Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 4 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
L-Glutamine
1,000 mg
†
Top Medical Research Studies
8
We investigated how dietary glutamine, a nutrient known to influence the immune system, impacts allergies, particularly in atopic dermatitis (AD). Our focus was on understanding the connection between glutamine and a specific protein called CARD11, which plays a crucial role in Th1 and Th17 immune responses.
In our study, we used mice that had been sensitized to house dust mites, a common trigger for allergic reactions. We found that these mice showed increased levels of certain immune markers, like interferon-gamma and interleukin-17, which are associated with allergic responses. However, when CARD11 was absent, these immune reactions were significantly diminished, highlighting CARD11's importance in managing allergic responses in AD.
Additionally, we looked at how blocking a signaling pathway linked to CARD11 influenced immune responses. Interestingly, when glutamine was added to the diet of mice lacking CARD11, we observed a restoration of those immune responses. This suggests that glutamine potentially enhances Th1 and Th17 responses through its action on the CARD11-mTORC1 pathway.
Overall, our findings suggest that glutamine supplementation could be a promising approach to improving immune responses in atopic dermatitis, opening the door for new dietary treatments for allergies.
In our study, we used mice that had been sensitized to house dust mites, a common trigger for allergic reactions. We found that these mice showed increased levels of certain immune markers, like interferon-gamma and interleukin-17, which are associated with allergic responses. However, when CARD11 was absent, these immune reactions were significantly diminished, highlighting CARD11's importance in managing allergic responses in AD.
Additionally, we looked at how blocking a signaling pathway linked to CARD11 influenced immune responses. Interestingly, when glutamine was added to the diet of mice lacking CARD11, we observed a restoration of those immune responses. This suggests that glutamine potentially enhances Th1 and Th17 responses through its action on the CARD11-mTORC1 pathway.
Overall, our findings suggest that glutamine supplementation could be a promising approach to improving immune responses in atopic dermatitis, opening the door for new dietary treatments for allergies.
Read More
9
This research explored how alanyl-glutamine (Ala-Gln) influences asthma-related lung injuries, specifically looking at its effects on airway epithelial cells. We established an asthma model using female C57BL/6 J mice and introduced ovalbumin (OVA) to mimic allergic reactions.
During the study, we examined the role of Ala-Gln in modulating airway changes caused by the enzyme sDPP4. We focused on the differentiation of immune cells and airway fibrosis, key factors in asthma severity. Our findings revealed that Ala-Gln effectively inhibits the transformation of bronchial epithelial cells into a fibrotic state, as well as the activation of harmful Th17 immune cells.
By combining Ala-Gln with traditional treatment such as budesonide, we noticed an enhancement in the therapeutic effects against OVA-induced asthma. This suggests that Ala-Gln could be a valuable addition to existing treatments, particularly for patients experiencing high levels of DPP4.
Overall, this study sheds light on the potential of Ala-Gln as a supportive strategy in managing asthma, indicating that it may help alleviate some associated symptoms and improve lung health.
During the study, we examined the role of Ala-Gln in modulating airway changes caused by the enzyme sDPP4. We focused on the differentiation of immune cells and airway fibrosis, key factors in asthma severity. Our findings revealed that Ala-Gln effectively inhibits the transformation of bronchial epithelial cells into a fibrotic state, as well as the activation of harmful Th17 immune cells.
By combining Ala-Gln with traditional treatment such as budesonide, we noticed an enhancement in the therapeutic effects against OVA-induced asthma. This suggests that Ala-Gln could be a valuable addition to existing treatments, particularly for patients experiencing high levels of DPP4.
Overall, this study sheds light on the potential of Ala-Gln as a supportive strategy in managing asthma, indicating that it may help alleviate some associated symptoms and improve lung health.
Read More
Most Useful Reviews
8
Doctor-recommended drug
I've recently used this product, recommended by my doctor for restoring the intestinal mucosa. I appreciate that it does not provoke any allergies, and I plan to continue taking it.
Read More
6
Helps with dryness
I initially tried this for allergy relief, and I believe it has aided in alleviating the dryness in my nose.
Read More
7
Strengthens intestinal lining
1 people found this helpful
Prominent Glutamine is ideal for those suffering from food allergies, as it effectively strengthens the intestinal lining. Fortunately, it is tasteless, making it easy to incorporate into my routine.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
- All Researches
9
This research explored how alanyl-glutamine (Ala-Gln) influences asthma-related lung injuries, specifically looking at its effects on airway epithelial cells. We established an asthma model using female C57BL/6 J mice and introduced ovalbumin (OVA) to mimic allergic reactions.
During the study, we examined the role of Ala-Gln in modulating airway changes caused by the enzyme sDPP4. We focused on the differentiation of immune cells and airway fibrosis, key factors in asthma severity. Our findings revealed that Ala-Gln effectively inhibits the transformation of bronchial epithelial cells into a fibrotic state, as well as the activation of harmful Th17 immune cells.
By combining Ala-Gln with traditional treatment such as budesonide, we noticed an enhancement in the therapeutic effects against OVA-induced asthma. This suggests that Ala-Gln could be a valuable addition to existing treatments, particularly for patients experiencing high levels of DPP4.
Overall, this study sheds light on the potential of Ala-Gln as a supportive strategy in managing asthma, indicating that it may help alleviate some associated symptoms and improve lung health.
During the study, we examined the role of Ala-Gln in modulating airway changes caused by the enzyme sDPP4. We focused on the differentiation of immune cells and airway fibrosis, key factors in asthma severity. Our findings revealed that Ala-Gln effectively inhibits the transformation of bronchial epithelial cells into a fibrotic state, as well as the activation of harmful Th17 immune cells.
By combining Ala-Gln with traditional treatment such as budesonide, we noticed an enhancement in the therapeutic effects against OVA-induced asthma. This suggests that Ala-Gln could be a valuable addition to existing treatments, particularly for patients experiencing high levels of DPP4.
Overall, this study sheds light on the potential of Ala-Gln as a supportive strategy in managing asthma, indicating that it may help alleviate some associated symptoms and improve lung health.
Read More
8
We investigated how dietary glutamine, a nutrient known to influence the immune system, impacts allergies, particularly in atopic dermatitis (AD). Our focus was on understanding the connection between glutamine and a specific protein called CARD11, which plays a crucial role in Th1 and Th17 immune responses.
In our study, we used mice that had been sensitized to house dust mites, a common trigger for allergic reactions. We found that these mice showed increased levels of certain immune markers, like interferon-gamma and interleukin-17, which are associated with allergic responses. However, when CARD11 was absent, these immune reactions were significantly diminished, highlighting CARD11's importance in managing allergic responses in AD.
Additionally, we looked at how blocking a signaling pathway linked to CARD11 influenced immune responses. Interestingly, when glutamine was added to the diet of mice lacking CARD11, we observed a restoration of those immune responses. This suggests that glutamine potentially enhances Th1 and Th17 responses through its action on the CARD11-mTORC1 pathway.
Overall, our findings suggest that glutamine supplementation could be a promising approach to improving immune responses in atopic dermatitis, opening the door for new dietary treatments for allergies.
In our study, we used mice that had been sensitized to house dust mites, a common trigger for allergic reactions. We found that these mice showed increased levels of certain immune markers, like interferon-gamma and interleukin-17, which are associated with allergic responses. However, when CARD11 was absent, these immune reactions were significantly diminished, highlighting CARD11's importance in managing allergic responses in AD.
Additionally, we looked at how blocking a signaling pathway linked to CARD11 influenced immune responses. Interestingly, when glutamine was added to the diet of mice lacking CARD11, we observed a restoration of those immune responses. This suggests that glutamine potentially enhances Th1 and Th17 responses through its action on the CARD11-mTORC1 pathway.
Overall, our findings suggest that glutamine supplementation could be a promising approach to improving immune responses in atopic dermatitis, opening the door for new dietary treatments for allergies.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
8
Doctor-recommended drug
I've recently used this product, recommended by my doctor for restoring the intestinal mucosa. I appreciate that it does not provoke any allergies, and I plan to continue taking it.
Read More
6
Helps with dryness
I initially tried this for allergy relief, and I believe it has aided in alleviating the dryness in my nose.
Read More
7
Strengthens intestinal lining
1 people found this helpful
Prominent Glutamine is ideal for those suffering from food allergies, as it effectively strengthens the intestinal lining. Fortunately, it is tasteless, making it easy to incorporate into my routine.
Read More
7.5
Decreased allergy symptoms
My brother used this product for one month to restore his intestinal mucous membrane, and he noticed a reduction in his allergies.
Read More
Frequently Asked Questions
6
Helps with dryness
I initially tried this for allergy relief, and I believe it has aided in alleviating the dryness in my nose.
7.5
Decreased allergy symptoms
My brother used this product for one month to restore his intestinal mucous membrane, and he noticed a reduction in his allergies.
7
Strengthens intestinal lining
1 people found this helpful
Prominent Glutamine is ideal for those suffering from food allergies, as it effectively strengthens the intestinal lining. Fortunately, it is tasteless, making it easy to incorporate into my routine.
9
This research explored how alanyl-glutamine (Ala-Gln) influences asthma-related lung injuries, specifically looking at its effects on airway epithelial cells. We established an asthma model using female C57BL/6 J mice and introduced ovalbumin (OVA) to mimic allergic reactions.
During the study, we examined the role of Ala-Gln in modulating airway changes caused by the enzyme sDPP4. We focused on the differentiation of immune cells and airway fibrosis, key factors in asthma severity. Our findings revealed that Ala-Gln effectively inhibits the transformation of bronchial epithelial cells into a fibrotic state, as well as the activation of harmful Th17 immune cells.
By combining Ala-Gln with traditional treatment such as budesonide, we noticed an enhancement in the therapeutic effects against OVA-induced asthma. This suggests that Ala-Gln could be a valuable addition to existing treatments, particularly for patients experiencing high levels of DPP4.
Overall, this study sheds light on the potential of Ala-Gln as a supportive strategy in managing asthma, indicating that it may help alleviate some associated symptoms and improve lung health.
During the study, we examined the role of Ala-Gln in modulating airway changes caused by the enzyme sDPP4. We focused on the differentiation of immune cells and airway fibrosis, key factors in asthma severity. Our findings revealed that Ala-Gln effectively inhibits the transformation of bronchial epithelial cells into a fibrotic state, as well as the activation of harmful Th17 immune cells.
By combining Ala-Gln with traditional treatment such as budesonide, we noticed an enhancement in the therapeutic effects against OVA-induced asthma. This suggests that Ala-Gln could be a valuable addition to existing treatments, particularly for patients experiencing high levels of DPP4.
Overall, this study sheds light on the potential of Ala-Gln as a supportive strategy in managing asthma, indicating that it may help alleviate some associated symptoms and improve lung health.
8
We investigated how dietary glutamine, a nutrient known to influence the immune system, impacts allergies, particularly in atopic dermatitis (AD). Our focus was on understanding the connection between glutamine and a specific protein called CARD11, which plays a crucial role in Th1 and Th17 immune responses.
In our study, we used mice that had been sensitized to house dust mites, a common trigger for allergic reactions. We found that these mice showed increased levels of certain immune markers, like interferon-gamma and interleukin-17, which are associated with allergic responses. However, when CARD11 was absent, these immune reactions were significantly diminished, highlighting CARD11's importance in managing allergic responses in AD.
Additionally, we looked at how blocking a signaling pathway linked to CARD11 influenced immune responses. Interestingly, when glutamine was added to the diet of mice lacking CARD11, we observed a restoration of those immune responses. This suggests that glutamine potentially enhances Th1 and Th17 responses through its action on the CARD11-mTORC1 pathway.
Overall, our findings suggest that glutamine supplementation could be a promising approach to improving immune responses in atopic dermatitis, opening the door for new dietary treatments for allergies.
In our study, we used mice that had been sensitized to house dust mites, a common trigger for allergic reactions. We found that these mice showed increased levels of certain immune markers, like interferon-gamma and interleukin-17, which are associated with allergic responses. However, when CARD11 was absent, these immune reactions were significantly diminished, highlighting CARD11's importance in managing allergic responses in AD.
Additionally, we looked at how blocking a signaling pathway linked to CARD11 influenced immune responses. Interestingly, when glutamine was added to the diet of mice lacking CARD11, we observed a restoration of those immune responses. This suggests that glutamine potentially enhances Th1 and Th17 responses through its action on the CARD11-mTORC1 pathway.
Overall, our findings suggest that glutamine supplementation could be a promising approach to improving immune responses in atopic dermatitis, opening the door for new dietary treatments for allergies.
References
- Ding K, He X, Liang D, Xu L, Xiao B, et al. Alanyl-Glutamine Inhibits the Epithelial-Mesenchymal Transition of Airway Epithelial Cells in Asthmatic Mice via DPP4-SIRT1 Pathway. Int Arch Allergy Immunol. 2024. doi:10.1159/000541681
- Fan J, Wang X, Wang Y, Song J, Chen M, et al. Dietary glutamine supplementation improves both Th1 and Th17 responses via CARD11-mTORC1 pathway in murine model of atopic dermatitis. Int Immunopharmacol. 2024;143:113316. doi:10.1016/j.intimp.2024.113316
