Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Vitamin E (as d-α-tocopheryl succinate)
126 mg
840%
Aged Garlic Extract™†† Powder (bulb)
600 mg
**
Hawthorn Berry (fruit)
100 mg
**
Cayenne Pepper (fruit)
20 mg
**
Top Medical Research Studies
2
We explored the relationship between vitamin E and heart attack risk through a two-sample mendelian randomization study. Using genetic variations from nearly 8,000 individuals of European descent, we dug into whether higher levels of vitamin E could protect against coronary artery disease (CAD) and myocardial infarction (MI).
Contrary to some previous beliefs about its benefits, our results suggested that increased vitamin E levels were actually associated with a higher risk of both CAD and MI. This means it's time to rethink the safety and effectiveness of vitamin E supplements for heart health.
Contrary to some previous beliefs about its benefits, our results suggested that increased vitamin E levels were actually associated with a higher risk of both CAD and MI. This means it's time to rethink the safety and effectiveness of vitamin E supplements for heart health.
9
We examined how vitamin E affects individuals with diabetes and the specific Haptoglobin 2-2 genotype, who are at greater risk for heart problems. By analyzing data from two trials, we found that taking vitamin E significantly reduced the risk of heart events like strokes and heart attacks in these patients.
The study suggests that screening diabetics for the Haptoglobin genotype and offering vitamin E as treatment could improve heart health and even extend life expectancy by three years for those affected.
The study suggests that screening diabetics for the Haptoglobin genotype and offering vitamin E as treatment could improve heart health and even extend life expectancy by three years for those affected.
8
Vitamin E reduces heart attack risk
We explored the effects of dietary vitamin E on heart attack and overall health by analyzing data from over 39,000 participants in the NHANES survey from 2003 to 2018. Our findings indicated that a higher intake of vitamin E was linked to a lower risk of cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E had significantly lower odds of developing cardiovascular issues, including heart attacks. However, the impact on cardiovascular mortality wasn't as strong. This suggests that while vitamin E-rich diets could enhance heart health, further research is necessary for clearer conclusions.
Specifically, those consuming more than 9.86 mg of vitamin E had significantly lower odds of developing cardiovascular issues, including heart attacks. However, the impact on cardiovascular mortality wasn't as strong. This suggests that while vitamin E-rich diets could enhance heart health, further research is necessary for clearer conclusions.
Most Useful Reviews
9.5
Reduces plaque thickness
I have used this product since 2014. Initially, I had significant thickening of plaque in my arteries. However, after a few years, doctors reported only mild plaque. I believe this improvement is due to my consistent use of Kyolic 106, which has proven to be highly effective. Given my family history of heart attacks, this product is essential and worth the investment.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.8
- All Researches
9
Garlic compounds improve heart health
We investigated how garlic oil (GO) and its active compound, diallyl disulfide (DADS), might protect the heart when used alongside carvedilol (CAR) in a study involving rats with induced heart damage. The experiment included different groups of rats that received GO, DADS, or CAR only, or a combination of these treatments, while being subjected to isoprenaline injections, which are known to cause heart issues.
After 14 days, our results revealed that rats treated with any combination of GO, DADS, and CAR showed improved heart health. Specifically, we found that these treatments led to increased antioxidant enzyme activities, which support heart function, and a decrease in harmful cardiac enzymes and inflammatory markers in the blood. Moreover, the presence of carvedilol seemed to enhance the positive effects of garlic treatments, suggesting a possible teamwork between these substances in providing heart protection.
While both GO and DADS demonstrated nearly equal effectiveness, it was clear that using them with carvedilol supported heart health even more robustly. These findings suggest that garlic and its compounds can contribute significantly to cardioprotection, especially when combined with established heart medications like carvedilol.
After 14 days, our results revealed that rats treated with any combination of GO, DADS, and CAR showed improved heart health. Specifically, we found that these treatments led to increased antioxidant enzyme activities, which support heart function, and a decrease in harmful cardiac enzymes and inflammatory markers in the blood. Moreover, the presence of carvedilol seemed to enhance the positive effects of garlic treatments, suggesting a possible teamwork between these substances in providing heart protection.
While both GO and DADS demonstrated nearly equal effectiveness, it was clear that using them with carvedilol supported heart health even more robustly. These findings suggest that garlic and its compounds can contribute significantly to cardioprotection, especially when combined with established heart medications like carvedilol.
9
We explored how an innovative hydrogel enhanced heart repair after a heart attack. This injectable hydrogel includes α-tocopherol, a form of vitamin E. In our study using a rabbit model, we implanted the hydrogel after inducing a heart attack.
Four weeks later, the results were promising. We noticed improved heart function and reduced damage to heart tissue. This suggests that the hydrogel, enriched with vitamin E, plays a vital role in helping the heart recover better after an injury.
Four weeks later, the results were promising. We noticed improved heart function and reduced damage to heart tissue. This suggests that the hydrogel, enriched with vitamin E, plays a vital role in helping the heart recover better after an injury.
9
β-Cryptoxanthin outperforming vitamin E
We investigated how three antioxidant compounds—β-cryptoxanthin, astaxanthin, and vitamin E—affect heart damage from ischemia-reperfusion injury in mice.
Mice were treated with these compounds before inducing heart injury.
Results showed that all treatments reduced heart damage, but β-cryptoxanthin was the most effective, shrinking heart injury by 60% compared to vitamin E and astaxanthin.
Ultimately, while vitamin E showed some benefits, β-cryptoxanthin stood out in reducing oxidative stress and cellular damage more effectively.
Mice were treated with these compounds before inducing heart injury.
Results showed that all treatments reduced heart damage, but β-cryptoxanthin was the most effective, shrinking heart injury by 60% compared to vitamin E and astaxanthin.
Ultimately, while vitamin E showed some benefits, β-cryptoxanthin stood out in reducing oxidative stress and cellular damage more effectively.
9
We examined how vitamin E affects individuals with diabetes and the specific Haptoglobin 2-2 genotype, who are at greater risk for heart problems. By analyzing data from two trials, we found that taking vitamin E significantly reduced the risk of heart events like strokes and heart attacks in these patients.
The study suggests that screening diabetics for the Haptoglobin genotype and offering vitamin E as treatment could improve heart health and even extend life expectancy by three years for those affected.
The study suggests that screening diabetics for the Haptoglobin genotype and offering vitamin E as treatment could improve heart health and even extend life expectancy by three years for those affected.
9
We aimed to explore how a combination of quercetin and vitamin E (alpha-tocopherol) may impact heart function in rats experiencing induced heart attacks. After treatment, all the essential heart enzyme levels returned to normal, suggesting these natural compounds might help stabilize heart membranes and reduce damage.
This is particularly hopeful for patients with heart conditions, as the combination proved to be more effective than either quercetin or vitamin E alone.
However, it’s important to note that while results are promising, further studies are necessary to fully understand these effects in humans.
This is particularly hopeful for patients with heart conditions, as the combination proved to be more effective than either quercetin or vitamin E alone.
However, it’s important to note that while results are promising, further studies are necessary to fully understand these effects in humans.
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Reduces plaque thickness
I have used this product since 2014. Initially, I had significant thickening of plaque in my arteries. However, after a few years, doctors reported only mild plaque. I believe this improvement is due to my consistent use of Kyolic 106, which has proven to be highly effective. Given my family history of heart attacks, this product is essential and worth the investment.
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Gao Y, Qin G, Liang S, Yin J, Wang B, et al. Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin. Drug Des Devel Ther. 2025;19:771. doi:10.2147/DDDT.S504884
- Asdaq SMB, Alamri AS, Alsanie WF, Alhomrani M. Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats. Molecules. 2021;26. doi:10.3390/molecules26175137
- Zeng Q, Liao M, Li Y, She F, Zhang P. Association between dietary vitamin E intake and incident cardiovascular disease, cardiovascular, and all-cause mortality: A prospective cohort study using NHANES 2003-2018 data. Int J Cardiol Cardiovasc Risk Prev. 2025;24:200340. doi:10.1016/j.ijcrp.2024.200340
- Zhang F, Zhang Y, Qian S, Qian X, Jiao J, et al. Injectable and Conductive Nanomicelle Hydrogel with α-Tocopherol Encapsulation for Enhanced Myocardial Infarction Repair. ACS Nano. 2024;18:10216. doi:10.1021/acsnano.4c00509
- Wang T, Xu L. Circulating Vitamin E Levels and Risk of Coronary Artery Disease and Myocardial Infarction: A Mendelian Randomization Study. Nutrients. 2019;11. doi:10.3390/nu11092153
- Pongkan W, Takatori O, Ni Y, Xu L, Nagata N, et al. β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice. Mol Nutr Food Res. 2017;61. doi:10.1002/mnfr.201601077
- Loffredo L, Perri L, Di Castelnuovo A, Iacoviello L, De Gaetano G, et al. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis. Nutr Metab Cardiovasc Dis. 2015;25:354. doi:10.1016/j.numecd.2015.01.008
- Shukla SK, Sharma SB, Singh UR. Pre-treatment with α-tocopherol and Terminalia arjuna ameliorates, pro-inflammatory cytokines, cardiac and apoptotic markers in myocardial infracted rats. Redox Rep. 2015;20:49. doi:10.1179/1351000214Y.0000000104
- Rodrigo R, Hasson D, Prieto JC, Dussaillant G, Ramos C, et al. The effectiveness of antioxidant vitamins C and E in reducing myocardial infarct size in patients subjected to percutaneous coronary angioplasty (PREVEC Trial): study protocol for a pilot randomized double-blind controlled trial. Trials. 2014;15:192. doi:10.1186/1745-6215-15-192
- Vardi M, Blum S, Levy AP. Haptoglobin genotype and cardiovascular outcomes in diabetes mellitus - natural history of the disease and the effect of vitamin E treatment. Meta-analysis of the medical literature. Eur J Intern Med. 2012;23:628. doi:10.1016/j.ejim.2012.04.009
- Rautiainen S, Akesson A, Levitan EB, Morgenstern R, Mittleman MA, et al. Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women. Am J Clin Nutr. 2010;92:1251. doi:10.3945/ajcn.2010.29371
- Blum S, Vardi M, Brown JB, Russell A, Milman U, et al. Vitamin E reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype. Pharmacogenomics. 2010;11:675. doi:10.2217/pgs.10.17
- Punithavathi VR, Prince PS. Pretreatment with a combination of quercetin and alpha-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats. Life Sci. 2010;86:178. doi:10.1016/j.lfs.2009.11.021
