' 
![]()
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 55 Reviews
8.8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
MethylSulfonylMethane (MSM)
1,000 mg
†
Top Medical Research Studies
8
MSM improves mild knee pain
Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.
Highly relevant to MSM and arthritis
In a well-structured randomized, double-blind, placebo-controlled trial, we explored how methylsulfonylmethane (MSM) affects those experiencing mild knee pain. The study involved 88 healthy Japanese participants, split evenly into two groups where one received 200 mg of MSM while the other received a placebo for 12 weeks.
By measuring the total score on the Japanese Knee Osteoarthritis Measure (JKOM) at the end of the trial, we found that the MSM group showed a significant improvement compared to the placebo group. Specifically, total JKOM scores changed markedly, with an improvement in knee and systemic health reported by participants who took MSM.
Our findings suggest that MSM might be beneficial for individuals with mild knee pain, marking it as a useful supplement for enhancing joint health. The positive outcomes underscore the potential of MSM as a supportive treatment option for managing mild arthritic conditions.
By measuring the total score on the Japanese Knee Osteoarthritis Measure (JKOM) at the end of the trial, we found that the MSM group showed a significant improvement compared to the placebo group. Specifically, total JKOM scores changed markedly, with an improvement in knee and systemic health reported by participants who took MSM.
Our findings suggest that MSM might be beneficial for individuals with mild knee pain, marking it as a useful supplement for enhancing joint health. The positive outcomes underscore the potential of MSM as a supportive treatment option for managing mild arthritic conditions.
Read More
8
MSM improves mild knee pain
Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.
Highly relevant to MSM and arthritis
In a well-structured randomized, double-blind, placebo-controlled trial, we explored how methylsulfonylmethane (MSM) affects those experiencing mild knee pain. The study involved 88 healthy Japanese participants, split evenly into two groups where one received 200 mg of MSM while the other received a placebo for 12 weeks.
By measuring the total score on the Japanese Knee Osteoarthritis Measure (JKOM) at the end of the trial, we found that the MSM group showed a significant improvement compared to the placebo group. Specifically, total JKOM scores changed markedly, with an improvement in knee and systemic health reported by participants who took MSM.
Our findings suggest that MSM might be beneficial for individuals with mild knee pain, marking it as a useful supplement for enhancing joint health. The positive outcomes underscore the potential of MSM as a supportive treatment option for managing mild arthritic conditions.
By measuring the total score on the Japanese Knee Osteoarthritis Measure (JKOM) at the end of the trial, we found that the MSM group showed a significant improvement compared to the placebo group. Specifically, total JKOM scores changed markedly, with an improvement in knee and systemic health reported by participants who took MSM.
Our findings suggest that MSM might be beneficial for individuals with mild knee pain, marking it as a useful supplement for enhancing joint health. The positive outcomes underscore the potential of MSM as a supportive treatment option for managing mild arthritic conditions.
Read More
8
MSM reduces gouty arthritis symptoms
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
Direct relevance to treatment explored.
We explored the therapeutic potential of Modified Simiaowan (MSM), a six-herb formula, specifically for its effects on gouty arthritis (GA). To understand how MSM influences the condition, we conducted a thorough investigation using mouse macrophages that were exposed to inflammatory stimuli and then treated with MSM.
Our findings showed that MSM effectively reduces inflammation and oxidative stress, which are key contributors to gouty arthritis. We measured the expression of inflammatory markers and the NLRP3 inflammasome pathway to see how MSM interacts at a biological level. This included utilizing techniques like western blotting and ELISA to gather essential data.
Furthermore, we validated MSM’s anti-inflammatory and antioxidant activities in rat models of GA. The treatments pointed to MSM alleviating symptoms through the Nrf2/HO-1/ROS/NLRP3 signaling pathway, indicating a promising mechanism of action. Overall, our results highlight MSM’s significant potential as a natural solution for managing gouty arthritis symptoms successfully.
Our findings showed that MSM effectively reduces inflammation and oxidative stress, which are key contributors to gouty arthritis. We measured the expression of inflammatory markers and the NLRP3 inflammasome pathway to see how MSM interacts at a biological level. This included utilizing techniques like western blotting and ELISA to gather essential data.
Furthermore, we validated MSM’s anti-inflammatory and antioxidant activities in rat models of GA. The treatments pointed to MSM alleviating symptoms through the Nrf2/HO-1/ROS/NLRP3 signaling pathway, indicating a promising mechanism of action. Overall, our results highlight MSM’s significant potential as a natural solution for managing gouty arthritis symptoms successfully.
Read More
Most Useful Reviews
9
Significant pain relief
I suffer from an undiagnosed condition producing daily musculoskeletal pain. After discovering that higher doses of MSM could provide relief, I began taking up to 16 capsules daily spaced out, which resulted in fantastic pain relief. Research suggests MSM is effective for knee arthritis. Now, I assess my pain level and adjust my MSM intake accordingly. This supplement is benign and very helpful, and I highly recommend it.
Read More
9
Daily joint maintenance
I take MSM daily, one teaspoon in the morning and evening. It’s excellent for maintaining my joints and has been beneficial for osteoarthritis. I’ve recommended it to many patients with positive results.
Read More
9.5
Reduced inflammation quickly
Great! This is the first product I found that immediately reduced inflammation in my joints and eased arthritis pain. I take two daily, and I also give my old dog one a day for his joints. I notice a distinct difference in his walking. It works systemically for many other issues too, like my rosacea, age spots, and sinus problems. A miracle drug!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
9
MSM and mobilee support cartilage health
Methylsulfonylmethane and mobilee prevent negative effect of IL-1β in human chondrocyte cultures via NF-κB signaling pathway.
Relevant but challenging to isolate effects
We investigated how methylsulfonylmethane (MSM) and a herbal extract called mobilee influence arthritis in human chondrocytes, the cells found in cartilage. By exposing these cells to interleukin (IL)-1β—a protein that can cause joint inflammation—we aimed to understand if these treatments could mitigate the damage commonly associated with osteoarthritis (OA).
We took chondrocytes from the femoral heads of patients undergoing hip replacement surgery and treated them with varying amounts of MSM and mobilee in the presence of IL-1β. Our tests measured cell survival and apoptosis—basically whether the cells lived or died—and assessed the levels of key proteins linked to cartilage breakdown and health.
Our results were encouraging. Both MSM and mobilee appeared to significantly reverse the negative effects brought on by IL-1β. Additionally, they managed to combat the activation of NF-κB, a pathway often implicated in inflammation and cell death. By reducing the levels of harmful enzymes and increasing beneficial proteins, these treatments seem to offer a potential new approach to improving joint health in arthritis patients.
In conclusion, this study suggests that MSM and mobilee could play a beneficial role in protecting cartilage cells from the inflammatory damage caused by IL-1β, providing a strong rationale for their consideration in arthritis treatment.
We took chondrocytes from the femoral heads of patients undergoing hip replacement surgery and treated them with varying amounts of MSM and mobilee in the presence of IL-1β. Our tests measured cell survival and apoptosis—basically whether the cells lived or died—and assessed the levels of key proteins linked to cartilage breakdown and health.
Our results were encouraging. Both MSM and mobilee appeared to significantly reverse the negative effects brought on by IL-1β. Additionally, they managed to combat the activation of NF-κB, a pathway often implicated in inflammation and cell death. By reducing the levels of harmful enzymes and increasing beneficial proteins, these treatments seem to offer a potential new approach to improving joint health in arthritis patients.
In conclusion, this study suggests that MSM and mobilee could play a beneficial role in protecting cartilage cells from the inflammatory damage caused by IL-1β, providing a strong rationale for their consideration in arthritis treatment.
Read More
9
MSM improves knee OA treatment
Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial.
Evaluates MSM's combined benefits
We conducted a thoughtful investigation into how Methylsulfonylmethane (MSM) impacts the treatment of knee osteoarthritis (OA) when paired with glucosamine and chondroitin sulfate. In our study, 147 patients diagnosed with Kellgren-Lawrence grade I-II knee OA were randomly divided into three groups. One group received a combination of glucosamine and chondroitin sulfate, the second group received the same combination with MSM, and the third group was given a placebo.
The patients took their assigned capsules daily for three months, and we measured their pain and mobility before treatment and then at 4, 8, and 12 weeks after starting the regimen. The results revealed that the combination of glucosamine, chondroitin sulfate, and MSM offered noticeable clinical benefits for patients with knee OA. However, those taking only glucosamine and chondroitin sulfate experienced no significant improvement compared to the placebo group.
Our findings highlight the potential advantage of supplementing glucosamine and chondroitin with MSM for managing knee osteoarthritis. Nonetheless, the lack of improvement with glucosamine and chondroitin alone calls into question their effectiveness independently of MSM.
The patients took their assigned capsules daily for three months, and we measured their pain and mobility before treatment and then at 4, 8, and 12 weeks after starting the regimen. The results revealed that the combination of glucosamine, chondroitin sulfate, and MSM offered noticeable clinical benefits for patients with knee OA. However, those taking only glucosamine and chondroitin sulfate experienced no significant improvement compared to the placebo group.
Our findings highlight the potential advantage of supplementing glucosamine and chondroitin with MSM for managing knee osteoarthritis. Nonetheless, the lack of improvement with glucosamine and chondroitin alone calls into question their effectiveness independently of MSM.
Read More
9
ARTRA MSM improves knee OA treatment
[Use of ARTRA MSM FORTE in patients with knee osteoarthritis: Results of a randomized open-label comparative study of the efficacy and tolerability of the drug].
MSM is significant in joint treatment
We aimed to explore how the combined medication ARTRA MSM FORTE could help patients suffering from knee osteoarthritis (OA). This study involved 100 individuals who were experiencing noticeable pain while walking.
We divided participants into two groups: one group took ARTRA MSM, while the other received a similar combination without the MSM. Over the course of four months, we conducted monthly evaluations to track improvements in pain levels, mobility, and overall quality of life.
Notably, we observed that those taking ARTRA MSM experienced quicker reductions in pain and improvements in functional tests compared to the other group. In fact, 72% of patients taking ARTRA MSM reported feeling relief from pain more rapidly than those on the standard treatment. Based on these findings, we can comfortably recommend ARTRA MSM for managing knee OA in clinical settings.
We divided participants into two groups: one group took ARTRA MSM, while the other received a similar combination without the MSM. Over the course of four months, we conducted monthly evaluations to track improvements in pain levels, mobility, and overall quality of life.
Notably, we observed that those taking ARTRA MSM experienced quicker reductions in pain and improvements in functional tests compared to the other group. In fact, 72% of patients taking ARTRA MSM reported feeling relief from pain more rapidly than those on the standard treatment. Based on these findings, we can comfortably recommend ARTRA MSM for managing knee OA in clinical settings.
Read More
9
MSM and mobilee support cartilage health
Methylsulfonylmethane and mobilee prevent negative effect of IL-1β in human chondrocyte cultures via NF-κB signaling pathway.
Relevant but challenging to isolate effects
We investigated how methylsulfonylmethane (MSM) and a herbal extract called mobilee influence arthritis in human chondrocytes, the cells found in cartilage. By exposing these cells to interleukin (IL)-1β—a protein that can cause joint inflammation—we aimed to understand if these treatments could mitigate the damage commonly associated with osteoarthritis (OA).
We took chondrocytes from the femoral heads of patients undergoing hip replacement surgery and treated them with varying amounts of MSM and mobilee in the presence of IL-1β. Our tests measured cell survival and apoptosis—basically whether the cells lived or died—and assessed the levels of key proteins linked to cartilage breakdown and health.
Our results were encouraging. Both MSM and mobilee appeared to significantly reverse the negative effects brought on by IL-1β. Additionally, they managed to combat the activation of NF-κB, a pathway often implicated in inflammation and cell death. By reducing the levels of harmful enzymes and increasing beneficial proteins, these treatments seem to offer a potential new approach to improving joint health in arthritis patients.
In conclusion, this study suggests that MSM and mobilee could play a beneficial role in protecting cartilage cells from the inflammatory damage caused by IL-1β, providing a strong rationale for their consideration in arthritis treatment.
We took chondrocytes from the femoral heads of patients undergoing hip replacement surgery and treated them with varying amounts of MSM and mobilee in the presence of IL-1β. Our tests measured cell survival and apoptosis—basically whether the cells lived or died—and assessed the levels of key proteins linked to cartilage breakdown and health.
Our results were encouraging. Both MSM and mobilee appeared to significantly reverse the negative effects brought on by IL-1β. Additionally, they managed to combat the activation of NF-κB, a pathway often implicated in inflammation and cell death. By reducing the levels of harmful enzymes and increasing beneficial proteins, these treatments seem to offer a potential new approach to improving joint health in arthritis patients.
In conclusion, this study suggests that MSM and mobilee could play a beneficial role in protecting cartilage cells from the inflammatory damage caused by IL-1β, providing a strong rationale for their consideration in arthritis treatment.
Read More
9
MSM improves knee OA treatment
Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial.
Evaluates MSM's combined benefits
We conducted a thoughtful investigation into how Methylsulfonylmethane (MSM) impacts the treatment of knee osteoarthritis (OA) when paired with glucosamine and chondroitin sulfate. In our study, 147 patients diagnosed with Kellgren-Lawrence grade I-II knee OA were randomly divided into three groups. One group received a combination of glucosamine and chondroitin sulfate, the second group received the same combination with MSM, and the third group was given a placebo.
The patients took their assigned capsules daily for three months, and we measured their pain and mobility before treatment and then at 4, 8, and 12 weeks after starting the regimen. The results revealed that the combination of glucosamine, chondroitin sulfate, and MSM offered noticeable clinical benefits for patients with knee OA. However, those taking only glucosamine and chondroitin sulfate experienced no significant improvement compared to the placebo group.
Our findings highlight the potential advantage of supplementing glucosamine and chondroitin with MSM for managing knee osteoarthritis. Nonetheless, the lack of improvement with glucosamine and chondroitin alone calls into question their effectiveness independently of MSM.
The patients took their assigned capsules daily for three months, and we measured their pain and mobility before treatment and then at 4, 8, and 12 weeks after starting the regimen. The results revealed that the combination of glucosamine, chondroitin sulfate, and MSM offered noticeable clinical benefits for patients with knee OA. However, those taking only glucosamine and chondroitin sulfate experienced no significant improvement compared to the placebo group.
Our findings highlight the potential advantage of supplementing glucosamine and chondroitin with MSM for managing knee osteoarthritis. Nonetheless, the lack of improvement with glucosamine and chondroitin alone calls into question their effectiveness independently of MSM.
Read More
User Reviews
USERS' SCORE
Good
Based on 55 Reviews
8.8
10
Arthritis prevention
Excellent! I continue to take it for preventing arthritis.
10
Elimination of stiffness
Amazing help for arthritic pain. Stiffness and pain from arthritis are gone. I have been taking it for four years without any side effects.
9.5
Joint pain decrease
MSM helps with my friend’s psoriatic arthritis. She suffers unbearable pain, and long-term painkiller use is harmful to her liver. After reading reviews on IHerb, I ordered these tablets, finding them convenient. Improvements were evident within days, as joint pain significantly decreased. She takes two tablets in the morning and evening.
Read More
9.5
Vitality restoration
Among the various supplements I take, I would choose MSM and vitamin C. This supplement has immensely helped my vitality and joint health; without it, walking would be difficult. I was off work due to pelvic arthritis, but now I’m back, having gradually increased my intake to four MSM pills alongside vitamin C.
Read More
9.5
Eliminated arthritis pain
I took MSM before dinner and couldn't sleep. I discovered that MSM may cause insomnia if taken at night. The ingredients are genuine. Since starting MSM, my knee and joint arthritis pain has disappeared completely. I'm very pleased with its effectiveness.
