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SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.3
USERS' SCORE
Good
Based on 6 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
Curcumin derivative shows Alzheimer's promise
New low-dose curcumin derivative with therapeutic potential in Alzheimer's disease: Results from an in vitro and in vivo study in mice.
Highly relevant to Alzheimer's treatment
We examined the potential of a curcumin derivative, known as Derivative 27, to treat Alzheimer's disease (AD). Curcumin, a compound found in turmeric, has previously been recognized for its ability to interfere with amyloid-β (Aβ) peptide aggregates, a hallmark of AD. The study focused on enhancing curcumin's effectiveness at lower doses, aiming to make treatment more accessible for patients.
Through rigorous testing, both in vitro and in vivo, we evaluated the anti-inflammatory, antioxidant, and anti-amyloidogenic properties of Derivative 27. In laboratory settings, the compound showed impressive results by significantly reducing the production of nitric oxide and various pro-inflammatory proteins. Additionally, it activated a key protective transcription factor known as Nrf2, illustrating its potential to combat neuroinflammation.
In a more practical application, we tested Derivative 27 on one-year-old APP/PS1 mice, a model for Alzheimer's. After administering the treatment daily for 28 days, we observed improvements in the mice's short-term spatial memory. Significant reductions in hippocampal pro-inflammatory markers and Aβ levels were also noted, supporting the idea that this new curcumin derivative could be beneficial in the fight against Alzheimer’s.
Overall, this research opens the door to developing modified curcumin compounds that could lead to effective low-dose treatments for Alzheimer's disease, all while highlighting the therapeutic potential of turmeric derivatives in neurodegenerative conditions.
Through rigorous testing, both in vitro and in vivo, we evaluated the anti-inflammatory, antioxidant, and anti-amyloidogenic properties of Derivative 27. In laboratory settings, the compound showed impressive results by significantly reducing the production of nitric oxide and various pro-inflammatory proteins. Additionally, it activated a key protective transcription factor known as Nrf2, illustrating its potential to combat neuroinflammation.
In a more practical application, we tested Derivative 27 on one-year-old APP/PS1 mice, a model for Alzheimer's. After administering the treatment daily for 28 days, we observed improvements in the mice's short-term spatial memory. Significant reductions in hippocampal pro-inflammatory markers and Aβ levels were also noted, supporting the idea that this new curcumin derivative could be beneficial in the fight against Alzheimer’s.
Overall, this research opens the door to developing modified curcumin compounds that could lead to effective low-dose treatments for Alzheimer's disease, all while highlighting the therapeutic potential of turmeric derivatives in neurodegenerative conditions.
Read More
9
Ar-turmerone shows neuroprotective promise
Structural optimization of naturally derived Ar-turmerone, as novel neuroinflammation suppressors effective in an Alzheimer mouse model.
Highly relevant to Alzheimer's treatment
We set out to understand the potential of turmeric, particularly a compound called ar-turmerone, in combating Alzheimer's disease. Our research focused on how ar-turmerone could address neuroinflammation, a key factor in Alzheimer’s and other neurodegenerative diseases.
Through our study, we synthesized various derivatives of ar-turmerone and tested their effects on microglia, the brain's immune cells. We observed that certain modified versions, specifically naphthyl-substituted and N-substituted amides, showed strong abilities to inhibit the release of proinflammatory substances like NO, TNF-α, and IL-1β in lab settings.
When we moved to a more complex model involving mice with neuroinflammation mimicked by lipopolysaccharide (LPS), these compounds did not only reduce harmful cytokine levels. They also exhibited protective benefits for neurons and improved memory and cognitive functions, as demonstrated in the Morris water maze tests.
Overall, this research underlines the potential of ar-turmerone derivatives as powerful agents against neuroinflammation linked to Alzheimer's disease, paving the way for future therapeutic options derived from natural sources like turmeric.
Through our study, we synthesized various derivatives of ar-turmerone and tested their effects on microglia, the brain's immune cells. We observed that certain modified versions, specifically naphthyl-substituted and N-substituted amides, showed strong abilities to inhibit the release of proinflammatory substances like NO, TNF-α, and IL-1β in lab settings.
When we moved to a more complex model involving mice with neuroinflammation mimicked by lipopolysaccharide (LPS), these compounds did not only reduce harmful cytokine levels. They also exhibited protective benefits for neurons and improved memory and cognitive functions, as demonstrated in the Morris water maze tests.
Overall, this research underlines the potential of ar-turmerone derivatives as powerful agents against neuroinflammation linked to Alzheimer's disease, paving the way for future therapeutic options derived from natural sources like turmeric.
Read More
8
Curcumin inhibits Aβ toxicity
Novel role of curcumin as inhibitor of β-amyloid-induced lamin fragmentation.
Highly relevant to Alzheimer's treatment
We examined how curcumin, a compound found in turmeric, affects the damaging effects of amyloid beta (Aβ), a protein linked to Alzheimer’s disease. Our research focused on understanding how curcumin can inhibit the harmful processes caused by Aβ, particularly the fragmentation of nuclear lamin and cell death.
Using human neuroblastoma cells, we observed that curcumin significantly reduced Aβ aggregation and decreased the uptake of this toxic protein by 45%. By preventing the increase in intracellular calcium levels triggered by Aβ, curcumin was able to lower the activity of an enzyme called cathepsin L, which is involved in lamin fragmentation.
The combination of these effects ultimately blocked the Aβ-induced destruction of lamin structures in the cells, which supports their vitality. Overall, our findings suggest that curcumin could be a promising option for protecting brain cells from Alzheimer’s-related damage, offering hope for future treatment strategies.
Using human neuroblastoma cells, we observed that curcumin significantly reduced Aβ aggregation and decreased the uptake of this toxic protein by 45%. By preventing the increase in intracellular calcium levels triggered by Aβ, curcumin was able to lower the activity of an enzyme called cathepsin L, which is involved in lamin fragmentation.
The combination of these effects ultimately blocked the Aβ-induced destruction of lamin structures in the cells, which supports their vitality. Overall, our findings suggest that curcumin could be a promising option for protecting brain cells from Alzheimer’s-related damage, offering hope for future treatment strategies.
Read More
Most Useful Reviews
9.5
Alzheimer prevention
A highly recommended product! This well-known brand provides quality ingredients, offering a capsule a day that potentially helps prevent Alzheimer's and cancer.
Read More
9.5
Supports Alzheimer's treatment
Turmeric is a powerful natural remedy, being used for over 2,500 years for its healing properties. Studies indicate it can aid in treating various conditions, including Alzheimer's disease. I consume Turmeric in cycles, and I believe it’s an invaluable supplement!
Read More
9.5
Alzheimer support
Excellent turmeric! The quality is superb and the results are noticeable quickly! Turmeric, rich in curcumin and various vitamins and minerals, is said to combat Alzheimer's disease. It may also help reduce swelling and block cancer cells while promoting overall health.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.3
9
Turmeric aids Alzheimer’s treatment
Curcuma wenyujin extract alleviates cognitive deficits and restrains pyroptosis through PINK1/Parkin mediated autophagy in Alzheimer's disease.
Study evaluates turmeric’s effectiveness
We explored the effects of Curcuma wenyujin extract, commonly known as turmeric, on Alzheimer's disease (AD) using a methodical approach. The research centered on how this traditional medicine could potentially improve cognitive function and combat the negative processes associated with AD.
To investigate these effects, mice that were induced with amyloid-beta (Aβ) to mimic AD received daily treatments with turmeric extracts for three weeks. We assessed their cognitive abilities through various behavioral tests and employed proteomics analysis to identify the therapeutic targets impacted by the extract.
Our findings revealed that the ethyl acetate fraction of turmeric showed the most promise in treating Alzheimer's. The treatment not only enhanced memory and cognition in the mice but also contributed to better neuronal health and reduced amyloid accumulation in the brain. Importantly, we observed that turmeric helped lower inflammation and promoted processes like mitophagy, key for cell health, through the activation of the PINK1/Parkin pathway.
To investigate these effects, mice that were induced with amyloid-beta (Aβ) to mimic AD received daily treatments with turmeric extracts for three weeks. We assessed their cognitive abilities through various behavioral tests and employed proteomics analysis to identify the therapeutic targets impacted by the extract.
Our findings revealed that the ethyl acetate fraction of turmeric showed the most promise in treating Alzheimer's. The treatment not only enhanced memory and cognition in the mice but also contributed to better neuronal health and reduced amyloid accumulation in the brain. Importantly, we observed that turmeric helped lower inflammation and promoted processes like mitophagy, key for cell health, through the activation of the PINK1/Parkin pathway.
Read More
9
Curcumin derivative shows Alzheimer's promise
New low-dose curcumin derivative with therapeutic potential in Alzheimer's disease: Results from an in vitro and in vivo study in mice.
Highly relevant to Alzheimer's treatment
We examined the potential of a curcumin derivative, known as Derivative 27, to treat Alzheimer's disease (AD). Curcumin, a compound found in turmeric, has previously been recognized for its ability to interfere with amyloid-β (Aβ) peptide aggregates, a hallmark of AD. The study focused on enhancing curcumin's effectiveness at lower doses, aiming to make treatment more accessible for patients.
Through rigorous testing, both in vitro and in vivo, we evaluated the anti-inflammatory, antioxidant, and anti-amyloidogenic properties of Derivative 27. In laboratory settings, the compound showed impressive results by significantly reducing the production of nitric oxide and various pro-inflammatory proteins. Additionally, it activated a key protective transcription factor known as Nrf2, illustrating its potential to combat neuroinflammation.
In a more practical application, we tested Derivative 27 on one-year-old APP/PS1 mice, a model for Alzheimer's. After administering the treatment daily for 28 days, we observed improvements in the mice's short-term spatial memory. Significant reductions in hippocampal pro-inflammatory markers and Aβ levels were also noted, supporting the idea that this new curcumin derivative could be beneficial in the fight against Alzheimer’s.
Overall, this research opens the door to developing modified curcumin compounds that could lead to effective low-dose treatments for Alzheimer's disease, all while highlighting the therapeutic potential of turmeric derivatives in neurodegenerative conditions.
Through rigorous testing, both in vitro and in vivo, we evaluated the anti-inflammatory, antioxidant, and anti-amyloidogenic properties of Derivative 27. In laboratory settings, the compound showed impressive results by significantly reducing the production of nitric oxide and various pro-inflammatory proteins. Additionally, it activated a key protective transcription factor known as Nrf2, illustrating its potential to combat neuroinflammation.
In a more practical application, we tested Derivative 27 on one-year-old APP/PS1 mice, a model for Alzheimer's. After administering the treatment daily for 28 days, we observed improvements in the mice's short-term spatial memory. Significant reductions in hippocampal pro-inflammatory markers and Aβ levels were also noted, supporting the idea that this new curcumin derivative could be beneficial in the fight against Alzheimer’s.
Overall, this research opens the door to developing modified curcumin compounds that could lead to effective low-dose treatments for Alzheimer's disease, all while highlighting the therapeutic potential of turmeric derivatives in neurodegenerative conditions.
Read More
9
Curcumin potentially aids Alzheimer's therapy
Modulation of β secretase and neuroinflammation by biomimetic nanodelivery system for Alzheimer's disease therapy.
Curcumin's role in combination therapy
We investigated the multifaceted effects of a biomimetic nanodelivery system designed to tackle Alzheimer’s disease (AD), particularly focusing on the role of curcumin. This inventive system employs a peptide derived from amyloid-β to enhance its effectiveness in crossing the blood-brain barrier.
By loading curcumin with other agents into these nanocarriers, we observed a significant decrease in β secretase expression. This is crucial because β secretase plays a critical role in the production of amyloid-β, the toxic peptide that accumulates in the brains of AD patients.
Moreover, the nanodelivery system demonstrated remarkable antioxidant and anti-inflammatory properties that helped to restore normal microglial activity. Normalizing microglial function is essential as these cells are vital for maintaining brain health and combating inflammation.
After treatment with the nanocarrier system containing curcumin, we noted significant improvements in measures of Aβ burden, neuron health, and overall cognitive function in transgenic AD mice. Overall, the combination of curcumin with innovative delivery methods shows promise as a multi-target strategy against early Alzheimer's disease.
By loading curcumin with other agents into these nanocarriers, we observed a significant decrease in β secretase expression. This is crucial because β secretase plays a critical role in the production of amyloid-β, the toxic peptide that accumulates in the brains of AD patients.
Moreover, the nanodelivery system demonstrated remarkable antioxidant and anti-inflammatory properties that helped to restore normal microglial activity. Normalizing microglial function is essential as these cells are vital for maintaining brain health and combating inflammation.
After treatment with the nanocarrier system containing curcumin, we noted significant improvements in measures of Aβ burden, neuron health, and overall cognitive function in transgenic AD mice. Overall, the combination of curcumin with innovative delivery methods shows promise as a multi-target strategy against early Alzheimer's disease.
Read More
9
Ar-turmerone shows neuroprotective promise
Structural optimization of naturally derived Ar-turmerone, as novel neuroinflammation suppressors effective in an Alzheimer mouse model.
Highly relevant to Alzheimer's treatment
We set out to understand the potential of turmeric, particularly a compound called ar-turmerone, in combating Alzheimer's disease. Our research focused on how ar-turmerone could address neuroinflammation, a key factor in Alzheimer’s and other neurodegenerative diseases.
Through our study, we synthesized various derivatives of ar-turmerone and tested their effects on microglia, the brain's immune cells. We observed that certain modified versions, specifically naphthyl-substituted and N-substituted amides, showed strong abilities to inhibit the release of proinflammatory substances like NO, TNF-α, and IL-1β in lab settings.
When we moved to a more complex model involving mice with neuroinflammation mimicked by lipopolysaccharide (LPS), these compounds did not only reduce harmful cytokine levels. They also exhibited protective benefits for neurons and improved memory and cognitive functions, as demonstrated in the Morris water maze tests.
Overall, this research underlines the potential of ar-turmerone derivatives as powerful agents against neuroinflammation linked to Alzheimer's disease, paving the way for future therapeutic options derived from natural sources like turmeric.
Through our study, we synthesized various derivatives of ar-turmerone and tested their effects on microglia, the brain's immune cells. We observed that certain modified versions, specifically naphthyl-substituted and N-substituted amides, showed strong abilities to inhibit the release of proinflammatory substances like NO, TNF-α, and IL-1β in lab settings.
When we moved to a more complex model involving mice with neuroinflammation mimicked by lipopolysaccharide (LPS), these compounds did not only reduce harmful cytokine levels. They also exhibited protective benefits for neurons and improved memory and cognitive functions, as demonstrated in the Morris water maze tests.
Overall, this research underlines the potential of ar-turmerone derivatives as powerful agents against neuroinflammation linked to Alzheimer's disease, paving the way for future therapeutic options derived from natural sources like turmeric.
Read More
9
Curcumin shows promise in AD treatment
Intranasal Delivery of Pure Nanodrug Loaded Liposomes for Alzheimer's Disease Treatment by Efficiently Regulating Microglial Polarization.
Moderate effect of curcumin observed
We explored a promising approach for treating Alzheimer’s disease (AD) by focusing on how curcumin, a component of turmeric, could help regulate inflammatory responses in the brain. The study turned its gaze towards the challenge presented by activated microglia, specifically those adopting a pro-inflammatory M1-like state.
To tackle this, researchers developed carrier-free curcumin nanoparticles (CNPs) that bind effectively to harmful amyloid-β (Aβ) aggregates. This self-assembly nature of curcumin allows for more robust inhibition of Aβ aggregation compared to free curcumin alone. The excitement continued as these curcumin nanoparticles were loaded into cardiolipin liposomes, designed to release their contents at the site of inflammation.
After administering these liposomes through the nasal route, they break down in the oxidative environment of AD, unleashing the CNPs. These CNPs not only reduce Aβ aggregation but also promote its clearance by microglia. This dual action clears the way for microglial reprogramming—shifting them from a harmful M1 state to a beneficial M2 state, thus combating neuroinflammation.
Moreover, cardiolipin was found to play a supportive role in normalizing microglial behavior, making sure that pro-inflammatory substances are kept in check. In tests conducted on AD transgenic mice, improvements were noted in terms of reduced neuroinflammation and memory issues following treatment. Overall, this delivery system shows significant potential for polarizing microglia and offers a compelling strategy for addressing Alzheimer’s disease.
To tackle this, researchers developed carrier-free curcumin nanoparticles (CNPs) that bind effectively to harmful amyloid-β (Aβ) aggregates. This self-assembly nature of curcumin allows for more robust inhibition of Aβ aggregation compared to free curcumin alone. The excitement continued as these curcumin nanoparticles were loaded into cardiolipin liposomes, designed to release their contents at the site of inflammation.
After administering these liposomes through the nasal route, they break down in the oxidative environment of AD, unleashing the CNPs. These CNPs not only reduce Aβ aggregation but also promote its clearance by microglia. This dual action clears the way for microglial reprogramming—shifting them from a harmful M1 state to a beneficial M2 state, thus combating neuroinflammation.
Moreover, cardiolipin was found to play a supportive role in normalizing microglial behavior, making sure that pro-inflammatory substances are kept in check. In tests conducted on AD transgenic mice, improvements were noted in terms of reduced neuroinflammation and memory issues following treatment. Overall, this delivery system shows significant potential for polarizing microglia and offers a compelling strategy for addressing Alzheimer’s disease.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Alzheimer prevention
A highly recommended product! This well-known brand provides quality ingredients, offering a capsule a day that potentially helps prevent Alzheimer's and cancer.
9.5
Supports Alzheimer's treatment
Turmeric is a powerful natural remedy, being used for over 2,500 years for its healing properties. Studies indicate it can aid in treating various conditions, including Alzheimer's disease. I consume Turmeric in cycles, and I believe it’s an invaluable supplement!
9.5
Alzheimer support
Excellent turmeric! The quality is superb and the results are noticeable quickly! Turmeric, rich in curcumin and various vitamins and minerals, is said to combat Alzheimer's disease. It may also help reduce swelling and block cancer cells while promoting overall health.
8.8
Memory improvement
Curcumin is known for its powerful antioxidant and anti-inflammatory properties. It may help improve memory in individuals with Alzheimer's, along with assisting in depression by boosting serotonin and dopamine levels. Although curcumin is not easily absorbed without fats, pairing it with black pepper can enhance absorption significantly. While it may also aid various health conditions, scientific evidence for memory improvement remains inconclusive.
Read More
8.8
Alzheimer prevention
The benefits of curcumin are remarkable! It alleviates inflammation, possesses antioxidant properties, enhances brain function, reduces heart disease risk, lowers cancer chances, and may help prevent Alzheimer's. I've started taking it to see if it truly works!
