Last update
3/8/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 5 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Biotin (as d-Biotin)
330 mcg
1,100%
Alpha Lipoic Acid (Thioctic Acid)
300 mg
†
Top Medical Research Studies
8
We explored the protective effects of alpha-lipoic acid (LA) against liver damage caused by arsenic, a well-known environmental toxin. In our examination, we uncovered the mechanisms through which arsenic harms the liver, including its ability to induce autophagy, apoptosis, and oxidative stress, as well as disrupt lipid metabolism.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
Read More
8
Alpha-lipoic acid improves liver health
We conducted a clinical trial to evaluate the effectiveness of a special formulation combining alpha-lipoic acid (ALA) with a Mediterranean diet in improving liver health for individuals with metabolic dysfunction-associated steatosis (MASLD). In this study, patients were divided into two groups: one received the ALA and Mediterranean diet while the other was given a placebo along with the Mediterranean diet over a span of 24 weeks.
Throughout the trial, we carefully measured various health indicators and liver function. Our findings were promising; those who took the ALA alongside the Mediterranean diet showed significant reductions in visceral fat and waist circumference, translating to improvements in metabolic parameters. Notably, the controlled attenuation parameter, an indicator of liver fat, steadily decreased in this group, reinforcing the potential benefits of ALA in conjunction with a healthy diet.
While both groups reported mild side effects at similar rates, these did not overshadow the positive outcomes associated with ALA and the Mediterranean diet. Overall, our results emphasize the potential of this combination approach in enhancing liver health among individuals dealing with MASLD.
Throughout the trial, we carefully measured various health indicators and liver function. Our findings were promising; those who took the ALA alongside the Mediterranean diet showed significant reductions in visceral fat and waist circumference, translating to improvements in metabolic parameters. Notably, the controlled attenuation parameter, an indicator of liver fat, steadily decreased in this group, reinforcing the potential benefits of ALA in conjunction with a healthy diet.
While both groups reported mild side effects at similar rates, these did not overshadow the positive outcomes associated with ALA and the Mediterranean diet. Overall, our results emphasize the potential of this combination approach in enhancing liver health among individuals dealing with MASLD.
Read More
Most Useful Reviews
9
Heals damaged liver
33 people found this helpful
A must. I never want to be without this one. I take one per day to heal my damaged liver due to fatty liver disease. This helps the entire body and I believe everyone should be taking it. It's a super antioxidant that does many things. I know of a doctor in Las Cruces who administers it in an IV to treat cancer, including pancreatic cancer.
Read More
7.5
Detoxing my liver
4 people found this helpful
I started using somderm gel about 7 months ago to detox my liver. Since 2007, I've been unwell after taking Cipro & Levoquin. The gel has really helped my body detox. After taking Alpha-Lipoic Acid and N-A-C sustain, my crippling back pain disappeared. I plan to continue taking these supplements daily to maintain the relief.
Read More
9
Improves liver health
5 people found this helpful
I have taken alpha lipoic acid from Jarrows five times now. This trusted company provides various dietary supplements, and I am pleased with all of them. I give it to my mother, who has fatty hepatosis. It fights free radicals, aids the liver, and protects against viruses. My mum enjoys the effect and taste of the pills. I take it consistently. This alpha lipoic acid is outstanding due to slow-release technology. With 120 tablets, it’s economical, and the yoghurt taste is pleasant.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
8
We explored the protective effects of alpha-lipoic acid (LA) against liver damage caused by arsenic, a well-known environmental toxin. In our examination, we uncovered the mechanisms through which arsenic harms the liver, including its ability to induce autophagy, apoptosis, and oxidative stress, as well as disrupt lipid metabolism.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
Read More
8
Alpha-lipoic acid improves liver health
We conducted a clinical trial to evaluate the effectiveness of a special formulation combining alpha-lipoic acid (ALA) with a Mediterranean diet in improving liver health for individuals with metabolic dysfunction-associated steatosis (MASLD). In this study, patients were divided into two groups: one received the ALA and Mediterranean diet while the other was given a placebo along with the Mediterranean diet over a span of 24 weeks.
Throughout the trial, we carefully measured various health indicators and liver function. Our findings were promising; those who took the ALA alongside the Mediterranean diet showed significant reductions in visceral fat and waist circumference, translating to improvements in metabolic parameters. Notably, the controlled attenuation parameter, an indicator of liver fat, steadily decreased in this group, reinforcing the potential benefits of ALA in conjunction with a healthy diet.
While both groups reported mild side effects at similar rates, these did not overshadow the positive outcomes associated with ALA and the Mediterranean diet. Overall, our results emphasize the potential of this combination approach in enhancing liver health among individuals dealing with MASLD.
Throughout the trial, we carefully measured various health indicators and liver function. Our findings were promising; those who took the ALA alongside the Mediterranean diet showed significant reductions in visceral fat and waist circumference, translating to improvements in metabolic parameters. Notably, the controlled attenuation parameter, an indicator of liver fat, steadily decreased in this group, reinforcing the potential benefits of ALA in conjunction with a healthy diet.
While both groups reported mild side effects at similar rates, these did not overshadow the positive outcomes associated with ALA and the Mediterranean diet. Overall, our results emphasize the potential of this combination approach in enhancing liver health among individuals dealing with MASLD.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Heals damaged liver
33 people found this helpful
A must. I never want to be without this one. I take one per day to heal my damaged liver due to fatty liver disease. This helps the entire body and I believe everyone should be taking it. It's a super antioxidant that does many things. I know of a doctor in Las Cruces who administers it in an IV to treat cancer, including pancreatic cancer.
Read More
7.5
Detoxing my liver
4 people found this helpful
I started using somderm gel about 7 months ago to detox my liver. Since 2007, I've been unwell after taking Cipro & Levoquin. The gel has really helped my body detox. After taking Alpha-Lipoic Acid and N-A-C sustain, my crippling back pain disappeared. I plan to continue taking these supplements daily to maintain the relief.
Read More
9
Improves liver health
5 people found this helpful
I have taken alpha lipoic acid from Jarrows five times now. This trusted company provides various dietary supplements, and I am pleased with all of them. I give it to my mother, who has fatty hepatosis. It fights free radicals, aids the liver, and protects against viruses. My mum enjoys the effect and taste of the pills. I take it consistently. This alpha lipoic acid is outstanding due to slow-release technology. With 120 tablets, it’s economical, and the yoghurt taste is pleasant.
Read More
7.5
Supports liver detoxification
5 people found this helpful
Excellent dosage of ALA; I have been using these tablets for years in the 60-count bottle and am delighted they are now available in a larger size. I can rely on ALA to support my liver in all its detoxification pathways. The sustain formula means I don’t experience a hypoglycaemic response.
Read More
7.5
Great liver support
3 people found this helpful
These tablets are quite large. The previous formula without fast-acting ALA was smaller and easier to take. Still, it is fantastic liver support when regular ALA drops my blood sugar too low.
Read More
Frequently Asked Questions
7.5
Supports liver detoxification
5 people found this helpful
Excellent dosage of ALA; I have been using these tablets for years in the 60-count bottle and am delighted they are now available in a larger size. I can rely on ALA to support my liver in all its detoxification pathways. The sustain formula means I don’t experience a hypoglycaemic response.
9
Improves liver health
5 people found this helpful
I have taken alpha lipoic acid from Jarrows five times now. This trusted company provides various dietary supplements, and I am pleased with all of them. I give it to my mother, who has fatty hepatosis. It fights free radicals, aids the liver, and protects against viruses. My mum enjoys the effect and taste of the pills. I take it consistently. This alpha lipoic acid is outstanding due to slow-release technology. With 120 tablets, it’s economical, and the yoghurt taste is pleasant.
8
Alpha-lipoic acid improves liver health
We conducted a clinical trial to evaluate the effectiveness of a special formulation combining alpha-lipoic acid (ALA) with a Mediterranean diet in improving liver health for individuals with metabolic dysfunction-associated steatosis (MASLD). In this study, patients were divided into two groups: one received the ALA and Mediterranean diet while the other was given a placebo along with the Mediterranean diet over a span of 24 weeks.
Throughout the trial, we carefully measured various health indicators and liver function. Our findings were promising; those who took the ALA alongside the Mediterranean diet showed significant reductions in visceral fat and waist circumference, translating to improvements in metabolic parameters. Notably, the controlled attenuation parameter, an indicator of liver fat, steadily decreased in this group, reinforcing the potential benefits of ALA in conjunction with a healthy diet.
While both groups reported mild side effects at similar rates, these did not overshadow the positive outcomes associated with ALA and the Mediterranean diet. Overall, our results emphasize the potential of this combination approach in enhancing liver health among individuals dealing with MASLD.
Throughout the trial, we carefully measured various health indicators and liver function. Our findings were promising; those who took the ALA alongside the Mediterranean diet showed significant reductions in visceral fat and waist circumference, translating to improvements in metabolic parameters. Notably, the controlled attenuation parameter, an indicator of liver fat, steadily decreased in this group, reinforcing the potential benefits of ALA in conjunction with a healthy diet.
While both groups reported mild side effects at similar rates, these did not overshadow the positive outcomes associated with ALA and the Mediterranean diet. Overall, our results emphasize the potential of this combination approach in enhancing liver health among individuals dealing with MASLD.
8
We explored the protective effects of alpha-lipoic acid (LA) against liver damage caused by arsenic, a well-known environmental toxin. In our examination, we uncovered the mechanisms through which arsenic harms the liver, including its ability to induce autophagy, apoptosis, and oxidative stress, as well as disrupt lipid metabolism.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
References
- Zhao Y, Guo M, Pei T, Shang C, Chen Y, et al. α-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal β-Oxidation and Reducing Lipophagy in Chicken Hepatocyte. Adv Sci (Weinh). 2025. 10.1002/advs.202413255
- Cano Contreras AD, Del Rocío Francisco M, Vargas Basurto JL, Gonzalez-Gomez KD, Amieva-Balmori M, et al. Effect of alpha-lipoic acid and supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis. World J Hepatol. 2025;17:101704. 10.4254/wjh.v17.i1.101704
Data last updated:
