I have struggled with elevated liver enzymes on and off for a couple of years. I have Rheumatoid arthritis and the medications I have been a contributing factor, along with the arthritis itself. About 18 months ago, my liver enzymes skyrocketed. Even after discontinuing methotrexate, enzymes remained very elevated for months afterward - not good for someone who requires multiple daily medications and will for the rest of her life. The wait-and-see approach was not working for me - I needed to do something to prevent permanent liver damage. After doing some research, I read about milk thistle and it looked like a good option. After checking with my docs and pharmacists to make sure it was safe, I ordered Jarrow's Formulas Milk Thistle. After taking the milk thistle for 2 months, all but one of my liver enzymes were in the normal range. The one that was still elevated had dropped significantly. After 4 months, all of my liver enzymes are normal! I have not had any elevated liver enzymes since. The price for the quantity and quality of this milk thistle supplement is amazing. I highly recommend it and will be a customer for life