinary health
2 people found this helpful
Over 30 years of clinical research confirms the effectiveness of the two patented probiotic strains in Fem-Dophilus®. These strains help balance vaginal microflora and support vaginal and urinary tract health. The special production process protects the strains from stomach acid, improving their survival and transfer to the vaginal tract.
Read More
Frequently Asked Questions
9
Condition greatly improved
Excellent! After taking this probiotic for a month, I feel very well. I used to experience frequent infections that necessitated a doctor's visit. However, since taking this probiotic, my condition has significantly improved, and I rarely feel itchy or uncomfortable. I believe the ingredients in this probiotic are excellent. It comes as a stick, the particles are small and easy to swallow, with no notable taste.
7.5
Easier urination
I use Femdophilus for my urinary tract. Since starting it about two weeks ago, I can now pee much more easily. Previously, I struggled to determine when I needed to go, but after using Femdophilus, I can genuinely feel the difference.
10
Soreness relief
I have struggled with ongoing yeast infections and soreness from long-term medication. I’ve tried various probiotic formulas and recently discovered specific strains beneficial for intimate area health, which this product contains. Initially starting with two capsules a day, I increased to three when I wasn’t seeing much improvement. Two days after increasing, all soreness, itching, and stinging vanished. Being a tall woman, I assume the two capsules weren't effective enough for me, but three proved beneficial.
10
No more recurrences
1 people found this helpful
Repurchasing it again! I've had my fair share of UTIs and wanted to improve my women's health. Having taken this supplement for almost a year now, I’m thrilled that my UTI hasn't recurred since! (fingers crossed!) Not only does it benefit my urinary tract health, but it also aids my digestion and gut health. I must emphasise that I’ve made concerted efforts to exercise, eat healthily, and practise good hygiene to ensure its effectiveness.
10
Enhances vaginal flora
2 people found this helpful
Fem-Dophilus® is backed by over 25 years of clinical studies and is free of major allergens. In a clinical trial, 75% of women taking GR-1® and RC-14® probiotics had a significant improvement in vaginal microflora compared to only 34% in the placebo group. This product effectively repopulates the vagina with beneficial microflora and improves urinary tract health.
7.5
Positive gut health
5 people found this helpful
This probiotic supplement contains both Lacticaseibacillus and Reuteri known to boost immunity. After nearly a month of use, I’ve noticed a significant improvement in my stomach health! I previously experienced frequent urination, but that has now improved. The intrauterine flora seems to have benefitted as well from just one daily tablet.
8
Dietary supplement improves UTI outcomes
We examined the effects of a specific supplement, combining Lactobacillus strains with proanthocyanidin-rich extracts from cranberry and cinnamon, on recurrent urinary tract infections (UTIs) in women.
In our controlled study with 80 participants over six months, we compared those taking the supplement to a non-supplemented group.
The results were striking: 64.9% of women on the supplement didn't experience any cystitis episodes, versus just 31.6% of those without. Additionally, the supplement significantly improved symptom severity and quality of life.
In our controlled study with 80 participants over six months, we compared those taking the supplement to a non-supplemented group.
The results were striking: 64.9% of women on the supplement didn't experience any cystitis episodes, versus just 31.6% of those without. Additionally, the supplement significantly improved symptom severity and quality of life.
8
We examined the potential of Lactobacillus probiotics to fend off recurrent urinary tract infections (UTIs) in females. By analyzing nine clinical trials involving 726 patients, we found that certain strains, particularly Lactobacillus rhamnosus and Lactobacillus reuteri, might effectively reduce the risk of recurrent UTIs.
While results are promising, with a notably lower risk ratio of recurrent episodes, it's important to note the presence of significant variability between studies and short follow-up times. This calls for further, more rigorous research to confirm these benefits and establish standardized practices in the future.
While results are promising, with a notably lower risk ratio of recurrent episodes, it's important to note the presence of significant variability between studies and short follow-up times. This calls for further, more rigorous research to confirm these benefits and establish standardized practices in the future.
8
We explored whether locally isolated strains of Lactobacillus bacteria could help tackle antibiotic-resistant bacteria responsible for urinary tract infections (UTIs). By screening lactic acid bacteria from spoiled fruits and vegetables, we found that these Lactobacillus strains demonstrated antimicrobial activity against most of the tested uropathogens.
Specifically, Lactobacillus rhamnosus and other isolates inhibited the growth of several harmful bacteria effectively. This indicates that Lactobacillus might serve as a natural approach to support UTI prevention and control, especially in an era of rising antibiotic resistance.
Specifically, Lactobacillus rhamnosus and other isolates inhibited the growth of several harmful bacteria effectively. This indicates that Lactobacillus might serve as a natural approach to support UTI prevention and control, especially in an era of rising antibiotic resistance.
7
We examined whether probiotics could prevent urinary tract infections (UTIs) in premenopausal women, given the rise in antibiotic resistance. By reviewing existing studies from 2001 to 2021 that compared probiotics to a placebo, we aimed to find out how effective these supplements are at reducing UTI recurrence.
Unfortunately, our analysis revealed no significant benefit of probiotics in preventing UTIs in this group. This suggests that, while investigating alternatives is crucial, probiotics may not be the solution we hoped for in addressing recurrent UTIs.
Unfortunately, our analysis revealed no significant benefit of probiotics in preventing UTIs in this group. This suggests that, while investigating alternatives is crucial, probiotics may not be the solution we hoped for in addressing recurrent UTIs.
References
- Ait Abdellah S, Leblanc A, Dauchet Q, Blondeau C, Bohbot JM. Effects of a supplement associating strains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, controlled study. Investig Clin Urol. 2025;66:36. 10.4111/icu.20240092
- Amigh P, Ahmadi Y, Mohkam M, Shokri D. Antimicrobial Potential of Probiotic Strains From Bulgarian Cheese and Shallot Yogurt Against . Biomed Res Int. 2024;2024:2978083. 10.1155/2024/2978083
- Bimbatti KF, Rocha RDS, Braido IZ, Lima IC, Benoso P, et al. Development and evaluation of fermented milk with Lactobacillus acidophilus added to concentrated cranberry (Vaccinium macrocarpon) juice with the potential to minimize the recurrence of urinary tract infections. Food Res Int. 2024;195:114997. 10.1016/j.foodres.2024.114997
- Daniel M, Szymanik-Grzelak H, Sierdziński J, Pańczyk-Tomaszewska M. PL1 and PM1 versus Placebo as Prophylaxis for Recurrence of Urinary Tract Infections in Children. Microorganisms. 2024;12. 10.3390/microorganisms12061037
- Gupta V, Mastromarino P, Garg R. Effectiveness of Prophylactic Oral and/or Vaginal Probiotic Supplementation in the Prevention of Recurrent Urinary Tract Infections: A Randomized, Double-Blind, Placebo-Controlled Trial. Clin Infect Dis. 2024;78:1154. 10.1093/cid/ciad766
- Shoureshi PS, Niino C, Eilber KS. Can vaginal lactobacillus suppositories help reduce urinary tract infections?. Int Urogynecol J. 2023;34:2713. 10.1007/s00192-023-05568-4
- Watanabe T, Sadahira T, Hirakawa H, Huang P, Zhou T, et al. Exploration of the protein-dependent mechanism of Lactobacillus crispatus GAI98322 to prevent recurrent cystitis. J Infect Chemother. 2023;29:1001. 10.1016/j.jiac.2023.06.013
- Das S, Konwar BK. Prophylactic application of vaginal lactic acid bacteria against urogenital pathogens and its prospective use in sanitary suppositories. Int Microbiol. 2024;27:179. 10.1007/s10123-023-00376-8
- Meštrović Popovič K, Povalej Bržan P, Langerholc T, Marčun Varda N. The Impact of Lactobacillus Plantarum PCS26 Supplementation on the Treatment and Recurrence of Urinary Tract Infections in Children-A Pilot Study. J Clin Med. 2022;11. 10.3390/jcm11237008
- Soltani N, Abbasi S, Baghaeifar S, Taheri E, Farhoudi Sefidan Jadid M, et al. Antibacterial and antibiofilm activity of Lactobacillus strains secretome and extraction against isolated from urinary tract infection. Biotechnol Rep (Amst). 2022;36:e00760. 10.1016/j.btre.2022.e00760
- Emami E, Mt Sherwin C, Heidari-Soureshjani S. Effect of Probiotics on Urinary Tract Infections in Children: A Systematic Review and Meta-Analysis. Curr Rev Clin Exp Pharmacol. 2023;19:111. 10.2174/2772432817666220501114505
- Abdullatif VA, Sur RL, Eshaghian E, Gaura KA, Goldman B, et al. Efficacy of Probiotics as Prophylaxis for Urinary Tract Infections in Premenopausal Women: A Systematic Review and Meta-Analysis. Cureus. 2021;13:e18843. 10.7759/cureus.18843
- Kyser AJ, Greiner A, Harris V, Patel R, Frieboes HB, et al. 3D-Bioprinted Urinary Catheters Enable Sustained Probiotic Recovery Under Flow and Improve Bladder Colonization In Vivo. Probiotics Antimicrob Proteins. 2025. 10.1007/s12602-024-10428-8
- Ghane M, Babaeekhou L, Ketabi SS. Antibiofilm Activity of Kefir Probiotic Lactobacilli Against Uropathogenic (UPEC). Avicenna J Med Biotechnol. 2020;12:221.
- Sadeghi-Bojd S, Naghshizadian R, Mazaheri M, Ghane Sharbaf F, Assadi F. Efficacy of Probiotic Prophylaxis After The First Febrile Urinary Tract Infection in Children With Normal Urinary Tracts. J Pediatric Infect Dis Soc. 2020;9:305. 10.1093/jpids/piz025
- Toh SL, Lee BB, Ryan S, Simpson JM, Clezy K, et al. Probiotics [LGG-BB12 or RC14-GR1] versus placebo as prophylaxis for urinary tract infection in persons with spinal cord injury [ProSCIUTTU]: a randomised controlled trial. Spinal Cord. 2019;57:550. 10.1038/s41393-019-0251-y
- Kara SS, Volkan B, Erten I. GG can protect malnourished children. Benef Microbes. 2019;10:237. 10.3920/BM2018.0071
- Ng QX, Peters C, Venkatanarayanan N, Goh YY, Ho CYX, et al. Use of Lactobacillus spp. to prevent recurrent urinary tract infections in females. Med Hypotheses. 2018;114:49. 10.1016/j.mehy.2018.03.001
- Shim YH, Lee SJ, Lee JW. Antimicrobial activity of lactobacillus strains against uropathogens. Pediatr Int. 2016;58:1009. 10.1111/ped.12949
- Montorsi F, Gandaglia G, Salonia A, Briganti A, Mirone V. Effectiveness of a Combination of Cranberries, Lactobacillus rhamnosus, and Vitamin C for the Management of Recurrent Urinary Tract Infections in Women: Results of a Pilot Study. Eur Urol. 2016;70:912. 10.1016/j.eururo.2016.05.042
- Manzoor A, Ul-Haq I, Baig S, Qazi JI, Seratlic S. Efficacy of Locally Isolated Lactic Acid Bacteria Against Antibiotic-Resistant Uropathogens. Jundishapur J Microbiol. 2016;9:e18952. 10.5812/jjm.18952
- Lee JW, Lee JH, Sung SH, Lee SJ. Preventive effects of Lactobacillus mixture on experimental E. coli urinary tract infection in infant rats. Yonsei Med J. 2013;54:489. 10.3349/ymj.2013.54.2.489
- Beerepoot MA, ter Riet G, Nys S, van der Wal WM, de Borgie CA, et al. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Arch Intern Med. 2012;172:704. 10.1001/archinternmed.2012.777
- Karlsson M, Scherbak N, Khalaf H, Olsson PE, Jass J. Substances released from probiotic Lactobacillus rhamnosus GR-1 potentiate NF-κB activity in Escherichia coli-stimulated urinary bladder cells. FEMS Immunol Med Microbiol. 2012;66:147. 10.1111/j.1574-695X.2012.00994.x
- Cadieux PA, Burton J, Devillard E, Reid G. Lactobacillus by-products inhibit the growth and virulence of uropathogenic Escherichia coli. J Physiol Pharmacol. 2009;60 Suppl 6:13.
- Anukam KC, Hayes K, Summers K, Reid G. Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 may help downregulate TNF-Alpha, IL-6, IL-8, IL-10 and IL-12 (p70) in the neurogenic bladder of spinal cord injured patient with urinary tract infections: a two-case study. Adv Urol. 2009;2009:680363. 10.1155/2009/680363
- Falagas ME, Betsi GI, Tokas T, Athanasiou S. Probiotics for prevention of recurrent urinary tract infections in women: a review of the evidence from microbiological and clinical studies. Drugs. 2006;66:1253.
