' 
SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.9
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D reduces eczema severity
Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis.
Directly addresses eczema treatment
We focused on understanding the impact of vitamin D supplementation on atopic dermatitis, commonly known as eczema, in both children and adults. This systematic review analyzed data from eleven randomized controlled trials (RCTs), involving a total of 686 participants.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Read More
8
Neonatal vitamin D influences eczema
Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.
High relevance to vitamin D study
We observed the potential effects of early-life vitamin D levels on the risk of developing eczema in children over a 25-year period. Our study involved measuring the levels of 25(OH)D3 from dried blood spots in 223 children at high risk for allergies. We then used statistical methods to assess different types of eczema that might occur as the children grew.
The findings revealed that higher levels of neonatal vitamin D were linked to a reduced risk of persistent eczema that starts early in life. Specifically, for every 10 nmol/L increase in vitamin D, there was about a 26% lower chance of developing early-onset persistent eczema. Conversely, these higher levels also seemed to increase the odds of early-onset-resolving eczema by around 30%.
However, it’s important to note that we did not find strong evidence connecting neonatal vitamin D levels with current eczema or other distinct eczema-related sensitization patterns. Overall, our results suggest that ensuring adequate vitamin D levels during pregnancy could potentially benefit the long-term skin health of children, particularly regarding the emergence of certain eczema types.
The findings revealed that higher levels of neonatal vitamin D were linked to a reduced risk of persistent eczema that starts early in life. Specifically, for every 10 nmol/L increase in vitamin D, there was about a 26% lower chance of developing early-onset persistent eczema. Conversely, these higher levels also seemed to increase the odds of early-onset-resolving eczema by around 30%.
However, it’s important to note that we did not find strong evidence connecting neonatal vitamin D levels with current eczema or other distinct eczema-related sensitization patterns. Overall, our results suggest that ensuring adequate vitamin D levels during pregnancy could potentially benefit the long-term skin health of children, particularly regarding the emergence of certain eczema types.
Read More
8
Vitamin D improves eczema symptoms
Oral vitamin D modulates the epidermal expression of the vitamin D receptor and cathelicidin in children with atopic dermatitis.
Study highlights vitamin D's effects
We investigated how oral vitamin D3 supplements influence eczema, specifically in children with atopic dermatitis (AD). Over six weeks, we administered weekly doses of vitamin D3 to a group of 22 children suffering from moderate to severe AD.
Before and after the treatment, we measured several key factors: serum vitamin D levels, the presence of Staphylococcus aureus on the skin, and the overall severity of eczema, assessed through the SCORAD index.
Remarkably, we found that vitamin D supplementation raised vitamin D levels in the children and led to significant improvements in eczema severity. The SCORAD scores dropped notably, indicating less severe symptoms. Additionally, we saw an increase in the expression of vital skin proteins, specifically Cathelicidin, in affected areas after treatment.
However, while the treatment was beneficial for overall skin condition, the expression of Thymic Stromal Lymphopoietin did not change. Importantly, our findings highlight the direct effects of vitamin D on skin health in children with AD, providing insight into its potential as a supportive treatment for eczema.
Before and after the treatment, we measured several key factors: serum vitamin D levels, the presence of Staphylococcus aureus on the skin, and the overall severity of eczema, assessed through the SCORAD index.
Remarkably, we found that vitamin D supplementation raised vitamin D levels in the children and led to significant improvements in eczema severity. The SCORAD scores dropped notably, indicating less severe symptoms. Additionally, we saw an increase in the expression of vital skin proteins, specifically Cathelicidin, in affected areas after treatment.
However, while the treatment was beneficial for overall skin condition, the expression of Thymic Stromal Lymphopoietin did not change. Importantly, our findings highlight the direct effects of vitamin D on skin health in children with AD, providing insight into its potential as a supportive treatment for eczema.
Read More
Most Useful Reviews
0.5
Exacerbates eczema
I have used this product intermittently and found that it worsens my eczema. The itching increased, prompting me to stop using it. I will consider buying a vegan version next time.
Read More
5.8
Supports bone health
Vitamin D3 helps improve the absorption of calcium and phosphorus, essential for maintaining strong bones. It effectively supports immunity and is packaged well. The dosage is convenient, with one tablet taken every other day, although daily intake is possible. It has a soft shell, making it suitable for those who struggle to swallow.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.9
- All Researches
8
Vitamin D's role in eczema severity
Changes and clinical significance of serum vitamin A, 25-(OH)D3, TG2, IL-4 and IL-13 levels in children with eczema.
High relevance; partial vitamin D focus
We investigated the levels of vitamin D and other related factors in children suffering from eczema to better understand their relationship with the severity of this condition. Our analysis included 159 children, categorized by the severity of their eczema symptoms into mild, moderate, and severe groups.
Over the course of the study, we observed that as eczema severity increased, serum levels of vitamin A and 25-(OH)D3 (a form of vitamin D) tended to decrease. Conversely, levels of tissue transglutaminase (TG2), interleukin-4 (IL-4), and interleukin-13 (IL-13), which are markers of inflammation, increased. Significant correlations emerged showing that lower levels of vitamin A and 25-(OH)D3 were linked to higher SCORAD scores (a measure of eczema severity), while increases in TG2, IL-4, and IL-13 levels paralleled worsening symptoms.
Importantly, vitamin D levels had the highest accuracy for assessing eczema severity compared to the other markers studied. After treatment over three months, we noted improvements in the levels of all measured indicators, suggesting that addressing these serum factors could have a positive impact on managing eczema symptoms.
Our findings indicate that monitoring vitamin D levels, along with other serum indicators, might offer valuable insights for clinicians in evaluating and treating eczema in children.
Over the course of the study, we observed that as eczema severity increased, serum levels of vitamin A and 25-(OH)D3 (a form of vitamin D) tended to decrease. Conversely, levels of tissue transglutaminase (TG2), interleukin-4 (IL-4), and interleukin-13 (IL-13), which are markers of inflammation, increased. Significant correlations emerged showing that lower levels of vitamin A and 25-(OH)D3 were linked to higher SCORAD scores (a measure of eczema severity), while increases in TG2, IL-4, and IL-13 levels paralleled worsening symptoms.
Importantly, vitamin D levels had the highest accuracy for assessing eczema severity compared to the other markers studied. After treatment over three months, we noted improvements in the levels of all measured indicators, suggesting that addressing these serum factors could have a positive impact on managing eczema symptoms.
Our findings indicate that monitoring vitamin D levels, along with other serum indicators, might offer valuable insights for clinicians in evaluating and treating eczema in children.
Read More
8
Vitamin D reduces eczema severity
Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis.
Directly addresses eczema treatment
We focused on understanding the impact of vitamin D supplementation on atopic dermatitis, commonly known as eczema, in both children and adults. This systematic review analyzed data from eleven randomized controlled trials (RCTs), involving a total of 686 participants.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Read More
8
Maternal vitamin D influences infant eczema
Correlation of Maternal Vitamin D Status in Early Pregnancy and Vitamin D Supplementation during Pregnancy with Atopic Dermatitis in Infants: A Prospective Birth Cohort Study.
Highlights complex AD risk factors
We examined the relationship between maternal vitamin D levels during early pregnancy and the occurrence of atopic dermatitis (AD), commonly known as eczema, in infants. Our study involved 4,051 woman-infant pairs, focusing on those with singleton pregnancies. We looked closely at the vitamin D levels of mothers in their first trimester and analyzed how these levels, along with vitamin D supplementation during pregnancy, influenced the likelihood of infants developing AD.
The results showed that infants born to mothers with low vitamin D levels faced a significantly higher risk of developing eczema. Specifically, mothers with vitamin D deficiency had a 77% increased risk of their infants developing AD. Interestingly, this heightened risk was mostly observed in naturally conceived pregnancies, while those conceived through assisted reproductive techniques didn't show the same association.
Additionally, we found that mothers who took vitamin D or multivitamin supplements during pregnancy had a lower risk of having infants with AD. This suggests that adequate vitamin D intake may play a protective role against eczema in infants. Our findings underscore the importance of monitoring vitamin D levels in expectant mothers, as doing so could help reduce the risk of eczema in their future children.
The results showed that infants born to mothers with low vitamin D levels faced a significantly higher risk of developing eczema. Specifically, mothers with vitamin D deficiency had a 77% increased risk of their infants developing AD. Interestingly, this heightened risk was mostly observed in naturally conceived pregnancies, while those conceived through assisted reproductive techniques didn't show the same association.
Additionally, we found that mothers who took vitamin D or multivitamin supplements during pregnancy had a lower risk of having infants with AD. This suggests that adequate vitamin D intake may play a protective role against eczema in infants. Our findings underscore the importance of monitoring vitamin D levels in expectant mothers, as doing so could help reduce the risk of eczema in their future children.
Read More
8
Vitamin D's unclear role in eczema
A systematic review and meta-analysis of nutritional and dietary interventions in randomized controlled trials for skin symptoms in children with atopic dermatitis and without food allergy: An EAACI task force report.
Limited effectiveness of vitamin D
We explored the effectiveness of dietary interventions, particularly vitamin D, in treating eczema symptoms in children without food allergies. Our systematic review included several randomized controlled trials (RCTs) that assessed various treatments. Among these, vitamin D was analyzed alongside other therapies like probiotics and evening primrose oil.
The findings revealed an overall trend suggesting that probiotics, especially when combined with prebiotics, could lead to a notable reduction in eczema symptoms as measured by standard scoring systems. However, the evidence specifically highlighting vitamin D's role in alleviating eczema was limited. This indicates that while some dietary approaches show promise, the impact of vitamin D alone remains less clear.
Thus, we recognize the need for more focused research that can specifically examine the effects of vitamin D on eczema, ideally isolating it from other dietary factors. Well-structured studies are essential to deepen our understanding and develop effective treatment strategies for managing eczema in children.
The findings revealed an overall trend suggesting that probiotics, especially when combined with prebiotics, could lead to a notable reduction in eczema symptoms as measured by standard scoring systems. However, the evidence specifically highlighting vitamin D's role in alleviating eczema was limited. This indicates that while some dietary approaches show promise, the impact of vitamin D alone remains less clear.
Thus, we recognize the need for more focused research that can specifically examine the effects of vitamin D on eczema, ideally isolating it from other dietary factors. Well-structured studies are essential to deepen our understanding and develop effective treatment strategies for managing eczema in children.
Read More
8
Neonatal vitamin D influences eczema
Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.
High relevance to vitamin D study
We observed the potential effects of early-life vitamin D levels on the risk of developing eczema in children over a 25-year period. Our study involved measuring the levels of 25(OH)D3 from dried blood spots in 223 children at high risk for allergies. We then used statistical methods to assess different types of eczema that might occur as the children grew.
The findings revealed that higher levels of neonatal vitamin D were linked to a reduced risk of persistent eczema that starts early in life. Specifically, for every 10 nmol/L increase in vitamin D, there was about a 26% lower chance of developing early-onset persistent eczema. Conversely, these higher levels also seemed to increase the odds of early-onset-resolving eczema by around 30%.
However, it’s important to note that we did not find strong evidence connecting neonatal vitamin D levels with current eczema or other distinct eczema-related sensitization patterns. Overall, our results suggest that ensuring adequate vitamin D levels during pregnancy could potentially benefit the long-term skin health of children, particularly regarding the emergence of certain eczema types.
The findings revealed that higher levels of neonatal vitamin D were linked to a reduced risk of persistent eczema that starts early in life. Specifically, for every 10 nmol/L increase in vitamin D, there was about a 26% lower chance of developing early-onset persistent eczema. Conversely, these higher levels also seemed to increase the odds of early-onset-resolving eczema by around 30%.
However, it’s important to note that we did not find strong evidence connecting neonatal vitamin D levels with current eczema or other distinct eczema-related sensitization patterns. Overall, our results suggest that ensuring adequate vitamin D levels during pregnancy could potentially benefit the long-term skin health of children, particularly regarding the emergence of certain eczema types.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
0.5
Exacerbates eczema
I have used this product intermittently and found that it worsens my eczema. The itching increased, prompting me to stop using it. I will consider buying a vegan version next time.
5.8
Supports bone health
Vitamin D3 helps improve the absorption of calcium and phosphorus, essential for maintaining strong bones. It effectively supports immunity and is packaged well. The dosage is convenient, with one tablet taken every other day, although daily intake is possible. It has a soft shell, making it suitable for those who struggle to swallow.
Read More
