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SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
Curcumin nanoparticles reduce asthma effects
Effect of curcumin nanoparticles on proliferation and migration of mouse airway smooth muscle cells and airway inflammatory infiltration.
Direct investigation of curcumin's impact
We set out to understand how turmeric, specifically its active component curcumin, can affect asthma-related issues in airway smooth muscle cells. To do this, we leveraged curcumin-loaded nanoparticles (CUR-NPs) which enhance the delivery and effectiveness of curcumin, overcoming its natural hurdles like hydrophobicity and instability.
In our study, we isolated airway smooth muscle cells from mice and subjected them to a process that mimics conditions present during asthma attacks, specifically looking at how these cells proliferate and migrate under the influence of a growth factor called TGF-β1. Our observations revealed that CUR-NPs significantly reduced the excessive cell growth and movement that TGF-β1 induces.
Not only did CUR-NPs appear to regulate curcumin’s release effectively, but they also inhibited key pathways involved in inflammation and remodeling of the airways. We also validated our findings using an asthma model in mice, where CUR-NPs treatment visibly reduced inflammatory markers in lung tissue compared to untreated control groups.
Overall, our research suggests that turmeric, through its nanoparticles form, may hold promise as a therapeutic approach for managing asthma by preventing the excessive growth and migration of airway smooth muscle cells.
In our study, we isolated airway smooth muscle cells from mice and subjected them to a process that mimics conditions present during asthma attacks, specifically looking at how these cells proliferate and migrate under the influence of a growth factor called TGF-β1. Our observations revealed that CUR-NPs significantly reduced the excessive cell growth and movement that TGF-β1 induces.
Not only did CUR-NPs appear to regulate curcumin’s release effectively, but they also inhibited key pathways involved in inflammation and remodeling of the airways. We also validated our findings using an asthma model in mice, where CUR-NPs treatment visibly reduced inflammatory markers in lung tissue compared to untreated control groups.
Overall, our research suggests that turmeric, through its nanoparticles form, may hold promise as a therapeutic approach for managing asthma by preventing the excessive growth and migration of airway smooth muscle cells.
Read More
9
Turmeric extract alleviates asthma inflammation
Turmeric extract alleviates airway inflammation via oxidative stress-driven MAPKs/MMPs pathway.
Moderately relevant asthma treatment study
We explored the effects of turmeric extract (CLE) on asthma-related inflammation, using an asthmatic mouse model and human airway cells to understand the underlying mechanisms. The study involved administering CLE in two different doses to BALB/c mice—100 and 300 mg/kg/day— while comparing it to a positive control, dexamethasone.
Our findings revealed that both doses of turmeric extract significantly reduced eosinophil counts, pro-inflammatory cytokine levels, and immunoglobulin-E in the mice. This suggests that turmeric may help lessen airway inflammation, a common issue in asthma patients.
Interestingly, we observed that CLE effectively decreased oxidative stress in lung tissues and inhibited important signaling molecules related to inflammation, known as MAPKs, and the activity of matrix metalloproteinases (MMPs). In laboratory tests with A549 cells, CLE treatment resulted in lower levels of pro-inflammatory markers and reduced MMP activity as well.
Consequently, our research indicates that turmeric extract holds potential as a natural treatment option for asthma by targeting inflammation through oxidative stress pathways. This opens doors for further exploration on how natural remedies can complement traditional asthma therapies.
Our findings revealed that both doses of turmeric extract significantly reduced eosinophil counts, pro-inflammatory cytokine levels, and immunoglobulin-E in the mice. This suggests that turmeric may help lessen airway inflammation, a common issue in asthma patients.
Interestingly, we observed that CLE effectively decreased oxidative stress in lung tissues and inhibited important signaling molecules related to inflammation, known as MAPKs, and the activity of matrix metalloproteinases (MMPs). In laboratory tests with A549 cells, CLE treatment resulted in lower levels of pro-inflammatory markers and reduced MMP activity as well.
Consequently, our research indicates that turmeric extract holds potential as a natural treatment option for asthma by targeting inflammation through oxidative stress pathways. This opens doors for further exploration on how natural remedies can complement traditional asthma therapies.
Read More
9
Curcumin formulation improves asthma treatment
Curcumin nanocrystals self-stabilized Pickering emulsion freeze-dried powder: Development, characterization, and suppression of airway inflammation.
Relevant to asthma treatment research
We explored the effects of curcumin, a natural compound derived from turmeric, particularly focusing on its potential to alleviate airway inflammation associated with asthma. To tackle curcumin's poor water solubility and low absorption in the body, researchers developed a specialized formulation called curcumin nanocrystalline self-stabilizing Pickering emulsion, along with a freeze-dried powder version.
Through a series of experiments, including both in vitro tests on cells and in vivo studies in mice, we observed significant improvements in curcumin's effectiveness. This advanced formulation not only enhanced the cumulative release of curcumin but also increased its absorption in the body, thereby boosting its oral bioavailability.
Most excitingly, this innovative approach led to a substantial reduction in markers of inflammation, such as NO, IL-6, and TNF-a, while increasing protective factors like IL-10. These findings suggest that curcumin, especially in this newly formulated form, could play a valuable role in managing asthma and enhancing overall respiratory health. Overall, this study indicates a promising avenue for utilizing turmeric in treating respiratory conditions, highlighting the importance of formulation in unlocking its therapeutic potential.
Through a series of experiments, including both in vitro tests on cells and in vivo studies in mice, we observed significant improvements in curcumin's effectiveness. This advanced formulation not only enhanced the cumulative release of curcumin but also increased its absorption in the body, thereby boosting its oral bioavailability.
Most excitingly, this innovative approach led to a substantial reduction in markers of inflammation, such as NO, IL-6, and TNF-a, while increasing protective factors like IL-10. These findings suggest that curcumin, especially in this newly formulated form, could play a valuable role in managing asthma and enhancing overall respiratory health. Overall, this study indicates a promising avenue for utilizing turmeric in treating respiratory conditions, highlighting the importance of formulation in unlocking its therapeutic potential.
Read More
Most Useful Reviews
9.5
Potential asthma aid
Curcumin is utilised in creating drugs for chronic inflammatory diseases in the body, including asthma. It may help alleviate pain and enhance joint mobility for those with arthritis.
Read More
8.8
Improved asthma symptoms
Good. This product seems to have numerous uses. My wife suffers from asthma, which has been worsening. Taking one curcumin capsule daily has improved her symptoms.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.5
9
Turmeric extract alleviates asthma inflammation
Turmeric extract alleviates airway inflammation via oxidative stress-driven MAPKs/MMPs pathway.
Moderately relevant asthma treatment study
We explored the effects of turmeric extract (CLE) on asthma-related inflammation, using an asthmatic mouse model and human airway cells to understand the underlying mechanisms. The study involved administering CLE in two different doses to BALB/c mice—100 and 300 mg/kg/day— while comparing it to a positive control, dexamethasone.
Our findings revealed that both doses of turmeric extract significantly reduced eosinophil counts, pro-inflammatory cytokine levels, and immunoglobulin-E in the mice. This suggests that turmeric may help lessen airway inflammation, a common issue in asthma patients.
Interestingly, we observed that CLE effectively decreased oxidative stress in lung tissues and inhibited important signaling molecules related to inflammation, known as MAPKs, and the activity of matrix metalloproteinases (MMPs). In laboratory tests with A549 cells, CLE treatment resulted in lower levels of pro-inflammatory markers and reduced MMP activity as well.
Consequently, our research indicates that turmeric extract holds potential as a natural treatment option for asthma by targeting inflammation through oxidative stress pathways. This opens doors for further exploration on how natural remedies can complement traditional asthma therapies.
Our findings revealed that both doses of turmeric extract significantly reduced eosinophil counts, pro-inflammatory cytokine levels, and immunoglobulin-E in the mice. This suggests that turmeric may help lessen airway inflammation, a common issue in asthma patients.
Interestingly, we observed that CLE effectively decreased oxidative stress in lung tissues and inhibited important signaling molecules related to inflammation, known as MAPKs, and the activity of matrix metalloproteinases (MMPs). In laboratory tests with A549 cells, CLE treatment resulted in lower levels of pro-inflammatory markers and reduced MMP activity as well.
Consequently, our research indicates that turmeric extract holds potential as a natural treatment option for asthma by targeting inflammation through oxidative stress pathways. This opens doors for further exploration on how natural remedies can complement traditional asthma therapies.
Read More
9
Curcumin nanoparticles reduce asthma effects
Effect of curcumin nanoparticles on proliferation and migration of mouse airway smooth muscle cells and airway inflammatory infiltration.
Direct investigation of curcumin's impact
We set out to understand how turmeric, specifically its active component curcumin, can affect asthma-related issues in airway smooth muscle cells. To do this, we leveraged curcumin-loaded nanoparticles (CUR-NPs) which enhance the delivery and effectiveness of curcumin, overcoming its natural hurdles like hydrophobicity and instability.
In our study, we isolated airway smooth muscle cells from mice and subjected them to a process that mimics conditions present during asthma attacks, specifically looking at how these cells proliferate and migrate under the influence of a growth factor called TGF-β1. Our observations revealed that CUR-NPs significantly reduced the excessive cell growth and movement that TGF-β1 induces.
Not only did CUR-NPs appear to regulate curcumin’s release effectively, but they also inhibited key pathways involved in inflammation and remodeling of the airways. We also validated our findings using an asthma model in mice, where CUR-NPs treatment visibly reduced inflammatory markers in lung tissue compared to untreated control groups.
Overall, our research suggests that turmeric, through its nanoparticles form, may hold promise as a therapeutic approach for managing asthma by preventing the excessive growth and migration of airway smooth muscle cells.
In our study, we isolated airway smooth muscle cells from mice and subjected them to a process that mimics conditions present during asthma attacks, specifically looking at how these cells proliferate and migrate under the influence of a growth factor called TGF-β1. Our observations revealed that CUR-NPs significantly reduced the excessive cell growth and movement that TGF-β1 induces.
Not only did CUR-NPs appear to regulate curcumin’s release effectively, but they also inhibited key pathways involved in inflammation and remodeling of the airways. We also validated our findings using an asthma model in mice, where CUR-NPs treatment visibly reduced inflammatory markers in lung tissue compared to untreated control groups.
Overall, our research suggests that turmeric, through its nanoparticles form, may hold promise as a therapeutic approach for managing asthma by preventing the excessive growth and migration of airway smooth muscle cells.
Read More
9
Curcumin helps alleviate asthma
Curcumin and PCI-34051 combined treatment ameliorates inflammation and fibrosis by affecting MAP kinase pathway.
Study shows combined effectiveness.
We explored the potential of curcumin, a compound derived from turmeric, along with a specific HDAC8 inhibitor called PCI-34051, to alleviate asthma symptoms. By developing a murine model of asthma, we were able to closely observe how these treatments affect inflammation, oxidative stress, and fibrosis—key players in the asthma experience.
In our experiments, Balb/c mice were sensitized and challenged with ovalbumin to mimic an asthmatic reaction. We administered curcumin both alone and in combination with PCI-34051 before exposing the mice to the allergen. The results showed that this combined treatment significantly reduced airway inflammation and fibrosis, suggesting a protective effect against asthma exacerbations.
Overall, our findings highlight the importance of the MAP kinase pathway in managing asthma symptoms, as the treatments appeared to mitigate bronchoconstriction by modulating this pathway. This suggests that curcumin, especially when combined with PCI-34051, could be a promising approach to tackle asthma-related complications.
In our experiments, Balb/c mice were sensitized and challenged with ovalbumin to mimic an asthmatic reaction. We administered curcumin both alone and in combination with PCI-34051 before exposing the mice to the allergen. The results showed that this combined treatment significantly reduced airway inflammation and fibrosis, suggesting a protective effect against asthma exacerbations.
Overall, our findings highlight the importance of the MAP kinase pathway in managing asthma symptoms, as the treatments appeared to mitigate bronchoconstriction by modulating this pathway. This suggests that curcumin, especially when combined with PCI-34051, could be a promising approach to tackle asthma-related complications.
Read More
9
Curcumin formulation improves asthma treatment
Curcumin nanocrystals self-stabilized Pickering emulsion freeze-dried powder: Development, characterization, and suppression of airway inflammation.
Relevant to asthma treatment research
We explored the effects of curcumin, a natural compound derived from turmeric, particularly focusing on its potential to alleviate airway inflammation associated with asthma. To tackle curcumin's poor water solubility and low absorption in the body, researchers developed a specialized formulation called curcumin nanocrystalline self-stabilizing Pickering emulsion, along with a freeze-dried powder version.
Through a series of experiments, including both in vitro tests on cells and in vivo studies in mice, we observed significant improvements in curcumin's effectiveness. This advanced formulation not only enhanced the cumulative release of curcumin but also increased its absorption in the body, thereby boosting its oral bioavailability.
Most excitingly, this innovative approach led to a substantial reduction in markers of inflammation, such as NO, IL-6, and TNF-a, while increasing protective factors like IL-10. These findings suggest that curcumin, especially in this newly formulated form, could play a valuable role in managing asthma and enhancing overall respiratory health. Overall, this study indicates a promising avenue for utilizing turmeric in treating respiratory conditions, highlighting the importance of formulation in unlocking its therapeutic potential.
Through a series of experiments, including both in vitro tests on cells and in vivo studies in mice, we observed significant improvements in curcumin's effectiveness. This advanced formulation not only enhanced the cumulative release of curcumin but also increased its absorption in the body, thereby boosting its oral bioavailability.
Most excitingly, this innovative approach led to a substantial reduction in markers of inflammation, such as NO, IL-6, and TNF-a, while increasing protective factors like IL-10. These findings suggest that curcumin, especially in this newly formulated form, could play a valuable role in managing asthma and enhancing overall respiratory health. Overall, this study indicates a promising avenue for utilizing turmeric in treating respiratory conditions, highlighting the importance of formulation in unlocking its therapeutic potential.
Read More
9
Curcumin potentially aids asthma treatment
Intranasal curcumin and dexamethasone combination ameliorates inflammasome (NLRP3) activation in lipopolysachharide exposed asthma exacerbations.
Moderate relevance for asthma treatment
We explored how curcumin, a well-known compound found in turmeric, can help manage asthma exacerbations caused by lipopolysaccharide (LPS), a common environmental trigger. In our study, Balb/c mice were sensitized with ovalbumin (OVA) injections and were later exposed to LPS along with OVA aerosol. One hour before this exposure, the mice received treatments of intranasal curcumin, alone or combined with dexamethasone, a corticosteroid.
Our findings showed a significant reduction in inflammatory cell recruitment and an improvement in the structural health of the lungs. We noticed positive changes in the expression levels of various inflammatory markers, such as TLR-4, NF-κB, NLRP3, and several interleukins. These changes suggest that curcumin, especially when used alongside the corticosteroid, has the potential to modulate immune responses and alleviate the inflammation associated with asthma exacerbations triggered by LPS.
Overall, this research highlights curcumin's promising role in asthma management. Further studies may help to confirm these beneficial effects in human subjects, particularly for those dealing with environmental triggers.
Our findings showed a significant reduction in inflammatory cell recruitment and an improvement in the structural health of the lungs. We noticed positive changes in the expression levels of various inflammatory markers, such as TLR-4, NF-κB, NLRP3, and several interleukins. These changes suggest that curcumin, especially when used alongside the corticosteroid, has the potential to modulate immune responses and alleviate the inflammation associated with asthma exacerbations triggered by LPS.
Overall, this research highlights curcumin's promising role in asthma management. Further studies may help to confirm these beneficial effects in human subjects, particularly for those dealing with environmental triggers.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Potential asthma aid
Curcumin is utilised in creating drugs for chronic inflammatory diseases in the body, including asthma. It may help alleviate pain and enhance joint mobility for those with arthritis.
8.8
Improved asthma symptoms
Good. This product seems to have numerous uses. My wife suffers from asthma, which has been worsening. Taking one curcumin capsule daily has improved her symptoms.
