Last update
5/27/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Ubiquinol
100 mg
â€
Top Medical Research Studies
8
CoQ10 reduces inflammation and oxidative stress
We engaged in a careful exploration of how Coenzyme Q10, commonly known as CoQ10, affects patients with rheumatoid arthritis. By conducting a double-blind, randomized controlled trial including 44 participants, we divided them into two groups: one received daily capsules of 100 mg CoQ10 while the other was given a placebo for two months.
Our main focus was on monitoring changes in proinflammatory cytokines, specifically TNF-α and IL-6, and assessing levels of oxidative stress markers like malondialdehyde (MDA) and total antioxidant capacity (TAC). The results were promising; we observed a significant drop in MDA levels among those taking CoQ10, which indicates a reduction in oxidative stress. Additionally, there was a noteworthy decrease in the levels of TNF-α in the CoQ10 group compared to those taking the placebo.
However, it is important to highlight that while this study demonstrates some beneficial effects of CoQ10 on inflammatory markers, we did not find significant differences in TAC and IL-6 between the groups. Overall, our findings suggest that CoQ10 supplementation may be a valuable addition to managing oxidative stress and inflammatory responses in rheumatoid arthritis patients.
Our main focus was on monitoring changes in proinflammatory cytokines, specifically TNF-α and IL-6, and assessing levels of oxidative stress markers like malondialdehyde (MDA) and total antioxidant capacity (TAC). The results were promising; we observed a significant drop in MDA levels among those taking CoQ10, which indicates a reduction in oxidative stress. Additionally, there was a noteworthy decrease in the levels of TNF-α in the CoQ10 group compared to those taking the placebo.
However, it is important to highlight that while this study demonstrates some beneficial effects of CoQ10 on inflammatory markers, we did not find significant differences in TAC and IL-6 between the groups. Overall, our findings suggest that CoQ10 supplementation may be a valuable addition to managing oxidative stress and inflammatory responses in rheumatoid arthritis patients.
Read More
Most Useful Reviews
9
High energy
37 people found this helpful
The best supplement I have ever used! This ubiquinol has worked miracles for me and my mother. Within two weeks, our energy levels soared, enabling us to engage in activities we hadn't done in years. I’ll never be without this supplement!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
CoQ10 reduces inflammation and oxidative stress
We engaged in a careful exploration of how Coenzyme Q10, commonly known as CoQ10, affects patients with rheumatoid arthritis. By conducting a double-blind, randomized controlled trial including 44 participants, we divided them into two groups: one received daily capsules of 100 mg CoQ10 while the other was given a placebo for two months.
Our main focus was on monitoring changes in proinflammatory cytokines, specifically TNF-α and IL-6, and assessing levels of oxidative stress markers like malondialdehyde (MDA) and total antioxidant capacity (TAC). The results were promising; we observed a significant drop in MDA levels among those taking CoQ10, which indicates a reduction in oxidative stress. Additionally, there was a noteworthy decrease in the levels of TNF-α in the CoQ10 group compared to those taking the placebo.
However, it is important to highlight that while this study demonstrates some beneficial effects of CoQ10 on inflammatory markers, we did not find significant differences in TAC and IL-6 between the groups. Overall, our findings suggest that CoQ10 supplementation may be a valuable addition to managing oxidative stress and inflammatory responses in rheumatoid arthritis patients.
Our main focus was on monitoring changes in proinflammatory cytokines, specifically TNF-α and IL-6, and assessing levels of oxidative stress markers like malondialdehyde (MDA) and total antioxidant capacity (TAC). The results were promising; we observed a significant drop in MDA levels among those taking CoQ10, which indicates a reduction in oxidative stress. Additionally, there was a noteworthy decrease in the levels of TNF-α in the CoQ10 group compared to those taking the placebo.
However, it is important to highlight that while this study demonstrates some beneficial effects of CoQ10 on inflammatory markers, we did not find significant differences in TAC and IL-6 between the groups. Overall, our findings suggest that CoQ10 supplementation may be a valuable addition to managing oxidative stress and inflammatory responses in rheumatoid arthritis patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
High energy
37 people found this helpful
The best supplement I have ever used! This ubiquinol has worked miracles for me and my mother. Within two weeks, our energy levels soared, enabling us to engage in activities we hadn't done in years. I’ll never be without this supplement!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Abdollahzad H, Aghdashi MA, Asghari Jafarabadi M, Alipour B. Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial. Arch Med Res. 2015;46:527. 10.1016/j.arcmed.2015.08.006
