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SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.6
USERS' SCORE
Good
Based on 1 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
8
Curcumin enhances tendon healing effectively
Curcumin improves tendon healing in rats: a histological, biochemical, and functional evaluation.
Highly relevant to tendon treatment.
We evaluated how curcumin, a compound found in turmeric, affects tendon healing, particularly in the context of tendon injuries. To do this, we created a controlled study using Sprague-Dawley rats, dividing them into two groups: one that received curcumin and a control group that did not. The curcumin treatment involved administering 100 mg per kg of body weight via oral gavage.
Throughout the experiments, we looked at various indicators of tendon healing, including the organization of collagen fibers, levels of oxidative stress markers, and overall biomechanical properties of the tendons. What we observed was quite promising—curcumin-treated tendons exhibited well-structured collagen, lower levels of malondialdehyde, and enhanced strength, which suggests improved healing.
Our findings indicate that curcumin can be a valuable addition to treatments aimed at promoting the healing of tendon injuries. While we didn’t study tendonitis directly, the positive impact we noted suggests that turmeric might hold potential for managing various tendon-related issues.
Throughout the experiments, we looked at various indicators of tendon healing, including the organization of collagen fibers, levels of oxidative stress markers, and overall biomechanical properties of the tendons. What we observed was quite promising—curcumin-treated tendons exhibited well-structured collagen, lower levels of malondialdehyde, and enhanced strength, which suggests improved healing.
Our findings indicate that curcumin can be a valuable addition to treatments aimed at promoting the healing of tendon injuries. While we didn’t study tendonitis directly, the positive impact we noted suggests that turmeric might hold potential for managing various tendon-related issues.
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8
Curcumin reduces tendon inflammation effects
Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway.
Highly relevant to turmeric treatment
We explored how curcumin, a compound found in turmeric, might help with tendon inflammation, particularly in conditions like tendinitis. Using an in vitro model of human tendon cells, we discovered that curcumin reduced inflammation and cell death caused by the inflammatory cytokine interleukin-1β (IL-1β).
At concentrations of 5-20 μM, curcumin effectively lowered levels of harmful substances connected to tendon degeneration, including matrix metalloproteinases and cyclooxygenase-2. It promoted cell survival by enhancing Bcl-2 levels, a protein that helps protect cells from apoptosis, while simultaneously suppressing indicators that lead to cell damage and death.
Additionally, curcumin blocked the activation of a crucial inflammation signaling pathway involving nuclear factor kappaB (NF-κB). This was achieved by preventing the phosphorylation and degradation of associated proteins. Notably, curcumin also interfered with the phosphatidylinositol 3-kinase/Akt signaling pathway, which seemed essential for the IL-1β response in tendon cells.
This study highlights that curcumin could play a significant role in treating tendon inflammation by targeting the NF-κB signaling pathway, suggesting a potential new avenue for addressing conditions like tendonitis without solely relying on traditional medications.
At concentrations of 5-20 μM, curcumin effectively lowered levels of harmful substances connected to tendon degeneration, including matrix metalloproteinases and cyclooxygenase-2. It promoted cell survival by enhancing Bcl-2 levels, a protein that helps protect cells from apoptosis, while simultaneously suppressing indicators that lead to cell damage and death.
Additionally, curcumin blocked the activation of a crucial inflammation signaling pathway involving nuclear factor kappaB (NF-κB). This was achieved by preventing the phosphorylation and degradation of associated proteins. Notably, curcumin also interfered with the phosphatidylinositol 3-kinase/Akt signaling pathway, which seemed essential for the IL-1β response in tendon cells.
This study highlights that curcumin could play a significant role in treating tendon inflammation by targeting the NF-κB signaling pathway, suggesting a potential new avenue for addressing conditions like tendonitis without solely relying on traditional medications.
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8
Curcumin’s role in tendonitis
Is Curcumine Useful in the Treatment and Prevention of the Tendinopathy and Myotendinous Junction Injury? A Scoping Review.
Curcumin shows significant benefits
We explored the potential benefits of curcumin—an active compound found in turmeric—on tendonitis and myotendinous junction injuries. The study reviewed various sources and found that curcumin has significant anti-inflammatory, pain-relieving, and antioxidant effects, which can support tendon health and recovery.
Our analysis highlighted how curcumin may help reduce inflammation and modulate the body's immune response during tendonitis. It appears to do this by influencing several biological systems, specifically those tied to inflammation and oxidative stress. Curcumin might even aid in repairing damaged tendons, emphasizing its potential role in both preventing and treating tendinopathy.
Overall, the findings suggest that supplementing with curcumin could be beneficial for individuals experiencing tendonitis. While we noted a lack of specific assessments of turmeric as a whole, curcumin's promising properties make it a worthy focus for improving tendon health and athletic performance.
Our analysis highlighted how curcumin may help reduce inflammation and modulate the body's immune response during tendonitis. It appears to do this by influencing several biological systems, specifically those tied to inflammation and oxidative stress. Curcumin might even aid in repairing damaged tendons, emphasizing its potential role in both preventing and treating tendinopathy.
Overall, the findings suggest that supplementing with curcumin could be beneficial for individuals experiencing tendonitis. While we noted a lack of specific assessments of turmeric as a whole, curcumin's promising properties make it a worthy focus for improving tendon health and athletic performance.
Read More
Most Useful Reviews
9.5
Effective for tendonitis
Forget pharmaceuticals! This stuff is fantastic. It works just as effectively as steroids, without the unpleasant side effects. I found it particularly helpful for bowel inflammation and tendonitis, and I felt 90% better the very next day. It's well worth trying before spending money on the pharmaceutical companies.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.6
9
Curcumin aids tendon recovery
Curcumin Improves Functional Recovery of Ruptured Tendon by Promoting Tenogenesis via PI3K/Akt Signaling.
Study shows curcumin's potential
We set out to explore how curcumin, a compound from turmeric, might improve tendon healing and reduce issues such as tendonitis. Our study involved a surgical model where we induced tendon rupture in rats and then assessed their healing process with and without curcumin treatment.
We found that curcumin not only reduced inflammation around the tendons but also promoted functional recovery. Interestingly, it appeared to advance the differentiation of tendon stem cells into specialized tendon cells, known as tenocytes, by activating a specific signaling pathway called PI3K/Akt. This suggests that curcumin could be beneficial in enhancing the healing response of tendons following injury.
However, we also noted that while curcumin has antioxidant and anti-inflammatory properties, it didn’t completely isolate these effects from its tenogenic benefits. Thus, the challenge remains to determine its direct impact on tendonitis specifically. Despite these complexities, the overall findings support curcumin as a promising option for improving tendon repair outcomes.
We found that curcumin not only reduced inflammation around the tendons but also promoted functional recovery. Interestingly, it appeared to advance the differentiation of tendon stem cells into specialized tendon cells, known as tenocytes, by activating a specific signaling pathway called PI3K/Akt. This suggests that curcumin could be beneficial in enhancing the healing response of tendons following injury.
However, we also noted that while curcumin has antioxidant and anti-inflammatory properties, it didn’t completely isolate these effects from its tenogenic benefits. Thus, the challenge remains to determine its direct impact on tendonitis specifically. Despite these complexities, the overall findings support curcumin as a promising option for improving tendon repair outcomes.
Read More
9
Turmeric's potential reduces tendonitis inflammation
Combined extract (Curcuma longa-Glycyrrhiza glabra) alleviates the inflammations of Achilles tendinopathy in Wistar rats.
Limited individual effect of turmeric
We explored the effects of turmeric, alongside licorice, on treating Achilles tendinopathy, a painful condition often caused by overuse. Our study involved 36 Wistar rats, with some receiving a combination of curcumin from turmeric and glycyrrhizin from licorice, while others were immobilized with or without ibuprofen.
The aim was to identify which treatment led to the lowest inflammatory markers and improved tissue structure. We looked at important indicators like HMGB-1, TNF-α, and CXCL-12, alongside assessing tissue morphology through the BONAR score.
We observed that the rats treated with the combined extract showed the most positive results, displaying the lowest inflammatory levels. This suggests that turmeric, when combined with licorice, may contribute effectively to healing tendon injuries. However, it's important to note that the study did not isolate the effects of turmeric alone, so we can't draw definitive conclusions about its standalone effectiveness.
The aim was to identify which treatment led to the lowest inflammatory markers and improved tissue structure. We looked at important indicators like HMGB-1, TNF-α, and CXCL-12, alongside assessing tissue morphology through the BONAR score.
We observed that the rats treated with the combined extract showed the most positive results, displaying the lowest inflammatory levels. This suggests that turmeric, when combined with licorice, may contribute effectively to healing tendon injuries. However, it's important to note that the study did not isolate the effects of turmeric alone, so we can't draw definitive conclusions about its standalone effectiveness.
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9
Turmeric's Calebin A reduces tendonitis
Calebin A, a Compound of Turmeric, Down-Regulates Inflammation in Tenocytes by NF-κB/Scleraxis Signaling.
Study examines turmeric's effects
We explored the effects of Calebin A, an active compound from turmeric known for its anti-inflammatory and antioxidant properties, on tendon inflammation, specifically in a condition known as tendinitis. Our investigation involved culturing tendon cells, or tenocytes, in different environments that mimic the natural inflammatory conditions (with T-lymphocytes or cytokines like TNF-α and TNF-β).
During our experiments, we observed that Calebin A successfully blocked the adhesion of T-lymphocytes to tenocytes, which is a crucial step in the inflammation process. It worked similarly to a specific inhibitor called BMS-345541, reducing the levels of important proteins linked to inflammation and tissue breakdown while preventing the activation of a key inflammation pathway, known as NF-κB.
Remarkably, Calebin A not only reduced signaling from T-lymphocytes but also inhibited the activity of NF-κB, a major regulatory protein in inflammatory responses. This indicates that Calebin A plays a significant role in diminishing the inflammatory response in tendon cells, underscoring its potential as a therapeutic agent for tendinitis.
In summary, our findings present Calebin A as a promising compound for preventing and treating tendon-related inflammation through its modulation of NF-κB and related pathways.
During our experiments, we observed that Calebin A successfully blocked the adhesion of T-lymphocytes to tenocytes, which is a crucial step in the inflammation process. It worked similarly to a specific inhibitor called BMS-345541, reducing the levels of important proteins linked to inflammation and tissue breakdown while preventing the activation of a key inflammation pathway, known as NF-κB.
Remarkably, Calebin A not only reduced signaling from T-lymphocytes but also inhibited the activity of NF-κB, a major regulatory protein in inflammatory responses. This indicates that Calebin A plays a significant role in diminishing the inflammatory response in tendon cells, underscoring its potential as a therapeutic agent for tendinitis.
In summary, our findings present Calebin A as a promising compound for preventing and treating tendon-related inflammation through its modulation of NF-κB and related pathways.
Read More
9
Curcumin shows mixed tendon healing effects
Effect of curcumin on tendon healing: an experimental study in a rat model of Achilles tendon injury.
Moderate relevance to tendonitis
We examined how curcumin, a compound found in turmeric, might influence tendon healing by using a rat model with surgically induced Achilles tendon injuries. In our study, we worked with eighteen male Wistar albino rats, dividing them into two groups. One group received curcumin orally, while the other group was given a saline solution for 28 days.
At the end of the study period, we found that all tendons had healed, but when we looked closer, the group receiving curcumin displayed improvements in several healing parameters. Specifically, we observed that certain scores related to tendon structure were lower in the curcumin group compared to the control group, indicating delayed healing. However, in terms of biomechanical strength, the curcumin group excelled in key measures, suggesting enhanced tensile properties of the tendons.
Despite the differences, we want to be clear that the results were mixed. While curcumin showed promise biomechanically, some aspects of tendon healing were not significantly better than the control. This study suggests that curcumin could serve as a useful adjunct in tendon healing management.
At the end of the study period, we found that all tendons had healed, but when we looked closer, the group receiving curcumin displayed improvements in several healing parameters. Specifically, we observed that certain scores related to tendon structure were lower in the curcumin group compared to the control group, indicating delayed healing. However, in terms of biomechanical strength, the curcumin group excelled in key measures, suggesting enhanced tensile properties of the tendons.
Despite the differences, we want to be clear that the results were mixed. While curcumin showed promise biomechanically, some aspects of tendon healing were not significantly better than the control. This study suggests that curcumin could serve as a useful adjunct in tendon healing management.
Read More
9
Curcumin shows promise for tendonitis
Controlled release of curcumin from curcumin-loaded nanomicelles to prevent peritendinous adhesion during Achilles tendon healing in rats.
Limited clarity on effectiveness
We explored the effects of curcumin, a compound found in turmeric, on tendon healing and adhesion in a study involving rats. In this experiment, 36 rats underwent surgery to repair their Achilles tendons. The researchers divided the rats into three groups. One group received an injection of curcumin loaded in tiny micelles, while the other two groups received either curcumin in saline or just saline.
After four weeks, we observed the treatment group, which received the curcumin-loaded nanomicelles and was also exposed to laser treatment, showed the lowest level of tendinous adhesion compared to the others. This suggests that the nanoparticle system helped to efficiently deliver curcumin, promoting better healing and reducing unwanted adhesion.
While the study showcased promising results for improved tendon strength and less adhesion with this specific method of delivering curcumin, it does not isolate the effectiveness of turmeric itself. Therefore, while these findings are encouraging, more research is needed to determine how turmeric alone can treat tendonitis effectively.
After four weeks, we observed the treatment group, which received the curcumin-loaded nanomicelles and was also exposed to laser treatment, showed the lowest level of tendinous adhesion compared to the others. This suggests that the nanoparticle system helped to efficiently deliver curcumin, promoting better healing and reducing unwanted adhesion.
While the study showcased promising results for improved tendon strength and less adhesion with this specific method of delivering curcumin, it does not isolate the effectiveness of turmeric itself. Therefore, while these findings are encouraging, more research is needed to determine how turmeric alone can treat tendonitis effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8.6
9.5
Effective for tendonitis
Forget pharmaceuticals! This stuff is fantastic. It works just as effectively as steroids, without the unpleasant side effects. I found it particularly helpful for bowel inflammation and tendonitis, and I felt 90% better the very next day. It's well worth trying before spending money on the pharmaceutical companies.
Read More
