Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.2
USERS' SCORE
Good
Based on 11 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
L-Glutamine
1,000 mg
†
Top Medical Research Studies
9
We examined the effects of Lachnum-derived polysaccharides, specifically a modified compound known as LAG, on gastric ulcers in mice. The study involved treating mice with acute ulcers using different doses of LAG and another polysaccharide, LEP2a.
Our findings revealed that both compounds significantly reduced gastric mucosal damage and inflammation. LAG showed greater effectiveness, improving antioxidant levels and reducing harmful inflammatory markers. Essentially, these polysaccharides help protect the stomach lining by tackling oxidative stress and inflammation.
Our findings revealed that both compounds significantly reduced gastric mucosal damage and inflammation. LAG showed greater effectiveness, improving antioxidant levels and reducing harmful inflammatory markers. Essentially, these polysaccharides help protect the stomach lining by tackling oxidative stress and inflammation.
Read More
9
We examined the impact of N-acetyl-L-glutamine aluminum complex (KW-110) on gastric ulcers exacerbated by common painkillers, like aspirin and indomethacin, in rats. After inducing ulcers, we found that while certain NSAIDs worsened the situation, KW-110 significantly reduced their damaging effects. This treatment not only helped in healing the ulcers but also prevented further gastric lesions caused by these medications. Importantly, KW-110 did not alter the pain-relieving effects of the NSAIDs used.
Read More
8
We aimed to explore if alanyl-glutamine (AG), a special dipeptide known to support gut healing, can help treat ulcers caused by indomethacin in rats. In our study, we divided the rats into five groups to observe the effects of AG, with some receiving additional treatments.
The results revealed that AG helped raise the pH of gastric juice, much like pantoprazole did. However, while AG showed some beneficial effects, it was less effective in groups where dexamethasone was administered beforehand. Thus, the overall impact of AG, though promising, involves complexities that need further investigation.
The results revealed that AG helped raise the pH of gastric juice, much like pantoprazole did. However, while AG showed some beneficial effects, it was less effective in groups where dexamethasone was administered beforehand. Thus, the overall impact of AG, though promising, involves complexities that need further investigation.
Read More
Most Useful Reviews
9
Long-term effectiveness
37 people found this helpful
I've used this product for two years with great results. I no longer take medication for my colitis. A nurse practitioner I know has a son with Crohn's disease who has relied on this product for over a decade rather than medication. I also have ulcerative colitis, and after using this product, I have achieved excellent results.
Read More
9
Improves digestion noted
28 people found this helpful
Makes your intestines feel better without unwanted side effects. I buy this for both my horses and myself. I started using it for my leaky gut, and I do feel like I digest better, without constant bloating, and it has definitely helped my ulcers. While I haven’t lost any weight or gained superpowers, I am pleased with the improvement in my gut health.
Read More
7.5
Effective for ulcers
18 people found this helpful
Helps with 1 tablet of Glutamine, which has a broad spectrum of action. Athletes need it, and it also aids in healing the intestinal wall from permeability. For allergy sufferers, I highly recommend it! It helps with stomach ulcers and exacerbations of gastritis. After taking zinc, my stomach ached terribly. I took 1 tablet of Glutamine, and an hour later, I felt better. Additionally, I have occasional allergies on my hands. The dryness reduces significantly after a few days of taking Glutamine.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.2
- All Researches
9
We examined the effects of Lachnum-derived polysaccharides, specifically a modified compound known as LAG, on gastric ulcers in mice. The study involved treating mice with acute ulcers using different doses of LAG and another polysaccharide, LEP2a.
Our findings revealed that both compounds significantly reduced gastric mucosal damage and inflammation. LAG showed greater effectiveness, improving antioxidant levels and reducing harmful inflammatory markers. Essentially, these polysaccharides help protect the stomach lining by tackling oxidative stress and inflammation.
Our findings revealed that both compounds significantly reduced gastric mucosal damage and inflammation. LAG showed greater effectiveness, improving antioxidant levels and reducing harmful inflammatory markers. Essentially, these polysaccharides help protect the stomach lining by tackling oxidative stress and inflammation.
Read More
9
We examined the impact of N-acetyl-L-glutamine aluminum complex (KW-110) on gastric ulcers exacerbated by common painkillers, like aspirin and indomethacin, in rats. After inducing ulcers, we found that while certain NSAIDs worsened the situation, KW-110 significantly reduced their damaging effects. This treatment not only helped in healing the ulcers but also prevented further gastric lesions caused by these medications. Importantly, KW-110 did not alter the pain-relieving effects of the NSAIDs used.
Read More
9
We explored how L-arginine, a precursor for nitric oxide, influences gastric health and ulcer healing. In this study on rats, L-arginine reduced acute gastric lesions caused by substances like 100% ethanol. It also improved blood flow, but interestingly, other related amino acids, including L-glutamine, did not show a significant impact on ulcers.
We discovered that L-arginine accelerated the healing process and promoted new blood vessel formation around ulcers, indicating its beneficial effects. However, L-glutamine treatment did not deliver notable results, suggesting that other factors may play a larger role in ulcer management.
We discovered that L-arginine accelerated the healing process and promoted new blood vessel formation around ulcers, indicating its beneficial effects. However, L-glutamine treatment did not deliver notable results, suggesting that other factors may play a larger role in ulcer management.
Read More
8
We aimed to explore if alanyl-glutamine (AG), a special dipeptide known to support gut healing, can help treat ulcers caused by indomethacin in rats. In our study, we divided the rats into five groups to observe the effects of AG, with some receiving additional treatments.
The results revealed that AG helped raise the pH of gastric juice, much like pantoprazole did. However, while AG showed some beneficial effects, it was less effective in groups where dexamethasone was administered beforehand. Thus, the overall impact of AG, though promising, involves complexities that need further investigation.
The results revealed that AG helped raise the pH of gastric juice, much like pantoprazole did. However, while AG showed some beneficial effects, it was less effective in groups where dexamethasone was administered beforehand. Thus, the overall impact of AG, though promising, involves complexities that need further investigation.
Read More
8
We investigated how peptides from cattle abomasum help heal stomach damage in rats caused by aspirin. Over 22 days, we divided Wistar rats into groups—some received a control treatment while others got a native or heated extract of the abomasum after inducing mucosal damage.
Our findings revealed that both extracts significantly improved healing, reduced harmful substances in the blood, and normalized immune cell counts, indicating recovery. Rats treated with these extracts showed healthier stomach lining, with no signs of irritation. Overall, the abomasum extracts demonstrated promising antiulcer effects.
Our findings revealed that both extracts significantly improved healing, reduced harmful substances in the blood, and normalized immune cell counts, indicating recovery. Rats treated with these extracts showed healthier stomach lining, with no signs of irritation. Overall, the abomasum extracts demonstrated promising antiulcer effects.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Long-term effectiveness
37 people found this helpful
I've used this product for two years with great results. I no longer take medication for my colitis. A nurse practitioner I know has a son with Crohn's disease who has relied on this product for over a decade rather than medication. I also have ulcerative colitis, and after using this product, I have achieved excellent results.
Read More
9
Improves digestion noted
28 people found this helpful
Makes your intestines feel better without unwanted side effects. I buy this for both my horses and myself. I started using it for my leaky gut, and I do feel like I digest better, without constant bloating, and it has definitely helped my ulcers. While I haven’t lost any weight or gained superpowers, I am pleased with the improvement in my gut health.
Read More
7.5
Effective for ulcers
18 people found this helpful
Helps with 1 tablet of Glutamine, which has a broad spectrum of action. Athletes need it, and it also aids in healing the intestinal wall from permeability. For allergy sufferers, I highly recommend it! It helps with stomach ulcers and exacerbations of gastritis. After taking zinc, my stomach ached terribly. I took 1 tablet of Glutamine, and an hour later, I felt better. Additionally, I have occasional allergies on my hands. The dryness reduces significantly after a few days of taking Glutamine.
Read More
9
Ulcer healing
3 people found this helpful
I took this for a stomach ulcer that I couldn't get rid of, and it did the job with just one bottle. I took one pill twice a day before meals, and I had no issues swallowing the pills.
Read More
7.5
Post-ulcer effectiveness
1 people found this helpful
Very effective for gastrointestinal health after experiencing a gastric ulcer.
Read More
Frequently Asked Questions
7.5
Effective for ulcers
18 people found this helpful
Helps with 1 tablet of Glutamine, which has a broad spectrum of action. Athletes need it, and it also aids in healing the intestinal wall from permeability. For allergy sufferers, I highly recommend it! It helps with stomach ulcers and exacerbations of gastritis. After taking zinc, my stomach ached terribly. I took 1 tablet of Glutamine, and an hour later, I felt better. Additionally, I have occasional allergies on my hands. The dryness reduces significantly after a few days of taking Glutamine.
7.5
Post-ulcer effectiveness
1 people found this helpful
Very effective for gastrointestinal health after experiencing a gastric ulcer.
2
No noticeable change
1 people found this helpful
I bought it for treating ulcers. I noted that glutamine contributes to the healing of mucous membranes. However, after completing my course, I did not notice any changes and will not buy it again.
9
Restores gut membrane
I take L-glutamine as prescribed by my gastroenterologist for intestinal issues. L-glutamine is known as the “intestinal permeability factor” and is used in therapy to restore the mucous membrane of the stomach and intestines with ulcers, gastritis, and hemorrhoids.
9
We examined the effects of Lachnum-derived polysaccharides, specifically a modified compound known as LAG, on gastric ulcers in mice. The study involved treating mice with acute ulcers using different doses of LAG and another polysaccharide, LEP2a.
Our findings revealed that both compounds significantly reduced gastric mucosal damage and inflammation. LAG showed greater effectiveness, improving antioxidant levels and reducing harmful inflammatory markers. Essentially, these polysaccharides help protect the stomach lining by tackling oxidative stress and inflammation.
Our findings revealed that both compounds significantly reduced gastric mucosal damage and inflammation. LAG showed greater effectiveness, improving antioxidant levels and reducing harmful inflammatory markers. Essentially, these polysaccharides help protect the stomach lining by tackling oxidative stress and inflammation.
8
We aimed to explore if alanyl-glutamine (AG), a special dipeptide known to support gut healing, can help treat ulcers caused by indomethacin in rats. In our study, we divided the rats into five groups to observe the effects of AG, with some receiving additional treatments.
The results revealed that AG helped raise the pH of gastric juice, much like pantoprazole did. However, while AG showed some beneficial effects, it was less effective in groups where dexamethasone was administered beforehand. Thus, the overall impact of AG, though promising, involves complexities that need further investigation.
The results revealed that AG helped raise the pH of gastric juice, much like pantoprazole did. However, while AG showed some beneficial effects, it was less effective in groups where dexamethasone was administered beforehand. Thus, the overall impact of AG, though promising, involves complexities that need further investigation.
8
We explored the protective effects of glutamine on stomach health amidst H. pylori infections in Mongolian gerbils. For three months, we provided a diet rich in glutamine or marzulene, another protective substance.
The results were promising; both glutamine and marzulene significantly reduced harmful changes in the stomach lining. They helped diminish ammonia buildup, a toxin related to ulcers, thereby enhancing cell survival and reducing inflammation.
Our findings suggest that glutamine could serve as a preventative treatment for those at risk of H. pylori-related gastric conditions.
The results were promising; both glutamine and marzulene significantly reduced harmful changes in the stomach lining. They helped diminish ammonia buildup, a toxin related to ulcers, thereby enhancing cell survival and reducing inflammation.
Our findings suggest that glutamine could serve as a preventative treatment for those at risk of H. pylori-related gastric conditions.
9
We examined the impact of N-acetyl-L-glutamine aluminum complex (KW-110) on gastric ulcers exacerbated by common painkillers, like aspirin and indomethacin, in rats. After inducing ulcers, we found that while certain NSAIDs worsened the situation, KW-110 significantly reduced their damaging effects. This treatment not only helped in healing the ulcers but also prevented further gastric lesions caused by these medications. Importantly, KW-110 did not alter the pain-relieving effects of the NSAIDs used.
References
- Zhang X, Liu D, Ye Z, Chen X, Chen H, et al. Gastroprotective effect of the Lachnum polysaccharide and polysaccharide-dipeptide conjugates against gastric ulcer. Food Chem Toxicol. 2023;174:113661. doi:10.1016/j.fct.2023.113661
- El-Lekawy AM, Abdallah DM, El-Abhar HS. Alanyl-glutamine Heals Indomethacin-induced Gastric Ulceration in Rats Via Antisecretory and Anti-apoptotic Mechanisms. J Pediatr Gastroenterol Nutr. 2019;69:710. doi:10.1097/MPG.0000000000002474
- Chernukha IM, Bogatyrev AN, Dydykin AS, Aslanova MA, Fedulova LV. [Effect of polypeptides isolated from cattle abomasum on stomach regenerative processes in rats]. Vopr Pitan. 2014;83:26.
- Amagase K, Nakamura E, Endo T, Hayashi S, Hasumura M, et al. New frontiers in gut nutrient sensor research: prophylactic effect of glutamine against Helicobacter pylori-induced gastric diseases in Mongolian gerbils. J Pharmacol Sci. 2010;112:25.
- Yan R, Sun Y, Sun R. [Early enteral feeding and supplement of glutamine prevent occurrence of stress ulcer following severe thermal injury]. Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1995;11:189.
- Tanaka H, Shuto K, Marumo H. Effect of N-acetyl-L-glutamine aluminum complex (KW-110), an antiulcer agent, on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats. Jpn J Pharmacol. 1982;32:307.
- Moriga M, Aono M, Murakami M, Uchino H. The role of gastric mucosal hexosamine in aspirin-induced ulcers. Gastroenterol Jpn. 1980;15:1.
- Li W, Wang Y, Wang Y, Yang C, Lu Z, et al. Recurrent intestinal ulcer with bloody stool for >10 years in an adolescent boy of 15 years: A case report. Medicine (Baltimore). 2023;102:e34096. doi:10.1097/MD.0000000000034096
- Brzozowski T, Konturek SJ, Sliwowski Z, Drozdowicz D, Zaczek M, et al. Role of L-arginine, a substrate for nitric oxide-synthase, in gastroprotection and ulcer healing. J Gastroenterol. 1997;32:442.
- Sukumar P, Loo A, Magur E, Nandi J, Oler A, et al. Dietary supplementation of nucleotides and arginine promotes healing of small bowel ulcers in experimental ulcerative ileitis. Dig Dis Sci. 1997;42:1530.
