Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
Cariban effectively relieves pregnancy nausea
We examined how Cariban, a combination of doxylamine and pyridoxine, helps alleviate nausea and vomiting during pregnancy. Using a controlled study involving 12 healthy women, we looked at how the modified-release capsules perform in the body compared to other forms.
Our findings showed that Cariban is absorbed quickly and maintains its effectiveness over an extended period. This makes it a reliable option for managing nausea in pregnant women, underscoring its value in clinical practice.
Our findings showed that Cariban is absorbed quickly and maintains its effectiveness over an extended period. This makes it a reliable option for managing nausea in pregnant women, underscoring its value in clinical practice.
Read More
9
We examined a case involving an 82-year-old woman with advanced cervical cancer who experienced nausea and significant dietary intake decline. Her thiamine levels were critically low, indicating a deficiency that might have contributed to her condition.
After receiving 100 mg of thiamine intravenously, we observed notable improvements within a couple of hours. Her dietary intake increased significantly, from barely eating to nearly full meals. This suggests that addressing thiamine deficiency can positively impact the quality of life in patients receiving palliative care and highlights the importance of proper diagnosis.
After receiving 100 mg of thiamine intravenously, we observed notable improvements within a couple of hours. Her dietary intake increased significantly, from barely eating to nearly full meals. This suggests that addressing thiamine deficiency can positively impact the quality of life in patients receiving palliative care and highlights the importance of proper diagnosis.
Read More
8
Pyridoxine reduces nausea in pregnancy
We explored the effects of pyridoxine, or Vitamin B6, on nausea and vomiting during pregnancy, conditions known as NVP. By reviewing several studies, we found that Vitamin B6 supplementation, whether on its own or combined with other treatments, showed notable improvements in reducing nausea.
Out of 18 studies examined, eight demonstrated that pyridoxine alone is effective, while six indicated positive results when it was paired with other therapies.
Overall, our findings suggest that Vitamin B6 can be a helpful option for pregnant women dealing with these uncomfortable symptoms.
Out of 18 studies examined, eight demonstrated that pyridoxine alone is effective, while six indicated positive results when it was paired with other therapies.
Overall, our findings suggest that Vitamin B6 can be a helpful option for pregnant women dealing with these uncomfortable symptoms.
Read More
Most Useful Reviews
8
Reduced nausea significantly
1 people found this helpful
Great buy. Recommended by my naturopathic doctor, this product helped me metabolise folate better when expecting. It supported my baby's health, reduced my nausea (I had none after seven weeks), and increased my energy.
Read More
10
Transforms nausea
Great for nausea! This product is of high quality and contains effective ingredients. My wife struggled with nausea during her pregnancy, leading her to eat little, but after just one tablet, her appetite and energy returned. I’m immensely grateful to Jarrow Formulas for this product that delivers active folic acid, B6, and B12 straight into the bloodstream.
Read More
9
Effective for nausea
Exactly what I needed! I’m really happy with this product. Being chewable, I could take it without issues related to morning sickness (no concerns about it coming back up). Given that it's methyl folate, I felt more assured about its bioavailability compared to folic acid. The B vitamins, particularly the P5P form of B6, were beneficial in tackling my nausea.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7
- All Researches
9
We examined a case involving an 82-year-old woman with advanced cervical cancer who experienced nausea and significant dietary intake decline. Her thiamine levels were critically low, indicating a deficiency that might have contributed to her condition.
After receiving 100 mg of thiamine intravenously, we observed notable improvements within a couple of hours. Her dietary intake increased significantly, from barely eating to nearly full meals. This suggests that addressing thiamine deficiency can positively impact the quality of life in patients receiving palliative care and highlights the importance of proper diagnosis.
After receiving 100 mg of thiamine intravenously, we observed notable improvements within a couple of hours. Her dietary intake increased significantly, from barely eating to nearly full meals. This suggests that addressing thiamine deficiency can positively impact the quality of life in patients receiving palliative care and highlights the importance of proper diagnosis.
Read More
9
Cariban effectively relieves pregnancy nausea
We examined how Cariban, a combination of doxylamine and pyridoxine, helps alleviate nausea and vomiting during pregnancy. Using a controlled study involving 12 healthy women, we looked at how the modified-release capsules perform in the body compared to other forms.
Our findings showed that Cariban is absorbed quickly and maintains its effectiveness over an extended period. This makes it a reliable option for managing nausea in pregnant women, underscoring its value in clinical practice.
Our findings showed that Cariban is absorbed quickly and maintains its effectiveness over an extended period. This makes it a reliable option for managing nausea in pregnant women, underscoring its value in clinical practice.
Read More
8
Pyridoxine reduces nausea in pregnancy
We explored the effects of pyridoxine, or Vitamin B6, on nausea and vomiting during pregnancy, conditions known as NVP. By reviewing several studies, we found that Vitamin B6 supplementation, whether on its own or combined with other treatments, showed notable improvements in reducing nausea.
Out of 18 studies examined, eight demonstrated that pyridoxine alone is effective, while six indicated positive results when it was paired with other therapies.
Overall, our findings suggest that Vitamin B6 can be a helpful option for pregnant women dealing with these uncomfortable symptoms.
Out of 18 studies examined, eight demonstrated that pyridoxine alone is effective, while six indicated positive results when it was paired with other therapies.
Overall, our findings suggest that Vitamin B6 can be a helpful option for pregnant women dealing with these uncomfortable symptoms.
Read More
8
Vitamin B12's role in nausea unclear
We explored the role of vitamin B12 in treating nausea related to cerebral venous thrombosis (CVT). In a case study involving a 28-year-old man, we noted that after undergoing treatment with heparin, warfarin, and vitamin B12, his nausea improved along with his persistent headache symptoms.
Although we observed positive outcomes associated with this vitamin, it was part of a broader treatment approach rather than a standalone intervention. The study indicated that the combination of these treatments effectively alleviated nausea, but we cannot draw firm conclusions on vitamin B12's isolated impact due to the lack of control or blinding in the study design.
Overall, while vitamin B12 may have contributed to symptom relief, we must recognize that its specific role remains uncertain within the context of CVT treatment. Further studies would be needed to better define its effectiveness solely for nausea.
Although we observed positive outcomes associated with this vitamin, it was part of a broader treatment approach rather than a standalone intervention. The study indicated that the combination of these treatments effectively alleviated nausea, but we cannot draw firm conclusions on vitamin B12's isolated impact due to the lack of control or blinding in the study design.
Overall, while vitamin B12 may have contributed to symptom relief, we must recognize that its specific role remains uncertain within the context of CVT treatment. Further studies would be needed to better define its effectiveness solely for nausea.
Read More
7
We investigated whether pyridoxine, or vitamin B6, could help reduce postoperative nausea and vomiting (PONV) in patients after gynecological laparoscopic surgery. In our study, patients were split into two groups: one received pyridoxine while the other got a placebo.
Those who took pyridoxine, alongside standard medications, reported lower levels of nausea post-surgery. While the results show promise, further research in varied populations is essential for a more definitive conclusion.
Those who took pyridoxine, alongside standard medications, reported lower levels of nausea post-surgery. While the results show promise, further research in varied populations is essential for a more definitive conclusion.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
8
Reduced nausea significantly
1 people found this helpful
Great buy. Recommended by my naturopathic doctor, this product helped me metabolise folate better when expecting. It supported my baby's health, reduced my nausea (I had none after seven weeks), and increased my energy.
Read More
10
Transforms nausea
Great for nausea! This product is of high quality and contains effective ingredients. My wife struggled with nausea during her pregnancy, leading her to eat little, but after just one tablet, her appetite and energy returned. I’m immensely grateful to Jarrow Formulas for this product that delivers active folic acid, B6, and B12 straight into the bloodstream.
Read More
9
Effective for nausea
Exactly what I needed! I’m really happy with this product. Being chewable, I could take it without issues related to morning sickness (no concerns about it coming back up). Given that it's methyl folate, I felt more assured about its bioavailability compared to folic acid. The B vitamins, particularly the P5P form of B6, were beneficial in tackling my nausea.
Read More
9
Recommended for nausea
I love this medication; it’s part of my protocols due to its good composition and pleasant taste. The results are quick to manifest! Vitamins B12 and B9 are essential in numerous biochemical processes, yet often without sufficient vitamin B6. This complex offers everything needed, and I particularly recommend it for pregnant women as it has greatly helped me with my nausea!
Read More
9
No nausea effects
An excellent solution for those unable to take regular folic acid. It absorbs well and does not induce nausea or adverse reactions. My health has noticeably improved after using this product. Additionally, the capsules are packaged in a dark container, demonstrating the manufacturer’s concern for the product's safety and efficacy.
Read More
Frequently Asked Questions
7.5
Relieves nausea
Good composition, fast delivery, and high-quality packaging. The capsules are slightly large but easy to swallow, with a pleasant citrus taste. I take one daily with meals, alongside vitamin D3+K2, magnesium, and vitamin B6. I've noticed significant benefits within just 10 days; my energy has increased, headaches have ceased, and my mood remains excellent throughout the day. This product is fantastic for those into fitness and following a diet, plus it has really helped address my nausea.
10
Transforms nausea
Great for nausea! This product is of high quality and contains effective ingredients. My wife struggled with nausea during her pregnancy, leading her to eat little, but after just one tablet, her appetite and energy returned. I’m immensely grateful to Jarrow Formulas for this product that delivers active folic acid, B6, and B12 straight into the bloodstream.
7.5
Less nausea experienced
Life-changing! This product has a refreshing lemon flavour that isn’t overpowering. Throughout my two pregnancies, I experienced severe nausea for 40 weeks, but during this pregnancy, I only feel what can be described as ‘sea sickness.’ The recommended usage is one daily, but I occasionally take two when I feel unwell, knowing it will help. I will certainly purchase this again.
7.5
Good for fatigue
Very pleased with the fast delivery and high-quality packaging. The capsules are slightly large, but easy to swallow and have a citrus taste. I take one daily with meals alongside vitamins D3+K2, magnesium, and B6. After 10 days, the benefits are clear; my energy levels are up, headaches have stopped, and I’m in a good mood throughout the day. This product is ideal for fitness enthusiasts and also helps with my nausea.
9
Effective for nausea
Exactly what I needed! I’m really happy with this product. Being chewable, I could take it without issues related to morning sickness (no concerns about it coming back up). Given that it's methyl folate, I felt more assured about its bioavailability compared to folic acid. The B vitamins, particularly the P5P form of B6, were beneficial in tackling my nausea.
7
We investigated whether pyridoxine, or vitamin B6, could help reduce postoperative nausea and vomiting (PONV) in patients after gynecological laparoscopic surgery. In our study, patients were split into two groups: one received pyridoxine while the other got a placebo.
Those who took pyridoxine, alongside standard medications, reported lower levels of nausea post-surgery. While the results show promise, further research in varied populations is essential for a more definitive conclusion.
Those who took pyridoxine, alongside standard medications, reported lower levels of nausea post-surgery. While the results show promise, further research in varied populations is essential for a more definitive conclusion.
8
Pyridoxine reduces nausea in pregnancy
We explored the effects of pyridoxine, or Vitamin B6, on nausea and vomiting during pregnancy, conditions known as NVP. By reviewing several studies, we found that Vitamin B6 supplementation, whether on its own or combined with other treatments, showed notable improvements in reducing nausea.
Out of 18 studies examined, eight demonstrated that pyridoxine alone is effective, while six indicated positive results when it was paired with other therapies.
Overall, our findings suggest that Vitamin B6 can be a helpful option for pregnant women dealing with these uncomfortable symptoms.
Out of 18 studies examined, eight demonstrated that pyridoxine alone is effective, while six indicated positive results when it was paired with other therapies.
Overall, our findings suggest that Vitamin B6 can be a helpful option for pregnant women dealing with these uncomfortable symptoms.
4
We investigated the use of vitamin B6 as a common treatment for nausea and vomiting during pregnancy. There has been an ongoing discussion about how effective high doses of this vitamin actually are, and we wanted to shed light on this issue.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
References
- Zhang Q, Ye X, Shi S, Zhou S, Ma D, et al. Pyridoxine Prevents Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery: A Double-blind Randomized Controlled Trial. Anesthesiology. 2024. doi:10.1097/ALN.0000000000005354
- Hayashi E, Matuura T, Takano J, Morofushi K, Toriizuka K, et al. Thiamine deficiency as a cause of anorexia in terminally ill cancer patients: A case of possible gastrointestinal beriberi. Palliat Support Care. 2024;22:1511. doi:10.1017/S1478951524000415
- Saz-Leal P, Zamorano-Domínguez L, Frías J, Guerra P, Saura-Valls M, et al. Bioavailability of Cariban Capsules: A Modified-Release Fixed-Dose Combination of Doxylamine and Pyridoxine to Relieve Nausea and Vomiting During Pregnancy. Drugs R D. 2023;23:185. doi:10.1007/s40268-023-00425-7
- Jayawardena R, Majeed S, Sooriyaarachchi P, Abeywarne U, Ranaweera P. The effects of pyridoxine (vitamin B6) supplementation in nausea and vomiting during pregnancy: a systematic review and meta-analysis. Arch Gynecol Obstet. 2023;308:1075. doi:10.1007/s00404-023-06925-w
- He L, Fan Y, Hu Y, Tian C, Tian Y, et al. The potential hazards of high doses of vitamin B6 in treating nausea and vomiting in pregnancy: A systematic review. Int J Gynaecol Obstet. 2024. doi:10.1002/ijgo.16032
- Adu-Afarwuah S, Arnold CD, Lartey A, Okronipa H, Maleta K, et al. Prevalence of morbidity symptoms among pregnant and postpartum women receiving different nutrient supplements in Ghana and Malawi: A secondary outcome analysis of two randomised controlled trials. Matern Child Nutr. 2023;19:e13501. doi:10.1111/mcn.13501
- Dikici S, Saritas A, Besir FH, Celbek G, Arslan G. May headache be the first sign of mutation in the MTHFR gene?. World J Emerg Med. 2013;4:69.
