Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.8
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
Our exploration focused on how curcumin, a key ingredient in turmeric, affects ulcerative colitis (UC), particularly its impact on memory helper T (mTh) cells. Through a carefully designed experiment using dextran sulfate sodium (DSS) to create a colitis model in mice, we aimed to understand curcumin’s role as a potential treatment.
We found that curcumin significantly improved various symptoms of colitis in the mice, including a reduction in disease activity levels and overall inflammation. Notably, curcumin helped in decreasing the structural damage within the colon and led to a restoration of colon length. Furthermore, the treatment adjusted cytokine levels, promoting beneficial ones like IL-2, IL-4, and IL-10 while suppressing IL-7 and IL-21, which are linked to inflammation.
Importantly, our study demonstrated that curcumin influences mTh7 cells and their activity. The findings from advanced techniques, such as molecular docking and Surface Plasmon Resonance (SPR), reinforced that curcumin interacts effectively with both IL-7 and its receptor, ultimately reducing their expression. This suggests that curcumin helps heal DSS-induced colitis by curbing the activity of mTh7 cells and blocking the pro-inflammatory IL-7/IL-7R signaling pathway.
We found that curcumin significantly improved various symptoms of colitis in the mice, including a reduction in disease activity levels and overall inflammation. Notably, curcumin helped in decreasing the structural damage within the colon and led to a restoration of colon length. Furthermore, the treatment adjusted cytokine levels, promoting beneficial ones like IL-2, IL-4, and IL-10 while suppressing IL-7 and IL-21, which are linked to inflammation.
Importantly, our study demonstrated that curcumin influences mTh7 cells and their activity. The findings from advanced techniques, such as molecular docking and Surface Plasmon Resonance (SPR), reinforced that curcumin interacts effectively with both IL-7 and its receptor, ultimately reducing their expression. This suggests that curcumin helps heal DSS-induced colitis by curbing the activity of mTh7 cells and blocking the pro-inflammatory IL-7/IL-7R signaling pathway.
Read More
9
We studied how curcumin, a key component of turmeric, helps treat ulcerative colitis (UC), an inflammatory bowel disease. Using a model with DSS-induced UC, we explored the effectiveness of curcumin in alleviating the symptoms and damage associated with this condition.
Our findings revealed that curcumin effectively reduced inflammation and intestinal damage. It also increased the number of goblet cells in the colon, which are important for gut health. Through various tests, we observed a significant decrease in inflammatory markers in both serum and colon tissues.
A deeper dive using RNA sequencing showed that curcumin notably lowered the levels of sphingosine kinase 1 (SphK1), a protein involved in inflammation. Additionally, our analyses indicated that curcumin interacts with SphK1 and the NF-κB signaling pathway, pivotal players in inflammation processes.
Importantly, curcumin showed a promising ability to inhibit these pathways, further supporting its anti-inflammatory effects in the context of UC. Overall, our study highlights the potential of curcumin as a natural therapeutic option for managing ulcerative colitis and reducing its inflammatory impact.
Our findings revealed that curcumin effectively reduced inflammation and intestinal damage. It also increased the number of goblet cells in the colon, which are important for gut health. Through various tests, we observed a significant decrease in inflammatory markers in both serum and colon tissues.
A deeper dive using RNA sequencing showed that curcumin notably lowered the levels of sphingosine kinase 1 (SphK1), a protein involved in inflammation. Additionally, our analyses indicated that curcumin interacts with SphK1 and the NF-κB signaling pathway, pivotal players in inflammation processes.
Importantly, curcumin showed a promising ability to inhibit these pathways, further supporting its anti-inflammatory effects in the context of UC. Overall, our study highlights the potential of curcumin as a natural therapeutic option for managing ulcerative colitis and reducing its inflammatory impact.
Read More
We investigated how curcumin, a compound found in turmeric, affects the healing of ulcers in a mice model of ulcerative colitis (UC) induced by dextran sulfate sodium (DSS). By observing changes in the intestinal structure and examining important proteins involved in a specific signaling pathway known as Wnt/β-catenin, we aimed to understand curcumin's potential benefits.
Our experiments revealed that curcumin had a positive effect on the differentiation of intestinal stem cells (ISCs). These findings suggest that curcumin works by inhibiting the Wnt/β-catenin signaling pathway, which in turn helps restore the normal function of ISCs, crucial for gut health. We further confirmed these effects by using agonists that activate the same pathway.
Overall, our study offers exciting insights into how curcumin might be developed into a novel treatment for ulcerative colitis by promoting the health of intestinal stem cells amidst inflammation.
Our experiments revealed that curcumin had a positive effect on the differentiation of intestinal stem cells (ISCs). These findings suggest that curcumin works by inhibiting the Wnt/β-catenin signaling pathway, which in turn helps restore the normal function of ISCs, crucial for gut health. We further confirmed these effects by using agonists that activate the same pathway.
Overall, our study offers exciting insights into how curcumin might be developed into a novel treatment for ulcerative colitis by promoting the health of intestinal stem cells amidst inflammation.
Read More
Most Useful Reviews
9
Effective for ulcers
The main active ingredient in turmeric is curcumin, which is known for its antioxidant and anti-inflammatory properties. Adding curcumin to anti-Helicobacter pylori therapy enhances its effectiveness. This opens new options for using turmeric to treat ulcers. Good results have also been reported for curcumin in conditions like ulcerative colitis and Crohn's disease. Moreover, it has therapeutic effects on inflammatory processes in the intestines and the pancreas, and it prevents fatty liver disease. Overall, turmeric holds promise for treating ulcers and various inflammatory conditions.
Read More
9
Ulcer treatment success
Excellent! I'm very fond of the Jarrow Formulas brand and have always found their products high-quality. I purchased this curcumin for treating my duodenal ulcers and for combating H. pylori. Curcumin is a powerful antibiotic and antioxidant. After a month’s course, I experienced no side effects and achieved excellent results. I'll be doing further tests to monitor my progress. Wishing everyone good health!
Read More
8
Supports ulcer recovery
I learned about curcumin in India; it’s a potent antioxidant and anti-inflammatory agent, beneficial for joint diseases, ulcers, and infections. It reduces oxidative stress, and I always keep it in my first aid kit. Though the capsules are large, they are easy to swallow. Recently, I took it while experiencing ARVI, and within two days, I was better. For ulcer support and other ailments, I find it essential.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.8
- All Researches
9.5
We developed a novel approach to treat oral ulcers using curcumin, a natural compound known for its health benefits. By creating microneedles that embed curcumin along with magnesium and gallic acid, we aimed to deliver these ingredients directly into the ulcers. This targeted delivery helps release curcumin and magnesium efficiently, helping us address inflammation and promote the healing process.
The combination of curcumin and gallic acid appears to have a positive impact by alleviating oxidative stress, which can hinder healing. We also found that the materials used in the microneedles, such as ε-poly-L-lysine, help form an antibacterial barrier, effectively inhibiting harmful pathogens from worsening the ulcers.
Testing the microneedles on rats with oral ulcers showed promising results, indicating significant therapeutic effects. This innovative treatment not only enhances our approach to managing oral ulcers but also represents a significant advancement in the field of nanobiomaterials and drug delivery technology.
Overall, our findings highlight the potential of curcumin and its synergistic effects when combined with other ingredients for improving oral ulcer treatment and enhancing patient quality of life.
The combination of curcumin and gallic acid appears to have a positive impact by alleviating oxidative stress, which can hinder healing. We also found that the materials used in the microneedles, such as ε-poly-L-lysine, help form an antibacterial barrier, effectively inhibiting harmful pathogens from worsening the ulcers.
Testing the microneedles on rats with oral ulcers showed promising results, indicating significant therapeutic effects. This innovative treatment not only enhances our approach to managing oral ulcers but also represents a significant advancement in the field of nanobiomaterials and drug delivery technology.
Overall, our findings highlight the potential of curcumin and its synergistic effects when combined with other ingredients for improving oral ulcer treatment and enhancing patient quality of life.
Read More
9
We explored the effectiveness of curcumin, a compound found in turmeric, in preventing gastric ulcers, especially given its known anti-inflammatory and antioxidant properties. To tackle the common issue of curcumin's poor absorption in the body, researchers developed special nanoparticles coated with oleanolic acid, which improved the stability and solubility of curcumin.
In our investigation, the oleanolic acid-coated curcumin nanoparticles, or OC NPs, were tested in both laboratory settings and live animal models. Not only did we observe a reduction in inflammation and oxidative stress in cells, but the nanoparticles also showed promising results in protecting mice from ethanol-induced gastric ulcers. This protection came with a decrease in inflammation and an increase in antioxidant levels in their systems.
Histological studies indicated that OC NPs better preserved the gastric mucosa while minimizing damage like fibrosis and cell death. Moreover, they stayed longer in the stomach, enhancing the targeted delivery of curcumin. Overall, our findings suggest that oleanolic acid-coated curcumin nanoparticles could be a safe and effective option to prevent gastric ulcers, making this approach a noteworthy advancement in gastrointestinal health.
In our investigation, the oleanolic acid-coated curcumin nanoparticles, or OC NPs, were tested in both laboratory settings and live animal models. Not only did we observe a reduction in inflammation and oxidative stress in cells, but the nanoparticles also showed promising results in protecting mice from ethanol-induced gastric ulcers. This protection came with a decrease in inflammation and an increase in antioxidant levels in their systems.
Histological studies indicated that OC NPs better preserved the gastric mucosa while minimizing damage like fibrosis and cell death. Moreover, they stayed longer in the stomach, enhancing the targeted delivery of curcumin. Overall, our findings suggest that oleanolic acid-coated curcumin nanoparticles could be a safe and effective option to prevent gastric ulcers, making this approach a noteworthy advancement in gastrointestinal health.
Read More
9
We explored the effectiveness of curcumin, a natural compound found in turmeric, as a treatment for ulcerative colitis. Our study involved preparing ginger-derived nanovesicles to enhance the delivery of curcumin, aiming to maximize its therapeutic potential.
We found that curcumin was successfully loaded into these nanovesicles and demonstrated remarkable results. Specifically, when administered in this form, curcumin showed a high loading capacity and effective encapsulation, which are crucial for its performance in the body.
Interestingly, after giving these curcumin-loaded nanovesicles to mice, we observed a significant distribution in the colon and improvements in various health markers related to ulcerative colitis. This included enhanced disease activity scores and better measurements of colon length and organ health.
Overall, our findings suggest that curcumin, when delivered via ginger-derived nanovesicles, could offer promising benefits in managing ulcerative colitis. This natural approach seems to modulate critical factors in the body, supporting its protective role against this condition.
We found that curcumin was successfully loaded into these nanovesicles and demonstrated remarkable results. Specifically, when administered in this form, curcumin showed a high loading capacity and effective encapsulation, which are crucial for its performance in the body.
Interestingly, after giving these curcumin-loaded nanovesicles to mice, we observed a significant distribution in the colon and improvements in various health markers related to ulcerative colitis. This included enhanced disease activity scores and better measurements of colon length and organ health.
Overall, our findings suggest that curcumin, when delivered via ginger-derived nanovesicles, could offer promising benefits in managing ulcerative colitis. This natural approach seems to modulate critical factors in the body, supporting its protective role against this condition.
Read More
9
We studied how curcumin, a key component of turmeric, helps treat ulcerative colitis (UC), an inflammatory bowel disease. Using a model with DSS-induced UC, we explored the effectiveness of curcumin in alleviating the symptoms and damage associated with this condition.
Our findings revealed that curcumin effectively reduced inflammation and intestinal damage. It also increased the number of goblet cells in the colon, which are important for gut health. Through various tests, we observed a significant decrease in inflammatory markers in both serum and colon tissues.
A deeper dive using RNA sequencing showed that curcumin notably lowered the levels of sphingosine kinase 1 (SphK1), a protein involved in inflammation. Additionally, our analyses indicated that curcumin interacts with SphK1 and the NF-κB signaling pathway, pivotal players in inflammation processes.
Importantly, curcumin showed a promising ability to inhibit these pathways, further supporting its anti-inflammatory effects in the context of UC. Overall, our study highlights the potential of curcumin as a natural therapeutic option for managing ulcerative colitis and reducing its inflammatory impact.
Our findings revealed that curcumin effectively reduced inflammation and intestinal damage. It also increased the number of goblet cells in the colon, which are important for gut health. Through various tests, we observed a significant decrease in inflammatory markers in both serum and colon tissues.
A deeper dive using RNA sequencing showed that curcumin notably lowered the levels of sphingosine kinase 1 (SphK1), a protein involved in inflammation. Additionally, our analyses indicated that curcumin interacts with SphK1 and the NF-κB signaling pathway, pivotal players in inflammation processes.
Importantly, curcumin showed a promising ability to inhibit these pathways, further supporting its anti-inflammatory effects in the context of UC. Overall, our study highlights the potential of curcumin as a natural therapeutic option for managing ulcerative colitis and reducing its inflammatory impact.
Read More
9
Our exploration focused on how curcumin, a key ingredient in turmeric, affects ulcerative colitis (UC), particularly its impact on memory helper T (mTh) cells. Through a carefully designed experiment using dextran sulfate sodium (DSS) to create a colitis model in mice, we aimed to understand curcumin’s role as a potential treatment.
We found that curcumin significantly improved various symptoms of colitis in the mice, including a reduction in disease activity levels and overall inflammation. Notably, curcumin helped in decreasing the structural damage within the colon and led to a restoration of colon length. Furthermore, the treatment adjusted cytokine levels, promoting beneficial ones like IL-2, IL-4, and IL-10 while suppressing IL-7 and IL-21, which are linked to inflammation.
Importantly, our study demonstrated that curcumin influences mTh7 cells and their activity. The findings from advanced techniques, such as molecular docking and Surface Plasmon Resonance (SPR), reinforced that curcumin interacts effectively with both IL-7 and its receptor, ultimately reducing their expression. This suggests that curcumin helps heal DSS-induced colitis by curbing the activity of mTh7 cells and blocking the pro-inflammatory IL-7/IL-7R signaling pathway.
We found that curcumin significantly improved various symptoms of colitis in the mice, including a reduction in disease activity levels and overall inflammation. Notably, curcumin helped in decreasing the structural damage within the colon and led to a restoration of colon length. Furthermore, the treatment adjusted cytokine levels, promoting beneficial ones like IL-2, IL-4, and IL-10 while suppressing IL-7 and IL-21, which are linked to inflammation.
Importantly, our study demonstrated that curcumin influences mTh7 cells and their activity. The findings from advanced techniques, such as molecular docking and Surface Plasmon Resonance (SPR), reinforced that curcumin interacts effectively with both IL-7 and its receptor, ultimately reducing their expression. This suggests that curcumin helps heal DSS-induced colitis by curbing the activity of mTh7 cells and blocking the pro-inflammatory IL-7/IL-7R signaling pathway.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for ulcers
The main active ingredient in turmeric is curcumin, which is known for its antioxidant and anti-inflammatory properties. Adding curcumin to anti-Helicobacter pylori therapy enhances its effectiveness. This opens new options for using turmeric to treat ulcers. Good results have also been reported for curcumin in conditions like ulcerative colitis and Crohn's disease. Moreover, it has therapeutic effects on inflammatory processes in the intestines and the pancreas, and it prevents fatty liver disease. Overall, turmeric holds promise for treating ulcers and various inflammatory conditions.
Read More
9
Ulcer treatment success
Excellent! I'm very fond of the Jarrow Formulas brand and have always found their products high-quality. I purchased this curcumin for treating my duodenal ulcers and for combating H. pylori. Curcumin is a powerful antibiotic and antioxidant. After a month’s course, I experienced no side effects and achieved excellent results. I'll be doing further tests to monitor my progress. Wishing everyone good health!
Read More
8
Supports ulcer recovery
I learned about curcumin in India; it’s a potent antioxidant and anti-inflammatory agent, beneficial for joint diseases, ulcers, and infections. It reduces oxidative stress, and I always keep it in my first aid kit. Though the capsules are large, they are easy to swallow. Recently, I took it while experiencing ARVI, and within two days, I was better. For ulcer support and other ailments, I find it essential.
Read More
Frequently Asked Questions
9
Ulcer treatment success
Excellent! I'm very fond of the Jarrow Formulas brand and have always found their products high-quality. I purchased this curcumin for treating my duodenal ulcers and for combating H. pylori. Curcumin is a powerful antibiotic and antioxidant. After a month’s course, I experienced no side effects and achieved excellent results. I'll be doing further tests to monitor my progress. Wishing everyone good health!
9
Effective for ulcers
The main active ingredient in turmeric is curcumin, which is known for its antioxidant and anti-inflammatory properties. Adding curcumin to anti-Helicobacter pylori therapy enhances its effectiveness. This opens new options for using turmeric to treat ulcers. Good results have also been reported for curcumin in conditions like ulcerative colitis and Crohn's disease. Moreover, it has therapeutic effects on inflammatory processes in the intestines and the pancreas, and it prevents fatty liver disease. Overall, turmeric holds promise for treating ulcers and various inflammatory conditions.
8
Supports ulcer recovery
I learned about curcumin in India; it’s a potent antioxidant and anti-inflammatory agent, beneficial for joint diseases, ulcers, and infections. It reduces oxidative stress, and I always keep it in my first aid kit. Though the capsules are large, they are easy to swallow. Recently, I took it while experiencing ARVI, and within two days, I was better. For ulcer support and other ailments, I find it essential.
9
We explored the effectiveness of curcumin, a compound found in turmeric, in preventing gastric ulcers, especially given its known anti-inflammatory and antioxidant properties. To tackle the common issue of curcumin's poor absorption in the body, researchers developed special nanoparticles coated with oleanolic acid, which improved the stability and solubility of curcumin.
In our investigation, the oleanolic acid-coated curcumin nanoparticles, or OC NPs, were tested in both laboratory settings and live animal models. Not only did we observe a reduction in inflammation and oxidative stress in cells, but the nanoparticles also showed promising results in protecting mice from ethanol-induced gastric ulcers. This protection came with a decrease in inflammation and an increase in antioxidant levels in their systems.
Histological studies indicated that OC NPs better preserved the gastric mucosa while minimizing damage like fibrosis and cell death. Moreover, they stayed longer in the stomach, enhancing the targeted delivery of curcumin. Overall, our findings suggest that oleanolic acid-coated curcumin nanoparticles could be a safe and effective option to prevent gastric ulcers, making this approach a noteworthy advancement in gastrointestinal health.
In our investigation, the oleanolic acid-coated curcumin nanoparticles, or OC NPs, were tested in both laboratory settings and live animal models. Not only did we observe a reduction in inflammation and oxidative stress in cells, but the nanoparticles also showed promising results in protecting mice from ethanol-induced gastric ulcers. This protection came with a decrease in inflammation and an increase in antioxidant levels in their systems.
Histological studies indicated that OC NPs better preserved the gastric mucosa while minimizing damage like fibrosis and cell death. Moreover, they stayed longer in the stomach, enhancing the targeted delivery of curcumin. Overall, our findings suggest that oleanolic acid-coated curcumin nanoparticles could be a safe and effective option to prevent gastric ulcers, making this approach a noteworthy advancement in gastrointestinal health.
8
We explored the effectiveness of a nanoemulsion combining turmeric, honey, and black pepper in healing gastric ulcers. This study built on the known benefits of turmeric, particularly its active component curcumin, which traditionally faces challenges like poor water solubility and low absorption in the body. By creating a nanoemulsion—a tiny droplet formulation—we aimed to enhance curcumin's bioavailability, making it more effective for ulcer treatment.
Our approach involved a systematic assessment, including stability tests and evaluations of key properties like droplet size and curcumin content. We conducted experiments on male Wistar albino rats with ethanol-induced gastric ulcers, dividing them into groups that received different treatments, including the nanoemulsion and a standard ulcer medication, omeprazole.
Promising results emerged, particularly from the nanoemulsion that contained turmeric and honey, which showed the smallest droplet size and notable stability upon storage. The ulcer indices from the treated rats indicated significant healing, positioning the nanoemulsion as a potential effective treatment for gastric ulcers. Thus, our findings offer exciting possibilities for new, natural ulcer therapies based on turmeric.
Our approach involved a systematic assessment, including stability tests and evaluations of key properties like droplet size and curcumin content. We conducted experiments on male Wistar albino rats with ethanol-induced gastric ulcers, dividing them into groups that received different treatments, including the nanoemulsion and a standard ulcer medication, omeprazole.
Promising results emerged, particularly from the nanoemulsion that contained turmeric and honey, which showed the smallest droplet size and notable stability upon storage. The ulcer indices from the treated rats indicated significant healing, positioning the nanoemulsion as a potential effective treatment for gastric ulcers. Thus, our findings offer exciting possibilities for new, natural ulcer therapies based on turmeric.
9
We explored the potential of curcumin, the active ingredient in turmeric, as a treatment for inflammatory bowel disease (IBD), particularly focusing on its effects on ulcers. Our investigation involved a specialized delivery system, known as a self-microemulsifying drug delivery system (SMEDDS), to enhance curcumin’s effectiveness and absorption.
The study involved various formulations of curcumin, combined with other components like Lauroglycol FCC, Tween 80, and Transcutol HP to create SMEDDS. We found that this formulation significantly improved curcumin's stability and bioavailability, which are critical factors for its therapeutic effects.
In testing its efficacy, we observed that curcumin-loaded SMEDDS showed promising antioxidant and anti-inflammatory properties, leading to a marked reduction in ulcer severity in our animal models. Specifically, the treatment notably lowered the disease activity index and macroscopic ulcer scores in rats subjected to acetic acid-induced IBD.
Overall, this study positions curcumin as a promising candidate for managing ulcers associated with IBD, showcasing its potential not just as a supplement but as a clinically relevant treatment option.
The study involved various formulations of curcumin, combined with other components like Lauroglycol FCC, Tween 80, and Transcutol HP to create SMEDDS. We found that this formulation significantly improved curcumin's stability and bioavailability, which are critical factors for its therapeutic effects.
In testing its efficacy, we observed that curcumin-loaded SMEDDS showed promising antioxidant and anti-inflammatory properties, leading to a marked reduction in ulcer severity in our animal models. Specifically, the treatment notably lowered the disease activity index and macroscopic ulcer scores in rats subjected to acetic acid-induced IBD.
Overall, this study positions curcumin as a promising candidate for managing ulcers associated with IBD, showcasing its potential not just as a supplement but as a clinically relevant treatment option.
9
Curcumin shows promise for ulcers
We explored the benefits of curcumin, a compound derived from turmeric, in treating ulcerative colitis, particularly when combined with specially developed polysaccharide microparticles. This innovative approach aimed to enhance curcumin’s poor absorption and bioavailability.
In our analysis, we observed that these curcumin-loaded microparticles significantly improved the symptoms of colitis in mice treated with dextran sulfate sodium (DSS), a substance that induces this condition. By extending the residence time of curcumin in the intestine, these microparticles not only increased the absorption efficiency of curcumin but also alleviated colonic inflammation.
Their effectiveness appeared to stem from a multi-faceted mechanism, inhibiting key inflammation pathways and regulating essential antioxidants. Additionally, we noted that these microparticles played a role in protecting gut barrier functions, ensuring the integrity of the colonic mucosal layer. Overall, our findings suggest that the combination of curcumin and polysaccharide microparticles holds promise for enhancing gut health in the context of ulcerative colitis.
In our analysis, we observed that these curcumin-loaded microparticles significantly improved the symptoms of colitis in mice treated with dextran sulfate sodium (DSS), a substance that induces this condition. By extending the residence time of curcumin in the intestine, these microparticles not only increased the absorption efficiency of curcumin but also alleviated colonic inflammation.
Their effectiveness appeared to stem from a multi-faceted mechanism, inhibiting key inflammation pathways and regulating essential antioxidants. Additionally, we noted that these microparticles played a role in protecting gut barrier functions, ensuring the integrity of the colonic mucosal layer. Overall, our findings suggest that the combination of curcumin and polysaccharide microparticles holds promise for enhancing gut health in the context of ulcerative colitis.
8
We explored the safety and effectiveness of curcumin, a natural compound found in turmeric, as an additional treatment for people suffering from ulcerative colitis (UC). By analyzing data from eight randomized controlled trials, which included 482 participants, we noted that curcumin seemed to improve clinical remission rates compared to placebo treatments.
Among the studies, seven reported on clinical remission, and we saw a significant improvement with curcumin, suggesting that it could help patients feel better during flare-ups. We also observed an encouraging trend in endoscopic remission, although it did not reach statistical significance.
Additionally, our analysis indicated that patients receiving curcumin experienced improvements in both clinical outcomes and endoscopic findings without experiencing serious side effects. However, due to the limited number of trials and variability in results, we believe more extensive studies are necessary to fully understand curcumin's role in UC treatment before drawing definitive conclusions.
Among the studies, seven reported on clinical remission, and we saw a significant improvement with curcumin, suggesting that it could help patients feel better during flare-ups. We also observed an encouraging trend in endoscopic remission, although it did not reach statistical significance.
Additionally, our analysis indicated that patients receiving curcumin experienced improvements in both clinical outcomes and endoscopic findings without experiencing serious side effects. However, due to the limited number of trials and variability in results, we believe more extensive studies are necessary to fully understand curcumin's role in UC treatment before drawing definitive conclusions.
References
- Zhang D, Tian W, Chen LH, Chen T, Wu D, et al. Synergistic effects of oleanolic acid and curcumin nanoparticles in gastric ulcer prevention. Int J Pharm. 2025. doi:10.1016/j.ijpharm.2025.125465
- Vergara D, Sanhueza C, Méndez S, Bustamante M, Vega B, et al. Evaluation of Preclinical Efficacy of Curcumin-Loaded Bicosome Systems in Amelioration of Oral Mucositis. Pharmaceutics. 2025;17. doi:10.3390/pharmaceutics17020181
- Adlia A, Aslan CC, Safitri L, Adnyana IK. Turmeric-black pepper-honey nanoemulsion formulation and antiulcerogenic effect evaluation against ethanol-induced gastric ulcers in rats. PLoS One. 2025;20:e0317899. doi:10.1371/journal.pone.0317899
- Huang S, Zhang M, Li X, Pei J, Zhou Z, et al. Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity. J Pharm Anal. 2024;14:101014. doi:10.1016/j.jpha.2024.101014
- Zhang X, Zhang H, Wang J, Chen Y, Lin J, et al. Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway. Biofactors. 2025;51:e70001. doi:10.1002/biof.70001
- Song L, Deng Y, Huang J, Zhu X, Zhong Y, et al. Effect of curcumin regulated memory Th7 cells in mice with DSS-induced colitis. Int Immunopharmacol. 2025;145:113770. doi:10.1016/j.intimp.2024.113770
- Peng Z, Li D, Wu N, Wang XY, Sun GX, et al. Safety and efficacy of curcumin in the treatment of ulcerative colitis: An updated systematic review and meta-analysis of randomized controlled trials. Explore (NY). 2025;21:103083. doi:10.1016/j.explore.2024.103083
- Liang S, Wang K, Mao D, Ouyang Q, Lv X, et al. Curcumin alleviated dextran sulfate sodium-induced ulcerative colitis via inhibition of the Wnt/β-catenin signaling pathway and regulation of the differentiation of intestinal stem cells. Toxicol Appl Pharmacol. 2025;494:117175. doi:10.1016/j.taap.2024.117175
- Ameer N, Hanif M, Abbas G, Azeem M, Mahmood K, et al. Treatment of Inflammatory Bowel Disease by Using Curcumin-Containing Self-Microemulsifying Delivery System: Macroscopic and Microscopic Analysis. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16111406
- Wang L, Zheng W, Men Q, Ren X, Song S, et al. Curcumin-loaded polysaccharide microparticles alleviated DSS-induced ulcerative colitis by improving intestinal microecology and regulating MAPK/NF-κB/Nrf2/NLRP3 pathways. Int J Biol Macromol. 2024;281:136687. doi:10.1016/j.ijbiomac.2024.136687
- Nachum NL, Salomon N, Yerushalmy-Feler A, Weintraub Y, Yogev D, et al. The efficacy of curcumin/Qing Dai combination in children with active ulcerative colitis: a multicenter retrospective cohort study. Front Pediatr. 2024;12:1342656. doi:10.3389/fped.2024.1342656
- Kang ZP, Xiao QP, Huang JQ, Wang MX, Huang J, et al. Curcumin Attenuates Dextran Sodium Sulfate Induced Colitis in Obese Mice. Mol Nutr Food Res. 2024;68:e2300598. doi:10.1002/mnfr.202300598
- Liu J, Zhang Z, Lin X, Hu J, Pan X, et al. Magnesium metal-organic framework microneedles loaded with curcumin for accelerating oral ulcer healing. J Nanobiotechnology. 2024;22:594. doi:10.1186/s12951-024-02873-y
- Zhang S, Li C. A curcumin-loaded biopolymeric nanocomposite alleviates dextran sulfate sodium induced ulcerative colitis via suppression of inflammation and oxidative stress. Int J Biol Macromol. 2024;275:133665. doi:10.1016/j.ijbiomac.2024.133665
