' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 7 Researches
7.6
USERS' SCORE
Excellent
Based on 9 Reviews
9.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D deficiency linked to allergies
Does vitamin D deficiency predispose to allergic proctocolitis?
Strong association with allergies
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
Read More
7
Vitamin D effects on asthma explored
Low CD46 expression on activated CD4 T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donors.
Relevant study on vitamin D
We explored the role of vitamin D, specifically calcitriol, in managing allergic eosinophilic asthma and how it interacts with a key molecule, CD46, in T cells. Our research involved stimulating CD4 T cells from patients and healthy donors with specific antibodies and measuring the production of two important immune signals: IFN-γ and IL-10.
Our findings suggest that lower levels of CD46 on activated CD4 T cells are linked to a more favorable Th1 cell response to calcitriol. This means that individuals with certain profiles might benefit more from vitamin D supplementation, potentially reducing inflammation associated with their asthma.
However, we need further validation of these results in clinical settings. If proven effective, this stratification could pave the way for personalized treatments for people with allergic conditions and possibly other diseases influenced by immune responses.
Our findings suggest that lower levels of CD46 on activated CD4 T cells are linked to a more favorable Th1 cell response to calcitriol. This means that individuals with certain profiles might benefit more from vitamin D supplementation, potentially reducing inflammation associated with their asthma.
However, we need further validation of these results in clinical settings. If proven effective, this stratification could pave the way for personalized treatments for people with allergic conditions and possibly other diseases influenced by immune responses.
Read More
7
Vitamin D's role in allergies explored
The evaluation of the serum levels of vitamin D and interleukin-33 in children with atopic dermatitis and its association with diseases severity.
Significant but not isolated findings
We set out to examine the relationship between vitamin D levels and atopic dermatitis (AD), a common chronic inflammatory condition in children that involves skin sensitivity and allergies. In our study, we evaluated blood samples from 51 children with AD and compared their vitamin D levels and other immune markers to those of 20 healthy kids.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
Read More
Most Useful Reviews
9.5
No allergies experienced
I consistently take this vitamin D, and I find the cost and quality to be optimal! There hasn’t been any intolerance, unlike other, cheaper supplements that caused allergies. My doctor recommended 2000 units, and I take this supplement every other day.
Read More
9.5
No allergies noted
This is an excellent vitamin D that does not cause allergies, unlike some brands.
Read More
9.5
No allergies experienced
Wonderful! I truly like the product! There are no allergies! I will buy it again.
Read More
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Medical Researches
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Most Likely Effective
Based on 7 Researches
7.6
9
Vitamin D aids asthma management
Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy.
Combination therapy assessed effectiveness
We explored the effects of vitamin D in combination with fluticasone propionate on allergy-related symptoms in children with bronchial asthma. In this study, we grouped participants into two treatment plans: one group received only fluticasone, while the other group received both fluticasone and vitamin D. By comparing their progress, we noted various health improvements related to asthma control.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
Read More
9
Vitamin D metabolites aid pulmonary health
Beneficial Impact of Inhaled 25(OH)-Vitamin D3 and 1,25(OH)2-Vitamin D3 on Pulmonary Response in the Murine Model of Hypersensitivity Pneumonitis.
Addresses vitamin D's role in HP
We explored the impact of vitamin D metabolites on respiratory health, particularly in the context of hypersensitivity pneumonitis (HP). Our study focused on C57BL/6J mice that were placed on a diet severely lacking in vitamin D to induce deficiency. These mice were then exposed to an antigen linked to HP while inhaling either 25(OH)-vitamin D3 or 1,25(OH)2-vitamin D3.
Over the course of the experiment, we observed significant changes in the respiratory function of vitamin D-deficient mice. The metabolites of vitamin D we tested seemed to counteract many adverse effects associated with vitamin D deficiency. Inhalations of these compounds not only improved respiratory functions but also reduced inflammation and fibrosis that was exacerbated by the HP-causing antigen.
This research suggests that inhaling vitamin D metabolites may restore normal levels of active vitamin D in the lungs of deficient mice, providing a promising avenue for further exploration into how vitamin D may help manage respiratory conditions related to allergies and hypersensitivity.
Over the course of the experiment, we observed significant changes in the respiratory function of vitamin D-deficient mice. The metabolites of vitamin D we tested seemed to counteract many adverse effects associated with vitamin D deficiency. Inhalations of these compounds not only improved respiratory functions but also reduced inflammation and fibrosis that was exacerbated by the HP-causing antigen.
This research suggests that inhaling vitamin D metabolites may restore normal levels of active vitamin D in the lungs of deficient mice, providing a promising avenue for further exploration into how vitamin D may help manage respiratory conditions related to allergies and hypersensitivity.
Read More
8
Vitamin D deficiency linked to allergies
Does vitamin D deficiency predispose to allergic proctocolitis?
Strong association with allergies
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
Read More
8
Vitamin D aids atopic dermatitis management
Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis.
Relevant to allergic conditions
We conducted an extensive review of multiple studies to understand how vitamin D might influence atopic dermatitis (AD), a skin condition that impacts many people, particularly children. Our focus was on randomized controlled trials that compared vitamin D supplementation with a placebo group.
After analyzing data from eleven studies involving a total of 686 participants, we found compelling evidence that vitamin D supplementation can significantly reduce the severity of AD. Participants who received vitamin D showed a marked improvement compared to those who did not, with a notable decrease in their disease severity scores.
It's important to highlight that while our findings are promising, we also recognize the need for larger and longer-term studies to confirm these results. By understanding the role of vitamin D, we can better explore potential treatments for managing allergy-related conditions like atopic dermatitis.
After analyzing data from eleven studies involving a total of 686 participants, we found compelling evidence that vitamin D supplementation can significantly reduce the severity of AD. Participants who received vitamin D showed a marked improvement compared to those who did not, with a notable decrease in their disease severity scores.
It's important to highlight that while our findings are promising, we also recognize the need for larger and longer-term studies to confirm these results. By understanding the role of vitamin D, we can better explore potential treatments for managing allergy-related conditions like atopic dermatitis.
Read More
7
Vitamin D's role in allergies explored
The evaluation of the serum levels of vitamin D and interleukin-33 in children with atopic dermatitis and its association with diseases severity.
Significant but not isolated findings
We set out to examine the relationship between vitamin D levels and atopic dermatitis (AD), a common chronic inflammatory condition in children that involves skin sensitivity and allergies. In our study, we evaluated blood samples from 51 children with AD and compared their vitamin D levels and other immune markers to those of 20 healthy kids.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 9 Reviews
9.3
9.5
No allergies experienced
I consistently take this vitamin D, and I find the cost and quality to be optimal! There hasn’t been any intolerance, unlike other, cheaper supplements that caused allergies. My doctor recommended 2000 units, and I take this supplement every other day.
9.5
No allergies noted
This is an excellent vitamin D that does not cause allergies, unlike some brands.
9.5
No allergies experienced
Wonderful! I truly like the product! There are no allergies! I will buy it again.
9.5
Allergy-free product
An excellent vitamin D! It did not cause allergies for me and is very good!
9.5
No allergies noted
I received this as a gift, and there were no allergies; I liked everything.
