We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
Read More
8
Zinc shows effectiveness against H. pylori
Comparison of antimicrobial activity of zinc chloride and bismuth subsalicylate against clinical isolates of Helicobacter pylori.
We explored the effectiveness of zinc chloride (ZnCl) in treating Helicobacter pylori (H. pylori) infections, particularly concerning various gastritis conditions. Our study involved testing 116 clinical isolates of H. pylori to see how they responded to ZnCl, bismuth subsalicylate (BSS), and clarithromycin (CLR).
Using a method called agar gel dilution, we found that 95% of the H. pylori strains tested were susceptible to ZnCl at a concentration of 40 μg/ml. This is a promising figure, especially when compared to 98% susceptibility for BSS and 79% for CLR. Interestingly, H. pylori isolates from patients with nonulcer dyspepsia and peptic ulcers showed similar levels of susceptibility to ZnCl.
It's important to note that while ZnCl demonstrated a significant antimicrobial effect against H. pylori, making it a potential candidate for treatment, the study also indicated that its effectiveness was comparable to CLR, but slightly less than BSS. This suggests that while ZnCl may be beneficial in treating H. pylori infections, it should not be viewed as a standalone solution, particularly in gastritis management.
Ultimately, our findings indicate that zinc chloride holds promise in tackling H. pylori, potentially contributing to improved treatment strategies for those suffering from gastritis and related disorders.
Read More
9.5
Zinc Carnosine Enhances Eradication
Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study.
We conducted a study to explore the effectiveness of a modified bismuth quadruple therapy that included zinc carnosine in treating gastritis, compared to the standard triple therapy. Our participant group consisted of 92 patients who showed symptoms of dyspepsia and tested positive on a urea breath test for the infection.
The study was structured with one group receiving the traditional 14-day standard treatment, which included esomeprazole, amoxicillin, and clarithromycin. The other group was treated with a 10-day regimen that added bismuth subcitrate and zinc carnosine to the same foundational therapies. After completing their courses, we retested the patients to assess the success of the eradication therapy.
Our findings revealed that the modified therapy group achieved a significantly higher eradication rate of 93.5% compared to just 69.6% in the standard treatment group. Besides dizziness, the side effects were similar between the two therapies, indicating that the addition of zinc carnosine did not introduce significant new risks.
This research suggests that zinc carnosine can be beneficial in enhancing the effectiveness of treatments for gastritis while maintaining a favorable safety profile. Therefore, those dealing with difficult-to-treat gastritis might find hope in this innovative approach.
Read More
Most Useful Reviews
0
Not good on empty stomach
1 people found this helpful
I developed gastritis after taking this on an empty stomach. It’s not advisable to do so; I followed the instructions but regretted it.
Read More
7.5
Protects mucous membrane
Zinc consistently strengthens my family's immune systems. It's particularly beneficial for my atrophic gastritis, helping to protect the mucous membrane. This zinc, balanced with copper, is a fantastic option, although it was notably more expensive when I purchased it in Russia.
Read More
2
Causes nausea
Suffering from gastritis, I tried taking a high dose once and it caused nausea.
We conducted a study to explore the effectiveness of a modified bismuth quadruple therapy that included zinc carnosine in treating gastritis, compared to the standard triple therapy. Our participant group consisted of 92 patients who showed symptoms of dyspepsia and tested positive on a urea breath test for the infection.
The study was structured with one group receiving the traditional 14-day standard treatment, which included esomeprazole, amoxicillin, and clarithromycin. The other group was treated with a 10-day regimen that added bismuth subcitrate and zinc carnosine to the same foundational therapies. After completing their courses, we retested the patients to assess the success of the eradication therapy.
Our findings revealed that the modified therapy group achieved a significantly higher eradication rate of 93.5% compared to just 69.6% in the standard treatment group. Besides dizziness, the side effects were similar between the two therapies, indicating that the addition of zinc carnosine did not introduce significant new risks.
This research suggests that zinc carnosine can be beneficial in enhancing the effectiveness of treatments for gastritis while maintaining a favorable safety profile. Therefore, those dealing with difficult-to-treat gastritis might find hope in this innovative approach.
Read More
9.5
Zinc supports recovery in CCS
Case of Cronkhite Canada syndrome shows improvement with enteral supplements.
Our examination focuses on the intriguing case of a 33-year-old man diagnosed with Cronkhite-Canada syndrome (CCS), a rare condition affecting the gastrointestinal tract and skin. During his hospital stay, he presented with severe gastrointestinal symptoms alongside notable skin changes.
To address his condition, the treatment regime included high protein supplements, proton pump inhibitors, and zinc-vitamin supplements. Over the course of five months, we observed a complete improvement in his symptoms. While this particular case emphasizes the role of zinc within a comprehensive treatment plan, it’s important to note that zinc was part of a multi-component strategy that makes it difficult to isolate its individual effects on gastritis directly.
Nonetheless, this case illustrates how early diagnosis and a well-structured treatment approach—integrating nutritional support—can lead to significant recovery in rare syndromes like CCS.
Read More
8
Zinc protects against gastritis damage
Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.
We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
Read More
8
Polaprezinc shows promise in gastritis
Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
We conducted a systematic review to assess how Polaprezinc, a zinc-l-carnosine complex, might influence the treatment of gastritis. Focusing on its effectiveness when combined with standard triple therapy, which includes antibiotics, we analyzed data from three randomized controlled trials involving 396 participants.
Our findings suggest that adding Polaprezinc to the triple therapy improved the eradication rates of the bacteria responsible for gastritis. Specifically, we observed a significant increase in successful treatment outcomes, indicating a potential advantage of Polaprezinc as a complementary approach.
However, it's important to note that while the combination therapy showed better results, both treatment groups reported similar instances of adverse events. This means that Polaprezinc appears to offer a beneficial effect on treatment outcomes without increasing side effects.
Despite these positive results, we recognize that the evidence is still limited. More extensive trials are needed to confirm these findings and establish Polaprezinc's role in gastritis management firmly. Overall, this treatment could be a promising addition but needs further exploration before becoming a standard approach.
Read More
8
Zinc's role in gastritis improvement
Study of Serum Ferritin, Zinc, and Copper Levels in Children With Helicobacter pylori Gastritis and the Effect of the Treatment.
We conducted a study to understand how zinc influences children suffering from gastritis due to Helicobacter pylori infection. Our investigation included 70 young patients exhibiting symptoms of upper gastrointestinal distress. By dividing the group into H. pylori-positive and H. pylori-negative children, we could directly observe the differences in serum levels of hemoglobin, ferritin, zinc, and copper.
Notably, we found that children with H. pylori had lower levels of serum ferritin and zinc compared to those without the infection. However, the copper levels remained unaffected. Interestingly, after treating the infected children, we observed significant improvements in their hemoglobin, ferritin, and zinc levels. This suggests that while zinc deficiency is often present in these patients, simply providing zinc treatment alone cannot solely isolate its specific impact on gastritis.
Furthermore, we noted that more severe gastritis correlated with lower hemoglobin and zinc levels, and higher transferrin receptor levels. Although zinc appears to play a crucial role in the overall health of these children, our findings indicate that its treatment effect should be viewed alongside other potential factors influencing gastritis recovery.
I developed gastritis after taking this on an empty stomach. It’s not advisable to do so; I followed the instructions but regretted it.
Read More
7.5
Protects mucous membrane
Zinc consistently strengthens my family's immune systems. It's particularly beneficial for my atrophic gastritis, helping to protect the mucous membrane. This zinc, balanced with copper, is a fantastic option, although it was notably more expensive when I purchased it in Russia.
Read More
2
Causes nausea
Suffering from gastritis, I tried taking a high dose once and it caused nausea.
Read More
2
Causes severe attack
I’m unsure if it’s directly responsible, but I haven’t fallen ill this season. A warning: the package advises taking it on an empty stomach, but when I tried this, I suffered a severe attack of gastritis and needed a week to recover. Taking it after meals, however, has been fine.
Read More
2
Take with food
Great supplement for the immune system; however, if you suffer from chronic gastritis as I do, it’s best to take it with food (never on an empty stomach). Zinc can irritate the stomach.
Read More
Frequently Asked Questions
Gastritis is an inflammation of the stomach lining, which can lead to a range of symptoms including abdominal pain, nausea, vomiting, and indigestion. This condition can be acute, arising suddenly and lasting for a short period, or chronic, developing gradually and persisting over time. Various factors can contribute to gastritis, such as excessive alcohol consumption, prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs), bacterial infections (most notably Helicobacter pylori), and autoimmune disorders.
Treatment for gastritis often focuses on addressing the underlying cause and might include medications to reduce stomach acid, antibiotics for infections, and lifestyle modifications like avoiding irritating foods and beverages. While many people recover from gastritis with adequate care, it's important to consult a healthcare professional for a proper diagnosis and treatment plan. If left untreated, gastritis can lead to more serious complications, such as stomach ulcers or even an increased risk for gastric cancer.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc is often recognized for its various health benefits, including its role in supporting the immune system and promoting wound healing. In the context of gastritis, which is an inflammation of the stomach lining, zinc may have a supportive role due to its potential anti-inflammatory properties and its involvement in cell regeneration. Some studies indicate that zinc supplements can help in healing gastric mucosal injuries and may alleviate symptoms associated with gastritis. However, the evidence is not definitive and varies based on the individual’s health status and the cause of their gastritis.
That said, it's essential to approach supplementation cautiously. While zinc can be beneficial, taking too much can lead to adverse effects, including nausea, diarrhea, and interference with the absorption of other essential minerals. If you suspect you have gastritis or are considering zinc supplements as part of your treatment plan, it’s always best to consult with a healthcare provider first. They can provide personalized advice and ensure that any supplements or changes in diet won't adversely affect your condition or interact with other medications you might be taking.
When taking zinc for gastritis, the timeframe for seeing results can vary significantly from person to person. Generally, some users report improvements in symptoms within a few days, while for others it may take several weeks of consistent use to notice a difference. This variability can depend on factors such as the severity of gastritis, individual health conditions, and adherence to a treatment plan.
It's important to note that, while zinc can help support gastrointestinal health, it should be part of a comprehensive approach that may include dietary changes and other medications as recommended by a healthcare professional. If you do not notice any improvement after a fair trial period, or if symptoms worsen, it is advisable to consult with your doctor. They can provide guidance on whether zinc is the right choice for your specific case or if alternative treatments should be considered.
The role of zinc in managing gastritis is increasingly supported by scientific research, showing its potential as a therapeutic agent. A systematic review evaluated Polaprezinc, a zinc-l-carnosine complex, and found that when used alongside standard triple therapy for gastritis caused by Helicobacter pylori, it significantly improved eradication rates compared to triple therapy alone [2]. Additionally, another study highlighted that zinc efficiently reduced inflammation and oxidative stress in chronic gastritis animal models, suggesting its protective benefits on gastric health [1].
Furthermore, investigations into zinc's influence on children with Helicobacter pylori gastritis revealed that, despite being associated with lower zinc levels in affected individuals, the treatment showed improved outcomes [3]. Another study established that zinc chloride exhibits a notable antimicrobial effect against H. pylori, reinforcing its potential role in gastritis management [7]. While these findings indicate that zinc and its compounds can enhance treatment for gastritis, further large-scale trials are needed for a clearer understanding of their effectiveness in clinical settings.
Based on user reviews, individuals have reported various improvements and experiences regarding their symptoms after taking zinc supplements. Users such as one with atrophic gastritis noted that zinc has been beneficial in strengthening their immune system and protecting the mucous membrane, which suggests a positive impact on their overall health Read Review. However, it’s crucial to note that individual results can vary significantly. Some users have experienced adverse effects, particularly those with pre-existing conditions like gastritis, reporting symptoms like nausea and severe discomfort when taking zinc on an empty stomach (review id='e4874c78-00a5-419f-a512-558c723cc467'; review id='82de27fd-c9b4-4875-ab21-ba370dff1767').
Additional reviewers echoed similar sentiments, emphasizing that zinc may irritate the stomach lining, prompting recommendations to consume it alongside food to mitigate potential gastrointestinal distress Read Review. While some have benefited from improved immune resilience and protection against illness Read Review, the consensus highlights the importance of individualized consumption methods, especially for those with sensitivities or existing stomach issues.
Based on user reviews, many individuals dealing with gastritis have reported that taking this zinc supplement on an empty stomach can lead to adverse effects, including severe gastric distress and nausea. One user specifically mentioned regretting taking it according to the package instructions, which recommended an empty stomach, and instead experienced a significant flare-up of their gastritis Read Review. Another reviewer echoed this advice, stating that taking it after meals proved to be a more comfortable approach and did not provoke their condition Read Review.
Additionally, some users recommend balancing zinc intake with other supplements, such as copper, to enhance its benefits while reducing potential irritation Read Review. Users suffering from chronic gastritis have also emphasized the critical need to consume zinc alongside food to mitigate stomach irritation and discomfort, reinforcing the importance of tailored supplementation strategies Read Review. Overall, it appears that combining zinc with food or other supplements may yield a more favorable result for those managing gastritis.
Based on user reviews, those dealing with gastritis report that the timing and dosage of zinc supplementation can greatly affect their experience. Several users have mentioned that high doses or taking zinc on an empty stomach can lead to nausea and stomach discomfort. For instance, one user noted that attempting a high dose caused them nausea, while another highlighted that following the package instructions to take it on an empty stomach resulted in a severe gastritis attack, taking them a week to recover Read ReviewRead Review.
Conversely, users with chronic gastritis emphasize the importance of taking zinc with food to mitigate irritation. A review indicated that when zinc was consumed post-meals, it did not cause discomfort Read Review. Another user mentioned that for their atrophic gastritis, zinc proved beneficial by protecting the mucous membrane, especially when balanced with copper Read Review. Overall, users strongly advise against high doses or taking zinc without food for those recovering from gastritis.
7.5
Protects mucous membrane
Zinc consistently strengthens my family's immune systems. It's particularly beneficial for my atrophic gastritis, helping to protect the mucous membrane. This zinc, balanced with copper, is a fantastic option, although it was notably more expensive when I purchased it in Russia.
2
Take with food
Great supplement for the immune system; however, if you suffer from chronic gastritis as I do, it’s best to take it with food (never on an empty stomach). Zinc can irritate the stomach.
2
Causes severe attack
I’m unsure if it’s directly responsible, but I haven’t fallen ill this season. A warning: the package advises taking it on an empty stomach, but when I tried this, I suffered a severe attack of gastritis and needed a week to recover. Taking it after meals, however, has been fine.
0
Not good on empty stomach
1 people found this helpful
I developed gastritis after taking this on an empty stomach. It’s not advisable to do so; I followed the instructions but regretted it.
2
Causes nausea
Suffering from gastritis, I tried taking a high dose once and it caused nausea.
8
Polaprezinc shows promise in gastritis
Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
We conducted a systematic review to assess how Polaprezinc, a zinc-l-carnosine complex, might influence the treatment of gastritis. Focusing on its effectiveness when combined with standard triple therapy, which includes antibiotics, we analyzed data from three randomized controlled trials involving 396 participants.
Our findings suggest that adding Polaprezinc to the triple therapy improved the eradication rates of the bacteria responsible for gastritis. Specifically, we observed a significant increase in successful treatment outcomes, indicating a potential advantage of Polaprezinc as a complementary approach.
However, it's important to note that while the combination therapy showed better results, both treatment groups reported similar instances of adverse events. This means that Polaprezinc appears to offer a beneficial effect on treatment outcomes without increasing side effects.
Despite these positive results, we recognize that the evidence is still limited. More extensive trials are needed to confirm these findings and establish Polaprezinc's role in gastritis management firmly. Overall, this treatment could be a promising addition but needs further exploration before becoming a standard approach.
8
Zinc protects against gastritis damage
Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.
We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
8
Zinc's role in gastritis improvement
Study of Serum Ferritin, Zinc, and Copper Levels in Children With Helicobacter pylori Gastritis and the Effect of the Treatment.
We conducted a study to understand how zinc influences children suffering from gastritis due to Helicobacter pylori infection. Our investigation included 70 young patients exhibiting symptoms of upper gastrointestinal distress. By dividing the group into H. pylori-positive and H. pylori-negative children, we could directly observe the differences in serum levels of hemoglobin, ferritin, zinc, and copper.
Notably, we found that children with H. pylori had lower levels of serum ferritin and zinc compared to those without the infection. However, the copper levels remained unaffected. Interestingly, after treating the infected children, we observed significant improvements in their hemoglobin, ferritin, and zinc levels. This suggests that while zinc deficiency is often present in these patients, simply providing zinc treatment alone cannot solely isolate its specific impact on gastritis.
Furthermore, we noted that more severe gastritis correlated with lower hemoglobin and zinc levels, and higher transferrin receptor levels. Although zinc appears to play a crucial role in the overall health of these children, our findings indicate that its treatment effect should be viewed alongside other potential factors influencing gastritis recovery.
8
Zinc shows effectiveness against H. pylori
Comparison of antimicrobial activity of zinc chloride and bismuth subsalicylate against clinical isolates of Helicobacter pylori.
We explored the effectiveness of zinc chloride (ZnCl) in treating Helicobacter pylori (H. pylori) infections, particularly concerning various gastritis conditions. Our study involved testing 116 clinical isolates of H. pylori to see how they responded to ZnCl, bismuth subsalicylate (BSS), and clarithromycin (CLR).
Using a method called agar gel dilution, we found that 95% of the H. pylori strains tested were susceptible to ZnCl at a concentration of 40 μg/ml. This is a promising figure, especially when compared to 98% susceptibility for BSS and 79% for CLR. Interestingly, H. pylori isolates from patients with nonulcer dyspepsia and peptic ulcers showed similar levels of susceptibility to ZnCl.
It's important to note that while ZnCl demonstrated a significant antimicrobial effect against H. pylori, making it a potential candidate for treatment, the study also indicated that its effectiveness was comparable to CLR, but slightly less than BSS. This suggests that while ZnCl may be beneficial in treating H. pylori infections, it should not be viewed as a standalone solution, particularly in gastritis management.
Ultimately, our findings indicate that zinc chloride holds promise in tackling H. pylori, potentially contributing to improved treatment strategies for those suffering from gastritis and related disorders.
References
Sun X, Xu S, Liu T, Wu J, Yang J, et al. Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model. Food Funct. 2024;15:7136. doi:10.1039/d4fo01142b
Mahmoud A, Abuelazm M, Ahmed AAS, Abdalshafy H, Abdelazeem B, et al. Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2022;14. doi:10.3390/nu14194126
Elsaadany E, Amin S, Abdel-Hafez M, El Amrousy D, Kasem S, et al. Study of Serum Ferritin, Zinc, and Copper Levels in Children With Helicobacter pylori Gastritis and the Effect of the Treatment. J Pediatr Gastroenterol Nutr. 2022;75:e88. doi:10.1097/MPG.0000000000003585
Lenti MV, Facciotti F, Miceli E, Vanoli A, Fornasa G, et al. Mucosal Overexpression of Thymic Stromal Lymphopoietin and Proinflammatory Cytokines in Patients With Autoimmune Atrophic Gastritis. Clin Transl Gastroenterol. 2022;13:e00510. doi:10.14309/ctg.0000000000000510
Ibrahim N, El Said H, Choukair A. Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study. World J Clin Cases. 2022;10:227. doi:10.12998/wjcc.v10.i1.227
Tan B, Luo HQ, Xu H, Lv NH, Shi RH, et al. Polaprezinc combined with clarithromycin-based triple therapy for Helicobacter pylori-associated gastritis: A prospective, multicenter, randomized clinical trial. PLoS One. 2017;12:e0175625. doi:10.1371/journal.pone.0175625
Yakoob J, Abbas Z, Usman MW, Awan S, Naz S, et al. Comparison of antimicrobial activity of zinc chloride and bismuth subsalicylate against clinical isolates of Helicobacter pylori. Microb Drug Resist. 2014;20:305. doi:10.1089/mdr.2013.0086
Lipin SP, Paul B, Nazimudeen E, Jacob BS. Case of Cronkhite Canada syndrome shows improvement with enteral supplements. J Assoc Physicians India. 2012;60:61.