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SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.8
USERS' SCORE
Good
Based on 3 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
Curcumin alleviates ulcerative colitis
Effect of curcumin regulated memory Th7 cells in mice with DSS-induced colitis.
Study focused on curcumin therapy
Our exploration focused on how curcumin, a key ingredient in turmeric, affects ulcerative colitis (UC), particularly its impact on memory helper T (mTh) cells. Through a carefully designed experiment using dextran sulfate sodium (DSS) to create a colitis model in mice, we aimed to understand curcumin’s role as a potential treatment.
We found that curcumin significantly improved various symptoms of colitis in the mice, including a reduction in disease activity levels and overall inflammation. Notably, curcumin helped in decreasing the structural damage within the colon and led to a restoration of colon length. Furthermore, the treatment adjusted cytokine levels, promoting beneficial ones like IL-2, IL-4, and IL-10 while suppressing IL-7 and IL-21, which are linked to inflammation.
Importantly, our study demonstrated that curcumin influences mTh7 cells and their activity. The findings from advanced techniques, such as molecular docking and Surface Plasmon Resonance (SPR), reinforced that curcumin interacts effectively with both IL-7 and its receptor, ultimately reducing their expression. This suggests that curcumin helps heal DSS-induced colitis by curbing the activity of mTh7 cells and blocking the pro-inflammatory IL-7/IL-7R signaling pathway.
We found that curcumin significantly improved various symptoms of colitis in the mice, including a reduction in disease activity levels and overall inflammation. Notably, curcumin helped in decreasing the structural damage within the colon and led to a restoration of colon length. Furthermore, the treatment adjusted cytokine levels, promoting beneficial ones like IL-2, IL-4, and IL-10 while suppressing IL-7 and IL-21, which are linked to inflammation.
Importantly, our study demonstrated that curcumin influences mTh7 cells and their activity. The findings from advanced techniques, such as molecular docking and Surface Plasmon Resonance (SPR), reinforced that curcumin interacts effectively with both IL-7 and its receptor, ultimately reducing their expression. This suggests that curcumin helps heal DSS-induced colitis by curbing the activity of mTh7 cells and blocking the pro-inflammatory IL-7/IL-7R signaling pathway.
Read More
9
Curcumin reduces inflammation in UC
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway.
Focuses on curcumin and UC
We studied how curcumin, a key component of turmeric, helps treat ulcerative colitis (UC), an inflammatory bowel disease. Using a model with DSS-induced UC, we explored the effectiveness of curcumin in alleviating the symptoms and damage associated with this condition.
Our findings revealed that curcumin effectively reduced inflammation and intestinal damage. It also increased the number of goblet cells in the colon, which are important for gut health. Through various tests, we observed a significant decrease in inflammatory markers in both serum and colon tissues.
A deeper dive using RNA sequencing showed that curcumin notably lowered the levels of sphingosine kinase 1 (SphK1), a protein involved in inflammation. Additionally, our analyses indicated that curcumin interacts with SphK1 and the NF-κB signaling pathway, pivotal players in inflammation processes.
Importantly, curcumin showed a promising ability to inhibit these pathways, further supporting its anti-inflammatory effects in the context of UC. Overall, our study highlights the potential of curcumin as a natural therapeutic option for managing ulcerative colitis and reducing its inflammatory impact.
Our findings revealed that curcumin effectively reduced inflammation and intestinal damage. It also increased the number of goblet cells in the colon, which are important for gut health. Through various tests, we observed a significant decrease in inflammatory markers in both serum and colon tissues.
A deeper dive using RNA sequencing showed that curcumin notably lowered the levels of sphingosine kinase 1 (SphK1), a protein involved in inflammation. Additionally, our analyses indicated that curcumin interacts with SphK1 and the NF-κB signaling pathway, pivotal players in inflammation processes.
Importantly, curcumin showed a promising ability to inhibit these pathways, further supporting its anti-inflammatory effects in the context of UC. Overall, our study highlights the potential of curcumin as a natural therapeutic option for managing ulcerative colitis and reducing its inflammatory impact.
Read More
8
Curcumin aids ulcer treatment
Curcumin alleviated dextran sulfate sodium-induced ulcerative colitis via inhibition of the Wnt/β-catenin signaling pathway and regulation of the differentiation of intestinal stem cells.
Curcumin's effects on UC
We investigated how curcumin, a compound found in turmeric, affects the healing of ulcers in a mice model of ulcerative colitis (UC) induced by dextran sulfate sodium (DSS). By observing changes in the intestinal structure and examining important proteins involved in a specific signaling pathway known as Wnt/β-catenin, we aimed to understand curcumin's potential benefits.
Our experiments revealed that curcumin had a positive effect on the differentiation of intestinal stem cells (ISCs). These findings suggest that curcumin works by inhibiting the Wnt/β-catenin signaling pathway, which in turn helps restore the normal function of ISCs, crucial for gut health. We further confirmed these effects by using agonists that activate the same pathway.
Overall, our study offers exciting insights into how curcumin might be developed into a novel treatment for ulcerative colitis by promoting the health of intestinal stem cells amidst inflammation.
Our experiments revealed that curcumin had a positive effect on the differentiation of intestinal stem cells (ISCs). These findings suggest that curcumin works by inhibiting the Wnt/β-catenin signaling pathway, which in turn helps restore the normal function of ISCs, crucial for gut health. We further confirmed these effects by using agonists that activate the same pathway.
Overall, our study offers exciting insights into how curcumin might be developed into a novel treatment for ulcerative colitis by promoting the health of intestinal stem cells amidst inflammation.
Read More
Most Useful Reviews
9.5
Effective for ulcers
The main active ingredient in turmeric is curcumin, which is known for its antioxidant and anti-inflammatory properties. Adding curcumin to anti-Helicobacter pylori therapy enhances its effectiveness. This opens new options for using turmeric to treat ulcers. Good results have also been reported for curcumin in conditions like ulcerative colitis and Crohn's disease. Moreover, it has therapeutic effects on inflammatory processes in the intestines and the pancreas, and it prevents fatty liver disease. Overall, turmeric holds promise for treating ulcers and various inflammatory conditions.
Read More
9.5
Ulcer treatment success
Excellent! I'm very fond of the Jarrow Formulas brand and have always found their products high-quality. I purchased this curcumin for treating my duodenal ulcers and for combating H. pylori. Curcumin is a powerful antibiotic and antioxidant. After a month’s course, I experienced no side effects and achieved excellent results. I'll be doing further tests to monitor my progress. Wishing everyone good health!
Read More
9
Supports ulcer recovery
I learned about curcumin in India; it’s a potent antioxidant and anti-inflammatory agent, beneficial for joint diseases, ulcers, and infections. It reduces oxidative stress, and I always keep it in my first aid kit. Though the capsules are large, they are easy to swallow. Recently, I took it while experiencing ARVI, and within two days, I was better. For ulcer support and other ailments, I find it essential.
Read More
Most Recommended Products for Ulcer
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.8
9.5
Curcumin aids oral ulcer healing
Magnesium metal-organic framework microneedles loaded with curcumin for accelerating oral ulcer healing.
Curcumin's combined effects unclear
We developed a novel approach to treat oral ulcers using curcumin, a natural compound known for its health benefits. By creating microneedles that embed curcumin along with magnesium and gallic acid, we aimed to deliver these ingredients directly into the ulcers. This targeted delivery helps release curcumin and magnesium efficiently, helping us address inflammation and promote the healing process.
The combination of curcumin and gallic acid appears to have a positive impact by alleviating oxidative stress, which can hinder healing. We also found that the materials used in the microneedles, such as ε-poly-L-lysine, help form an antibacterial barrier, effectively inhibiting harmful pathogens from worsening the ulcers.
Testing the microneedles on rats with oral ulcers showed promising results, indicating significant therapeutic effects. This innovative treatment not only enhances our approach to managing oral ulcers but also represents a significant advancement in the field of nanobiomaterials and drug delivery technology.
Overall, our findings highlight the potential of curcumin and its synergistic effects when combined with other ingredients for improving oral ulcer treatment and enhancing patient quality of life.
The combination of curcumin and gallic acid appears to have a positive impact by alleviating oxidative stress, which can hinder healing. We also found that the materials used in the microneedles, such as ε-poly-L-lysine, help form an antibacterial barrier, effectively inhibiting harmful pathogens from worsening the ulcers.
Testing the microneedles on rats with oral ulcers showed promising results, indicating significant therapeutic effects. This innovative treatment not only enhances our approach to managing oral ulcers but also represents a significant advancement in the field of nanobiomaterials and drug delivery technology.
Overall, our findings highlight the potential of curcumin and its synergistic effects when combined with other ingredients for improving oral ulcer treatment and enhancing patient quality of life.
Read More
9
Curcumin nanoparticles effective for ulcers
Synergistic effects of oleanolic acid and curcumin nanoparticles in gastric ulcer prevention.
Study combines turmeric and oleanolic acid
We explored the effectiveness of curcumin, a compound found in turmeric, in preventing gastric ulcers, especially given its known anti-inflammatory and antioxidant properties. To tackle the common issue of curcumin's poor absorption in the body, researchers developed special nanoparticles coated with oleanolic acid, which improved the stability and solubility of curcumin.
In our investigation, the oleanolic acid-coated curcumin nanoparticles, or OC NPs, were tested in both laboratory settings and live animal models. Not only did we observe a reduction in inflammation and oxidative stress in cells, but the nanoparticles also showed promising results in protecting mice from ethanol-induced gastric ulcers. This protection came with a decrease in inflammation and an increase in antioxidant levels in their systems.
Histological studies indicated that OC NPs better preserved the gastric mucosa while minimizing damage like fibrosis and cell death. Moreover, they stayed longer in the stomach, enhancing the targeted delivery of curcumin. Overall, our findings suggest that oleanolic acid-coated curcumin nanoparticles could be a safe and effective option to prevent gastric ulcers, making this approach a noteworthy advancement in gastrointestinal health.
In our investigation, the oleanolic acid-coated curcumin nanoparticles, or OC NPs, were tested in both laboratory settings and live animal models. Not only did we observe a reduction in inflammation and oxidative stress in cells, but the nanoparticles also showed promising results in protecting mice from ethanol-induced gastric ulcers. This protection came with a decrease in inflammation and an increase in antioxidant levels in their systems.
Histological studies indicated that OC NPs better preserved the gastric mucosa while minimizing damage like fibrosis and cell death. Moreover, they stayed longer in the stomach, enhancing the targeted delivery of curcumin. Overall, our findings suggest that oleanolic acid-coated curcumin nanoparticles could be a safe and effective option to prevent gastric ulcers, making this approach a noteworthy advancement in gastrointestinal health.
Read More
9
Curcumin shows promise in ulcerative colitis
Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity.
Relevant effectiveness of curcumin treatment.
We explored the effectiveness of curcumin, a natural compound found in turmeric, as a treatment for ulcerative colitis. Our study involved preparing ginger-derived nanovesicles to enhance the delivery of curcumin, aiming to maximize its therapeutic potential.
We found that curcumin was successfully loaded into these nanovesicles and demonstrated remarkable results. Specifically, when administered in this form, curcumin showed a high loading capacity and effective encapsulation, which are crucial for its performance in the body.
Interestingly, after giving these curcumin-loaded nanovesicles to mice, we observed a significant distribution in the colon and improvements in various health markers related to ulcerative colitis. This included enhanced disease activity scores and better measurements of colon length and organ health.
Overall, our findings suggest that curcumin, when delivered via ginger-derived nanovesicles, could offer promising benefits in managing ulcerative colitis. This natural approach seems to modulate critical factors in the body, supporting its protective role against this condition.
We found that curcumin was successfully loaded into these nanovesicles and demonstrated remarkable results. Specifically, when administered in this form, curcumin showed a high loading capacity and effective encapsulation, which are crucial for its performance in the body.
Interestingly, after giving these curcumin-loaded nanovesicles to mice, we observed a significant distribution in the colon and improvements in various health markers related to ulcerative colitis. This included enhanced disease activity scores and better measurements of colon length and organ health.
Overall, our findings suggest that curcumin, when delivered via ginger-derived nanovesicles, could offer promising benefits in managing ulcerative colitis. This natural approach seems to modulate critical factors in the body, supporting its protective role against this condition.
Read More
9
Curcumin reduces inflammation in UC
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway.
Focuses on curcumin and UC
We studied how curcumin, a key component of turmeric, helps treat ulcerative colitis (UC), an inflammatory bowel disease. Using a model with DSS-induced UC, we explored the effectiveness of curcumin in alleviating the symptoms and damage associated with this condition.
Our findings revealed that curcumin effectively reduced inflammation and intestinal damage. It also increased the number of goblet cells in the colon, which are important for gut health. Through various tests, we observed a significant decrease in inflammatory markers in both serum and colon tissues.
A deeper dive using RNA sequencing showed that curcumin notably lowered the levels of sphingosine kinase 1 (SphK1), a protein involved in inflammation. Additionally, our analyses indicated that curcumin interacts with SphK1 and the NF-κB signaling pathway, pivotal players in inflammation processes.
Importantly, curcumin showed a promising ability to inhibit these pathways, further supporting its anti-inflammatory effects in the context of UC. Overall, our study highlights the potential of curcumin as a natural therapeutic option for managing ulcerative colitis and reducing its inflammatory impact.
Our findings revealed that curcumin effectively reduced inflammation and intestinal damage. It also increased the number of goblet cells in the colon, which are important for gut health. Through various tests, we observed a significant decrease in inflammatory markers in both serum and colon tissues.
A deeper dive using RNA sequencing showed that curcumin notably lowered the levels of sphingosine kinase 1 (SphK1), a protein involved in inflammation. Additionally, our analyses indicated that curcumin interacts with SphK1 and the NF-κB signaling pathway, pivotal players in inflammation processes.
Importantly, curcumin showed a promising ability to inhibit these pathways, further supporting its anti-inflammatory effects in the context of UC. Overall, our study highlights the potential of curcumin as a natural therapeutic option for managing ulcerative colitis and reducing its inflammatory impact.
Read More
9
Curcumin alleviates ulcerative colitis
Effect of curcumin regulated memory Th7 cells in mice with DSS-induced colitis.
Study focused on curcumin therapy
Our exploration focused on how curcumin, a key ingredient in turmeric, affects ulcerative colitis (UC), particularly its impact on memory helper T (mTh) cells. Through a carefully designed experiment using dextran sulfate sodium (DSS) to create a colitis model in mice, we aimed to understand curcumin’s role as a potential treatment.
We found that curcumin significantly improved various symptoms of colitis in the mice, including a reduction in disease activity levels and overall inflammation. Notably, curcumin helped in decreasing the structural damage within the colon and led to a restoration of colon length. Furthermore, the treatment adjusted cytokine levels, promoting beneficial ones like IL-2, IL-4, and IL-10 while suppressing IL-7 and IL-21, which are linked to inflammation.
Importantly, our study demonstrated that curcumin influences mTh7 cells and their activity. The findings from advanced techniques, such as molecular docking and Surface Plasmon Resonance (SPR), reinforced that curcumin interacts effectively with both IL-7 and its receptor, ultimately reducing their expression. This suggests that curcumin helps heal DSS-induced colitis by curbing the activity of mTh7 cells and blocking the pro-inflammatory IL-7/IL-7R signaling pathway.
We found that curcumin significantly improved various symptoms of colitis in the mice, including a reduction in disease activity levels and overall inflammation. Notably, curcumin helped in decreasing the structural damage within the colon and led to a restoration of colon length. Furthermore, the treatment adjusted cytokine levels, promoting beneficial ones like IL-2, IL-4, and IL-10 while suppressing IL-7 and IL-21, which are linked to inflammation.
Importantly, our study demonstrated that curcumin influences mTh7 cells and their activity. The findings from advanced techniques, such as molecular docking and Surface Plasmon Resonance (SPR), reinforced that curcumin interacts effectively with both IL-7 and its receptor, ultimately reducing their expression. This suggests that curcumin helps heal DSS-induced colitis by curbing the activity of mTh7 cells and blocking the pro-inflammatory IL-7/IL-7R signaling pathway.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Effective for ulcers
The main active ingredient in turmeric is curcumin, which is known for its antioxidant and anti-inflammatory properties. Adding curcumin to anti-Helicobacter pylori therapy enhances its effectiveness. This opens new options for using turmeric to treat ulcers. Good results have also been reported for curcumin in conditions like ulcerative colitis and Crohn's disease. Moreover, it has therapeutic effects on inflammatory processes in the intestines and the pancreas, and it prevents fatty liver disease. Overall, turmeric holds promise for treating ulcers and various inflammatory conditions.
Read More
9.5
Ulcer treatment success
Excellent! I'm very fond of the Jarrow Formulas brand and have always found their products high-quality. I purchased this curcumin for treating my duodenal ulcers and for combating H. pylori. Curcumin is a powerful antibiotic and antioxidant. After a month’s course, I experienced no side effects and achieved excellent results. I'll be doing further tests to monitor my progress. Wishing everyone good health!
Read More
9
Supports ulcer recovery
I learned about curcumin in India; it’s a potent antioxidant and anti-inflammatory agent, beneficial for joint diseases, ulcers, and infections. It reduces oxidative stress, and I always keep it in my first aid kit. Though the capsules are large, they are easy to swallow. Recently, I took it while experiencing ARVI, and within two days, I was better. For ulcer support and other ailments, I find it essential.
Read More
