Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 12 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
We explored the effects of vitamin B6, specifically its active form called pyridoxal phosphate (PLP), on allergic responses. Our research focused on how this vitamin might influence interleukin-33 (IL-33), a key cytokine involved in type 2 inflammation, typically seen in asthma and other allergic conditions.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
Read More
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Read More
7
We dove deep into the question of whether vitamin B6 has any impact on allergic reactions associated with Dengzhan Xixin, a medication given through injections. Our analysis was based on a nested case-control study, leveraging data from 20 hospitals across China. The participants included patients who received dexamethasone due to suspected allergic reactions after being administered Dengzhan Xixin, allowing us to compare them with those who did not experience such reactions.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Read More
Most Useful Reviews
10
Metabolism improved
Excellent quality product with well-chosen ingredients. I experienced no allergies or negative reactions. The packaging is ample, and the capsules are medium in size with a neutral taste. After one week, I noticed improved bowel function and a calmer nervous system. I have no doubt regarding its effectiveness – just ensure you check the dosage based on your age.
Read More
10
Highly recommended
Super beneficial and effective with no allergies. I definitely recommend it.
Read More
9
Long-lasting supply
Super! Excellent quality product with perfectly selected ingredients and no allergies or negative reactions. The large package will last quite a while, and the capsules are medium-sized with a neutral taste. The dietary supplement arrived quickly and undamaged. It contains only beneficial natural components and folic acid. My bowel function and metabolism have improved, and I noticed the results after a week. My nervous system is functioning better, and I've become less anxious. I like everything about it and trust the vitamin's effectiveness. Just remember to check your dosage according to your age.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
- All Researches
8
We evaluated how D-Pinitol affects allergic rhinitis (AR) in a controlled study using mice.
By sensitizing BALB/c mice with ovalbumin (OVA), we created an AR model. After giving treatment groups various doses of pinitol or montelukast, we found that higher doses of pinitol significantly reduced symptoms like sneezing and nasal discharge.
Notably, it also balanced specific immune responses typically seen in allergies. However, montelukast showed clearer results in some areas, indicating that while pinitol is promising, more research is necessary.
By sensitizing BALB/c mice with ovalbumin (OVA), we created an AR model. After giving treatment groups various doses of pinitol or montelukast, we found that higher doses of pinitol significantly reduced symptoms like sneezing and nasal discharge.
Notably, it also balanced specific immune responses typically seen in allergies. However, montelukast showed clearer results in some areas, indicating that while pinitol is promising, more research is necessary.
Read More
8
We explored the effects of vitamin B6, specifically its active form called pyridoxal phosphate (PLP), on allergic responses. Our research focused on how this vitamin might influence interleukin-33 (IL-33), a key cytokine involved in type 2 inflammation, typically seen in asthma and other allergic conditions.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
Read More
7
We dove deep into the question of whether vitamin B6 has any impact on allergic reactions associated with Dengzhan Xixin, a medication given through injections. Our analysis was based on a nested case-control study, leveraging data from 20 hospitals across China. The participants included patients who received dexamethasone due to suspected allergic reactions after being administered Dengzhan Xixin, allowing us to compare them with those who did not experience such reactions.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Read More
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
10
Metabolism improved
Excellent quality product with well-chosen ingredients. I experienced no allergies or negative reactions. The packaging is ample, and the capsules are medium in size with a neutral taste. After one week, I noticed improved bowel function and a calmer nervous system. I have no doubt regarding its effectiveness – just ensure you check the dosage based on your age.
Read More
10
Highly recommended
Super beneficial and effective with no allergies. I definitely recommend it.
Read More
9
Long-lasting supply
Super! Excellent quality product with perfectly selected ingredients and no allergies or negative reactions. The large package will last quite a while, and the capsules are medium-sized with a neutral taste. The dietary supplement arrived quickly and undamaged. It contains only beneficial natural components and folic acid. My bowel function and metabolism have improved, and I noticed the results after a week. My nervous system is functioning better, and I've become less anxious. I like everything about it and trust the vitamin's effectiveness. Just remember to check your dosage according to your age.
Read More
9
Doctor recommended
Top-quality folic acid, very pleasant to taste, with no allergies observed. It comes highly recommended by my doctor/nutritionist. I will certainly order more.
Read More
9
Recommended for absorption
Really working! If you struggle to absorb folic acid, feel free to use this tablet! I experienced no allergies with it.
Read More
Frequently Asked Questions
10
Metabolism improved
Excellent quality product with well-chosen ingredients. I experienced no allergies or negative reactions. The packaging is ample, and the capsules are medium in size with a neutral taste. After one week, I noticed improved bowel function and a calmer nervous system. I have no doubt regarding its effectiveness – just ensure you check the dosage based on your age.
9
Long-lasting supply
Super! Excellent quality product with perfectly selected ingredients and no allergies or negative reactions. The large package will last quite a while, and the capsules are medium-sized with a neutral taste. The dietary supplement arrived quickly and undamaged. It contains only beneficial natural components and folic acid. My bowel function and metabolism have improved, and I noticed the results after a week. My nervous system is functioning better, and I've become less anxious. I like everything about it and trust the vitamin's effectiveness. Just remember to check your dosage according to your age.
2
No benefits observed
Didn't see much effect. I have nearly finished the bottle but haven’t observed any benefits in reducing allergies or itching.
10
Highly recommended
Super beneficial and effective with no allergies. I definitely recommend it.
9
Immunity boost
A superb combination of vitamin B12 and folate that enhances immunity and combats allergies effectively.
9
Suitable for condition
I began using this supplement recently due to a genetic folate cycle disorder that prevents absorption of common B9 and B12 forms. I have struggled with vitamin deficiencies and high homocysteine levels. I suck on one tablet after lunch; the taste is pleasant and not overly sugary. It does not cause any allergies.
8
We evaluated how D-Pinitol affects allergic rhinitis (AR) in a controlled study using mice.
By sensitizing BALB/c mice with ovalbumin (OVA), we created an AR model. After giving treatment groups various doses of pinitol or montelukast, we found that higher doses of pinitol significantly reduced symptoms like sneezing and nasal discharge.
Notably, it also balanced specific immune responses typically seen in allergies. However, montelukast showed clearer results in some areas, indicating that while pinitol is promising, more research is necessary.
By sensitizing BALB/c mice with ovalbumin (OVA), we created an AR model. After giving treatment groups various doses of pinitol or montelukast, we found that higher doses of pinitol significantly reduced symptoms like sneezing and nasal discharge.
Notably, it also balanced specific immune responses typically seen in allergies. However, montelukast showed clearer results in some areas, indicating that while pinitol is promising, more research is necessary.
8
We explored the effects of vitamin B6, specifically its active form called pyridoxal phosphate (PLP), on allergic responses. Our research focused on how this vitamin might influence interleukin-33 (IL-33), a key cytokine involved in type 2 inflammation, typically seen in asthma and other allergic conditions.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
7
We dove deep into the question of whether vitamin B6 has any impact on allergic reactions associated with Dengzhan Xixin, a medication given through injections. Our analysis was based on a nested case-control study, leveraging data from 20 hospitals across China. The participants included patients who received dexamethasone due to suspected allergic reactions after being administered Dengzhan Xixin, allowing us to compare them with those who did not experience such reactions.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
References
- You X, Sun X, Kong J, Tian J, Shi Y, et al. D-Pinitol Attenuated Ovalbumin-induced Allergic Rhinitis in Experimental Mice via Balancing Th1/Th2 Response. Iran J Allergy Asthma Immunol. 2021;20:672. doi:10.18502/ijaai.v20i6.8017
- Zhu S, Zhong S, Cheng K, Zhang LS, Bai JW, et al. Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation. Cell Mol Immunol. 2023;20:794. doi:10.1038/s41423-023-01029-6
- Yang W, Cheng H, Xie YM, Yang H, Zhuang Y. [Nested case control study to analyze suspected cases and their related factors of allargic reactions to parenterally administered dengzhan xixin]. Zhongguo Zhong Yao Za Zhi. 2013;38:3024.
- El Rhermoul FZ, Mustafa A, Wagner A, Nakonechna A, Kayode OS, et al. Vitamin B Hypersensitivity: A Retrospective Multicenter Study. J Allergy Clin Immunol Pract. 2024;12:699. doi:10.1016/j.jaip.2023.10.037
