We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
Most Useful Reviews
9
Pet transformation
193 people found this helpful
This product is AMAZING! Jarrow colostrum has saved us thousands in vet bills and provided relief for our 4-year-old golden/shepherd mix, whose health issues stemmed from severe allergies. After researching solutions, I added colostrum to her food, and her condition improved remarkably in just seven weeks. Her skin has healed, and the unpleasant odour is gone! I highly recommend this for pets with health problems related to allergies.
Read More
9
Child's nails
1 people found this helpful
I gave this zinc to my child, as he had white stripes on his nails due to zinc deficiency. The small capsules were easy to swallow, and he had no allergic reactions. His levels have normalised.
Read More
9
Rash reduction
1 people found this helpful
Very effective zinc! I noticed that when a food allergy triggered rashes, taking two tablets dried them out by the next morning. I also take it during a cold, and recovery is faster. The small capsules are easy to swallow.
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
Read More
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
8
Zinc supplementation may reduce allergies
Zinc Deficiency and Zinc Supplementation in Allergic Diseases.
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.
Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.
Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.
In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
This product is AMAZING! Jarrow colostrum has saved us thousands in vet bills and provided relief for our 4-year-old golden/shepherd mix, whose health issues stemmed from severe allergies. After researching solutions, I added colostrum to her food, and her condition improved remarkably in just seven weeks. Her skin has healed, and the unpleasant odour is gone! I highly recommend this for pets with health problems related to allergies.
Read More
9
Child's nails
1 people found this helpful
I gave this zinc to my child, as he had white stripes on his nails due to zinc deficiency. The small capsules were easy to swallow, and he had no allergic reactions. His levels have normalised.
Read More
9
Rash reduction
1 people found this helpful
Very effective zinc! I noticed that when a food allergy triggered rashes, taking two tablets dried them out by the next morning. I also take it during a cold, and recovery is faster. The small capsules are easy to swallow.
Read More
9
Reduced discharge
After a month of taking it, my nasal discharge and allergies have significantly decreased, and it appears to improve my immune function greatly.
Read More
9
Hay fever relief
Since I started taking it, my hay fever symptoms have improved, suggesting that I was lacking in zinc. The tablets are small and tasteless, and they contain copper, preventing any deficiency.
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc has been studied for its potential effects on the immune system, and some research suggests that it may play a role in managing allergic responses. While zinc is essential for maintaining overall immune function, a direct link between zinc supplementation and reduction in allergy symptoms has not been firmly established. Some studies indicate that zinc may help modulate inflammation and could potentially benefit those with allergic rhinitis or other allergic conditions, but results can vary widely among individuals.
If you're considering zinc as a supplement for allergies, it’s vital to consult with a healthcare professional first. They can provide personalized advice based on your health status and any medications you might be taking. Additionally, focusing on a balanced diet rich in zinc-containing foods like nuts, seeds, legumes, and whole grains can offer support to your overall health and immune function, which may indirectly influence how your body handles allergens.
Based on user reviews, the timeframe to see results from taking zinc for allergies varies among individuals. Several users noted that they experienced significant improvements in their allergy symptoms within a month of consistent use. For instance, one user reported a notable decrease in nasal discharge and allergies after taking the supplement for about a month Read Review. Others have indicated that effects can be seen even sooner; one reviewer stated that taking two tablets helped mitigate food allergy rashes by the following morning Read Review.
However, individual experiences can differ widely due to factors like personal health conditions and dosage. Some users, such as one who noted improvements in hay fever symptoms shortly after starting the supplement Read Review, suggest that early relief is possible. Overall, it appears that while some individuals might feel relief within a couple of days, most users report better results with sustained use over a period of weeks.
Recent research indicates that zinc may play a significant role in alleviating allergy symptoms, particularly those associated with allergic rhinitis. A systematic review found that the combination of zinc with quail egg supplements improved nasal flow and reduced symptoms like congestion and sneezing, while also diminishing reliance on standard allergy medications [1]. Another study highlighted the positive effects of intranasal zinc on patients with Japanese cedar pollinosis, where zinc treatment significantly improved allergy symptoms in mice that mirrored human responses [2]. These findings suggest that incorporating zinc into allergy management strategies could yield beneficial results.
Moreover, zinc's immune-modulating properties further support its potential in managing allergies. Research has shown that zinc can inhibit processes associated with allergic reactions and reduce inflammation, which correlates with a lower incidence of allergic diseases like asthma and atopic dermatitis [5]. The cumulative evidence points to zinc's integral role in bolstering immune responses against allergies, although additional studies are necessary for more definitive conclusions [6]. Therefore, those dealing with allergies might find zinc supplementation to be an effective adjunct to their treatment regimen.
Based on user reviews, there are several reported improvements in symptoms associated with taking zinc supplements. Many users have noted beneficial effects on their allergy symptoms. For example, one parent found that their child's white stripes on nails—indicative of zinc deficiency—normalized after supplementation, which implies a positive impact on overall health and nutritional balance Read Review. Others have experienced rapid relief from food allergies; one user remarked that taking two tablets helped dry out a rash triggered by food allergies by the following morning Read Review.
Moreover, users have highlighted improvements in conditions like hay fever after incorporating zinc into their routine, suggesting that they could have been deficient in the mineral Read Review. Overall, many report enhanced immune function and reduced allergy symptoms after consistent use, with one user noting significant decreases in nasal discharge over a month Read Review. As always, individual experiences can vary, and factors like dosage and personal health conditions will play a significant role in the observed effects.
Users have reported various experiences when combining this zinc supplement with other supplements for handling allergies. For instance, one user mentioned taking zinc in conjunction with selenium, taurine, and lutein to support vision and noted that they experienced no allergies or nausea as a result Read Review. Another review indicated that users often pair zinc with copper, which is beneficial to prevent deficiencies that can affect bone health and overall wellbeing Read Review.
However, not all experiences have been positive. One user reported a mild metal allergy that worsened after starting the zinc supplement, indicating that some individuals may react adversely when combining it with specific minerals like copper Read Review. Overall, while many users see improvements in their allergy symptoms and immune function—especially when zinc is taken regularly—it's clear that individual reactions can vary, suggesting that caution should be exercised when combining supplements Read Review.
Users report varied experiences regarding the appropriate dose of Zinc for treating allergies. Many found success with different dosages, with some taking a daily intake of three capsules, which they noted sufficiently supported their allergies without leading to deficiencies in copper Read Review. Others mentioned effective results from simply taking two capsules when allergy symptoms flared, which reportedly helped alleviate skin rashes by the next morning Read Review.
Additionally, several users emphasized the importance of combining zinc with copper to prevent potential deficiencies and ensure overall effectiveness. For instance, one user noted that the combination was beneficial in managing both allergies and thyroid health Read Review. Overall, the reviews suggest that while specific needs may vary, a regimen including consistent zinc intake appears to offer tangible relief from allergy symptoms.
9
Reduced discharge
After a month of taking it, my nasal discharge and allergies have significantly decreased, and it appears to improve my immune function greatly.
9
Rash reduction
1 people found this helpful
Very effective zinc! I noticed that when a food allergy triggered rashes, taking two tablets dried them out by the next morning. I also take it during a cold, and recovery is faster. The small capsules are easy to swallow.
9
Hay fever relief
Since I started taking it, my hay fever symptoms have improved, suggesting that I was lacking in zinc. The tablets are small and tasteless, and they contain copper, preventing any deficiency.
9
Child's nails
1 people found this helpful
I gave this zinc to my child, as he had white stripes on his nails due to zinc deficiency. The small capsules were easy to swallow, and he had no allergic reactions. His levels have normalised.
7.5
Vision support
11 people found this helpful
Good zinc, though the odour is peculiar. I took zinc to support my vision, paired with selenium, taurine, and lutein. There were no allergies or nausea. I also make a mask using half an Ester-C tablet, half a zinc capsule, and a teaspoon of sour cream. I mix and apply it to my face, which helps disinfect and nourish my skin.
6
Copper concern
6 people found this helpful
I need to supplement with zinc for my allergies; otherwise, my thyroid suffers. I take three daily, which provides ample copper despite zinc's impact on absorption. Insufficient copper could lead to bone loss, as some studies suggest.
0
Allergic reaction
1 people found this helpful
I have a mild metal allergy which resurfaced after taking this zinc. My skin reacted, turning red in sensitive areas. I chose this brand for its copper, thinking it beneficial, but it caused an unexpected reaction.
7.5
Hypothyroidism aid
1 people found this helpful
Zinc is essential for my hypothyroidism and associated allergies. It supports gut health, immune function, and tissue healing. I must take it carefully to avoid deficiencies, as too much can lower copper and iron levels.
9
Zinc and QES alleviate allergies
Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies.
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
7
Zinc's mixed effects on allergies
Micronutrients and Allergic Diseases: A Mendelian Randomization Study.
We examined the relationship between zinc levels and common allergic diseases like allergic asthma, atopic dermatitis, and allergic rhinitis. By leveraging Mendelian randomization analysis, we looked into how varying concentrations of zinc could influence the risk of these allergies.
Our findings suggest that higher zinc levels in the bloodstream may help lower the chances of developing allergic asthma and atopic dermatitis. However, we also observed that an increase in vitamin C could potentially raise the risk of atopic dermatitis, indicating a complex interaction among nutrients.
Additionally, it seems that zinc, alongside phosphorus, could play a role in reducing the risk of allergic rhinitis. While these results are promising, it's important to note that they don't fully isolate zinc’s effects from other micronutrients, which means more focused research could clarify its role in managing allergies.
8
Zinc supplementation may reduce allergies
Zinc Deficiency and Zinc Supplementation in Allergic Diseases.
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.
Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.
Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.
In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
References
Antonelli M, Mazzoleni E, Donelli D. Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies. Nutrients. 2025;17. doi:10.3390/nu17040712
Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. doi:10.1016/j.jacig.2025.100408
Otsuka T, Sato K, Kamiya T, Tanaka H, Hara H. Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells. Eur J Pharmacol. 2025;994:177391. doi:10.1016/j.ejphar.2025.177391
Wang S, Ilves M, Mäenpää K, Zhao L, El-Nezami H, et al. ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice. ACS Nano. 2024;18:29479. doi:10.1021/acsnano.4c04270
Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. doi:10.1159/000540376
Maywald M, Rink L. Zinc Deficiency and Zinc Supplementation in Allergic Diseases. Biomolecules. 2024;14. doi:10.3390/biom14070863
Wei Y, Zhu X, Lin S, Yang W, Wang T, et al. Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation. Biomed Pharmacother. 2024;177:117129. doi:10.1016/j.biopha.2024.117129