' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.6
USERS' SCORE
Very Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D aids rheumatoid arthritis
The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review.
Directly addresses vitamin D's benefits.
We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
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4
Vitamin D may aid knee OA
The effectiveness of vitamin D supplementation in patients with end-stage knee osteoarthritis: Study protocol for a double-blinded, randomized controlled trial.
Highly relevant to vitamin D and OA
We set out to explore the potential benefits of vitamin D supplementation for people suffering from end-stage knee osteoarthritis (OA). Our research took the form of a double-blinded, randomized controlled trial involving 56 patients with vitamin D insufficiency. This careful design allowed us to compare the effects of vitamin D against a placebo, ensuring that neither the patients nor the assessors knew who received what treatment.
Over six months, participants in the vitamin D group took capsules containing 4,000 IU daily, while the others received a placebo. We measured muscle strength, pain levels, physical function, and signs of sarcopenia at several points: at the start, after three months, and again at the six-month mark.
We aimed to see whether this cost-effective and well-tolerated supplement could improve quality of life by boosting muscle strength and reducing pain for knee OA patients. Given the growing number of people waiting for knee replacements in Hong Kong, our findings could have significant implications for patient care.
Our study's findings may help clarify whether vitamin D supplementation is a viable option for alleviating some symptoms associated with knee osteoarthritis. With ongoing interest in non-surgical therapies, understanding the role of vitamin D (particularly in muscle health) is more relevant than ever.
Over six months, participants in the vitamin D group took capsules containing 4,000 IU daily, while the others received a placebo. We measured muscle strength, pain levels, physical function, and signs of sarcopenia at several points: at the start, after three months, and again at the six-month mark.
We aimed to see whether this cost-effective and well-tolerated supplement could improve quality of life by boosting muscle strength and reducing pain for knee OA patients. Given the growing number of people waiting for knee replacements in Hong Kong, our findings could have significant implications for patient care.
Our study's findings may help clarify whether vitamin D supplementation is a viable option for alleviating some symptoms associated with knee osteoarthritis. With ongoing interest in non-surgical therapies, understanding the role of vitamin D (particularly in muscle health) is more relevant than ever.
Read More
9
Vitamin D mitigates arthritis damage
1,25(OH)D induces chondrocyte autophagy and reduces the loss of proteoglycans in osteoarthritis through inhibiting the NF-κB pathway.
Highly relevant to arthritis research
We explored how vitamin D (VD) affects osteoarthritis (OA), a condition that commonly leads to joint pain and stiffness. Our research focused on the idea that vitamin D might help reduce inflammation and tissue damage driven by the NF-κB pathway, a crucial player in OA development.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
Read More
Most Useful Reviews
8.3
High-quality relief
During this challenging year due to COVID-19, I started taking vitamin D on my rheumatologist's advice. It works well against my rheumatoid arthritis and prevents colds and viruses. Having used other brands, I find Jarrow's quality outstanding. The delivery to Kazakhstan is also good, and everything is well packaged.
Read More
9.5
Improved wellbeing
I feel much better after taking this product for my arthritis. My vitamin D levels were found to be extremely low, affecting my joints. After starting this supplement, I noticed significant improvement. The tiny capsules are ideal for me, containing olive oil which helps avoid inflammation. I take two every morning and will continue, as it is said to be a 'happy pill' and supports my wellbeing, particularly when sunlight exposure is inadequate.
Read More
9
Effective medication
The drug works well for my rheumatoid arthritis and I would recommend it. It has been beneficial for us.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.6
9
Vitamin D mitigates arthritis damage
1,25(OH)D induces chondrocyte autophagy and reduces the loss of proteoglycans in osteoarthritis through inhibiting the NF-κB pathway.
Highly relevant to arthritis research
We explored how vitamin D (VD) affects osteoarthritis (OA), a condition that commonly leads to joint pain and stiffness. Our research focused on the idea that vitamin D might help reduce inflammation and tissue damage driven by the NF-κB pathway, a crucial player in OA development.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
Read More
8
Vitamin D shows promise for RA
Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis.
Directly addresses vitamin D effects
We explored the effects of vitamin D supplementation on adults with rheumatoid arthritis (RA), an inflammatory condition affecting millions worldwide. By examining clinical studies that compared vitamin D to either a placebo or standard care, we focused on how these supplements might influence various health outcomes for those suffering from RA.
Our analysis included 11 studies, highlighting several noteworthy findings. We observed a significant improvement in key measures: the Disease Activity Score 28 (DAS-28) showed a meaningful reduction, while levels of C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) also decreased. Furthermore, vitamin D supplementation led to an increase in serum vitamin D levels.
Despite these positive results, vitamin D supplementation did not appear to significantly impact the health assessment questionnaire (HAQ) and visual analog scale for pain (VAS-pain) scores. Consequently, while vitamin D can help reduce inflammation and improve specific health parameters in RA patients, the optimal dosage and duration of treatment remain unclear.
Overall, our findings suggest that boosting vitamin D levels might offer benefits for managing RA, and further research may help refine treatment strategies for optimal outcomes.
Our analysis included 11 studies, highlighting several noteworthy findings. We observed a significant improvement in key measures: the Disease Activity Score 28 (DAS-28) showed a meaningful reduction, while levels of C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) also decreased. Furthermore, vitamin D supplementation led to an increase in serum vitamin D levels.
Despite these positive results, vitamin D supplementation did not appear to significantly impact the health assessment questionnaire (HAQ) and visual analog scale for pain (VAS-pain) scores. Consequently, while vitamin D can help reduce inflammation and improve specific health parameters in RA patients, the optimal dosage and duration of treatment remain unclear.
Overall, our findings suggest that boosting vitamin D levels might offer benefits for managing RA, and further research may help refine treatment strategies for optimal outcomes.
Read More
8
Vitamin D's role in arthritis relief
Impact of Reduced Vitamin D Levels on Pain, Function, and Severity in Knee or Hip Osteoarthritis.
High relevance to vitamin D impact
We aimed to understand how vitamin D deficiency impacts elderly people suffering from osteoarthritis (OA) in their hips and knees. Our study involved 105 OA patients and 152 healthy individuals to compare their vitamin D levels and functional abilities, using criteria like the WOMAC questionnaire to assess pain and functional impairment.
Our findings revealed that patients with low vitamin D levels experienced more severe OA symptoms. They reported higher pain levels and greater difficulties in daily activities compared to those with normal vitamin D levels. Furthermore, their vitamin D deficiency was associated with increased levels of inflammatory markers, TNF-α and IL-6, suggesting a link between inflammation and vitamin D status.
Ultimately, the evidence indicates that maintaining adequate vitamin D levels may be crucial in managing the symptoms of hip and knee osteoarthritis. While further research is necessary to fully understand these relationships, our results hint at the potential benefits of vitamin D supplementation to help alleviate OA symptoms and slow disease progression.
Our findings revealed that patients with low vitamin D levels experienced more severe OA symptoms. They reported higher pain levels and greater difficulties in daily activities compared to those with normal vitamin D levels. Furthermore, their vitamin D deficiency was associated with increased levels of inflammatory markers, TNF-α and IL-6, suggesting a link between inflammation and vitamin D status.
Ultimately, the evidence indicates that maintaining adequate vitamin D levels may be crucial in managing the symptoms of hip and knee osteoarthritis. While further research is necessary to fully understand these relationships, our results hint at the potential benefits of vitamin D supplementation to help alleviate OA symptoms and slow disease progression.
Read More
8
Vitamin D aids knee osteoarthritis
Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction.
Combination therapy limits isolated assessment
We investigated how vitamin D affects arthritis, specifically focusing on knee osteoarthritis (OA) using a rat model. In our study, male Wistar rats were divided into five groups to evaluate the effects of curcumin, vitamin D, and their combination over 12 weeks.
Both vitamin D and curcumin independently reduced pain in the rats. However, when combined, they provided enhanced pain relief. We observed that vitamin D, alongside curcumin, showed promising results by reducing inflammation and improving joint health. The treatment groups exhibited lower levels of pro-inflammatory cytokines and higher levels of the anti-inflammatory cytokine interleukin-10 (IL-10).
Importantly, the supplements also helped restore some antioxidative markers and led to a significant reduction in the oxidative stress marker known as Cartilage Oligomeric Matrix Protein (COMP). Histological examinations revealed that those treated with vitamin D and curcumin maintained better cartilage integrity and had reduced inflammation in the synovium.
Overall, our findings suggest that vitamin D, particularly in combination with curcumin, could play a vital role in managing knee OA by addressing both pain and the underlying inflammation, making it a potential option for arthritis treatment in clinical settings.
Both vitamin D and curcumin independently reduced pain in the rats. However, when combined, they provided enhanced pain relief. We observed that vitamin D, alongside curcumin, showed promising results by reducing inflammation and improving joint health. The treatment groups exhibited lower levels of pro-inflammatory cytokines and higher levels of the anti-inflammatory cytokine interleukin-10 (IL-10).
Importantly, the supplements also helped restore some antioxidative markers and led to a significant reduction in the oxidative stress marker known as Cartilage Oligomeric Matrix Protein (COMP). Histological examinations revealed that those treated with vitamin D and curcumin maintained better cartilage integrity and had reduced inflammation in the synovium.
Overall, our findings suggest that vitamin D, particularly in combination with curcumin, could play a vital role in managing knee OA by addressing both pain and the underlying inflammation, making it a potential option for arthritis treatment in clinical settings.
Read More
8
Vitamin D may help arthritis
Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice.
Combination treatment's isolated effects unclear
We explored the potential of calcitriol, a form of vitamin D, in treating rheumatoid arthritis (RA) through its interaction with mesenchymal stem cells (MSCs) in a mouse model. The study initiated by inducing arthritis in BALB/c mice using collagen, which mimicked the inflammatory processes seen in human RA.
The mice were then divided into groups receiving either untreated MSCs or those treated with calcitriol. This setup allowed us to evaluate the difference in immune responses from these treatments over a week.
Our findings highlighted that MSCs treated with calcitriol showed improved regulatory functions and reduced the inflammatory responses in immune cells, particularly affecting splenocytes. Notably, there was a significant increase in beneficial cytokines while the levels of pro-inflammatory cytokines decreased compared to the untreated group.
This suggests that vitamin D, in combination with MSCs, could play a valuable role in modulating immune responses in RA, indicating a promising pathway for future therapies. However, the specific isolated effects of vitamin D alone remain less clear due to the combination approach taken in this study.
The mice were then divided into groups receiving either untreated MSCs or those treated with calcitriol. This setup allowed us to evaluate the difference in immune responses from these treatments over a week.
Our findings highlighted that MSCs treated with calcitriol showed improved regulatory functions and reduced the inflammatory responses in immune cells, particularly affecting splenocytes. Notably, there was a significant increase in beneficial cytokines while the levels of pro-inflammatory cytokines decreased compared to the untreated group.
This suggests that vitamin D, in combination with MSCs, could play a valuable role in modulating immune responses in RA, indicating a promising pathway for future therapies. However, the specific isolated effects of vitamin D alone remain less clear due to the combination approach taken in this study.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 5 Reviews
8.6
9.5
Improved wellbeing
I feel much better after taking this product for my arthritis. My vitamin D levels were found to be extremely low, affecting my joints. After starting this supplement, I noticed significant improvement. The tiny capsules are ideal for me, containing olive oil which helps avoid inflammation. I take two every morning and will continue, as it is said to be a 'happy pill' and supports my wellbeing, particularly when sunlight exposure is inadequate.
Read More
9
Effective medication
The drug works well for my rheumatoid arthritis and I would recommend it. It has been beneficial for us.
8.8
Crucial vitamin D
This great product is excellent value for money. The capsule size makes it easy to swallow. Vitamin D3 is essential, especially as its deficiency can lead to serious health issues, including arthritis. I appreciate how it helps maintain health and wellbeing.
8.8
Arthritis relief
This product effectively helps with arthritis and serves as an excellent preventive remedy against colds and viral illnesses. The small, easy-to-swallow capsules are of excellent quality.
8.3
High-quality relief
During this challenging year due to COVID-19, I started taking vitamin D on my rheumatologist's advice. It works well against my rheumatoid arthritis and prevents colds and viruses. Having used other brands, I find Jarrow's quality outstanding. The delivery to Kazakhstan is also good, and everything is well packaged.
Read More
