5/18/2025
Last update
5/18/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Good
Based on 8 Reviews
8.2
Supplement Facts
Serving Size: 2 capsules
Amount Per Serving
%DV
Aged Garlic Extract™†† Powder (bulb)
400 mg
**
Nattokinase (NSK-SD®)
70 mg
**
L-Theanine (Suntheanine®)
24 mg
**
Top Medical Research Studies
9
We examined the effectiveness of garlic as a treatment to prevent cold symptoms based on a comprehensive review of systematic reviews. This analysis included various studies that compared garlic and other preventative interventions against a control group receiving no treatment or a placebo.
Our findings indicated that garlic demonstrated notable advantages in reducing instances of influenza, a key player in the spectrum of cold-like illnesses. However, we also learned that the evidence surrounding garlic specifically for cold prevention isn't robust enough to make definitive claims.
It's essential to note that while garlic showed potential, vitamin C did not present any significant benefits in this context. Ultimately, the effectiveness of other interventions remains to be convincingly validated with strong scientific evidence.
Our findings indicated that garlic demonstrated notable advantages in reducing instances of influenza, a key player in the spectrum of cold-like illnesses. However, we also learned that the evidence surrounding garlic specifically for cold prevention isn't robust enough to make definitive claims.
It's essential to note that while garlic showed potential, vitamin C did not present any significant benefits in this context. Ultimately, the effectiveness of other interventions remains to be convincingly validated with strong scientific evidence.
Read More
8
Nattokinase aids cold recovery
We conducted a study to explore how a single dose of nattokinase (NK) influences recovery of skin temperature after exposure to cold water. This double-blind, placebo-controlled crossover study involved nine healthy men who took either NK or a placebo before submerging their hands in ice-cold water at 10 °C for one minute.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
Read More
8
Garlic improves cold-induced circulation
In our exploration of how garlic affects circulation during cold exposure, we investigated the specific sulfur compound, -1-propenylcysteine, found in aged garlic extract (AGE). Our study examined how this compound could help alleviate the reduction in blood flow when rats were exposed to cold water.
We conducted a series of tests using Wistar rats subjected to a cold treatment after being administered AGE or its individual components, including -1-propenylcysteine, -allylcysteine, and -allylmercaptocysteine. The results revealed that both AGE and -1-propenylcysteine effectively improved blood flow in the rats' tails, especially at a certain dose of -1-propenylcysteine.
Notably, we found that the improvement in blood flow could be linked to a boost in certain blood components and enzymes related to blood circulation. These findings suggest that -1-propenylcysteine plays a significant role in enhancing blood flow during cold exposure by activating specific pathways in the body.
Our research indicates that while garlic components, particularly -1-propenylcysteine, have the potential to benefit circulation in cold conditions, larger studies are needed to fully understand the implications for human health.
We conducted a series of tests using Wistar rats subjected to a cold treatment after being administered AGE or its individual components, including -1-propenylcysteine, -allylcysteine, and -allylmercaptocysteine. The results revealed that both AGE and -1-propenylcysteine effectively improved blood flow in the rats' tails, especially at a certain dose of -1-propenylcysteine.
Notably, we found that the improvement in blood flow could be linked to a boost in certain blood components and enzymes related to blood circulation. These findings suggest that -1-propenylcysteine plays a significant role in enhancing blood flow during cold exposure by activating specific pathways in the body.
Our research indicates that while garlic components, particularly -1-propenylcysteine, have the potential to benefit circulation in cold conditions, larger studies are needed to fully understand the implications for human health.
Read More
Most Useful Reviews
7.5
Lowered colds incidence
5 people found this helpful
Dropped BP by ~25 points and fewer colds! I'm amazed. After two months of using this, my blood pressure fell ~25 points. Although I started taking Magnesium simultaneously, I noticed the distinct effects of Kyolic Garlic alone. I'm not overweight and maintain a healthy diet, yet I had blood pressure concerns. Most impressively, I'm not falling ill with the common cold as often, which was typical since I teach and kids can be germy.
Read More
9
Recommended for colds
I purchased it for my mother, and everything is fine. I also give it to my children and take it myself during colds; I recommend it.
Read More
9
Prevents colds
Kyolic aged garlic never leaves a garlic smell on my breath, and when I take it, I never catch a cold or the flu.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
- All Researches
9
We examined the effectiveness of garlic as a treatment to prevent cold symptoms based on a comprehensive review of systematic reviews. This analysis included various studies that compared garlic and other preventative interventions against a control group receiving no treatment or a placebo.
Our findings indicated that garlic demonstrated notable advantages in reducing instances of influenza, a key player in the spectrum of cold-like illnesses. However, we also learned that the evidence surrounding garlic specifically for cold prevention isn't robust enough to make definitive claims.
It's essential to note that while garlic showed potential, vitamin C did not present any significant benefits in this context. Ultimately, the effectiveness of other interventions remains to be convincingly validated with strong scientific evidence.
Our findings indicated that garlic demonstrated notable advantages in reducing instances of influenza, a key player in the spectrum of cold-like illnesses. However, we also learned that the evidence surrounding garlic specifically for cold prevention isn't robust enough to make definitive claims.
It's essential to note that while garlic showed potential, vitamin C did not present any significant benefits in this context. Ultimately, the effectiveness of other interventions remains to be convincingly validated with strong scientific evidence.
Read More
9
We explored the potential of combining garlic oil with acyclovir (ACV) to tackle the challenges of cold sores caused by the herpes simplex virus. By creating a unique nanoemulsion delivery system, we aimed to enhance how effective ACV is in treating these annoying outbreaks.
Our work involved developing a garlic oil-acylcovir nanoemulsion, which we then incorporated into a transdermal film. This innovative approach was put to the test for its ability to improve skin absorption of the medication. The results were quite promising, showing that our formulation significantly increased ACV's effectiveness compared to regular transdermal methods. We observed a remarkable 2.3 times increase in the absorption of ACV when combined with garlic oil, indicating that garlic may indeed amplify its therapeutic benefits.
However, while this study shows that garlic oil can enhance the performance of acyclovir, we must note that the isolated effects of garlic on cold sores cannot be fully established, as it was tested alongside ACV. Overall, our findings suggest that the garlic oil-ACV blend does make strides toward more effective treatment options for cold sores, paving the way for future explorations in this area of research.
Our work involved developing a garlic oil-acylcovir nanoemulsion, which we then incorporated into a transdermal film. This innovative approach was put to the test for its ability to improve skin absorption of the medication. The results were quite promising, showing that our formulation significantly increased ACV's effectiveness compared to regular transdermal methods. We observed a remarkable 2.3 times increase in the absorption of ACV when combined with garlic oil, indicating that garlic may indeed amplify its therapeutic benefits.
However, while this study shows that garlic oil can enhance the performance of acyclovir, we must note that the isolated effects of garlic on cold sores cannot be fully established, as it was tested alongside ACV. Overall, our findings suggest that the garlic oil-ACV blend does make strides toward more effective treatment options for cold sores, paving the way for future explorations in this area of research.
Read More
8
Garlic improves cold-induced circulation
In our exploration of how garlic affects circulation during cold exposure, we investigated the specific sulfur compound, -1-propenylcysteine, found in aged garlic extract (AGE). Our study examined how this compound could help alleviate the reduction in blood flow when rats were exposed to cold water.
We conducted a series of tests using Wistar rats subjected to a cold treatment after being administered AGE or its individual components, including -1-propenylcysteine, -allylcysteine, and -allylmercaptocysteine. The results revealed that both AGE and -1-propenylcysteine effectively improved blood flow in the rats' tails, especially at a certain dose of -1-propenylcysteine.
Notably, we found that the improvement in blood flow could be linked to a boost in certain blood components and enzymes related to blood circulation. These findings suggest that -1-propenylcysteine plays a significant role in enhancing blood flow during cold exposure by activating specific pathways in the body.
Our research indicates that while garlic components, particularly -1-propenylcysteine, have the potential to benefit circulation in cold conditions, larger studies are needed to fully understand the implications for human health.
We conducted a series of tests using Wistar rats subjected to a cold treatment after being administered AGE or its individual components, including -1-propenylcysteine, -allylcysteine, and -allylmercaptocysteine. The results revealed that both AGE and -1-propenylcysteine effectively improved blood flow in the rats' tails, especially at a certain dose of -1-propenylcysteine.
Notably, we found that the improvement in blood flow could be linked to a boost in certain blood components and enzymes related to blood circulation. These findings suggest that -1-propenylcysteine plays a significant role in enhancing blood flow during cold exposure by activating specific pathways in the body.
Our research indicates that while garlic components, particularly -1-propenylcysteine, have the potential to benefit circulation in cold conditions, larger studies are needed to fully understand the implications for human health.
Read More
8
Nattokinase aids cold recovery
We conducted a study to explore how a single dose of nattokinase (NK) influences recovery of skin temperature after exposure to cold water. This double-blind, placebo-controlled crossover study involved nine healthy men who took either NK or a placebo before submerging their hands in ice-cold water at 10 °C for one minute.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Lowered colds incidence
5 people found this helpful
Dropped BP by ~25 points and fewer colds! I'm amazed. After two months of using this, my blood pressure fell ~25 points. Although I started taking Magnesium simultaneously, I noticed the distinct effects of Kyolic Garlic alone. I'm not overweight and maintain a healthy diet, yet I had blood pressure concerns. Most impressively, I'm not falling ill with the common cold as often, which was typical since I teach and kids can be germy.
Read More
9
Recommended for colds
I purchased it for my mother, and everything is fine. I also give it to my children and take it myself during colds; I recommend it.
Read More
9
Prevents colds
Kyolic aged garlic never leaves a garlic smell on my breath, and when I take it, I never catch a cold or the flu.
Read More
7.5
Helpful for colds
2 people found this helpful
I did not notice the pressure effect, and they have a strong smell. However, they helped me well with my cold.
Read More
7.5
Strengthens immunity
1 people found this helpful
A good garlic complex. Garlic possesses numerous useful properties: it boosts immunity, assists in fighting colds, protects the cardiovascular system, and combats bacteria. It is beneficial to take for normalising pressure.
Read More
Frequently Asked Questions
7.5
Cleanses the body
Very high-quality garlic; I have purchased from this manufacturer multiple times. I have tried different types. Garlic is remarkably beneficial for colds, assists with pressure, and cleanses the body. The ingredients are natural, the composition is excellent, and it’s very healthy.
7.5
Essential for viruses
I always keep garlic in my first aid kit. This time, we took it on an antiparasitic programme, but we consistently use it for viruses and colds.
9
Prevents colds
Kyolic aged garlic never leaves a garlic smell on my breath, and when I take it, I never catch a cold or the flu.
7.5
Helpful for colds
2 people found this helpful
I did not notice the pressure effect, and they have a strong smell. However, they helped me well with my cold.
7.5
Improves circulation
Garlic is quite beneficial too. Since using this product regularly, my cold hands and feet have significantly improved. The quality is good, the ingredients are excellent, and it helps my blood pressure.
7.5
Strengthens immunity
1 people found this helpful
A good garlic complex. Garlic possesses numerous useful properties: it boosts immunity, assists in fighting colds, protects the cardiovascular system, and combats bacteria. It is beneficial to take for normalising pressure.
9
Recommended for colds
I purchased it for my mother, and everything is fine. I also give it to my children and take it myself during colds; I recommend it.
9
We examined the effectiveness of garlic as a treatment to prevent cold symptoms based on a comprehensive review of systematic reviews. This analysis included various studies that compared garlic and other preventative interventions against a control group receiving no treatment or a placebo.
Our findings indicated that garlic demonstrated notable advantages in reducing instances of influenza, a key player in the spectrum of cold-like illnesses. However, we also learned that the evidence surrounding garlic specifically for cold prevention isn't robust enough to make definitive claims.
It's essential to note that while garlic showed potential, vitamin C did not present any significant benefits in this context. Ultimately, the effectiveness of other interventions remains to be convincingly validated with strong scientific evidence.
Our findings indicated that garlic demonstrated notable advantages in reducing instances of influenza, a key player in the spectrum of cold-like illnesses. However, we also learned that the evidence surrounding garlic specifically for cold prevention isn't robust enough to make definitive claims.
It's essential to note that while garlic showed potential, vitamin C did not present any significant benefits in this context. Ultimately, the effectiveness of other interventions remains to be convincingly validated with strong scientific evidence.
8
Garlic improves cold-induced circulation
In our exploration of how garlic affects circulation during cold exposure, we investigated the specific sulfur compound, -1-propenylcysteine, found in aged garlic extract (AGE). Our study examined how this compound could help alleviate the reduction in blood flow when rats were exposed to cold water.
We conducted a series of tests using Wistar rats subjected to a cold treatment after being administered AGE or its individual components, including -1-propenylcysteine, -allylcysteine, and -allylmercaptocysteine. The results revealed that both AGE and -1-propenylcysteine effectively improved blood flow in the rats' tails, especially at a certain dose of -1-propenylcysteine.
Notably, we found that the improvement in blood flow could be linked to a boost in certain blood components and enzymes related to blood circulation. These findings suggest that -1-propenylcysteine plays a significant role in enhancing blood flow during cold exposure by activating specific pathways in the body.
Our research indicates that while garlic components, particularly -1-propenylcysteine, have the potential to benefit circulation in cold conditions, larger studies are needed to fully understand the implications for human health.
We conducted a series of tests using Wistar rats subjected to a cold treatment after being administered AGE or its individual components, including -1-propenylcysteine, -allylcysteine, and -allylmercaptocysteine. The results revealed that both AGE and -1-propenylcysteine effectively improved blood flow in the rats' tails, especially at a certain dose of -1-propenylcysteine.
Notably, we found that the improvement in blood flow could be linked to a boost in certain blood components and enzymes related to blood circulation. These findings suggest that -1-propenylcysteine plays a significant role in enhancing blood flow during cold exposure by activating specific pathways in the body.
Our research indicates that while garlic components, particularly -1-propenylcysteine, have the potential to benefit circulation in cold conditions, larger studies are needed to fully understand the implications for human health.
References
- Yuan Y, Wang RT, Xia J, Cao HJ. Interventions for preventing influenza: An overview of Cochrane systematic reviews and a Bayesian network meta-analysis. J Integr Med. 2021;19:503. 10.1016/j.joim.2021.09.001
- Almehmady AM, Ali SA. Transdermal Film Loaded with Garlic Oil-Acyclovir Nanoemulsion to Overcome Barriers for Its Use in Alleviating Cold Sore Conditions. Pharmaceutics. 2021;13. 10.3390/pharmaceutics13050669
- Ushijima M, Kunimura K, Suzuki JI. -1-Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway. Exp Ther Med. 2020;20:2815. 10.3892/etm.2020.8969
- Nara N, Kurosawa Y, Fuse-Hamaoka S, Kuroiwa M, Endo T, et al. A single dose of oral nattokinase accelerates skin temperature recovery after cold water immersion: A double-blind, placebo-controlled crossover study. Heliyon. 2023;9:e17951. 10.1016/j.heliyon.2023.e17951
