Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg

Top Medical Research Studies

9
Curcumin nanoparticles reduce asthma effects
We set out to understand how turmeric, specifically its active component curcumin, can affect asthma-related issues in airway smooth muscle cells. To do this, we leveraged curcumin-loaded nanoparticles (CUR-NPs) which enhance the delivery and effectiveness of curcumin, overcoming its natural hurdles like hydrophobicity and instability.

In our study, we isolated airway smooth muscle cells from mice and subjected them to a process that mimics conditions present during asthma attacks, specifically looking at how these cells proliferate and migrate under the influence of a growth factor called TGF-β1. Our observations revealed that CUR-NPs significantly reduced the excessive cell growth and movement that TGF-β1 induces.

Not only did CUR-NPs appear to regulate curcumin’s release effectively, but they also inhibited key pathways involved in inflammation and remodeling of the airways. We also validated our findings using an asthma model in mice, where CUR-NPs treatment visibly reduced inflammatory markers in lung tissue compared to untreated control groups.

Overall, our research suggests that turmeric, through its nanoparticles form, may hold promise as a therapeutic approach for managing asthma by preventing the excessive growth and migration of airway smooth muscle cells.
Read More
9
We explored the effects of turmeric extract (CLE) on asthma-related inflammation, using an asthmatic mouse model and human airway cells to understand the underlying mechanisms. The study involved administering CLE in two different doses to BALB/c mice—100 and 300 mg/kg/day— while comparing it to a positive control, dexamethasone.

Our findings revealed that both doses of turmeric extract significantly reduced eosinophil counts, pro-inflammatory cytokine levels, and immunoglobulin-E in the mice. This suggests that turmeric may help lessen airway inflammation, a common issue in asthma patients.

Interestingly, we observed that CLE effectively decreased oxidative stress in lung tissues and inhibited important signaling molecules related to inflammation, known as MAPKs, and the activity of matrix metalloproteinases (MMPs). In laboratory tests with A549 cells, CLE treatment resulted in lower levels of pro-inflammatory markers and reduced MMP activity as well.

Consequently, our research indicates that turmeric extract holds potential as a natural treatment option for asthma by targeting inflammation through oxidative stress pathways. This opens doors for further exploration on how natural remedies can complement traditional asthma therapies.
Read More
9
Curcumin formulation improves asthma treatment
We explored the effects of curcumin, a natural compound derived from turmeric, particularly focusing on its potential to alleviate airway inflammation associated with asthma. To tackle curcumin's poor water solubility and low absorption in the body, researchers developed a specialized formulation called curcumin nanocrystalline self-stabilizing Pickering emulsion, along with a freeze-dried powder version.

Through a series of experiments, including both in vitro tests on cells and in vivo studies in mice, we observed significant improvements in curcumin's effectiveness. This advanced formulation not only enhanced the cumulative release of curcumin but also increased its absorption in the body, thereby boosting its oral bioavailability.

Most excitingly, this innovative approach led to a substantial reduction in markers of inflammation, such as NO, IL-6, and TNF-a, while increasing protective factors like IL-10. These findings suggest that curcumin, especially in this newly formulated form, could play a valuable role in managing asthma and enhancing overall respiratory health. Overall, this study indicates a promising avenue for utilizing turmeric in treating respiratory conditions, highlighting the importance of formulation in unlocking its therapeutic potential.
Read More

Most Useful Reviews

9
Potential asthma aid
Curcumin is utilised in creating drugs for chronic inflammatory diseases in the body, including asthma. It may help alleviate pain and enhance joint mobility for those with arthritis.
Read More
7.5
Improved asthma symptoms
16 people found this helpful
Good. This product seems to have numerous uses. My wife suffers from asthma, which has been worsening. Taking one curcumin capsule daily has improved her symptoms.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.5
  • All Researches
9
We explored the effects of turmeric extract (CLE) on asthma-related inflammation, using an asthmatic mouse model and human airway cells to understand the underlying mechanisms. The study involved administering CLE in two different doses to BALB/c mice—100 and 300 mg/kg/day— while comparing it to a positive control, dexamethasone.

Our findings revealed that both doses of turmeric extract significantly reduced eosinophil counts, pro-inflammatory cytokine levels, and immunoglobulin-E in the mice. This suggests that turmeric may help lessen airway inflammation, a common issue in asthma patients.

Interestingly, we observed that CLE effectively decreased oxidative stress in lung tissues and inhibited important signaling molecules related to inflammation, known as MAPKs, and the activity of matrix metalloproteinases (MMPs). In laboratory tests with A549 cells, CLE treatment resulted in lower levels of pro-inflammatory markers and reduced MMP activity as well.

Consequently, our research indicates that turmeric extract holds potential as a natural treatment option for asthma by targeting inflammation through oxidative stress pathways. This opens doors for further exploration on how natural remedies can complement traditional asthma therapies.
Read More
9
Curcumin nanoparticles reduce asthma effects
We set out to understand how turmeric, specifically its active component curcumin, can affect asthma-related issues in airway smooth muscle cells. To do this, we leveraged curcumin-loaded nanoparticles (CUR-NPs) which enhance the delivery and effectiveness of curcumin, overcoming its natural hurdles like hydrophobicity and instability.

In our study, we isolated airway smooth muscle cells from mice and subjected them to a process that mimics conditions present during asthma attacks, specifically looking at how these cells proliferate and migrate under the influence of a growth factor called TGF-β1. Our observations revealed that CUR-NPs significantly reduced the excessive cell growth and movement that TGF-β1 induces.

Not only did CUR-NPs appear to regulate curcumin’s release effectively, but they also inhibited key pathways involved in inflammation and remodeling of the airways. We also validated our findings using an asthma model in mice, where CUR-NPs treatment visibly reduced inflammatory markers in lung tissue compared to untreated control groups.

Overall, our research suggests that turmeric, through its nanoparticles form, may hold promise as a therapeutic approach for managing asthma by preventing the excessive growth and migration of airway smooth muscle cells.
Read More
9
Curcumin helps alleviate asthma
We explored the potential of curcumin, a compound derived from turmeric, along with a specific HDAC8 inhibitor called PCI-34051, to alleviate asthma symptoms. By developing a murine model of asthma, we were able to closely observe how these treatments affect inflammation, oxidative stress, and fibrosis—key players in the asthma experience.

In our experiments, Balb/c mice were sensitized and challenged with ovalbumin to mimic an asthmatic reaction. We administered curcumin both alone and in combination with PCI-34051 before exposing the mice to the allergen. The results showed that this combined treatment significantly reduced airway inflammation and fibrosis, suggesting a protective effect against asthma exacerbations.

Overall, our findings highlight the importance of the MAP kinase pathway in managing asthma symptoms, as the treatments appeared to mitigate bronchoconstriction by modulating this pathway. This suggests that curcumin, especially when combined with PCI-34051, could be a promising approach to tackle asthma-related complications.
Read More
9
Curcumin formulation improves asthma treatment
We explored the effects of curcumin, a natural compound derived from turmeric, particularly focusing on its potential to alleviate airway inflammation associated with asthma. To tackle curcumin's poor water solubility and low absorption in the body, researchers developed a specialized formulation called curcumin nanocrystalline self-stabilizing Pickering emulsion, along with a freeze-dried powder version.

Through a series of experiments, including both in vitro tests on cells and in vivo studies in mice, we observed significant improvements in curcumin's effectiveness. This advanced formulation not only enhanced the cumulative release of curcumin but also increased its absorption in the body, thereby boosting its oral bioavailability.

Most excitingly, this innovative approach led to a substantial reduction in markers of inflammation, such as NO, IL-6, and TNF-a, while increasing protective factors like IL-10. These findings suggest that curcumin, especially in this newly formulated form, could play a valuable role in managing asthma and enhancing overall respiratory health. Overall, this study indicates a promising avenue for utilizing turmeric in treating respiratory conditions, highlighting the importance of formulation in unlocking its therapeutic potential.
Read More
9
Curcumin potentially aids asthma treatment
We explored how curcumin, a well-known compound found in turmeric, can help manage asthma exacerbations caused by lipopolysaccharide (LPS), a common environmental trigger. In our study, Balb/c mice were sensitized with ovalbumin (OVA) injections and were later exposed to LPS along with OVA aerosol. One hour before this exposure, the mice received treatments of intranasal curcumin, alone or combined with dexamethasone, a corticosteroid.

Our findings showed a significant reduction in inflammatory cell recruitment and an improvement in the structural health of the lungs. We noticed positive changes in the expression levels of various inflammatory markers, such as TLR-4, NF-κB, NLRP3, and several interleukins. These changes suggest that curcumin, especially when used alongside the corticosteroid, has the potential to modulate immune responses and alleviate the inflammation associated with asthma exacerbations triggered by LPS.

Overall, this research highlights curcumin's promising role in asthma management. Further studies may help to confirm these beneficial effects in human subjects, particularly for those dealing with environmental triggers.
Read More

User Reviews

USERS' SCORE
Good
Based on 2 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Potential asthma aid
Curcumin is utilised in creating drugs for chronic inflammatory diseases in the body, including asthma. It may help alleviate pain and enhance joint mobility for those with arthritis.
Read More
7.5
Improved asthma symptoms
16 people found this helpful
Good. This product seems to have numerous uses. My wife suffers from asthma, which has been worsening. Taking one curcumin capsule daily has improved her symptoms.
Read More

Frequently Asked Questions

7.5
Improved asthma symptoms
16 people found this helpful
Good. This product seems to have numerous uses. My wife suffers from asthma, which has been worsening. Taking one curcumin capsule daily has improved her symptoms.
9
Potential asthma aid
Curcumin is utilised in creating drugs for chronic inflammatory diseases in the body, including asthma. It may help alleviate pain and enhance joint mobility for those with arthritis.
9
We explored the effects of turmeric extract (CLE) on asthma-related inflammation, using an asthmatic mouse model and human airway cells to understand the underlying mechanisms. The study involved administering CLE in two different doses to BALB/c mice—100 and 300 mg/kg/day— while comparing it to a positive control, dexamethasone.

Our findings revealed that both doses of turmeric extract significantly reduced eosinophil counts, pro-inflammatory cytokine levels, and immunoglobulin-E in the mice. This suggests that turmeric may help lessen airway inflammation, a common issue in asthma patients.

Interestingly, we observed that CLE effectively decreased oxidative stress in lung tissues and inhibited important signaling molecules related to inflammation, known as MAPKs, and the activity of matrix metalloproteinases (MMPs). In laboratory tests with A549 cells, CLE treatment resulted in lower levels of pro-inflammatory markers and reduced MMP activity as well.

Consequently, our research indicates that turmeric extract holds potential as a natural treatment option for asthma by targeting inflammation through oxidative stress pathways. This opens doors for further exploration on how natural remedies can complement traditional asthma therapies.
8
Curcumin delivery method for asthma
We examined the potential of curcumin, a compound derived from turmeric, to treat asthma, focusing specifically on its delivery method. Curcumin is celebrated for its anti-inflammatory and antioxidant properties, which could be beneficial for asthma patients. However, its effectiveness has been limited by its poor solubility in water and overall stability.

To enhance curcumin's absorption, we developed a unique deep eutectic solvent (DES) in oil microemulsion system designed for intranasal administration. This method aimed to increase both the solubility and permeability of curcumin, thereby boosting its bioavailability. Our study included designing and optimizing the microemulsion for uniformity, stability, and overall effectiveness.

Through comprehensive evaluations, we found that this innovative DES/O-ME system demonstrated promising results in increasing the solubility of curcumin and reducing mucosal cytotoxicity. In a mouse model of allergic asthma, we assessed the therapeutic effects of our formulation. These findings suggest that our approach could significantly improve the clinical application of curcumin in asthma treatment, although the actual benefits of curcumin alone remain challenging to quantify due to the presence of other components in the delivery system.
8
Curcumin micelles reduce asthma inflammation
We focused on how curcumin, the active ingredient found in turmeric, could potentially help treat asthma by reducing inflammation. The researchers created tiny carriers, called mixed micelles, to improve curcumin's delivery and effectiveness in the body. These micelles were tested in laboratory models to see how well they worked in lowering inflammation, particularly in lung tissues affected by asthma.

The study found that these curcumin-loaded micelles not only had a high effectiveness in reaching biological targets but also showed a remarkable ability to reduce inflammation compared to regular curcumin. Specifically, they observed that the micelles improved the absorption of curcumin, leading to about nine times better oral bioavailability. This means the body can utilize curcumin much more efficiently when delivered through these micelles.

Moreover, in an experimental asthma model, the mixed micelles noticeably lessened airway inflammation and hyperresponsiveness triggered by allergens. Overall, this study opens up new avenues for leveraging turmeric in a more effective way to manage asthma and possibly other inflammatory conditions as well.
8
Curcumin reduces asthma inflammation
We explored the potential of intranasal curcumin, a compound found in turmeric, and sodium butyrate in managing asthma symptoms. Our aim was to understand how these substances affect airway inflammation and fibrosis, key issues in asthma.

Using a model that involved sensitizing mice to ovalbumin (OVA), we administered curcumin and sodium butyrate before exposing the mice to OVA aerosol. This setup allowed us to measure various inflammatory markers and assess the structural changes in the lungs.

Our findings highlighted the effectiveness of intranasal curcumin in reducing asthma severity by inhibiting histone deacetylase (HDAC) activity, leading to decreased inflammation. This is the first study demonstrating that curcumin can impact asthma by promoting beneficial changes in lung function.
9
Curcumin potentially aids asthma treatment
We explored how curcumin, a well-known compound found in turmeric, can help manage asthma exacerbations caused by lipopolysaccharide (LPS), a common environmental trigger. In our study, Balb/c mice were sensitized with ovalbumin (OVA) injections and were later exposed to LPS along with OVA aerosol. One hour before this exposure, the mice received treatments of intranasal curcumin, alone or combined with dexamethasone, a corticosteroid.

Our findings showed a significant reduction in inflammatory cell recruitment and an improvement in the structural health of the lungs. We noticed positive changes in the expression levels of various inflammatory markers, such as TLR-4, NF-κB, NLRP3, and several interleukins. These changes suggest that curcumin, especially when used alongside the corticosteroid, has the potential to modulate immune responses and alleviate the inflammation associated with asthma exacerbations triggered by LPS.

Overall, this research highlights curcumin's promising role in asthma management. Further studies may help to confirm these beneficial effects in human subjects, particularly for those dealing with environmental triggers.

References

  1. Liu Y, Liu R, Yang Q, Yang G. DES/O microemulsion for solubilizing and delivering curcumin via the nasal administration to treat acute asthma. Int J Pharm. 2024;667:124900. doi:10.1016/j.ijpharm.2024.124900
  2. Kim JW, Jeong JS, Kim JH, Kim CY, Chung EH, et al. Turmeric extract alleviates airway inflammation via oxidative stress-driven MAPKs/MMPs pathway. Int Immunopharmacol. 2024;141:113018. doi:10.1016/j.intimp.2024.113018
  3. Ma Y, Ye S, Sun K, Gu Y. Effect of curcumin nanoparticles on proliferation and migration of mouse airway smooth muscle cells and airway inflammatory infiltration. Front Pharmacol. 2024;15:1344333. doi:10.3389/fphar.2024.1344333
  4. Wang X, Wang Y, Tang T, Zhao G, Dong W, et al. Curcumin-Loaded RH60/F127 Mixed Micelles: Characterization, Biopharmaceutical Characters and Anti-Inflammatory Modulation of Airway Inflammation. Pharmaceutics. 2023;15. doi:10.3390/pharmaceutics15122710
  5. Islam R, Singh R. Curcumin and PCI-34051 combined treatment ameliorates inflammation and fibrosis by affecting MAP kinase pathway. Inflammopharmacology. 2023;31:3063. doi:10.1007/s10787-023-01371-1
  6. Wang X, Liao Z, Zhao G, Dong W, Huang X, et al. Curcumin nanocrystals self-stabilized Pickering emulsion freeze-dried powder: Development, characterization, and suppression of airway inflammation. Int J Biol Macromol. 2023;245:125493. doi:10.1016/j.ijbiomac.2023.125493
  7. Islam R, Dash D, Singh R. An antioxidant ameliorates allergic airway inflammation by inhibiting HDAC 1 via HIF-1α/VEGF axis suppression in mice. Sci Rep. 2023;13:9637. doi:10.1038/s41598-023-36678-0
  8. Jaiswal A, Dash D, Singh R. Intranasal curcumin and dexamethasone combination ameliorates inflammasome (NLRP3) activation in lipopolysachharide exposed asthma exacerbations. Toxicol Appl Pharmacol. 2022;436:115861. doi:10.1016/j.taap.2021.115861
  9. Boskabady MH, Amin F, Shakeri F. The Effect of on Inflammatory Mediators and Immunological, Oxidant, and Antioxidant Biomarkers in Asthmatic Rats. Evid Based Complement Alternat Med. 2021;2021:4234326. doi:10.1155/2021/4234326
  10. Islam R, Dash D, Singh R. Intranasal curcumin and sodium butyrate modulates airway inflammation and fibrosis via HDAC inhibition in allergic asthma. Cytokine. 2022;149:155720. doi:10.1016/j.cyto.2021.155720
  11. Wu Y, Chen Y, Li Q, Ye X, Guo X, et al. Tetrahydrocurcumin alleviates allergic airway inflammation in asthmatic mice by modulating the gut microbiota. Food Funct. 2021;12:6830. doi:10.1039/d1fo00194a
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