Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.4
USERS' SCORE
Good
Based on 13 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Zinc (as Zinc L-Methionine Sulfate)
15 mg
136%
Copper (as Gluconate)
1 mg
111%

Top Medical Research Studies

We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.

Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.

Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.

Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.

Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.

We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More

Most Useful Reviews

9
Pet transformation
193 people found this helpful
This product is AMAZING! Jarrow colostrum has saved us thousands in vet bills and provided relief for our 4-year-old golden/shepherd mix, whose health issues stemmed from severe allergies. After researching solutions, I added colostrum to her food, and her condition improved remarkably in just seven weeks. Her skin has healed, and the unpleasant odour is gone! I highly recommend this for pets with health problems related to allergies.
Read More
9
Child's nails
1 people found this helpful
I gave this zinc to my child, as he had white stripes on his nails due to zinc deficiency. The small capsules were easy to swallow, and he had no allergic reactions. His levels have normalised.
Read More
9
Rash reduction
1 people found this helpful
Very effective zinc! I noticed that when a food allergy triggered rashes, taking two tablets dried them out by the next morning. I also take it during a cold, and recovery is faster. The small capsules are easy to swallow.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.4
  • All Researches
9
Zinc and QES alleviate allergies
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.

The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.

Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
Read More
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.

Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.

Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.

Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.

Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.

We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
8
Zinc supplementation may reduce allergies
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.

Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.

Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.

In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
Read More

User Reviews

USERS' SCORE
Good
Based on 13 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Pet transformation
193 people found this helpful
This product is AMAZING! Jarrow colostrum has saved us thousands in vet bills and provided relief for our 4-year-old golden/shepherd mix, whose health issues stemmed from severe allergies. After researching solutions, I added colostrum to her food, and her condition improved remarkably in just seven weeks. Her skin has healed, and the unpleasant odour is gone! I highly recommend this for pets with health problems related to allergies.
Read More
9
Child's nails
1 people found this helpful
I gave this zinc to my child, as he had white stripes on his nails due to zinc deficiency. The small capsules were easy to swallow, and he had no allergic reactions. His levels have normalised.
Read More
9
Rash reduction
1 people found this helpful
Very effective zinc! I noticed that when a food allergy triggered rashes, taking two tablets dried them out by the next morning. I also take it during a cold, and recovery is faster. The small capsules are easy to swallow.
Read More
9
Reduced discharge
After a month of taking it, my nasal discharge and allergies have significantly decreased, and it appears to improve my immune function greatly.
Read More
9
Hay fever relief
Since I started taking it, my hay fever symptoms have improved, suggesting that I was lacking in zinc. The tablets are small and tasteless, and they contain copper, preventing any deficiency.
Read More

Frequently Asked Questions

9
Reduced discharge
After a month of taking it, my nasal discharge and allergies have significantly decreased, and it appears to improve my immune function greatly.
9
Rash reduction
1 people found this helpful
Very effective zinc! I noticed that when a food allergy triggered rashes, taking two tablets dried them out by the next morning. I also take it during a cold, and recovery is faster. The small capsules are easy to swallow.
9
Hay fever relief
Since I started taking it, my hay fever symptoms have improved, suggesting that I was lacking in zinc. The tablets are small and tasteless, and they contain copper, preventing any deficiency.
9
Child's nails
1 people found this helpful
I gave this zinc to my child, as he had white stripes on his nails due to zinc deficiency. The small capsules were easy to swallow, and he had no allergic reactions. His levels have normalised.
7.5
Vision support
11 people found this helpful
Good zinc, though the odour is peculiar. I took zinc to support my vision, paired with selenium, taurine, and lutein. There were no allergies or nausea. I also make a mask using half an Ester-C tablet, half a zinc capsule, and a teaspoon of sour cream. I mix and apply it to my face, which helps disinfect and nourish my skin.
6
Copper concern
6 people found this helpful
I need to supplement with zinc for my allergies; otherwise, my thyroid suffers. I take three daily, which provides ample copper despite zinc's impact on absorption. Insufficient copper could lead to bone loss, as some studies suggest.
0
Allergic reaction
1 people found this helpful
I have a mild metal allergy which resurfaced after taking this zinc. My skin reacted, turning red in sensitive areas. I chose this brand for its copper, thinking it beneficial, but it caused an unexpected reaction.
7.5
Hypothyroidism aid
1 people found this helpful
Zinc is essential for my hypothyroidism and associated allergies. It supports gut health, immune function, and tissue healing. I must take it carefully to avoid deficiencies, as too much can lower copper and iron levels.
9
Zinc and QES alleviate allergies
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.

The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.

Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
We examined the relationship between zinc levels and common allergic diseases like allergic asthma, atopic dermatitis, and allergic rhinitis. By leveraging Mendelian randomization analysis, we looked into how varying concentrations of zinc could influence the risk of these allergies.

Our findings suggest that higher zinc levels in the bloodstream may help lower the chances of developing allergic asthma and atopic dermatitis. However, we also observed that an increase in vitamin C could potentially raise the risk of atopic dermatitis, indicating a complex interaction among nutrients.

Additionally, it seems that zinc, alongside phosphorus, could play a role in reducing the risk of allergic rhinitis. While these results are promising, it's important to note that they don't fully isolate zinc’s effects from other micronutrients, which means more focused research could clarify its role in managing allergies.
8
Zinc supplementation may reduce allergies
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.

Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.

Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.

In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.

References

  1. Antonelli M, Mazzoleni E, Donelli D. Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies. Nutrients. 2025;17. doi:10.3390/nu17040712
  2. Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. doi:10.1016/j.jacig.2025.100408
  3. Otsuka T, Sato K, Kamiya T, Tanaka H, Hara H. Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells. Eur J Pharmacol. 2025;994:177391. doi:10.1016/j.ejphar.2025.177391
  4. Wang S, Ilves M, Mäenpää K, Zhao L, El-Nezami H, et al. ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice. ACS Nano. 2024;18:29479. doi:10.1021/acsnano.4c04270
  5. Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. doi:10.1159/000540376
  6. Maywald M, Rink L. Zinc Deficiency and Zinc Supplementation in Allergic Diseases. Biomolecules. 2024;14. doi:10.3390/biom14070863
  7. Wei Y, Zhu X, Lin S, Yang W, Wang T, et al. Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation. Biomed Pharmacother. 2024;177:117129. doi:10.1016/j.biopha.2024.117129
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