Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
We investigated the effects of vitamin D, specifically its active form calcitriol, on glioblastoma, the most common type of primary brain cancer in adults. With very limited treatment options and a grim prognosis, glioblastoma poses a serious challenge due to its ability to develop resistance to therapies and acquire stem-like properties that fuel its growth.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
Read More
8
We delved into the complex relationship between vitamin D and glioma, particularly amid the challenges COVID-19 poses for patients with this aggressive brain cancer. Through our investigation, we identified 203 genes that were commonly altered in both glioma and COVID-19 infections. Among these, we pinpointed six key genes that can influence patient outcomes, including MYBL2, RBM6, VEPH1, AHNAK2, GNG10, and DUSP14.
After further examination, five of these genes showed potential interactions with vitamin D, suggesting that this vitamin might play a role in improving the prognosis for glioma patients who contract COVID-19. Specifically, vitamin D appears to influence the PI3K-Akt signaling pathway, which is critical in regulating numerous cellular functions linked to cancer progression.
Our molecular docking and single-cell RNA analyses indicate that vitamin D could help enhance the health and longevity of glioma patients during COVID-19 infections. However, it’s essential to note that while we observed potential benefits, the complex interplay between these factors warrants further research for a clearer understanding. Overall, this study sheds light on the promising connections between vitamin D, glioma, and COVID-19, paving the way for future treatment strategies.
After further examination, five of these genes showed potential interactions with vitamin D, suggesting that this vitamin might play a role in improving the prognosis for glioma patients who contract COVID-19. Specifically, vitamin D appears to influence the PI3K-Akt signaling pathway, which is critical in regulating numerous cellular functions linked to cancer progression.
Our molecular docking and single-cell RNA analyses indicate that vitamin D could help enhance the health and longevity of glioma patients during COVID-19 infections. However, it’s essential to note that while we observed potential benefits, the complex interplay between these factors warrants further research for a clearer understanding. Overall, this study sheds light on the promising connections between vitamin D, glioma, and COVID-19, paving the way for future treatment strategies.
Read More
8
We examined the connection between vitamin D levels and survival rates in patients undergoing craniotomy for brain malignancies. In this study, 56 patients participated, divided into three groups: one receiving a high dose of vitamin D, a control group without treatment, and a group with optimal vitamin D levels at admission.
Our findings revealed that patients with optimal vitamin D levels at admission had significantly better survival rates compared to those in the other groups. Specifically, the average vitamin D levels were notably higher for those with optimal status, indicating a potential link between higher vitamin D levels and improved outcomes after brain surgery.
Additionally, we discovered that total calcium levels and age also played important roles in predicting mortality risk. While the correlation between vitamin D levels and improved survival is promising, we suggest that further studies are needed to explore this important area of research more deeply.
Our findings revealed that patients with optimal vitamin D levels at admission had significantly better survival rates compared to those in the other groups. Specifically, the average vitamin D levels were notably higher for those with optimal status, indicating a potential link between higher vitamin D levels and improved outcomes after brain surgery.
Additionally, we discovered that total calcium levels and age also played important roles in predicting mortality risk. While the correlation between vitamin D levels and improved survival is promising, we suggest that further studies are needed to explore this important area of research more deeply.
Read More
Most Useful Reviews
10
Migraine relief
40 people found this helpful
I've suffered from migraines for over two decades, since my youth, to the extent that doctors suspected a brain tumour, leading to an MRI and spinal tap. A suggestion to try vitamin D initially met with scepticism from me, but after considerable persuasion, I gave it a shot. Remarkably, I have not experienced a migraine in TWO MONTHS. This is absolutely unprecedented for me. I am continually anticipating its return, yet it has not happened. It's an absolute life changer! I take 1,000 IU in the morning and 1,000 IU at night, though consulting your doctor for your specific needs is advisable. I'm incredibly thankful for this product!
Read More
7.5
Essential medication
I take this small capsule three times a week to maintain my levels. I undergo a blood test annually, and my doctor determines the appropriate dosage. I have a rare condition, Fahr's disease, which calcifies my brain, necessitating precise dosage to support my treatment for the brain tumour.
Read More
6
Supports brain health
Good for bone, skin, and brain.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
- All Researches
8
We developed an innovative method to tackle glioblastoma, a particularly aggressive brain tumor. Our approach involved creating a unique nanoplatform that combines vitamin D3, lipids, and neutrophil membranes to enhance the treatment's effectiveness.
Through this method, we incorporated doxorubicin-loaded manganese dioxide nanoparticles, which not only provided chemotherapy but also activated immune responses. Impressively, this nanoplatform significantly boosted the body's immune reaction, stimulating the release of type I interferon-β and inflaming cytokines to target glioma tissues.
We observed a transformation in the tumor's environment, shifting from an immunosuppressive "cold" tumor to a more responsive "hot" tumor, thereby increasing the presence of crucial immune cells like CD8T cells. Although the specific isolated effects of vitamin D3 on its own cannot be determined from this study, its synergistic role within this multimodal strategy showcases promising potential for future cancer treatments, particularly in harnessing the body's innate immune responses against glioblastoma.
Through this method, we incorporated doxorubicin-loaded manganese dioxide nanoparticles, which not only provided chemotherapy but also activated immune responses. Impressively, this nanoplatform significantly boosted the body's immune reaction, stimulating the release of type I interferon-β and inflaming cytokines to target glioma tissues.
We observed a transformation in the tumor's environment, shifting from an immunosuppressive "cold" tumor to a more responsive "hot" tumor, thereby increasing the presence of crucial immune cells like CD8T cells. Although the specific isolated effects of vitamin D3 on its own cannot be determined from this study, its synergistic role within this multimodal strategy showcases promising potential for future cancer treatments, particularly in harnessing the body's innate immune responses against glioblastoma.
Read More
8
We delved into the complex relationship between vitamin D and glioma, particularly amid the challenges COVID-19 poses for patients with this aggressive brain cancer. Through our investigation, we identified 203 genes that were commonly altered in both glioma and COVID-19 infections. Among these, we pinpointed six key genes that can influence patient outcomes, including MYBL2, RBM6, VEPH1, AHNAK2, GNG10, and DUSP14.
After further examination, five of these genes showed potential interactions with vitamin D, suggesting that this vitamin might play a role in improving the prognosis for glioma patients who contract COVID-19. Specifically, vitamin D appears to influence the PI3K-Akt signaling pathway, which is critical in regulating numerous cellular functions linked to cancer progression.
Our molecular docking and single-cell RNA analyses indicate that vitamin D could help enhance the health and longevity of glioma patients during COVID-19 infections. However, it’s essential to note that while we observed potential benefits, the complex interplay between these factors warrants further research for a clearer understanding. Overall, this study sheds light on the promising connections between vitamin D, glioma, and COVID-19, paving the way for future treatment strategies.
After further examination, five of these genes showed potential interactions with vitamin D, suggesting that this vitamin might play a role in improving the prognosis for glioma patients who contract COVID-19. Specifically, vitamin D appears to influence the PI3K-Akt signaling pathway, which is critical in regulating numerous cellular functions linked to cancer progression.
Our molecular docking and single-cell RNA analyses indicate that vitamin D could help enhance the health and longevity of glioma patients during COVID-19 infections. However, it’s essential to note that while we observed potential benefits, the complex interplay between these factors warrants further research for a clearer understanding. Overall, this study sheds light on the promising connections between vitamin D, glioma, and COVID-19, paving the way for future treatment strategies.
Read More
8
We investigated the effects of vitamin D, specifically its active form calcitriol, on glioblastoma, the most common type of primary brain cancer in adults. With very limited treatment options and a grim prognosis, glioblastoma poses a serious challenge due to its ability to develop resistance to therapies and acquire stem-like properties that fuel its growth.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
Read More
8
We examined the connection between vitamin D levels and survival rates in patients undergoing craniotomy for brain malignancies. In this study, 56 patients participated, divided into three groups: one receiving a high dose of vitamin D, a control group without treatment, and a group with optimal vitamin D levels at admission.
Our findings revealed that patients with optimal vitamin D levels at admission had significantly better survival rates compared to those in the other groups. Specifically, the average vitamin D levels were notably higher for those with optimal status, indicating a potential link between higher vitamin D levels and improved outcomes after brain surgery.
Additionally, we discovered that total calcium levels and age also played important roles in predicting mortality risk. While the correlation between vitamin D levels and improved survival is promising, we suggest that further studies are needed to explore this important area of research more deeply.
Our findings revealed that patients with optimal vitamin D levels at admission had significantly better survival rates compared to those in the other groups. Specifically, the average vitamin D levels were notably higher for those with optimal status, indicating a potential link between higher vitamin D levels and improved outcomes after brain surgery.
Additionally, we discovered that total calcium levels and age also played important roles in predicting mortality risk. While the correlation between vitamin D levels and improved survival is promising, we suggest that further studies are needed to explore this important area of research more deeply.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Migraine relief
40 people found this helpful
I've suffered from migraines for over two decades, since my youth, to the extent that doctors suspected a brain tumour, leading to an MRI and spinal tap. A suggestion to try vitamin D initially met with scepticism from me, but after considerable persuasion, I gave it a shot. Remarkably, I have not experienced a migraine in TWO MONTHS. This is absolutely unprecedented for me. I am continually anticipating its return, yet it has not happened. It's an absolute life changer! I take 1,000 IU in the morning and 1,000 IU at night, though consulting your doctor for your specific needs is advisable. I'm incredibly thankful for this product!
Read More
7.5
Essential medication
I take this small capsule three times a week to maintain my levels. I undergo a blood test annually, and my doctor determines the appropriate dosage. I have a rare condition, Fahr's disease, which calcifies my brain, necessitating precise dosage to support my treatment for the brain tumour.
Read More
6
Supports brain health
Good for bone, skin, and brain.
Read More
Frequently Asked Questions
7.5
Essential medication
I take this small capsule three times a week to maintain my levels. I undergo a blood test annually, and my doctor determines the appropriate dosage. I have a rare condition, Fahr's disease, which calcifies my brain, necessitating precise dosage to support my treatment for the brain tumour.
6
Supports brain health
Good for bone, skin, and brain.
8
We developed an innovative method to tackle glioblastoma, a particularly aggressive brain tumor. Our approach involved creating a unique nanoplatform that combines vitamin D3, lipids, and neutrophil membranes to enhance the treatment's effectiveness.
Through this method, we incorporated doxorubicin-loaded manganese dioxide nanoparticles, which not only provided chemotherapy but also activated immune responses. Impressively, this nanoplatform significantly boosted the body's immune reaction, stimulating the release of type I interferon-β and inflaming cytokines to target glioma tissues.
We observed a transformation in the tumor's environment, shifting from an immunosuppressive "cold" tumor to a more responsive "hot" tumor, thereby increasing the presence of crucial immune cells like CD8T cells. Although the specific isolated effects of vitamin D3 on its own cannot be determined from this study, its synergistic role within this multimodal strategy showcases promising potential for future cancer treatments, particularly in harnessing the body's innate immune responses against glioblastoma.
Through this method, we incorporated doxorubicin-loaded manganese dioxide nanoparticles, which not only provided chemotherapy but also activated immune responses. Impressively, this nanoplatform significantly boosted the body's immune reaction, stimulating the release of type I interferon-β and inflaming cytokines to target glioma tissues.
We observed a transformation in the tumor's environment, shifting from an immunosuppressive "cold" tumor to a more responsive "hot" tumor, thereby increasing the presence of crucial immune cells like CD8T cells. Although the specific isolated effects of vitamin D3 on its own cannot be determined from this study, its synergistic role within this multimodal strategy showcases promising potential for future cancer treatments, particularly in harnessing the body's innate immune responses against glioblastoma.
8
We delved into the complex relationship between vitamin D and glioma, particularly amid the challenges COVID-19 poses for patients with this aggressive brain cancer. Through our investigation, we identified 203 genes that were commonly altered in both glioma and COVID-19 infections. Among these, we pinpointed six key genes that can influence patient outcomes, including MYBL2, RBM6, VEPH1, AHNAK2, GNG10, and DUSP14.
After further examination, five of these genes showed potential interactions with vitamin D, suggesting that this vitamin might play a role in improving the prognosis for glioma patients who contract COVID-19. Specifically, vitamin D appears to influence the PI3K-Akt signaling pathway, which is critical in regulating numerous cellular functions linked to cancer progression.
Our molecular docking and single-cell RNA analyses indicate that vitamin D could help enhance the health and longevity of glioma patients during COVID-19 infections. However, it’s essential to note that while we observed potential benefits, the complex interplay between these factors warrants further research for a clearer understanding. Overall, this study sheds light on the promising connections between vitamin D, glioma, and COVID-19, paving the way for future treatment strategies.
After further examination, five of these genes showed potential interactions with vitamin D, suggesting that this vitamin might play a role in improving the prognosis for glioma patients who contract COVID-19. Specifically, vitamin D appears to influence the PI3K-Akt signaling pathway, which is critical in regulating numerous cellular functions linked to cancer progression.
Our molecular docking and single-cell RNA analyses indicate that vitamin D could help enhance the health and longevity of glioma patients during COVID-19 infections. However, it’s essential to note that while we observed potential benefits, the complex interplay between these factors warrants further research for a clearer understanding. Overall, this study sheds light on the promising connections between vitamin D, glioma, and COVID-19, paving the way for future treatment strategies.
8
We investigated the effects of vitamin D, specifically its active form calcitriol, on glioblastoma, the most common type of primary brain cancer in adults. With very limited treatment options and a grim prognosis, glioblastoma poses a serious challenge due to its ability to develop resistance to therapies and acquire stem-like properties that fuel its growth.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
References
- He W, Lv W, Liu L, Gong Y, Song K, et al. Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform. ACS Nano. 2024;18:35559. doi:10.1021/acsnano.4c13470
- Zhang BT, Leung PC, Wong CK, Wang DJ. The Immunomodulatory Effects of Vitamin D on COVID-19 Induced Glioblastoma Recurrence via the PI3K-AKT Signaling Pathway. Int J Mol Sci. 2024;25. doi:10.3390/ijms252312952
- Rehbein S, Possmayer AL, Bozkurt S, Lotsch C, Gerstmeier J, et al. Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells. Cancers (Basel). 2023;15. doi:10.3390/cancers15215249
- Shahmohammadi M, Hajimohammadebrahim-Ketabforoush M, Shariatpanahi ZV. Optimal vitamin D status at admission appears to improve survival after craniotomy in patients with brain malignancies. Clin Nutr ESPEN. 2023;55:428. doi:10.1016/j.clnesp.2023.04.009
