Overview
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.4
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
We aimed to understand how vitamin D influences the progression of Alzheimer’s disease (AD) by examining its effects on the brain. Our study involved male 5xFAD mice that underwent various dietary regimes and received vitamin D injections. This allowed us to investigate both vitamin D deficiency and supplementation in relation to AD symptoms.
Through careful analysis of brain tissue, we looked for changes in amyloid-β (Aβ) plaques and the presence of reactive astrocytes—important cells that interact with neurons in the brain. Our findings demonstrated a noteworthy association between vitamin D levels and reductions in harmful Aβ pathways and reactive astrogliosis.
This is significant since it suggests that maintaining adequate vitamin D levels might be a promising strategy for preventing or treating Alzheimer’s disease. Overall, our study provides crucial insights into how vitamin D could potentially alter the course of AD, opening the door for new therapeutic approaches.
Through careful analysis of brain tissue, we looked for changes in amyloid-β (Aβ) plaques and the presence of reactive astrocytes—important cells that interact with neurons in the brain. Our findings demonstrated a noteworthy association between vitamin D levels and reductions in harmful Aβ pathways and reactive astrogliosis.
This is significant since it suggests that maintaining adequate vitamin D levels might be a promising strategy for preventing or treating Alzheimer’s disease. Overall, our study provides crucial insights into how vitamin D could potentially alter the course of AD, opening the door for new therapeutic approaches.
8
We examined the relationship between 25-OH vitamin D and Alzheimer's disease (AD) through an innovative approach called Mendelian randomization. This method allows us to analyze the effect of different nutrients on brain health by leveraging genetic data, while also assessing how these nutrients may influence MRI findings related to AD.
Our findings reveal a significant negative association between 25-OH vitamin D levels and the likelihood of developing Alzheimer's. Specifically, we observed that higher vitamin D is linked to a lower risk of Alzheimer's, with a notable odds ratio suggesting a protective effect. Remarkably, we also discovered that about 7% of the impact of vitamin D on Alzheimer's could be explained by changes in specific brain regions, particularly the Superior_fronto-occipital_fasciculus_L.
Overall, our study provides compelling evidence that vitamin D may serve as a protective factor against Alzheimer's disease. However, we note that its mediating role in brain structures is relatively small, indicating further research is needed to fully understand these relationships and mechanisms.
Our findings reveal a significant negative association between 25-OH vitamin D levels and the likelihood of developing Alzheimer's. Specifically, we observed that higher vitamin D is linked to a lower risk of Alzheimer's, with a notable odds ratio suggesting a protective effect. Remarkably, we also discovered that about 7% of the impact of vitamin D on Alzheimer's could be explained by changes in specific brain regions, particularly the Superior_fronto-occipital_fasciculus_L.
Overall, our study provides compelling evidence that vitamin D may serve as a protective factor against Alzheimer's disease. However, we note that its mediating role in brain structures is relatively small, indicating further research is needed to fully understand these relationships and mechanisms.
8
We collected data from numerous studies to understand how vitamin D deficiency relates to the risk of Alzheimer's disease (AD) and cognitive impairment. Our analysis included 23 studies and revealed some compelling findings regarding vitamin D levels and the likelihood of developing AD.
Specifically, we found that individuals with low vitamin D levels faced a 57% higher risk of Alzheimer's, while vitamin D deficiency raised the overall risk of dementia by 42%. Even more interestingly, the results indicated a non-linear relationship; optimal vitamin D levels for reducing dementia risk seemed to be around 77.5-100 nmol/L. For Alzheimer's specifically, a level above 40.1 nmol/L appeared beneficial.
Although the study does not focus on the effects of vitamin D treatment itself, it still suggests that maintaining adequate vitamin D might help lessen the risk of cognitive decline. Therefore, boosting our vitamin D intake could be a simple yet effective approach to promoting brain health as we age.
Specifically, we found that individuals with low vitamin D levels faced a 57% higher risk of Alzheimer's, while vitamin D deficiency raised the overall risk of dementia by 42%. Even more interestingly, the results indicated a non-linear relationship; optimal vitamin D levels for reducing dementia risk seemed to be around 77.5-100 nmol/L. For Alzheimer's specifically, a level above 40.1 nmol/L appeared beneficial.
Although the study does not focus on the effects of vitamin D treatment itself, it still suggests that maintaining adequate vitamin D might help lessen the risk of cognitive decline. Therefore, boosting our vitamin D intake could be a simple yet effective approach to promoting brain health as we age.
Most Useful Reviews
9.5
Supports Alzheimer's treatment
Jarrow is our trusted source for supplements. My wife takes this daily, as she has alzheimer's disease and suffers from vitamin D deficiency, which may influence its progression. A chiropractor recommended Jarrow when we sought a calcium supplement, and their BoneUp formulation reversed my wife's osteopenia.
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.4
- All Researches
8
We dove into a systematic review focused on the effects of micronutrient supplementation, particularly vitamin D, on cognitive decline associated with Alzheimer's disease (AD). The study highlighted previous research from the last twenty years, focusing on individuals aged 65 and older, encompassing those with normal cognitive functions, mild cognitive impairment (MCI), and Alzheimer's.
We found that vitamin D supplementation may show promise in reducing cognitive decline and dementia progression. However, the results also pointed out a significant variability among the studies, making it challenging to pinpoint exactly how effective vitamin D is when used independently of other treatments.
Our review included thirty-three primary studies, showcasing that while vitamin D appeared beneficial, its impact can’t solely be isolated from other interventions. We noticed that factors such as individual health variations and dietary habits played a role in the overall effectiveness of vitamin D supplementation.
We found that vitamin D supplementation may show promise in reducing cognitive decline and dementia progression. However, the results also pointed out a significant variability among the studies, making it challenging to pinpoint exactly how effective vitamin D is when used independently of other treatments.
Our review included thirty-three primary studies, showcasing that while vitamin D appeared beneficial, its impact can’t solely be isolated from other interventions. We noticed that factors such as individual health variations and dietary habits played a role in the overall effectiveness of vitamin D supplementation.
8
We examined the relationship between 25-OH vitamin D and Alzheimer's disease (AD) through an innovative approach called Mendelian randomization. This method allows us to analyze the effect of different nutrients on brain health by leveraging genetic data, while also assessing how these nutrients may influence MRI findings related to AD.
Our findings reveal a significant negative association between 25-OH vitamin D levels and the likelihood of developing Alzheimer's. Specifically, we observed that higher vitamin D is linked to a lower risk of Alzheimer's, with a notable odds ratio suggesting a protective effect. Remarkably, we also discovered that about 7% of the impact of vitamin D on Alzheimer's could be explained by changes in specific brain regions, particularly the Superior_fronto-occipital_fasciculus_L.
Overall, our study provides compelling evidence that vitamin D may serve as a protective factor against Alzheimer's disease. However, we note that its mediating role in brain structures is relatively small, indicating further research is needed to fully understand these relationships and mechanisms.
Our findings reveal a significant negative association between 25-OH vitamin D levels and the likelihood of developing Alzheimer's. Specifically, we observed that higher vitamin D is linked to a lower risk of Alzheimer's, with a notable odds ratio suggesting a protective effect. Remarkably, we also discovered that about 7% of the impact of vitamin D on Alzheimer's could be explained by changes in specific brain regions, particularly the Superior_fronto-occipital_fasciculus_L.
Overall, our study provides compelling evidence that vitamin D may serve as a protective factor against Alzheimer's disease. However, we note that its mediating role in brain structures is relatively small, indicating further research is needed to fully understand these relationships and mechanisms.
8
We collected data from numerous studies to understand how vitamin D deficiency relates to the risk of Alzheimer's disease (AD) and cognitive impairment. Our analysis included 23 studies and revealed some compelling findings regarding vitamin D levels and the likelihood of developing AD.
Specifically, we found that individuals with low vitamin D levels faced a 57% higher risk of Alzheimer's, while vitamin D deficiency raised the overall risk of dementia by 42%. Even more interestingly, the results indicated a non-linear relationship; optimal vitamin D levels for reducing dementia risk seemed to be around 77.5-100 nmol/L. For Alzheimer's specifically, a level above 40.1 nmol/L appeared beneficial.
Although the study does not focus on the effects of vitamin D treatment itself, it still suggests that maintaining adequate vitamin D might help lessen the risk of cognitive decline. Therefore, boosting our vitamin D intake could be a simple yet effective approach to promoting brain health as we age.
Specifically, we found that individuals with low vitamin D levels faced a 57% higher risk of Alzheimer's, while vitamin D deficiency raised the overall risk of dementia by 42%. Even more interestingly, the results indicated a non-linear relationship; optimal vitamin D levels for reducing dementia risk seemed to be around 77.5-100 nmol/L. For Alzheimer's specifically, a level above 40.1 nmol/L appeared beneficial.
Although the study does not focus on the effects of vitamin D treatment itself, it still suggests that maintaining adequate vitamin D might help lessen the risk of cognitive decline. Therefore, boosting our vitamin D intake could be a simple yet effective approach to promoting brain health as we age.
8
We aimed to understand how vitamin D influences the progression of Alzheimer’s disease (AD) by examining its effects on the brain. Our study involved male 5xFAD mice that underwent various dietary regimes and received vitamin D injections. This allowed us to investigate both vitamin D deficiency and supplementation in relation to AD symptoms.
Through careful analysis of brain tissue, we looked for changes in amyloid-β (Aβ) plaques and the presence of reactive astrocytes—important cells that interact with neurons in the brain. Our findings demonstrated a noteworthy association between vitamin D levels and reductions in harmful Aβ pathways and reactive astrogliosis.
This is significant since it suggests that maintaining adequate vitamin D levels might be a promising strategy for preventing or treating Alzheimer’s disease. Overall, our study provides crucial insights into how vitamin D could potentially alter the course of AD, opening the door for new therapeutic approaches.
Through careful analysis of brain tissue, we looked for changes in amyloid-β (Aβ) plaques and the presence of reactive astrocytes—important cells that interact with neurons in the brain. Our findings demonstrated a noteworthy association between vitamin D levels and reductions in harmful Aβ pathways and reactive astrogliosis.
This is significant since it suggests that maintaining adequate vitamin D levels might be a promising strategy for preventing or treating Alzheimer’s disease. Overall, our study provides crucial insights into how vitamin D could potentially alter the course of AD, opening the door for new therapeutic approaches.
7
We explored the link between vitamin D levels and cognitive impairment among older adults with chronic kidney disease (CKD). This research involved individuals over 60 years old who had higher levels of albumin in their urine, indicating kidney issues.
Cognitive function was measured using a specific test designed to assess memory and learning skills. We discovered a notable relationship between serum levels of 25-hydroxyvitamin D3 (the main form of vitamin D in the blood) and cognitive performance. Those with lower vitamin D levels tended to have poorer cognitive function, particularly in patients showing early signs of kidney problems, specifically microalbuminuria.
Our findings suggest that addressing vitamin D deficiency could be a meaningful approach to help maintain cognitive health in aging CKD patients. Recognizing and treating low vitamin D levels earlier may prevent further cognitive decline, especially as kidney function worsens.
Cognitive function was measured using a specific test designed to assess memory and learning skills. We discovered a notable relationship between serum levels of 25-hydroxyvitamin D3 (the main form of vitamin D in the blood) and cognitive performance. Those with lower vitamin D levels tended to have poorer cognitive function, particularly in patients showing early signs of kidney problems, specifically microalbuminuria.
Our findings suggest that addressing vitamin D deficiency could be a meaningful approach to help maintain cognitive health in aging CKD patients. Recognizing and treating low vitamin D levels earlier may prevent further cognitive decline, especially as kidney function worsens.
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Supports Alzheimer's treatment
Jarrow is our trusted source for supplements. My wife takes this daily, as she has alzheimer's disease and suffers from vitamin D deficiency, which may influence its progression. A chiropractor recommended Jarrow when we sought a calcium supplement, and their BoneUp formulation reversed my wife's osteopenia.
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Liu W, Zheng D, Li X, Wang T, Wang L, et al. Effects of Vitamin D3 Combined with Folic Acid on Domain and Specific Cognitive Function among Patients with Mild Cognitive Impairment: A Randomized Clinical Trial. J Prev Alzheimers Dis. 2024;11:1626. doi:10.14283/jpad.2024.165
- Zaman Z, Islam R, Koganti B, Falki V, Osentoski T, et al. Highly prevalent geriatric medications and their effect on β-amyloid fibril formation. BMC Neurol. 2024;24:445. doi:10.1186/s12883-024-03930-7
- Fu Q, DeJager J, Gardner EM. Supplementation and Mitigating Cognitive Decline in Older Adults With or Without Mild Cognitive Impairment or Dementia: A Systematic Review. Nutrients. 2024;16. doi:10.3390/nu16203567
- Park J, Byun MS, Yi D, Ahn H, Jung JH, et al. The Moderating Effect of Serum Vitamin D on the Relationship between Beta-amyloid Deposition and Neurodegeneration. Clin Psychopharmacol Neurosci. 2024;22:646. doi:10.9758/cpn.24.1189
- Fu LL, Vollkommer T, Fuest S, Gosau M, Feng H, et al. The role of 25-OH vitamin D in Alzheimer's disease through Mendelian randomization and MRI. QJM. 2025;118:24. doi:10.1093/qjmed/hcae166
- Zhang J, Zhang A. Association between serum 25-hydroxyvitamin D3 level and cognitive impairment in older chronic kidney disease patients. Sci Rep. 2024;14:12403. doi:10.1038/s41598-024-63350-y
- Zhang XX, Wang HR, Hu YZ, Sun HM, Feng YX, et al. Association of Vitamin D Levels with Risk of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Prospective Studies. J Alzheimers Dis. 2024;98:373. doi:10.3233/JAD-231381
- Kang J, Park M, Kim T. Vitamin D Reduces GABA-Positive Astrocytes in the 5xFAD Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2024;97:1939. doi:10.3233/JAD-231033
- Chen LJ, Sha S, Stocker H, Brenner H, Schöttker B. The associations of serum vitamin D status and vitamin D supplements use with all-cause dementia, Alzheimer's disease, and vascular dementia: a UK Biobank based prospective cohort study. Am J Clin Nutr. 2024;119:1052. doi:10.1016/j.ajcnut.2024.01.020
