' 
![]()
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.3
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 2 capsules
Amount Per Serving
%DV
Aged Garlic Extract™†† Powder (bulb)
1200 mg
**
Top Medical Research Studies
9
Garlic exosomes benefit osteoarthritis
Garlic-derived Exosomes Alleviate Osteoarthritis Through Inhibiting the MAPK Signaling Pathway.
Highly relevant study on garlic
In our exploration of garlic's potential benefits for arthritis, we focused on a type of tiny particle called garlic-derived exosomes (GDEs). These particles come from garlic and have shown promise in reducing inflammation in various health issues. We specifically examined how they affect osteoarthritis (OA), a condition that impacts millions by causing joint pain and stiffness.
Our study involved both laboratory and animal models. We treated chondrocytes, the cells in cartilage, with a pro-inflammatory substance while exposing them to GDEs. We found that the garlic-derived particles helped to boost the levels of beneficial cartilage components while inhibiting harmful enzymes that break down cartilage. Additionally, GDEs appeared to reduce the activity of key signaling pathways related to inflammation.
On the animal side, we used a surgical model to simulate OA and injected GDEs directly into the knee joints of mice. The results were encouraging; the GDEs alleviated pain and improved how the mice moved. Histological examinations revealed less joint destruction, suggesting that these garlic particles could indeed help slow the progression of OA without causing toxicity.
Overall, our findings indicate that garlic-derived exosomes hold potential as a treatment for osteoarthritis, making it a significant area for future research into disease-modifying therapies.
Our study involved both laboratory and animal models. We treated chondrocytes, the cells in cartilage, with a pro-inflammatory substance while exposing them to GDEs. We found that the garlic-derived particles helped to boost the levels of beneficial cartilage components while inhibiting harmful enzymes that break down cartilage. Additionally, GDEs appeared to reduce the activity of key signaling pathways related to inflammation.
On the animal side, we used a surgical model to simulate OA and injected GDEs directly into the knee joints of mice. The results were encouraging; the GDEs alleviated pain and improved how the mice moved. Histological examinations revealed less joint destruction, suggesting that these garlic particles could indeed help slow the progression of OA without causing toxicity.
Overall, our findings indicate that garlic-derived exosomes hold potential as a treatment for osteoarthritis, making it a significant area for future research into disease-modifying therapies.
Read More
8
Garlic extract aids osteoarthritis treatment
Diallyl disulfide knee joint injection protects against the early pathologic changes of articular cartilage and subchondral bone in ovariectomized rats.
Significant study on garlic's effects
We explored how diallyl disulfide (DADS), a component found in garlic oil, affects osteoarthritis (OA) in a study on rats. The research involved thirty-four female Sprague-Dawley rats, with some undergoing a surgery to induce OA, while others had a sham procedure. After six weeks, we administered DADS in hydrogel through a knee joint injection to some of the OA rats while others received a vehicle solution or saline for comparison.
Over the following weeks, we observed significant benefits in the rats treated with DADS. The results indicated that DADS not only improved cartilage health but also helped in maintaining the bone structure beneath the cartilage. This suggests that garlic, in the form of a concentrated extract, could have a protective effect against early OA progression, which is particularly relevant for postmenopausal women predisposed to this joint condition.
Our findings reveal a potential new avenue in OA treatment through natural extracts, highlighting the importance of garlic and its derivatives in supporting joint health. While this research primarily focuses on animal models, it opens up exciting possibilities for further studies in humans.
Over the following weeks, we observed significant benefits in the rats treated with DADS. The results indicated that DADS not only improved cartilage health but also helped in maintaining the bone structure beneath the cartilage. This suggests that garlic, in the form of a concentrated extract, could have a protective effect against early OA progression, which is particularly relevant for postmenopausal women predisposed to this joint condition.
Our findings reveal a potential new avenue in OA treatment through natural extracts, highlighting the importance of garlic and its derivatives in supporting joint health. While this research primarily focuses on animal models, it opens up exciting possibilities for further studies in humans.
Read More
8
SMG shows promise in arthritis
In-vitro antioxidant and anti-inflammatory potential along with p.o. pharmacokinetic profile of key bioactive phytocompounds of Snow Mountain Garlic: a comparative analysis vis-à-vis normal garlic.
Significant anti-inflammatory properties
We explored the potential of Snow Mountain Garlic (SMG) in treating inflammatory arthritis, comparing it with normal garlic. This study looked into key bioactive compounds like S-allyl-L-cysteine (SAC), alliin, and S-methyl-L-cysteine (SMC), which are believed to have various health benefits, particularly in fighting inflammation.
Using advanced techniques, we found that SMG contains significantly higher levels of alliin than regular garlic, along with SMC being unique to SMG. In our experiments on immune cells activated by inflammation, both SMG extract and its purified compounds demonstrated strong antioxidant and anti-inflammatory effects. They were effective in reducing oxidative stress and suppressing the expression of various inflammatory markers, showing comparable results to a well-known anti-inflammatory treatment, dexamethasone.
We also examined the pharmacokinetics of SAC found in both types of garlic. The SMG extract resulted in higher plasma concentrations and longer-lasting effects compared to normal garlic, further supporting the idea that SMG might be more beneficial for managing arthritis. Overall, the unique compounds and their enhanced absorption from SMG could explain its superior medicinal properties over normal garlic, making it a promising candidate for arthritis treatment.
Using advanced techniques, we found that SMG contains significantly higher levels of alliin than regular garlic, along with SMC being unique to SMG. In our experiments on immune cells activated by inflammation, both SMG extract and its purified compounds demonstrated strong antioxidant and anti-inflammatory effects. They were effective in reducing oxidative stress and suppressing the expression of various inflammatory markers, showing comparable results to a well-known anti-inflammatory treatment, dexamethasone.
We also examined the pharmacokinetics of SAC found in both types of garlic. The SMG extract resulted in higher plasma concentrations and longer-lasting effects compared to normal garlic, further supporting the idea that SMG might be more beneficial for managing arthritis. Overall, the unique compounds and their enhanced absorption from SMG could explain its superior medicinal properties over normal garlic, making it a promising candidate for arthritis treatment.
Read More
Most Useful Reviews
10
Works remarkably
Great for arthritis! This product works fantastically for my arthritis.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.3
9
Garlic exosomes benefit osteoarthritis
Garlic-derived Exosomes Alleviate Osteoarthritis Through Inhibiting the MAPK Signaling Pathway.
Highly relevant study on garlic
In our exploration of garlic's potential benefits for arthritis, we focused on a type of tiny particle called garlic-derived exosomes (GDEs). These particles come from garlic and have shown promise in reducing inflammation in various health issues. We specifically examined how they affect osteoarthritis (OA), a condition that impacts millions by causing joint pain and stiffness.
Our study involved both laboratory and animal models. We treated chondrocytes, the cells in cartilage, with a pro-inflammatory substance while exposing them to GDEs. We found that the garlic-derived particles helped to boost the levels of beneficial cartilage components while inhibiting harmful enzymes that break down cartilage. Additionally, GDEs appeared to reduce the activity of key signaling pathways related to inflammation.
On the animal side, we used a surgical model to simulate OA and injected GDEs directly into the knee joints of mice. The results were encouraging; the GDEs alleviated pain and improved how the mice moved. Histological examinations revealed less joint destruction, suggesting that these garlic particles could indeed help slow the progression of OA without causing toxicity.
Overall, our findings indicate that garlic-derived exosomes hold potential as a treatment for osteoarthritis, making it a significant area for future research into disease-modifying therapies.
Our study involved both laboratory and animal models. We treated chondrocytes, the cells in cartilage, with a pro-inflammatory substance while exposing them to GDEs. We found that the garlic-derived particles helped to boost the levels of beneficial cartilage components while inhibiting harmful enzymes that break down cartilage. Additionally, GDEs appeared to reduce the activity of key signaling pathways related to inflammation.
On the animal side, we used a surgical model to simulate OA and injected GDEs directly into the knee joints of mice. The results were encouraging; the GDEs alleviated pain and improved how the mice moved. Histological examinations revealed less joint destruction, suggesting that these garlic particles could indeed help slow the progression of OA without causing toxicity.
Overall, our findings indicate that garlic-derived exosomes hold potential as a treatment for osteoarthritis, making it a significant area for future research into disease-modifying therapies.
Read More
8
Garlic extract aids osteoarthritis treatment
Diallyl disulfide knee joint injection protects against the early pathologic changes of articular cartilage and subchondral bone in ovariectomized rats.
Significant study on garlic's effects
We explored how diallyl disulfide (DADS), a component found in garlic oil, affects osteoarthritis (OA) in a study on rats. The research involved thirty-four female Sprague-Dawley rats, with some undergoing a surgery to induce OA, while others had a sham procedure. After six weeks, we administered DADS in hydrogel through a knee joint injection to some of the OA rats while others received a vehicle solution or saline for comparison.
Over the following weeks, we observed significant benefits in the rats treated with DADS. The results indicated that DADS not only improved cartilage health but also helped in maintaining the bone structure beneath the cartilage. This suggests that garlic, in the form of a concentrated extract, could have a protective effect against early OA progression, which is particularly relevant for postmenopausal women predisposed to this joint condition.
Our findings reveal a potential new avenue in OA treatment through natural extracts, highlighting the importance of garlic and its derivatives in supporting joint health. While this research primarily focuses on animal models, it opens up exciting possibilities for further studies in humans.
Over the following weeks, we observed significant benefits in the rats treated with DADS. The results indicated that DADS not only improved cartilage health but also helped in maintaining the bone structure beneath the cartilage. This suggests that garlic, in the form of a concentrated extract, could have a protective effect against early OA progression, which is particularly relevant for postmenopausal women predisposed to this joint condition.
Our findings reveal a potential new avenue in OA treatment through natural extracts, highlighting the importance of garlic and its derivatives in supporting joint health. While this research primarily focuses on animal models, it opens up exciting possibilities for further studies in humans.
Read More
8
SMG shows promise in arthritis
In-vitro antioxidant and anti-inflammatory potential along with p.o. pharmacokinetic profile of key bioactive phytocompounds of Snow Mountain Garlic: a comparative analysis vis-à-vis normal garlic.
Significant anti-inflammatory properties
We explored the potential of Snow Mountain Garlic (SMG) in treating inflammatory arthritis, comparing it with normal garlic. This study looked into key bioactive compounds like S-allyl-L-cysteine (SAC), alliin, and S-methyl-L-cysteine (SMC), which are believed to have various health benefits, particularly in fighting inflammation.
Using advanced techniques, we found that SMG contains significantly higher levels of alliin than regular garlic, along with SMC being unique to SMG. In our experiments on immune cells activated by inflammation, both SMG extract and its purified compounds demonstrated strong antioxidant and anti-inflammatory effects. They were effective in reducing oxidative stress and suppressing the expression of various inflammatory markers, showing comparable results to a well-known anti-inflammatory treatment, dexamethasone.
We also examined the pharmacokinetics of SAC found in both types of garlic. The SMG extract resulted in higher plasma concentrations and longer-lasting effects compared to normal garlic, further supporting the idea that SMG might be more beneficial for managing arthritis. Overall, the unique compounds and their enhanced absorption from SMG could explain its superior medicinal properties over normal garlic, making it a promising candidate for arthritis treatment.
Using advanced techniques, we found that SMG contains significantly higher levels of alliin than regular garlic, along with SMC being unique to SMG. In our experiments on immune cells activated by inflammation, both SMG extract and its purified compounds demonstrated strong antioxidant and anti-inflammatory effects. They were effective in reducing oxidative stress and suppressing the expression of various inflammatory markers, showing comparable results to a well-known anti-inflammatory treatment, dexamethasone.
We also examined the pharmacokinetics of SAC found in both types of garlic. The SMG extract resulted in higher plasma concentrations and longer-lasting effects compared to normal garlic, further supporting the idea that SMG might be more beneficial for managing arthritis. Overall, the unique compounds and their enhanced absorption from SMG could explain its superior medicinal properties over normal garlic, making it a promising candidate for arthritis treatment.
Read More
8
Dietary insights on arthritis
Diets and Joint Symptoms: A Survey of Moroccan Patients With Chronic Inflammatory Rheumatic Disease.
Highlights garlic's potential benefits
We conducted a survey to explore whether Moroccan patients with chronic inflammatory rheumatic diseases perceive any relationship between their diet and the symptoms they experience. Our research surveyed patients about their dietary habits and their beliefs regarding food's impact on their joint symptoms.
Interestingly, we found that 34% of the respondents believed their diet influenced their symptoms. Within this group, 25% reported that certain foods exacerbated their discomfort. Notably, garlic was identified as one of the foods that many patients felt improved their joint symptoms. In contrast, red meat, fish, and legumes were commonly linked to worsening symptoms.
It’s worth noting that discussions about diet in relation to arthritis were limited, with only 23% of participants having talked about dietary changes with their healthcare providers. Yet, a strong interest in such discussions was evident, as 85.7% expressed a desire to learn more about how diet might affect their condition.
Overall, while we observed some anecdotal evidence of garlic being beneficial for arthritis symptoms, further research specifically focusing on garlic itself would be needed to confirm its effectiveness as a treatment option.
Interestingly, we found that 34% of the respondents believed their diet influenced their symptoms. Within this group, 25% reported that certain foods exacerbated their discomfort. Notably, garlic was identified as one of the foods that many patients felt improved their joint symptoms. In contrast, red meat, fish, and legumes were commonly linked to worsening symptoms.
It’s worth noting that discussions about diet in relation to arthritis were limited, with only 23% of participants having talked about dietary changes with their healthcare providers. Yet, a strong interest in such discussions was evident, as 85.7% expressed a desire to learn more about how diet might affect their condition.
Overall, while we observed some anecdotal evidence of garlic being beneficial for arthritis symptoms, further research specifically focusing on garlic itself would be needed to confirm its effectiveness as a treatment option.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
10
Works remarkably
Great for arthritis! This product works fantastically for my arthritis.
