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SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.8
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
Curcumin alleviates diarrhea inflammation
Protective effects of curcumin against rat intestinal inflammation‑related motility disorders.
Effectively addresses diarrhea treatment
In a recent study, we examined how curcumin, a component from the ginger family known for its anti-inflammatory properties, affects diarrhea in rats facing intestinal inflammation. We utilized a model involving Sprague-Dawley rats to induce conditions resembling diarrhea through the instillation of acetic acid.
Our findings highlighted that curcumin played a significant role in reversing the increase of pro-inflammatory cytokines, such as IL-1β and TNF-α, through the inhibition of the NF-κB pathway. Notably, we observed that curcumin effectively reduced myosin light chain (MLC) phosphorylation in the jejunum of rats experiencing diarrhea. This reduction was closely linked to improved motility in the context of inflammation.
Additionally, the study revealed that curcumin not only mitigated hypermotility related to diarrhea but also positively influenced inflammatory responses. This indicates that curcumin may hold therapeutic potential for managing intestinal inflammation-related motility disorders like diarrhea. Overall, our research suggests that incorporating curcumin could offer an effective strategy for those struggling with this condition.
Our findings highlighted that curcumin played a significant role in reversing the increase of pro-inflammatory cytokines, such as IL-1β and TNF-α, through the inhibition of the NF-κB pathway. Notably, we observed that curcumin effectively reduced myosin light chain (MLC) phosphorylation in the jejunum of rats experiencing diarrhea. This reduction was closely linked to improved motility in the context of inflammation.
Additionally, the study revealed that curcumin not only mitigated hypermotility related to diarrhea but also positively influenced inflammatory responses. This indicates that curcumin may hold therapeutic potential for managing intestinal inflammation-related motility disorders like diarrhea. Overall, our research suggests that incorporating curcumin could offer an effective strategy for those struggling with this condition.
Read More
9
Curcumin may protect gut barriers
Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction by .
Study shows moderate relevance
We investigated how curcumin, a natural compound found in turmeric, might help combat diarrhea caused by a common bacterial infection. This study specifically looked at how curcumin can protect our gut's epithelial barrier from dysfunction triggered by immune responses during such infections.
Our experiments were conducted using special cell cultures that mimicked human intestinal cells and immune responses. We found that the infection led to reduced electrical resistance across the cell barrier, meaning the barrier was compromised. Additionally, we noted increased permeability, allowing substances like fluorescein to leak through, indicating a loss of barrier function after the infection.
Remarkably, treatment with curcumin seemed to protect against this permeability increase, demonstrating its potential protective effects. We also observed that the infection caused cell apoptosis and disruption of tight junctions, along with heightened inflammatory responses, which curcumin helped reverse.
Overall, while curcumin shows promise in mitigating the adverse effects linked with immune-induced barrier defects, further research is necessary to fully understand its role in treating diarrhea directly. This makes curcumin a candidate worth considering as a supportive treatment for patients facing such challenges.
Our experiments were conducted using special cell cultures that mimicked human intestinal cells and immune responses. We found that the infection led to reduced electrical resistance across the cell barrier, meaning the barrier was compromised. Additionally, we noted increased permeability, allowing substances like fluorescein to leak through, indicating a loss of barrier function after the infection.
Remarkably, treatment with curcumin seemed to protect against this permeability increase, demonstrating its potential protective effects. We also observed that the infection caused cell apoptosis and disruption of tight junctions, along with heightened inflammatory responses, which curcumin helped reverse.
Overall, while curcumin shows promise in mitigating the adverse effects linked with immune-induced barrier defects, further research is necessary to fully understand its role in treating diarrhea directly. This makes curcumin a candidate worth considering as a supportive treatment for patients facing such challenges.
Read More
9
Curcumin protects against irinotecan-induced diarrhea
Protective effect of curcumin against irinotecan‑induced intestinal mucosal injury via attenuation of NF‑κB activation, oxidative stress and endoplasmic reticulum stress.
Curcumin shows protective effect
We aimed to understand how curcumin, a compound found in turmeric, can help protect against diarrhea caused by the chemotherapy drug irinotecan (CPT-11). This drug is effective for treating colorectal cancer, but it often leads to significant digestive issues, particularly late-onset diarrhea.
To investigate, we used both lab studies and animal models, specifically mice, that were given CPT-11 to induce symptoms of diarrhea. Before the administration of the drug, we treated the mice with curcumin and then observed the effects on their intestinal health. We noted improvements in the structure of the intestinal tissues and a reduction in diarrhea symptoms in those treated with curcumin.
On a cellular level, we found that curcumin helped enhance the survival of gut cells, reducing cell damage and oxidative stress which are often triggered by CPT-11. This protective effect appears to be linked to curcumin's ability to block a specific signaling pathway involved in inflammation (NF-κB activation) and to support cellular mechanisms that manage stress in the endoplasmic reticulum.
Overall, our findings suggest that curcumin may be a beneficial treatment for alleviating some of the harmful side effects associated with irinotecan, particularly concerning intestinal health and diarrhea. This study adds to our understanding of how natural compounds like curcumin can play a role in chemotherapy-related side effects.
To investigate, we used both lab studies and animal models, specifically mice, that were given CPT-11 to induce symptoms of diarrhea. Before the administration of the drug, we treated the mice with curcumin and then observed the effects on their intestinal health. We noted improvements in the structure of the intestinal tissues and a reduction in diarrhea symptoms in those treated with curcumin.
On a cellular level, we found that curcumin helped enhance the survival of gut cells, reducing cell damage and oxidative stress which are often triggered by CPT-11. This protective effect appears to be linked to curcumin's ability to block a specific signaling pathway involved in inflammation (NF-κB activation) and to support cellular mechanisms that manage stress in the endoplasmic reticulum.
Overall, our findings suggest that curcumin may be a beneficial treatment for alleviating some of the harmful side effects associated with irinotecan, particularly concerning intestinal health and diarrhea. This study adds to our understanding of how natural compounds like curcumin can play a role in chemotherapy-related side effects.
Read More
Most Useful Reviews
2.5
NSAIDs unnecessary
After an exacerbation of my multiple sclerosis, I experienced muscle pain and headaches. Initially, I took curcumin at 1 tablet, but after 2 weeks with no effect, I increased to 2. I no longer needed NSAIDs, but then I had diarrhoea. While reviewing its effects, I noted potential side effects like kidney stones and iron deficiency. Sadly, the drug did not suit me.
Read More
2.5
Experience with diarrhoea
Caution: my intake of one curcumin capsule caused diarrhoea and flatulence! If this is significant for you, please consider the potential side effects of curcumin.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.8
9
Curcumin alleviates diarrhea inflammation
Protective effects of curcumin against rat intestinal inflammation‑related motility disorders.
Effectively addresses diarrhea treatment
In a recent study, we examined how curcumin, a component from the ginger family known for its anti-inflammatory properties, affects diarrhea in rats facing intestinal inflammation. We utilized a model involving Sprague-Dawley rats to induce conditions resembling diarrhea through the instillation of acetic acid.
Our findings highlighted that curcumin played a significant role in reversing the increase of pro-inflammatory cytokines, such as IL-1β and TNF-α, through the inhibition of the NF-κB pathway. Notably, we observed that curcumin effectively reduced myosin light chain (MLC) phosphorylation in the jejunum of rats experiencing diarrhea. This reduction was closely linked to improved motility in the context of inflammation.
Additionally, the study revealed that curcumin not only mitigated hypermotility related to diarrhea but also positively influenced inflammatory responses. This indicates that curcumin may hold therapeutic potential for managing intestinal inflammation-related motility disorders like diarrhea. Overall, our research suggests that incorporating curcumin could offer an effective strategy for those struggling with this condition.
Our findings highlighted that curcumin played a significant role in reversing the increase of pro-inflammatory cytokines, such as IL-1β and TNF-α, through the inhibition of the NF-κB pathway. Notably, we observed that curcumin effectively reduced myosin light chain (MLC) phosphorylation in the jejunum of rats experiencing diarrhea. This reduction was closely linked to improved motility in the context of inflammation.
Additionally, the study revealed that curcumin not only mitigated hypermotility related to diarrhea but also positively influenced inflammatory responses. This indicates that curcumin may hold therapeutic potential for managing intestinal inflammation-related motility disorders like diarrhea. Overall, our research suggests that incorporating curcumin could offer an effective strategy for those struggling with this condition.
Read More
9
Curcumin reduces chemotherapy-related diarrhea
Structure-based design of charge-conversional drug self-delivery systems for better targeted cancer therapy.
Relevant co-treatment analysis
We explored the effectiveness of a new drug delivery system combining curcumin with camptothecin derivatives to refine cancer treatments, specifically focusing on the impact this system has on gastrointestinal side effects like diarrhea.
The study showcased how these nanoparticles, which deliver curcumin alongside irinotecan (a camptothecin derivative), improve targeted therapy for colorectal cancer. We observed that this combined approach not only enhanced the targeting of cancer cells but also significantly decreased life-threatening diarrhea, a common side effect associated with traditional treatments.
Through experimentation on mice, it was revealed that the nanoparticles achieved better targeting and reduced adverse effects, compared to irinotecan alone.
Overall, the findings present a promising avenue for more effective cancer therapies, with curcumin playing a pivotal role in mitigating one of the challenging side effects of treatment.
The study showcased how these nanoparticles, which deliver curcumin alongside irinotecan (a camptothecin derivative), improve targeted therapy for colorectal cancer. We observed that this combined approach not only enhanced the targeting of cancer cells but also significantly decreased life-threatening diarrhea, a common side effect associated with traditional treatments.
Through experimentation on mice, it was revealed that the nanoparticles achieved better targeting and reduced adverse effects, compared to irinotecan alone.
Overall, the findings present a promising avenue for more effective cancer therapies, with curcumin playing a pivotal role in mitigating one of the challenging side effects of treatment.
Read More
9
Curcumin may protect gut barriers
Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction by .
Study shows moderate relevance
We investigated how curcumin, a natural compound found in turmeric, might help combat diarrhea caused by a common bacterial infection. This study specifically looked at how curcumin can protect our gut's epithelial barrier from dysfunction triggered by immune responses during such infections.
Our experiments were conducted using special cell cultures that mimicked human intestinal cells and immune responses. We found that the infection led to reduced electrical resistance across the cell barrier, meaning the barrier was compromised. Additionally, we noted increased permeability, allowing substances like fluorescein to leak through, indicating a loss of barrier function after the infection.
Remarkably, treatment with curcumin seemed to protect against this permeability increase, demonstrating its potential protective effects. We also observed that the infection caused cell apoptosis and disruption of tight junctions, along with heightened inflammatory responses, which curcumin helped reverse.
Overall, while curcumin shows promise in mitigating the adverse effects linked with immune-induced barrier defects, further research is necessary to fully understand its role in treating diarrhea directly. This makes curcumin a candidate worth considering as a supportive treatment for patients facing such challenges.
Our experiments were conducted using special cell cultures that mimicked human intestinal cells and immune responses. We found that the infection led to reduced electrical resistance across the cell barrier, meaning the barrier was compromised. Additionally, we noted increased permeability, allowing substances like fluorescein to leak through, indicating a loss of barrier function after the infection.
Remarkably, treatment with curcumin seemed to protect against this permeability increase, demonstrating its potential protective effects. We also observed that the infection caused cell apoptosis and disruption of tight junctions, along with heightened inflammatory responses, which curcumin helped reverse.
Overall, while curcumin shows promise in mitigating the adverse effects linked with immune-induced barrier defects, further research is necessary to fully understand its role in treating diarrhea directly. This makes curcumin a candidate worth considering as a supportive treatment for patients facing such challenges.
Read More
9
Curcumin protects against irinotecan-induced diarrhea
Protective effect of curcumin against irinotecan‑induced intestinal mucosal injury via attenuation of NF‑κB activation, oxidative stress and endoplasmic reticulum stress.
Curcumin shows protective effect
We aimed to understand how curcumin, a compound found in turmeric, can help protect against diarrhea caused by the chemotherapy drug irinotecan (CPT-11). This drug is effective for treating colorectal cancer, but it often leads to significant digestive issues, particularly late-onset diarrhea.
To investigate, we used both lab studies and animal models, specifically mice, that were given CPT-11 to induce symptoms of diarrhea. Before the administration of the drug, we treated the mice with curcumin and then observed the effects on their intestinal health. We noted improvements in the structure of the intestinal tissues and a reduction in diarrhea symptoms in those treated with curcumin.
On a cellular level, we found that curcumin helped enhance the survival of gut cells, reducing cell damage and oxidative stress which are often triggered by CPT-11. This protective effect appears to be linked to curcumin's ability to block a specific signaling pathway involved in inflammation (NF-κB activation) and to support cellular mechanisms that manage stress in the endoplasmic reticulum.
Overall, our findings suggest that curcumin may be a beneficial treatment for alleviating some of the harmful side effects associated with irinotecan, particularly concerning intestinal health and diarrhea. This study adds to our understanding of how natural compounds like curcumin can play a role in chemotherapy-related side effects.
To investigate, we used both lab studies and animal models, specifically mice, that were given CPT-11 to induce symptoms of diarrhea. Before the administration of the drug, we treated the mice with curcumin and then observed the effects on their intestinal health. We noted improvements in the structure of the intestinal tissues and a reduction in diarrhea symptoms in those treated with curcumin.
On a cellular level, we found that curcumin helped enhance the survival of gut cells, reducing cell damage and oxidative stress which are often triggered by CPT-11. This protective effect appears to be linked to curcumin's ability to block a specific signaling pathway involved in inflammation (NF-κB activation) and to support cellular mechanisms that manage stress in the endoplasmic reticulum.
Overall, our findings suggest that curcumin may be a beneficial treatment for alleviating some of the harmful side effects associated with irinotecan, particularly concerning intestinal health and diarrhea. This study adds to our understanding of how natural compounds like curcumin can play a role in chemotherapy-related side effects.
Read More
8
Curcumin reduces diarrhea severity
Oral curcumin ameliorates acute murine campylobacteriosis.
Moderate relevance to diarrhea
In exploring the potential of curcumin, a compound found in turmeric, we conducted a study to evaluate its effects on diarrhea caused by campylobacteriosis. Our study involved pre-treating mice with curcumin before they were exposed to the bacteria. This approach allowed us to see how well curcumin could mitigate the clinical symptoms associated with the infection, specifically diarrhea.
We discovered that mice receiving curcumin treatment experienced significantly fewer symptoms of severe enterocolitis, which is characterized by weight loss and bloody diarrhea. Instead, these mice showed less inflammation and improved gut health compared to their untreated counterparts. The curcumin treatment not only lessened the severity of diarrhea but also helped maintain the integrity of the intestinal barrier, which is critical for gut health.
Overall, our findings suggest that curcumin has beneficial effects in reducing diarrhea associated with campylobacter infection, offering a promising alternative to antibiotic treatments. With its unique ability to dampen inflammation and protect gut function, curcumin could be an effective strategy in managing acute foodborne infections.
We discovered that mice receiving curcumin treatment experienced significantly fewer symptoms of severe enterocolitis, which is characterized by weight loss and bloody diarrhea. Instead, these mice showed less inflammation and improved gut health compared to their untreated counterparts. The curcumin treatment not only lessened the severity of diarrhea but also helped maintain the integrity of the intestinal barrier, which is critical for gut health.
Overall, our findings suggest that curcumin has beneficial effects in reducing diarrhea associated with campylobacter infection, offering a promising alternative to antibiotic treatments. With its unique ability to dampen inflammation and protect gut function, curcumin could be an effective strategy in managing acute foodborne infections.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.5
2.5
NSAIDs unnecessary
After an exacerbation of my multiple sclerosis, I experienced muscle pain and headaches. Initially, I took curcumin at 1 tablet, but after 2 weeks with no effect, I increased to 2. I no longer needed NSAIDs, but then I had diarrhoea. While reviewing its effects, I noted potential side effects like kidney stones and iron deficiency. Sadly, the drug did not suit me.
Read More
2.5
Experience with diarrhoea
Caution: my intake of one curcumin capsule caused diarrhoea and flatulence! If this is significant for you, please consider the potential side effects of curcumin.
