Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
N-Acetyl-D-Glucosamine
700 mg
†
Top Medical Research Studies
8
We investigated how levels of -GlcNAcylation, a modification involving N-acetyl glucosamine, relate to heart disease. Using transgenic mouse models, we found that excessive -GlcNAcylation can lead to serious heart issues, including cardiomyopathy and arrhythmias. Interestingly, reducing -GlcNAcylation levels through enhanced OGA activity shows promise in protecting against heart damage, especially under stress conditions. These insights suggest targeting -GlcNAcylation could be a new strategy in heart disease treatment.
Read More
8
O-GlcNAc's dual role in heart health
We investigated how O-GlcNAc transferase influences heart function amid pressure overload, focusing on both early and sustained effects of O-GlcNAcylation. Our findings indicated that while O-GlcNAcylation can enhance heart function during early stress, it may have detrimental effects long term, leading to significant left ventricular dysfunction.
By observing mice with reduced O-GlcNAc levels after surgery, we noted that disrupted calcium handling proteins could negatively impact cardiac performance. Overall, our study sheds light on the complex role of O-GlcNAcylation in heart health, indicating that managing its levels may be critical.
By observing mice with reduced O-GlcNAc levels after surgery, we noted that disrupted calcium handling proteins could negatively impact cardiac performance. Overall, our study sheds light on the complex role of O-GlcNAcylation in heart health, indicating that managing its levels may be critical.
Read More
9
We examined how manipulating specific enzymes linked to O-GlcNAcylation, a sugar modification affecting heart proteins, impacts heart function in diabetes. Our research found that O-GlcNAc modification was higher in diabetic hearts, leading to left ventricular dysfunction. By delivering the right enzymes to mice, we saw that enhancing de-O-GlcNAcylation improved heart function, while adding more O-GlcNAc worsened it. This suggests targeted enzyme therapy could be a promising new way to help those with diabetes-related heart issues.
Read More
Most Useful Reviews
9
Restores sensitivity
12 people found this helpful
I purchase this for an adult with multiple sclerosis. Research suggests that this amino acid helps restore nerve connections in experimental models. Given the lack of alternatives aside from symptomatic treatment, we took the plunge. After one month, finger sensitivity improved, speech clarity increased, and overall, there were only positive outcomes. I have ordered another jar.
Read More
0
Avoid this product
This new form of NAG, made from chemically modified vegan sources, caused me severe heart palpitations and arrhythmia twice, each lasting 12 hours along with head pressure. I find it to be toxic and strongly recommend avoiding it.
Read More
6
Protects cell health
21 people found this helpful
N-acetylglucosamine, or NAG, is derived from glucosamine, a crucial component of peptidoglycan in bacterial cell walls. This compound is beneficial in treating multiple sclerosis and Crohn's disease, significantly alleviating the symptoms. Its mechanism involves filling voids in cells, thereby safeguarding them and allowing for regeneration. Ensure that you purchase products sourced from shellfish and fish, as synthetic NAG is ineffective.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
- All Researches
9
We examined how manipulating specific enzymes linked to O-GlcNAcylation, a sugar modification affecting heart proteins, impacts heart function in diabetes. Our research found that O-GlcNAc modification was higher in diabetic hearts, leading to left ventricular dysfunction. By delivering the right enzymes to mice, we saw that enhancing de-O-GlcNAcylation improved heart function, while adding more O-GlcNAc worsened it. This suggests targeted enzyme therapy could be a promising new way to help those with diabetes-related heart issues.
Read More
8
We explored the effects of hypoxic acclimation (HA) on heart injury caused by ischemia-reperfusion (I/R). Our study involved male adult mice subjected to low oxygen conditions, revealing that HA significantly reduced oxidative stress and heart damage from I/R events.
Notably, this protective effect is linked to increased O-GlcNAc modification, which helps enhance important metabolic pathways in the heart. However, further research is necessary to solidify these findings and understand the therapeutic potential of targeting O-GlcNAc in heart disease.
Notably, this protective effect is linked to increased O-GlcNAc modification, which helps enhance important metabolic pathways in the heart. However, further research is necessary to solidify these findings and understand the therapeutic potential of targeting O-GlcNAc in heart disease.
Read More
8
We investigated how levels of -GlcNAcylation, a modification involving N-acetyl glucosamine, relate to heart disease. Using transgenic mouse models, we found that excessive -GlcNAcylation can lead to serious heart issues, including cardiomyopathy and arrhythmias. Interestingly, reducing -GlcNAcylation levels through enhanced OGA activity shows promise in protecting against heart damage, especially under stress conditions. These insights suggest targeting -GlcNAcylation could be a new strategy in heart disease treatment.
Read More
8
N-acetylglucosamine shows heart benefits
We examined the effects of a unique polysaccharide, derived from the edible portion of Amphioctopus neglectus, on heart disease, specifically regarding its influence on cardiac hypertrophy linked to high blood pressure.
Our in-vitro analysis revealed that this compound reduced cardiac cell surface area significantly and improved cell viability, indicating its potential as a natural remedy against hypertension.
Although promising, further research is needed to fully establish how safe and effective this treatment is for heart disease in humans.
Our in-vitro analysis revealed that this compound reduced cardiac cell surface area significantly and improved cell viability, indicating its potential as a natural remedy against hypertension.
Although promising, further research is needed to fully establish how safe and effective this treatment is for heart disease in humans.
Read More
8
We investigated how deleting the gene E2f1 influences heart function after a heart attack. Our research involved male and female mice that underwent myocardial infarction and were monitored over four weeks.
While we found that deleting E2f1 improved heart function and reduced damage after the heart attack, it did not significantly change levels of O-GlcNAcylation, a protein modification linked to heart health. We observed that although the heart muscle changed after E2f1 ablation, the overall enzymatic impact on O-GlcNAcylation remained limited. This suggests E2f1 deletion helps in heart recovery, but not through the pathways we expected.
While we found that deleting E2f1 improved heart function and reduced damage after the heart attack, it did not significantly change levels of O-GlcNAcylation, a protein modification linked to heart health. We observed that although the heart muscle changed after E2f1 ablation, the overall enzymatic impact on O-GlcNAcylation remained limited. This suggests E2f1 deletion helps in heart recovery, but not through the pathways we expected.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Restores sensitivity
12 people found this helpful
I purchase this for an adult with multiple sclerosis. Research suggests that this amino acid helps restore nerve connections in experimental models. Given the lack of alternatives aside from symptomatic treatment, we took the plunge. After one month, finger sensitivity improved, speech clarity increased, and overall, there were only positive outcomes. I have ordered another jar.
Read More
0
Avoid this product
This new form of NAG, made from chemically modified vegan sources, caused me severe heart palpitations and arrhythmia twice, each lasting 12 hours along with head pressure. I find it to be toxic and strongly recommend avoiding it.
Read More
6
Protects cell health
21 people found this helpful
N-acetylglucosamine, or NAG, is derived from glucosamine, a crucial component of peptidoglycan in bacterial cell walls. This compound is beneficial in treating multiple sclerosis and Crohn's disease, significantly alleviating the symptoms. Its mechanism involves filling voids in cells, thereby safeguarding them and allowing for regeneration. Ensure that you purchase products sourced from shellfish and fish, as synthetic NAG is ineffective.
Read More
7.5
Heals the gut
10 people found this helpful
This product is fantastic! I cannot believe I have lived with Crohn's disease for so long without discovering it. It genuinely aids in healing my gut and helps maintain stability. I will certainly keep a supply on hand.
Read More
7.5
Reduces disease symptoms
4 people found this helpful
This product effectively alleviates symptoms of both multiple sclerosis and Crohn's disease. Its action relies on filling cavities, protecting cells from harm, and allowing for their regeneration.
Read More
Frequently Asked Questions
9
Restores sensitivity
12 people found this helpful
I purchase this for an adult with multiple sclerosis. Research suggests that this amino acid helps restore nerve connections in experimental models. Given the lack of alternatives aside from symptomatic treatment, we took the plunge. After one month, finger sensitivity improved, speech clarity increased, and overall, there were only positive outcomes. I have ordered another jar.
7.5
Slows MS progression
6 people found this helpful
My knees are feeling great. With multiple sclerosis, I came across a study indicating this supplement aids in alleviating various symptoms and potentially slows progression. Since 2009, I've been using it alongside traditional MS medications, and I'm grateful for the slow progression of my condition, possibly due to this.
7.5
Decreases symptoms
2 people found this helpful
I order NAG frequently and appreciate its effects; my symptoms have slightly diminished. I will continue to order more.
7.5
Heals the gut
10 people found this helpful
This product is fantastic! I cannot believe I have lived with Crohn's disease for so long without discovering it. It genuinely aids in healing my gut and helps maintain stability. I will certainly keep a supply on hand.
6
Alleviates joint pain
1 people found this helpful
I suffer from severe rheumatoid arthritis due to an autoimmune issue linked to a leaky gut, which causes pain in my hips and knees while walking. Thankfully, I am now experiencing some improvement.
0
Avoid this product
This new form of NAG, made from chemically modified vegan sources, caused me severe heart palpitations and arrhythmia twice, each lasting 12 hours along with head pressure. I find it to be toxic and strongly recommend avoiding it.
7.5
Reduces inflammation
The quality of all iHerb products is superb! They contain all-natural ingredients, are advantageous for health, come in convenient packaging, and are suitable for all ages. Derived solely from clean fish, they help reduce inflammation, benefit heart health, and my hair has become thicker with fewer split ends.
7
We delved into how a specific protein pathway can offer protection after cardiac arrest. By using various mouse models, we found that activating the XBP1s pathway helps improve brain function during recovery.
We explored the impact of N-acetyl glucosamine treatment on young and aged mice post-cardiac arrest. Remarkably, young mice showed reduced functional deficits, while aged mice demonstrated better performance in behavioral tests after treatment.
Overall, our findings suggest N-acetyl glucosamine could be a valuable therapy for enhancing recovery after cardiac events.
We explored the impact of N-acetyl glucosamine treatment on young and aged mice post-cardiac arrest. Remarkably, young mice showed reduced functional deficits, while aged mice demonstrated better performance in behavioral tests after treatment.
Overall, our findings suggest N-acetyl glucosamine could be a valuable therapy for enhancing recovery after cardiac events.
8
We investigated how levels of -GlcNAcylation, a modification involving N-acetyl glucosamine, relate to heart disease. Using transgenic mouse models, we found that excessive -GlcNAcylation can lead to serious heart issues, including cardiomyopathy and arrhythmias. Interestingly, reducing -GlcNAcylation levels through enhanced OGA activity shows promise in protecting against heart damage, especially under stress conditions. These insights suggest targeting -GlcNAcylation could be a new strategy in heart disease treatment.
9
We examined how manipulating specific enzymes linked to O-GlcNAcylation, a sugar modification affecting heart proteins, impacts heart function in diabetes. Our research found that O-GlcNAc modification was higher in diabetic hearts, leading to left ventricular dysfunction. By delivering the right enzymes to mice, we saw that enhancing de-O-GlcNAcylation improved heart function, while adding more O-GlcNAc worsened it. This suggests targeted enzyme therapy could be a promising new way to help those with diabetes-related heart issues.
8
N-acetylglucosamine shows heart benefits
We examined the effects of a unique polysaccharide, derived from the edible portion of Amphioctopus neglectus, on heart disease, specifically regarding its influence on cardiac hypertrophy linked to high blood pressure.
Our in-vitro analysis revealed that this compound reduced cardiac cell surface area significantly and improved cell viability, indicating its potential as a natural remedy against hypertension.
Although promising, further research is needed to fully establish how safe and effective this treatment is for heart disease in humans.
Our in-vitro analysis revealed that this compound reduced cardiac cell surface area significantly and improved cell viability, indicating its potential as a natural remedy against hypertension.
Although promising, further research is needed to fully establish how safe and effective this treatment is for heart disease in humans.
References
- Li R, Shen Y, Li X, Lu L, Wang Z, et al. Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice. Shock. 2021;56:755. doi:10.1097/SHK.0000000000001732
- Ou W, Liang Y, Qin Y, Wu W, Xie M, et al. Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation. Redox Biol. 2021;43:101994. doi:10.1016/j.redox.2021.101994
- Umapathi P, Mesubi OO, Banerjee PS, Abrol N, Wang Q, et al. Excessive -GlcNAcylation Causes Heart Failure and Sudden Death. Circulation. 2021;143:1687. doi:10.1161/CIRCULATIONAHA.120.051911
- Prakoso D, Lim SY, Erickson JR, Wallace RS, Lees JG, et al. Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart. Cardiovasc Res. 2022;118:212. doi:10.1093/cvr/cvab043
- Chakraborty K, Krishnan S, Joy M. Sulfated N-acetylglucosamino-glucuronopyranosyl-arabinopyranan from seafood Amphioctopus neglectus attenuates angiotensin-II prompted cardiac hypertrophy. Int J Biol Macromol. 2020;163:1223. doi:10.1016/j.ijbiomac.2020.07.037
- Dassanayaka S, Brittian KR, Jurkovic A, Higgins LA, Audam TN, et al. E2f1 deletion attenuates infarct-induced ventricular remodeling without affecting O-GlcNAcylation. Basic Res Cardiol. 2019;114:28. doi:10.1007/s00395-019-0737-y
- Zhu WZ, El-Nachef D, Yang X, Ledee D, Olson AK. O-GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O-GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload. J Am Heart Assoc. 2019;8:e011260. doi:10.1161/JAHA.118.011260
