Overview
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.8
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
We explored the link between vitamin D supplementation and its effectiveness in preventing influenza. In our analysis, we reviewed ten randomized controlled trials, which included a total of 4,859 participants. This rigorous investigation was thorough, pulling data from trusted sources such as PubMed, Cochrane Library, and Embase.
Our findings showed that vitamin D supplementation was associated with a significant reduction in the risk of influenza infections. Specifically, we noted a 22% decrease in risk, with our calculations presenting a risk ratio of 0.78. Notably, there was little variability in outcomes among the included studies, suggesting that the results were quite consistent.
Additionally, our research indicated no signs of publication bias, adding credibility to our findings. This suggests that incorporating vitamin D supplementation into preventive strategies for influenza could be beneficial. Overall, vitamin D stands out as a promising option for reducing the risk of influenza infections, reinforcing the idea that it plays a crucial role in bolstering our immune defenses.
Our findings showed that vitamin D supplementation was associated with a significant reduction in the risk of influenza infections. Specifically, we noted a 22% decrease in risk, with our calculations presenting a risk ratio of 0.78. Notably, there was little variability in outcomes among the included studies, suggesting that the results were quite consistent.
Additionally, our research indicated no signs of publication bias, adding credibility to our findings. This suggests that incorporating vitamin D supplementation into preventive strategies for influenza could be beneficial. Overall, vitamin D stands out as a promising option for reducing the risk of influenza infections, reinforcing the idea that it plays a crucial role in bolstering our immune defenses.
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3
We explored whether vitamin D supplementation could help reduce the risk of influenza infection among elderly nursing home residents who had been vaccinated against the flu. In this study, we observed 97 participants, primarily women, who received a seasonal flu vaccine. They were split into two groups: one received vitamin D drops for three months, while the other did not.
During the study, we checked for confirmed influenza infections through nasal swabs and measured the participants' vitamin D levels at the end of the trial. While we noted that there were fewer cases of confirmed influenza in the vitamin D group (5 cases versus 12 in the control), the difference was not statistically significant. Additionally, the expected increase in vitamin D levels after supplementation did not occur, meaning that the treatment did not effectively address the vitamin D deficiency present in our participants.
In conclusion, despite some initial hope, standard vitamin D supplementation did not prove beneficial in reducing influenza infections among the vaccinated elderly residents. This finding highlights important considerations for effective supplementation strategies in populations at risk of vitamin D deficiency.
During the study, we checked for confirmed influenza infections through nasal swabs and measured the participants' vitamin D levels at the end of the trial. While we noted that there were fewer cases of confirmed influenza in the vitamin D group (5 cases versus 12 in the control), the difference was not statistically significant. Additionally, the expected increase in vitamin D levels after supplementation did not occur, meaning that the treatment did not effectively address the vitamin D deficiency present in our participants.
In conclusion, despite some initial hope, standard vitamin D supplementation did not prove beneficial in reducing influenza infections among the vaccinated elderly residents. This finding highlights important considerations for effective supplementation strategies in populations at risk of vitamin D deficiency.
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7
Vitamin D3 reduces respiratory infections
Our research aimed to explore whether daily supplementation of 5000 IU of vitamin D3 could help reduce the incidence of influenza-like illness (ILI) among healthcare workers. We conducted a well-structured trial at a university hospital, where a random selection of healthcare workers received vitamin D3 while others were assigned to a control group.
Over the course of nine months, we monitored symptoms and COVID-19 testing results among the participants. The key finding was that those taking vitamin D3 experienced a lower overall risk of ILI, particularly for non-COVID-19 cases. However, when it came to preventing COVID-19 ILI, there was no significant difference noted between the two groups.
So, while vitamin D3 supplementation appears to have a positive effect on reducing general influenza-like illnesses, it does not seem to provide any notable advantage in preventing COVID-19 specifically. Overall, this study indicates that vitamin D could be beneficial for healthcare workers in terms of respiratory health, but caution should be taken regarding its effectiveness against COVID-19.
Over the course of nine months, we monitored symptoms and COVID-19 testing results among the participants. The key finding was that those taking vitamin D3 experienced a lower overall risk of ILI, particularly for non-COVID-19 cases. However, when it came to preventing COVID-19 ILI, there was no significant difference noted between the two groups.
So, while vitamin D3 supplementation appears to have a positive effect on reducing general influenza-like illnesses, it does not seem to provide any notable advantage in preventing COVID-19 specifically. Overall, this study indicates that vitamin D could be beneficial for healthcare workers in terms of respiratory health, but caution should be taken regarding its effectiveness against COVID-19.
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Most Useful Reviews
9
Maintains immunity
The dosage serves a prophylactic purpose; we take it during periods of ARVI and influenza to support our immunity.
Read More
7.5
Boosts immunity
Jarrow is my preferred Vitamin D3, as it effectively promotes immune function and wellbeing. The size is quite small, which is great. There is evidence suggesting that maintaining sufficient vitamin D reduces the long-term risk of certain types of cancer. Additionally, vitamin D supplementation may be linked to a decreased risk of infections, including influenza and COVID-19.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.8
- All Researches
9
We aimed to explore how vitamin D supplementation affects the risk of influenza, particularly in healthy children aged 0 to 18 years. By analyzing eight randomized controlled trials that included a total of nearly 9,000 participants, we sought to understand if vitamin D can help reduce the incidence of acute respiratory tract infections, especially influenza.
Our findings indicate that vitamin D supplementation does not significantly reduce the overall rates of acute respiratory tract infections among healthy children. We observed no notable differences in infection rates between those receiving vitamin D and those given a placebo. This suggests that for general respiratory infections, the benefits of vitamin D supplementation might not be as impactful as once thought.
However, there was a noteworthy reduction in Influenza A cases among the children who received higher doses of vitamin D compared to those receiving lower doses. This finding could signal potential benefits for preventing this specific virus, though we must also note that only a couple of studies reported side effects, which were generally minimal.
Overall, while vitamin D shows some promise in reducing Influenza A cases, it does not appear to enhance protection against acute respiratory tract infections as a whole in the healthy pediatric population.
Our findings indicate that vitamin D supplementation does not significantly reduce the overall rates of acute respiratory tract infections among healthy children. We observed no notable differences in infection rates between those receiving vitamin D and those given a placebo. This suggests that for general respiratory infections, the benefits of vitamin D supplementation might not be as impactful as once thought.
However, there was a noteworthy reduction in Influenza A cases among the children who received higher doses of vitamin D compared to those receiving lower doses. This finding could signal potential benefits for preventing this specific virus, though we must also note that only a couple of studies reported side effects, which were generally minimal.
Overall, while vitamin D shows some promise in reducing Influenza A cases, it does not appear to enhance protection against acute respiratory tract infections as a whole in the healthy pediatric population.
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8
We explored the effects of vitamin D (VD) on airway health, particularly in relation to influenza infections. Our investigation stemmed from ongoing observations that link vitamin D deficiency to chronic respiratory issues, specifically chronic rhinosinusitis (CRS). We gathered clinical data from 142 patients to examine these connections and then turned to a more controlled environment using airway epithelial organoids to simulate how vitamin D treatment affects the airway’s response to viral infections.
Through our experiments, we found that long-term exposure to vitamin D significantly improved the health of respiratory cells. This treatment not only boosted the proliferation of these cells but also enhanced their ability to defend against influenza H1N1 virus. We observed that vitamin D helped strengthen immune responses—like increasing levels of the antimicrobial peptide LL37 and reducing harmful inflammatory cytokines. Furthermore, it improved epithelial integrity and aided in mucociliary clearance, which is crucial for keeping the airways clear of pathogens.
Our analyses indicated that vitamin D influences important signaling pathways involved in cell proliferation and immune responses. Notably, it appears to enhance the airway's ability to cope with infections in ways that do not rely on the more common TGF-β signaling pathway, suggesting unique mechanisms at play.
Overall, our findings highlight the potential of vitamin D as a crucial ally in airway health, particularly in combating infections like influenza. Enhancing vitamin D levels may be an effective strategy for improving epithelial repair and boosting immune defenses in the respiratory system.
Through our experiments, we found that long-term exposure to vitamin D significantly improved the health of respiratory cells. This treatment not only boosted the proliferation of these cells but also enhanced their ability to defend against influenza H1N1 virus. We observed that vitamin D helped strengthen immune responses—like increasing levels of the antimicrobial peptide LL37 and reducing harmful inflammatory cytokines. Furthermore, it improved epithelial integrity and aided in mucociliary clearance, which is crucial for keeping the airways clear of pathogens.
Our analyses indicated that vitamin D influences important signaling pathways involved in cell proliferation and immune responses. Notably, it appears to enhance the airway's ability to cope with infections in ways that do not rely on the more common TGF-β signaling pathway, suggesting unique mechanisms at play.
Overall, our findings highlight the potential of vitamin D as a crucial ally in airway health, particularly in combating infections like influenza. Enhancing vitamin D levels may be an effective strategy for improving epithelial repair and boosting immune defenses in the respiratory system.
Read More
8
We explored the link between vitamin D supplementation and its effectiveness in preventing influenza. In our analysis, we reviewed ten randomized controlled trials, which included a total of 4,859 participants. This rigorous investigation was thorough, pulling data from trusted sources such as PubMed, Cochrane Library, and Embase.
Our findings showed that vitamin D supplementation was associated with a significant reduction in the risk of influenza infections. Specifically, we noted a 22% decrease in risk, with our calculations presenting a risk ratio of 0.78. Notably, there was little variability in outcomes among the included studies, suggesting that the results were quite consistent.
Additionally, our research indicated no signs of publication bias, adding credibility to our findings. This suggests that incorporating vitamin D supplementation into preventive strategies for influenza could be beneficial. Overall, vitamin D stands out as a promising option for reducing the risk of influenza infections, reinforcing the idea that it plays a crucial role in bolstering our immune defenses.
Our findings showed that vitamin D supplementation was associated with a significant reduction in the risk of influenza infections. Specifically, we noted a 22% decrease in risk, with our calculations presenting a risk ratio of 0.78. Notably, there was little variability in outcomes among the included studies, suggesting that the results were quite consistent.
Additionally, our research indicated no signs of publication bias, adding credibility to our findings. This suggests that incorporating vitamin D supplementation into preventive strategies for influenza could be beneficial. Overall, vitamin D stands out as a promising option for reducing the risk of influenza infections, reinforcing the idea that it plays a crucial role in bolstering our immune defenses.
Read More
7
We explored the role of vitamin D and its receptor, VDR, in immune cell development and how these factors influence the body's response to influenza. By using a special type of mouse with a fluorescent marker to indicate VDR expression, we tracked when and where VDR is present in immune cells during both fetal and adult stages.
Our findings revealed that when mothers were deficient in vitamin D during pregnancy, their offspring had fewer immune cells capable of expressing VDR. This deficiency was linked to reduced immune responses; when we challenged these mice with the H1N1 influenza virus, the vitamin D-deficient mice exhibited greater susceptibility compared to those with adequate vitamin D.
Importantly, we discovered that treating the vitamin D-deficient mice with vitamin D can bring back some VDR expression in their immune cells and improve their resistance to the virus. This suggests that developmental vitamin D deficiency can have lasting effects on the immune system, demonstrating the importance of vitamin D for both fetal development and adult immune function.
Our findings revealed that when mothers were deficient in vitamin D during pregnancy, their offspring had fewer immune cells capable of expressing VDR. This deficiency was linked to reduced immune responses; when we challenged these mice with the H1N1 influenza virus, the vitamin D-deficient mice exhibited greater susceptibility compared to those with adequate vitamin D.
Importantly, we discovered that treating the vitamin D-deficient mice with vitamin D can bring back some VDR expression in their immune cells and improve their resistance to the virus. This suggests that developmental vitamin D deficiency can have lasting effects on the immune system, demonstrating the importance of vitamin D for both fetal development and adult immune function.
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7
We observed that care home residents are particularly vulnerable to respiratory infections, including influenza, which can lead to severe illnesses. Our exploration delved into the effectiveness of certain interventions, focusing on high-dose Vitamin D supplementation as a potential aid in preventing influenza.
In our systematic review, we found that high-dose Vitamin D supplementation significantly reduced the incidence of acute respiratory infections, including influenza. In one trial, the incidence rate was reduced by about 40% when participants received this high-dose vitamin. This suggests that Vitamin D might play a beneficial role in enhancing the immune response against influenza viruses, thus potentially lowering the risk of infection.
While additional research is necessary to further validate these findings, the initial evidence shows promise for high-dose Vitamin D as an intervention in care homes. We also highlighted that other studies examining various supplements and interventions did not yield significant effects, emphasizing that high-dose Vitamin D could be worth considering.
In conclusion, our findings call for continued exploration of high-dose Vitamin D treatment, especially in settings that are highly susceptible to respiratory infections like influenza. The potential for such a simple intervention to positively impact care home residents is quite encouraging.
In our systematic review, we found that high-dose Vitamin D supplementation significantly reduced the incidence of acute respiratory infections, including influenza. In one trial, the incidence rate was reduced by about 40% when participants received this high-dose vitamin. This suggests that Vitamin D might play a beneficial role in enhancing the immune response against influenza viruses, thus potentially lowering the risk of infection.
While additional research is necessary to further validate these findings, the initial evidence shows promise for high-dose Vitamin D as an intervention in care homes. We also highlighted that other studies examining various supplements and interventions did not yield significant effects, emphasizing that high-dose Vitamin D could be worth considering.
In conclusion, our findings call for continued exploration of high-dose Vitamin D treatment, especially in settings that are highly susceptible to respiratory infections like influenza. The potential for such a simple intervention to positively impact care home residents is quite encouraging.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Maintains immunity
The dosage serves a prophylactic purpose; we take it during periods of ARVI and influenza to support our immunity.
Read More
7.5
Boosts immunity
Jarrow is my preferred Vitamin D3, as it effectively promotes immune function and wellbeing. The size is quite small, which is great. There is evidence suggesting that maintaining sufficient vitamin D reduces the long-term risk of certain types of cancer. Additionally, vitamin D supplementation may be linked to a decreased risk of infections, including influenza and COVID-19.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Arora J, Froelich NE, Tang M, Weaver V, Paulson RF, et al. Developmental Vitamin D Deficiency and the Vitamin D Receptor Control Hematopoiesis. J Immunol. 2024;213:1479. doi:10.4049/jimmunol.2400292
- Willcox ML, Lavu D, Yousaf U, Dalton S, Roberts N, et al. The effectiveness of interventions to reduce the transmission of acute respiratory infections in care homes: a systematic review. J Public Health (Oxf). 2024;46:551. doi:10.1093/pubmed/fdae178
- Carboo JA, Dolman-Macleod RC, Malan L, Lombard MJ. High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 months: a systematic review and meta-analysis. Nutr Rev. 2024;82:579. doi:10.1093/nutrit/nuad082
- Fang Q, Wu Y, Lu J, Zheng H. A meta-analysis of the association between vitamin D supplementation and the risk of acute respiratory tract infection in the healthy pediatric group. Front Nutr. 2023;10:1188958. doi:10.3389/fnut.2023.1188958
- Liao S, Huang Y, Zhang J, Xiong Q, Chi M, et al. Vitamin D promotes epithelial tissue repair and host defense responses against influenza H1N1 virus and Staphylococcus aureus infections. Respir Res. 2023;24:175. doi:10.1186/s12931-023-02477-4
- Park JH, Lee Y, Choi M, Park E. The Role of Some Vitamins in Respiratory-related Viral Infections: A Narrative Review. Clin Nutr Res. 2023;12:77. doi:10.7762/cnr.2023.12.1.77
- van Helmond N, Brobyn TL, LaRiccia PJ, Cafaro T, Hunter K, et al. Vitamin D3 Supplementation at 5000 IU Daily for the Prevention of Influenza-like Illness in Healthcare Workers: A Pragmatic Randomized Clinical Trial. Nutrients. 2022;15. doi:10.3390/nu15010180
- Arora J, Patel DR, Nicol MJ, Field CJ, Restori KH, et al. Vitamin D and the Ability to Produce 1,25(OH)D Are Critical for Protection from Viral Infection of the Lungs. Nutrients. 2022;14. doi:10.3390/nu14153061
- Huang YN, Chi H, Chiu NC, Huang CY, Li ST, et al. A randomized trial of vitamin D supplementation to prevent seasonal influenza and enterovirus infection in children. J Microbiol Immunol Infect. 2022;55:803. doi:10.1016/j.jmii.2022.01.003
- Zhu Z, Zhu X, Gu L, Zhan Y, Chen L, et al. Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials. Front Nutr. 2021;8:799709. doi:10.3389/fnut.2021.799709
- Godan Hauptman A, Lukić-Grlić A, Vraneš J, Milošević M, Gagro A. The effect of standard-dose wintertime vitamin D supplementation on influenza infection in immunized nursing home elderly residents. Croat Med J. 2021;62:495.
