Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Good
Based on 19 Reviews
8.1
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Vitamin E (as d-α-tocopheryl succinate)
126 mg
840%
Aged Garlic Extract™†† Powder (bulb)
600 mg
**
Hawthorn Berry (fruit)
100 mg
**
Cayenne Pepper (fruit)
20 mg
**
Top Medical Research Studies
9
We investigated whether vitamin E supplementation affects the risk of blood clots, specifically venous thromboembolism (VTE), in women. The Women's Health Study involved nearly 40,000 women who received either vitamin E or a placebo over more than ten years.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
9
We explored how vitamin E affects blood clot breakdown in patients suffering from coronary spastic angina. In a well-structured study, 40 participants were split into groups receiving either vitamin E or a placebo over a month.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
8
We explored how inducing heme oxygenase-1 (HO-1) could impact blood clot formation in a mouse model. Through a series of tests, we observed that mice treated with a HO-1 inducer showed a significant delay in thrombus formation.
This effect was linked to the production of bilirubin and carbon monoxide, which have protective roles in the bloodstream. Interestingly, when we used a vitamin E analogue, it almost entirely restored this delay in clotting. Overall, these findings suggest that enhancing HO-1 activity may offer a promising approach to prevent undesirable blood clots.
This effect was linked to the production of bilirubin and carbon monoxide, which have protective roles in the bloodstream. Interestingly, when we used a vitamin E analogue, it almost entirely restored this delay in clotting. Overall, these findings suggest that enhancing HO-1 activity may offer a promising approach to prevent undesirable blood clots.
Most Useful Reviews
9.5
Eliminated medication
Having been on Kyolic garlic for a long time, I have managed to discontinue my blood pressure medication.
8.8
Lowers blood pressure
It’s great! I have been ordering Wakunaga-Kyolic Aged Garlic Extract and have noticed my blood pressure decreasing.
8.8
Normalises cholesterol
This garlic product is useful without the unpleasant smell or taste! While the health benefits of garlic are numerous, the strong odour has deterred me until I discovered this remedy. After about 5.5 months of my husband taking it, his elevated cholesterol levels returned to the upper normal limit, and his blood pressure normalised. A significant "side" benefit is that no one in our family had severe illness from viral infections or colds during the year we used the product. Any illness was mild and resolved quickly. This drug's effect is undeniable, and I trust the manufacturer without considering cheaper alternatives.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
- All Researches
9
Our exploration focused on how tocotrienols, a form of vitamin E, influence blood clotting, especially in the context of risk factors like stroke. Using a canine model, we assessed the effects of tocotrienols on platelet aggregation and thrombus formation.
The findings revealed that tocotrienols significantly inhibited both platelet thrombus formation and collagen-induced platelet aggregation. We noticed that tocotrienols could be converted to tocopherols, which might add to their effectiveness. Overall, these results suggest tocotrienols could offer a therapeutic advantage in preventing serious cardiovascular events.
The findings revealed that tocotrienols significantly inhibited both platelet thrombus formation and collagen-induced platelet aggregation. We noticed that tocotrienols could be converted to tocopherols, which might add to their effectiveness. Overall, these results suggest tocotrienols could offer a therapeutic advantage in preventing serious cardiovascular events.
9
We investigated whether vitamin E supplementation affects the risk of blood clots, specifically venous thromboembolism (VTE), in women. The Women's Health Study involved nearly 40,000 women who received either vitamin E or a placebo over more than ten years.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
9
We explored the effects of vitamin E and sesamin on blood pressure and blood clot formation using young rats prone to stroke. The rats were divided into four groups: a control group, a vitamin E group, a sesamin group, and a combination group for five weeks.
Notably, the rats receiving vitamin E and sesamin showed lower blood pressure and thrombotic tendencies compared to the control group. However, while there was some reduction in clot formation, it was not substantial enough to conclude a significant clinical benefit.
Thus, we observed that while vitamin E and sesamin may have some protective effects, their impact on blood clot prevention is not definitively established.
Notably, the rats receiving vitamin E and sesamin showed lower blood pressure and thrombotic tendencies compared to the control group. However, while there was some reduction in clot formation, it was not substantial enough to conclude a significant clinical benefit.
Thus, we observed that while vitamin E and sesamin may have some protective effects, their impact on blood clot prevention is not definitively established.
9
We explored how vitamin E affects blood clot breakdown in patients suffering from coronary spastic angina. In a well-structured study, 40 participants were split into groups receiving either vitamin E or a placebo over a month.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
8
We explored how inducing heme oxygenase-1 (HO-1) could impact blood clot formation in a mouse model. Through a series of tests, we observed that mice treated with a HO-1 inducer showed a significant delay in thrombus formation.
This effect was linked to the production of bilirubin and carbon monoxide, which have protective roles in the bloodstream. Interestingly, when we used a vitamin E analogue, it almost entirely restored this delay in clotting. Overall, these findings suggest that enhancing HO-1 activity may offer a promising approach to prevent undesirable blood clots.
This effect was linked to the production of bilirubin and carbon monoxide, which have protective roles in the bloodstream. Interestingly, when we used a vitamin E analogue, it almost entirely restored this delay in clotting. Overall, these findings suggest that enhancing HO-1 activity may offer a promising approach to prevent undesirable blood clots.
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Eliminated medication
Having been on Kyolic garlic for a long time, I have managed to discontinue my blood pressure medication.
8.8
Lowers blood pressure
It’s great! I have been ordering Wakunaga-Kyolic Aged Garlic Extract and have noticed my blood pressure decreasing.
8.8
Normalises cholesterol
This garlic product is useful without the unpleasant smell or taste! While the health benefits of garlic are numerous, the strong odour has deterred me until I discovered this remedy. After about 5.5 months of my husband taking it, his elevated cholesterol levels returned to the upper normal limit, and his blood pressure normalised. A significant "side" benefit is that no one in our family had severe illness from viral infections or colds during the year we used the product. Any illness was mild and resolved quickly. This drug's effect is undeniable, and I trust the manufacturer without considering cheaper alternatives.
8.8
Helps circulation
Wonderful! I took it to improve circulation, which has been really beneficial for individuals experiencing blocked blood vessels. I take it twice daily with meals based on my nutritionist’s excellent advice.
8.8
Aids recovery
Great for recovery and blood pressure.
Frequently Asked Questions
3
Gradual improvement
It's been about a month since I started taking this due to poor blood circulation. My feet used to itch a lot, but I can feel gradual improvement.
8.8
Normalises cholesterol
This garlic product is useful without the unpleasant smell or taste! While the health benefits of garlic are numerous, the strong odour has deterred me until I discovered this remedy. After about 5.5 months of my husband taking it, his elevated cholesterol levels returned to the upper normal limit, and his blood pressure normalised. A significant "side" benefit is that no one in our family had severe illness from viral infections or colds during the year we used the product. Any illness was mild and resolved quickly. This drug's effect is undeniable, and I trust the manufacturer without considering cheaper alternatives.
3.5
No visible effects
This is my first time buying it. After taking it for a while, I did not observe any drop in my blood pressure.
3.5
No effects noted
I didn’t notice any effect on my blood pressure.
9.5
Eliminated medication
Having been on Kyolic garlic for a long time, I have managed to discontinue my blood pressure medication.
8.8
Significant cholesterol reduction
It worked! I bought this in June and waited until November for a proper review. My LDL cholesterol was 163 in May. I don’t smoke or drink, and I run at least 15 kilometres each week. I changed my diet and took half the recommended dosage of Aged Garlic Extract. I recently had my blood test, and my LDL is now 127. While I'd like it to be lower, I'm amazed that it works, likely in combination with my dietary changes.
8.8
Good for inflammation
This is a great product. It benefits circulation, normalises blood pressure, and has anti-inflammatory properties. Highly recommend!
8.8
Improved circulation
Excellent! I took it to improve my blood circulation, and it has been very beneficial for my condition related to blocked blood vessels. A nutritionist highly advised me to take it twice daily with meals.
8
Benefits blood thickness
I've switched to Formula 104 to lower my bad cholesterol levels. This formula targets blood thickness, which is a great advantage for my circulation and immune system.
8.8
Helps circulation
Wonderful! I took it to improve circulation, which has been really beneficial for individuals experiencing blocked blood vessels. I take it twice daily with meals based on my nutritionist’s excellent advice.
8.8
Lowers blood pressure
It’s great! I have been ordering Wakunaga-Kyolic Aged Garlic Extract and have noticed my blood pressure decreasing.
7
We explored whether vitamin E influences the apoptosis, or cell death, of endothelial cells in the carotid arteries of male rabbits fed a cholesterol-rich diet. In this study, groups of rabbits received different treatments for six weeks, including vitamin E and iron.
Ultimately, our findings suggest that while vitamin E can have a positive effect by potentially preventing the progression of atherosclerosis and related cardiovascular issues, the specifics surrounding its role in blood clotting were not definitively established through this study.
Ultimately, our findings suggest that while vitamin E can have a positive effect by potentially preventing the progression of atherosclerosis and related cardiovascular issues, the specifics surrounding its role in blood clotting were not definitively established through this study.
9
We investigated whether vitamin E supplementation affects the risk of blood clots, specifically venous thromboembolism (VTE), in women. The Women's Health Study involved nearly 40,000 women who received either vitamin E or a placebo over more than ten years.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
7
We examined how vitamin E influences bleeding risks in patients with nonvalvular atrial fibrillation undergoing anticoagulant therapy. In our retrospective study of 566 patients, higher levels of serum vitamin E were associated with increased bleeding events.
Specifically, those who experienced bleeding had significantly higher vitamin E concentrations compared to those who did not. This suggests that elevated vitamin E may predict a higher risk of hemorrhage in patients taking anticoagulants, prompting the need for further research to clarify this relationship with newer medications.
Specifically, those who experienced bleeding had significantly higher vitamin E concentrations compared to those who did not. This suggests that elevated vitamin E may predict a higher risk of hemorrhage in patients taking anticoagulants, prompting the need for further research to clarify this relationship with newer medications.
References
- Jafar Haeri SM, Dashti G, Mardani M, Rashidi B, Nikgoftar Fathi A, et al. Effect of Vitamin E on Apoptosis of the Endothelial Cells of the Carotid Arteries in Hypercholesterolemic Male Rabbits. ARYA Atheroscler. 2023;19:10. doi:10.48305/arya.2022.39175.2824
- Ho JI, Ng EY, Chiew Y, Koay YY, Chuar PF, et al. The effects of vitamin E on non-proliferative diabetic retinopathy in type 2 diabetes mellitus: Are they sustainable with 12 months of therapy. SAGE Open Med. 2022;10:20503121221095324. doi:10.1177/20503121221095324
- Ceran C, Aksam E, Aksam B, Yenidünya S, Suludere Z, et al. Tamoxifen-Related Thrombosis: An Experimental Study in Rat Venous Microvascular Anastomosis Model. Ann Plast Surg. 2017;78:213. doi:10.1097/SAP.0000000000000798
- Pastori D, Carnevale R, Cangemi R, Saliola M, Nocella C, et al. Vitamin E serum levels and bleeding risk in patients receiving oral anticoagulant therapy: a retrospective cohort study. J Am Heart Assoc. 2013;2:e000364. doi:10.1161/JAHA.113.000364
- Sasaki Y, Kobara N, Higashino S, Giddings JC, Yamamoto J. Astaxanthin inhibits thrombosis in cerebral vessels of stroke-prone spontaneously hypertensive rats. Nutr Res. 2011;31:784. doi:10.1016/j.nutres.2011.09.010
- Fahim MA, Nemmar A, Singh S, Hassan MY. Antioxidants alleviate nicotine-induced platelet aggregation in cerebral arterioles of mice in vivo. Physiol Res. 2011;60:695.
- Qureshi AA, Karpen CW, Qureshi N, Papasian CJ, Morrison DC, et al. Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries. Lipids Health Dis. 2011;10:58. doi:10.1186/1476-511X-10-58
- Ristow B. Preoperative use of alpha tocopherol does not increase the risk of hematoma in the face lift patient: a preliminary report. Plast Reconstr Surg. 2009;124:1696. doi:10.1097/PRS.0b013e3181b98a3a
- Ping-Chia L, I-Ju L, Yu-Ching L, Li-Ching C, Wen-Chung C. Substance P scavenger enhances antioxidant defenses and prevents prothrombotic effects on the rat lung after acute exposure to oil smoke. J Biomed Sci. 2009;16:58. doi:10.1186/1423-0127-16-58
- Glynn RJ, Ridker PM, Goldhaber SZ, Zee RY, Buring JE. Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study. Circulation. 2007;116:1497.
- Singh I, Turner AH, Sinclair AJ, Li D, Hawley JA. Effects of gamma-tocopherol supplementation on thrombotic risk factors. Asia Pac J Clin Nutr. 2007;16:422.
- Allman-Farinelli MA, Dawson B. Diet and aging: bearing on thrombosis and hemostasis. Semin Thromb Hemost. 2005;31:111.
- Noguchi T, Ikeda K, Sasaki Y, Yamamoto J, Yamori Y. Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 2004;31 Suppl 2:S24.
- Miyamoto S, Kawano H, Takazoe K, Soejima H, Sakamoto T, et al. Vitamin E improves fibrinolytic activity in patients with coronary spastic angina. Thromb Res. 2004;113:345.
- Lindenblatt N, Bordel R, Schareck W, Menger MD, Vollmar B. Vascular heme oxygenase-1 induction suppresses microvascular thrombus formation in vivo. Arterioscler Thromb Vasc Biol. 2004;24:601.
