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SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.3
USERS' SCORE
Good
Based on 25 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
N-Acetyl-D-Glucosamine
700 mg
†
Top Medical Research Studies
9.5
N-Acetyl Glucosamine reduces arthritis
Collagen-induced arthritis: severity and immune response attenuation using multivalent N-acetyl glucosamine.
Study closely examines arthritis treatment
We aimed to understand how N-acetyl glucosamine (GlcNAc), a compound known for its anti-inflammatory properties, affects the development and severity of collagen-induced arthritis (CIA). Our investigation involved applying a special multivalent GlcNAc-terminated glycoconjugate and assessing its influence through various methodologies.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
Read More
9
Potential OA treatment advancements
Novel phosphoramidate prodrugs of N-acetyl-(D)-glucosamine with antidegenerative activity on bovine and human cartilage explants.
Directly addresses N-acetylglucosamine effects
We explored the potential of N-acetyl-(D)-glucosamine, a compound often used as a dietary supplement for osteoarthritis (OA), to provide effective relief from this chronic joint condition. Our research focused on a series of newly developed prodrugs, specifically targeting ways to enhance the compound's absorption and effectiveness within the body.
We found that some modified versions of N-acetyl-(D)-glucosamine, known as O-3 and O-4 phosphate prodrugs, demonstrated significant chondroprotective effects in vitro. In simple terms, this means they helped protect and support cartilage health, which is vital for those suffering from OA. Notably, the prodrugs that included a specific amino acid called (L)-proline were particularly effective, even outperforming earlier versions.
Overall, our findings suggest that these novel compounds hold promise as new leads in the search for more effective treatments for osteoarthritis. They signify a positive step toward improving the management of this painful and degenerative joint disease.
We found that some modified versions of N-acetyl-(D)-glucosamine, known as O-3 and O-4 phosphate prodrugs, demonstrated significant chondroprotective effects in vitro. In simple terms, this means they helped protect and support cartilage health, which is vital for those suffering from OA. Notably, the prodrugs that included a specific amino acid called (L)-proline were particularly effective, even outperforming earlier versions.
Overall, our findings suggest that these novel compounds hold promise as new leads in the search for more effective treatments for osteoarthritis. They signify a positive step toward improving the management of this painful and degenerative joint disease.
Read More
8
N-acetylglucosamine derivatives show promise
Novel biologically active series of N-acetylglucosamine derivatives for the suppressive activities on GAG release.
Highly relevant to osteoarthritis treatment
We focused our research on the potential of N-acetylglucosamine, a modified form of glucosamine, to impact osteoarthritis, a common degenerative joint disease. Our investigations revealed that N-acetylglucosamine could enhance the oral bioavailability of glucosamine and is reported to have better in vitro chondroprotective effects compared to its parent compound.
To delve deeper into this, we examined N-acetylglucosamine derivatives modified specifically at the N position, using different chemical groups such as benzenesulfonyl and isoxazole. Among the many compounds we tested, we found that the derivatives with 3-(2-chlorobenzene)-5-methyl-isoxazole formyl chloride and p-methoxybenzenesulfonyl chloride were particularly effective at promoting chondrocyte health in our laboratory studies.
Our findings suggest that these newly developed compounds may hold promise as future treatments for osteoarthritis by enhancing joint health and potentially improving the quality of life for those affected by this condition.
To delve deeper into this, we examined N-acetylglucosamine derivatives modified specifically at the N position, using different chemical groups such as benzenesulfonyl and isoxazole. Among the many compounds we tested, we found that the derivatives with 3-(2-chlorobenzene)-5-methyl-isoxazole formyl chloride and p-methoxybenzenesulfonyl chloride were particularly effective at promoting chondrocyte health in our laboratory studies.
Our findings suggest that these newly developed compounds may hold promise as future treatments for osteoarthritis by enhancing joint health and potentially improving the quality of life for those affected by this condition.
Read More
Most Useful Reviews
9.5
Pain relief
I discovered this supplement by chance on the iHerb website. I suffer from various food allergies, digestive issues, and arthritis. After a difficult weekend with an upset stomach and aching arthritis, I began taking this supplement. My stomach felt soothed immediately, and my arthritis pain vanished. I can hardly believe the improvement in my arthritis and digestion. I have no plans to stop taking this supplement.
Read More
8.8
Minimal discomfort
This glucosamine product helps my system significantly. It manages my irritable bowel syndrome and alleviates my back and muscle pain. While I take it, I can keep any discomfort to a minimum. Thank you, iHerb, for providing this product for my benefit.
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9.5
Effective for osteoarthritis
Sodium-free and the most effective I've tried, this product greatly alleviates my osteoarthritis pain and improves my mobility. I switched brands recently, but it was nearly twice the cost and ineffective. Upon returning to this brand, the pain subsided remarkably. Highly recommended.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.3
9.5
N-Acetyl Glucosamine reduces arthritis
Collagen-induced arthritis: severity and immune response attenuation using multivalent N-acetyl glucosamine.
Study closely examines arthritis treatment
We aimed to understand how N-acetyl glucosamine (GlcNAc), a compound known for its anti-inflammatory properties, affects the development and severity of collagen-induced arthritis (CIA). Our investigation involved applying a special multivalent GlcNAc-terminated glycoconjugate and assessing its influence through various methodologies.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
Read More
9
N-acetylglucosamine shows promise
Partially acetylated chitooligosaccharides bind to YKL-40 and stimulate growth of human osteoarthritic chondrocytes.
Highly relevant findings
We investigated how partially acetylated chitooligosaccharides, specifically the oligomers of N-acetylglucosamine, might influence the growth of chondrocytes—the cells crucial for cartilage health—in people with osteoarthritis. The study focused on the binding of these sugars to YKL-40, a protein that is often associated with inflammation in joints.
Through careful processing of chitin, we derived two forms of chitooligosaccharides: Oligomin™ and T-ChOS™. Our results unveiled that larger versions of these oligosaccharides showed a strong attraction to YKL-40. More significantly, when we exposed osteoarthritic chondrocytes to these compounds, we noted a noteworthy increase in cell growth—up to three times more under certain conditions.
Interestingly, Oligomin™ required a higher concentration compared to T-ChOS™, which demonstrated that smaller oligosaccharides could be effective at lower doses. However, more isn't always better; excessively high concentrations led to reduced benefits. When we introduced chitotriose, a smaller oligosaccharide, it hampered the positive effects seen with the larger forms, suggesting a complex interplay in oligosaccharide behavior in relation to cellular responses.
Overall, these findings indicate a promising new direction in treating joint inflammation and give us hope for developing new therapies aimed at alleviating the discomfort of arthritis.
Through careful processing of chitin, we derived two forms of chitooligosaccharides: Oligomin™ and T-ChOS™. Our results unveiled that larger versions of these oligosaccharides showed a strong attraction to YKL-40. More significantly, when we exposed osteoarthritic chondrocytes to these compounds, we noted a noteworthy increase in cell growth—up to three times more under certain conditions.
Interestingly, Oligomin™ required a higher concentration compared to T-ChOS™, which demonstrated that smaller oligosaccharides could be effective at lower doses. However, more isn't always better; excessively high concentrations led to reduced benefits. When we introduced chitotriose, a smaller oligosaccharide, it hampered the positive effects seen with the larger forms, suggesting a complex interplay in oligosaccharide behavior in relation to cellular responses.
Overall, these findings indicate a promising new direction in treating joint inflammation and give us hope for developing new therapies aimed at alleviating the discomfort of arthritis.
Read More
9
Potential OA treatment advancements
Novel phosphoramidate prodrugs of N-acetyl-(D)-glucosamine with antidegenerative activity on bovine and human cartilage explants.
Directly addresses N-acetylglucosamine effects
We explored the potential of N-acetyl-(D)-glucosamine, a compound often used as a dietary supplement for osteoarthritis (OA), to provide effective relief from this chronic joint condition. Our research focused on a series of newly developed prodrugs, specifically targeting ways to enhance the compound's absorption and effectiveness within the body.
We found that some modified versions of N-acetyl-(D)-glucosamine, known as O-3 and O-4 phosphate prodrugs, demonstrated significant chondroprotective effects in vitro. In simple terms, this means they helped protect and support cartilage health, which is vital for those suffering from OA. Notably, the prodrugs that included a specific amino acid called (L)-proline were particularly effective, even outperforming earlier versions.
Overall, our findings suggest that these novel compounds hold promise as new leads in the search for more effective treatments for osteoarthritis. They signify a positive step toward improving the management of this painful and degenerative joint disease.
We found that some modified versions of N-acetyl-(D)-glucosamine, known as O-3 and O-4 phosphate prodrugs, demonstrated significant chondroprotective effects in vitro. In simple terms, this means they helped protect and support cartilage health, which is vital for those suffering from OA. Notably, the prodrugs that included a specific amino acid called (L)-proline were particularly effective, even outperforming earlier versions.
Overall, our findings suggest that these novel compounds hold promise as new leads in the search for more effective treatments for osteoarthritis. They signify a positive step toward improving the management of this painful and degenerative joint disease.
Read More
8
Glucosamine derivatives aid cartilage health
The Hexosamine Biosynthetic Pathway as a Therapeutic Target after Cartilage Trauma: Modification of Chondrocyte Survival and Metabolism by Glucosamine Derivatives and PUGNAc in an Ex Vivo Model.
Moderate relevance to cartilage therapy
We examined how glucosamine derivatives, particularly n-acetylglucosamine (GlcNAc), impact chondrocyte behavior following cartilage trauma. In our study, human cartilage samples were subjected to trauma and then treated with GlcNAc, glucosamine sulfate, or an O-GlcNAcase inhibitor called PUGNAc, alongside a GFAT-1 inhibitor named azaserine. Over the course of the experiment, we looked at factors such as cell viability, the expression of key genes related to cartilage health, and the content of important cartilage components like type II collagen.
Our findings revealed that exposing cartilage to trauma disrupted the balance of enzymes involved in the hexosamine biosynthetic pathway (HBP), mimicking the conditions seen in advanced osteoarthritis. Both GlcNAc and PUGNAc showed encouraging results by protecting cells after trauma. However, while PUGNAc led to an increase in type II collagen production, GlcNAc did not demonstrate this same enhancement, indicating that it may not be as effective on its own.
Importantly, PUGNAc, along with the glucosamine derivatives, demonstrated anti-catabolic effects, helping counteract degrading processes in the cartilage. Conversely, the use of azaserine raised catabolic activity, which wasn't beneficial. Overall, we found that supporting the HBP through glucosamine derivatives or O-GlcNAcase inhibition can help protect cartilage cells following trauma, presenting a promising area for future arthritis therapies despite the variable effects of GlcNAc alone.
Our findings revealed that exposing cartilage to trauma disrupted the balance of enzymes involved in the hexosamine biosynthetic pathway (HBP), mimicking the conditions seen in advanced osteoarthritis. Both GlcNAc and PUGNAc showed encouraging results by protecting cells after trauma. However, while PUGNAc led to an increase in type II collagen production, GlcNAc did not demonstrate this same enhancement, indicating that it may not be as effective on its own.
Importantly, PUGNAc, along with the glucosamine derivatives, demonstrated anti-catabolic effects, helping counteract degrading processes in the cartilage. Conversely, the use of azaserine raised catabolic activity, which wasn't beneficial. Overall, we found that supporting the HBP through glucosamine derivatives or O-GlcNAcase inhibition can help protect cartilage cells following trauma, presenting a promising area for future arthritis therapies despite the variable effects of GlcNAc alone.
Read More
8
Movardol® may improve osteoarthritis
Movardol® (N-acetylglucosamine, Boswellia serrata, ginger) supplementation in the management of knee osteoarthritis: preliminary results from a 6-month registry study.
Potential benefits of ingredient synergy
We explored the impact of Movardol®, a supplement containing N-acetylglucosamine, on individuals suffering from knee osteoarthritis (OA). This condition is characterized by joint pain, stiffness, and reduced mobility, so finding effective management options is crucial.
In our study, 54 participants with moderate knee OA were given the choice between standard management and a combination of standard management plus Movardol® supplementation. Over six months, we assessed various factors like pain levels, physical function, and inflammatory markers.
Our preliminary results indicate that Movardol® supplementation may help alleviate some of the symptoms associated with knee OA, showing both efficacy and safety. While we cannot isolate the effects of N-acetylglucosamine due to the combined ingredients in the supplement, it appears to contribute positively to the management of this chronic condition.
Overall, this study provides encouraging insights into how such dietary supplements can support individuals dealing with knee osteoarthritis, potentially enhancing their quality of life and mobility through complementary treatment options.
In our study, 54 participants with moderate knee OA were given the choice between standard management and a combination of standard management plus Movardol® supplementation. Over six months, we assessed various factors like pain levels, physical function, and inflammatory markers.
Our preliminary results indicate that Movardol® supplementation may help alleviate some of the symptoms associated with knee OA, showing both efficacy and safety. While we cannot isolate the effects of N-acetylglucosamine due to the combined ingredients in the supplement, it appears to contribute positively to the management of this chronic condition.
Overall, this study provides encouraging insights into how such dietary supplements can support individuals dealing with knee osteoarthritis, potentially enhancing their quality of life and mobility through complementary treatment options.
Read More
User Reviews
USERS' SCORE
Good
Based on 25 Reviews
8.7
9.5
Pain relief
I discovered this supplement by chance on the iHerb website. I suffer from various food allergies, digestive issues, and arthritis. After a difficult weekend with an upset stomach and aching arthritis, I began taking this supplement. My stomach felt soothed immediately, and my arthritis pain vanished. I can hardly believe the improvement in my arthritis and digestion. I have no plans to stop taking this supplement.
Read More
9.5
Highly recommended
My gastroenterologist recommended NAG for my Ulcerative Colitis and arthritis. I have been using it for years and highly recommend it.
9.5
Effective treatment
I began using this for arthritis in one knee. I have noticed virtually no pain now and can walk downhill freely, which was previously painful. Additionally, it may assist with intestinal health, but my main focus is on the arthritis aspect. It's good value for the 120 capsules, and I will continue taking it.
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9.5
Very effective
It's a regular medicine for my mother to treat arthritis, and she finds it very good.
9.5
Pleasantly surprised
This supplement by Jarrow has been extremely helpful for my early-stage arthritis in my hands. After discovering my adrenals were not functioning well, I suddenly developed arthritis there. I preferred not to go with heavy medications, and so I started using N-A-G 700 mg with positive results. The pain and swelling have minimised greatly!
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