We explored how zinc oxide (ZnO), often used as a feed additive, affects diarrhea and gut health in piglets infected with the ETEC K88 strain. Through careful observation, we found that piglets suffering from this infection exhibited significantly increased fecal scores compared to those not affected. The ETEC K88 strain harms the small intestine, leading to a loss of villus height and a decrease in important antioxidant activities.
Our findings revealed that ZnO administration counteracts these negative effects effectively. It not only improved the overall health of the intestine but also enhanced its ability to combat oxidative stress. We also observed a balanced restoration of gut microbiota, as ZnO helped normalize the populations of certain beneficial bacteria altered by the infection.
In summary, our study indicates that ZnO can play a vital role in easing diarrhea in piglets infected with ETEC K88 by reducing intestinal damage, supporting antioxidative defenses, and restoring healthy gut flora.
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Most Useful Reviews
0
Bad combination
2 people found this helpful
I had a terrible experience with this supplement. It caused severe diarrhoea when taken in high doses; I believe combining copper and zinc in one tablet isn’t advisable.
Read More
0
Stomach pain caution
1 people found this helpful
I do not advise taking zinc on an empty stomach as it raised my temperature and caused severe stomach pain and diarrhoea. After eating, I experienced no adverse symptoms.
Read More
0
Stomach issues
1 people found this helpful
Taking zinc on an empty stomach resulted in a strong stomach ache and diarrhoea. I would not recommend it in that manner.
We explored how zinc oxide (ZnO), often used as a feed additive, affects diarrhea and gut health in piglets infected with the ETEC K88 strain. Through careful observation, we found that piglets suffering from this infection exhibited significantly increased fecal scores compared to those not affected. The ETEC K88 strain harms the small intestine, leading to a loss of villus height and a decrease in important antioxidant activities.
Our findings revealed that ZnO administration counteracts these negative effects effectively. It not only improved the overall health of the intestine but also enhanced its ability to combat oxidative stress. We also observed a balanced restoration of gut microbiota, as ZnO helped normalize the populations of certain beneficial bacteria altered by the infection.
In summary, our study indicates that ZnO can play a vital role in easing diarrhea in piglets infected with ETEC K88 by reducing intestinal damage, supporting antioxidative defenses, and restoring healthy gut flora.
Read More
User Reviews
USERS' SCORE
Questionable
Based on 14 Reviews
5.1
All Reviews
Positive Reviews
Negative Reviews
0
Bad combination
2 people found this helpful
I had a terrible experience with this supplement. It caused severe diarrhoea when taken in high doses; I believe combining copper and zinc in one tablet isn’t advisable.
Read More
0
Stomach pain caution
1 people found this helpful
I do not advise taking zinc on an empty stomach as it raised my temperature and caused severe stomach pain and diarrhoea. After eating, I experienced no adverse symptoms.
Read More
0
Stomach issues
1 people found this helpful
Taking zinc on an empty stomach resulted in a strong stomach ache and diarrhoea. I would not recommend it in that manner.
Read More
0
Good for course use
This zinc is effective for a course, given its importance as a cofactor for over 300 enzymes. Deficiency symptoms include hair loss and decreased immunity. I've taken this zinc before, and it contains copper to prevent deficiency. When I need urgent immunity support, I use higher doses.
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0
Overwhelming smell
The smell is slightly overwhelming, and I experienced diarrhoea shortly after taking it. This product may not be suitable for me.
Diarrhea is a condition characterized by the frequent passage of loose or watery stools, which can occur due to various factors, including infections, dietary choices, and underlying health conditions. It often results from the body's response to an irritation of the gastrointestinal tract, which can be caused by viruses, bacteria, parasites, or certain medications. While most cases tend to be short-lived and resolve on their own, diarrhea can lead to dehydration, especially in vulnerable populations such as young children and the elderly.
Managing diarrhea typically involves staying hydrated by drinking clear fluids and, when necessary, replenishing lost electrolytes. In some cases, over-the-counter medications may provide relief, although it’s essential to consult a healthcare professional for persistent or severe symptoms. A focus on bland, easy-to-digest foods can also help during recovery. Remember, if diarrhea persists for more than a couple of days or is accompanied by other concerning symptoms—like high fever, severe abdominal pain, or blood in stools—seeking medical attention is crucial.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc has been recognized for its role in supporting the immune system and maintaining gut health, and research indicates that it may help reduce the duration and severity of diarrhea, particularly in children suffering from acute diarrhea. Several studies have shown that zinc supplementation can effectively shorten the length of an episode and improve recovery. The World Health Organization (WHO) recommends zinc as a complementary treatment alongside rehydration therapy for managing diarrhea, highlighting its importance in treatment protocols.
However, it’s essential to note that while zinc can be beneficial, it should not be seen as a standalone solution for all diarrhea cases. The effectiveness of zinc can vary depending on factors such as the underlying cause of diarrhea, age, and overall health. It's always advisable to consult with a healthcare professional before starting any supplementation, especially in children, to determine the appropriate dosage and ensure safety. In cases of persistent or severe diarrhea, or when accompanied by symptoms like dehydration, medical attention should be sought promptly.
Based on user reviews, the timeline for experiencing results from this supplement appears to vary significantly among individuals, particularly when it comes to managing diarrhea. Some users report immediate adverse effects, such as diarrhea occurring shortly after taking the supplement (e.g., Read Review, Read Review). Others discuss better outcomes when taken with food, suggesting it may take longer to see positive results if not consumed correctly, as empty stomach administration often leads to digestive upset (e.g., Read Review, Read Review).
Additionally, while some users mention that zinc can help improve diarrhea symptoms, especially in specific populations like malnourished children (Read Review) or those recovering from illnesses (Read Review), others emphasize the importance of monitoring intake to avoid side effects. Therefore, users generally advise caution and to possibly expect initial reactions before any beneficial effects are seen.
Zinc oxide (ZnO) has shown promise in easing diarrhea, particularly in animal studies. Research focused on piglets infected with the ETEC K88 strain revealed that the administration of ZnO not only improved gut health but also counteracted the adverse effects of the infection on the small intestine. The study observed a significant reduction in fecal scores among the ZnO-treated piglets, suggesting a notable improvement in their condition [1]. Furthermore, ZnO was effective in restoring healthy gut microbiota, which plays a crucial role in maintaining digestive health.
While these findings are compelling, it's important to note that the research was conducted in piglets, and further studies are needed to determine the effectiveness of Zinc oxide in humans. While it may offer potential benefits based on this evidence, anyone considering ZnO as a supplement for diarrhea should consult with a healthcare professional to understand its applicable use for their specific situation.
Based on user reviews, several individuals noted improvements in their health when taking zinc, particularly regarding immune support and hair loss. One user highlighted zinc's effectiveness as a cofactor for numerous enzymes, mentioning it as vital for immune function, especially after experiencing Covid, indicating some positive outcomes for their father who took it after recovery (Read Review, Read Review). Another user emphasized the importance of proper dosage and timing, focusing on its role in bolstering immunity during viral infections (Read Review, Read Review).
However, it should be noted that anecdotal experiences can vary widely. Some users reported adverse effects like abdominal pain and diarrhea, particularly when taking the supplement on an empty stomach or in high doses (Read Review, Read Review). While many acknowledged the potential benefits of zinc, they strongly advised caution regarding taking it improperly, which can result in negative gastrointestinal symptoms that overshadow the intended positive effects (Read Review). Thus, individual results can significantly differ based on personal health and how the supplement is consumed.
Users report mixed experiences when combining this supplement with other supplements, particularly in the context of managing diarrhea. A common theme in the reviews indicates that taking zinc on an empty stomach can exacerbate gastrointestinal issues, including diarrhea. Many users, such as those identified in Read Review, Read Review, and Read Review, emphasize the importance of consumption timing, suggesting zinc should be taken after meals to minimize adverse effects.
Further complicating matters, some users warn against combining zinc with copper in a single tablet, citing worsened outcomes like severe diarrhea, as mentioned in Read Review. Conversely, others find that the presence of copper is beneficial, promoting zinc's effectiveness in supporting immune function. Despite these mixed opinions, a consistent recommendation across reviews is to be cautious with higher doses, particularly when combined with other supplements, to avoid negative gastrointestinal reactions (Read Review).
Based on user reviews, there's a consensus that the right dosage of zinc can vary, and taking it in higher doses or on an empty stomach often leads to gastrointestinal distress, including diarrhea. For instance, one user reported severe diarrhea when taking high doses and recommended avoiding formulations that combine copper and zinc together Read Review. Another user advised against taking zinc without food, explaining that it caused stomach pain and diarrhea, while they experienced no adverse effects when taken after meals Read Review.
Users generally indicated that moderation is key. A user who recommended taking 30 mg of zinc to boost immunity during virus infections cautioned against high doses, indicating that excess zinc can indeed cause problems Read Review. In summary, while zinc is often praised for its health benefits, it's crucial for individuals to be aware of their dosage and to take it properly to avoid side effects such as diarrhea.
0
Overwhelming smell
The smell is slightly overwhelming, and I experienced diarrhoea shortly after taking it. This product may not be suitable for me.
0
Post-meal advises
I faced severe headache, diarrhoea, and stomach pain after taking it on an empty stomach. It's best to consume it after eating.
0
Stomach pain caution
1 people found this helpful
I do not advise taking zinc on an empty stomach as it raised my temperature and caused severe stomach pain and diarrhoea. After eating, I experienced no adverse symptoms.
0
Diarrhea observed
2 people found this helpful
The endocrinologist referred me to the doctor, but I found that zinc sulfate is the cheapest form and can be toxic, causing vomiting and diarrhea. I noticed nausea when taking it on an empty stomach. Although I take zinc for hypothyroidism and it helps with recovery from colds, I will request a different form after I finish this one.
7.5
Immune support benefits
Zinc is vital for many bodily functions, including immune system support. Low levels increase infection risks, and it may help with diarrhoea, especially in malnourished children. It’s beneficial for sexual health too and helps in memory and cognitive functions.
0
Side effects noted
I ordered this for my parents after they had Covid. My father benefited, but my mother experienced side effects including nausea and diarrhoea.
0
Good for course use
This zinc is effective for a course, given its importance as a cofactor for over 300 enzymes. Deficiency symptoms include hair loss and decreased immunity. I've taken this zinc before, and it contains copper to prevent deficiency. When I need urgent immunity support, I use higher doses.
7.5
Immunity boost
20 people found this helpful
Excellent zinc composition! Chelated zinc can be combined with copper, and it helps immensely during viruses. To strengthen immunity against colds, I recommend taking 30 mg of zinc and vitamin C every two hours. However, be cautious with high doses; zinc should be taken separately from carotenoids and iron.
6
Hair loss help
I purchased this for hair loss and slight diarrhoea, but it has helped a bit. However, I experienced some heartburn.
0
Bad combination
2 people found this helpful
I had a terrible experience with this supplement. It caused severe diarrhoea when taken in high doses; I believe combining copper and zinc in one tablet isn’t advisable.
0
Stomach issues
1 people found this helpful
Taking zinc on an empty stomach resulted in a strong stomach ache and diarrhoea. I would not recommend it in that manner.
9
Zinc oxide mitigates diarrhea impacts
Zinc Oxide Administration Relieves the Diarrhea of ETEC K88-Infected Piglets by Reducing Ileal Apoptosis and Maintaining Gut Microbial Balance.
We explored how zinc oxide (ZnO), often used as a feed additive, affects diarrhea and gut health in piglets infected with the ETEC K88 strain. Through careful observation, we found that piglets suffering from this infection exhibited significantly increased fecal scores compared to those not affected. The ETEC K88 strain harms the small intestine, leading to a loss of villus height and a decrease in important antioxidant activities.
Our findings revealed that ZnO administration counteracts these negative effects effectively. It not only improved the overall health of the intestine but also enhanced its ability to combat oxidative stress. We also observed a balanced restoration of gut microbiota, as ZnO helped normalize the populations of certain beneficial bacteria altered by the infection.
In summary, our study indicates that ZnO can play a vital role in easing diarrhea in piglets infected with ETEC K88 by reducing intestinal damage, supporting antioxidative defenses, and restoring healthy gut flora.
References
Zhang Y, Liu J, Li M, Dong Y, Li Z, et al. Zinc Oxide Administration Relieves the Diarrhea of ETEC K88-Infected Piglets by Reducing Ileal Apoptosis and Maintaining Gut Microbial Balance. Vet Sci. 2025;12. 10.3390/vetsci12020115