5/5/2025
Last update
5/5/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.4
USERS' SCORE
Good
Based on 60 Reviews
8
Supplement Facts
Serving Size: 1 Vegetarian capsule
Amount Per Serving
%DV
Bio-Quercetin® Proprietary Blend providing 35% quercetin (10 mg) [from Japanese sophora concentrate flower bud)], 30% galactomannans (8 mg) [from fenugreek (seed)]
30 mg
**
Top Medical Research Studies
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Read More
8
We explored how quercetin may help alleviate allergies by examining its impact on certain immune cells involved in allergic reactions. Using different types of mast cells, we observed that quercetin triggered the production of heme oxygenase-1 (HO-1), which plays a key role in this process.
Interestingly, when we inhibited HO-1, the protective effects of quercetin vanished, suggesting that the Nrf2-HO-1 pathway is crucial for its anti-allergic actions. Our findings strongly indicate that quercetin could be valuable in managing allergic responses.
Interestingly, when we inhibited HO-1, the protective effects of quercetin vanished, suggesting that the Nrf2-HO-1 pathway is crucial for its anti-allergic actions. Our findings strongly indicate that quercetin could be valuable in managing allergic responses.
Read More
9.5
We delved into the effects of quercetin on peanut-induced anaphylactic reactions using a rat model. The study involved sensitized Wistar rats divided into treatment and control groups. After four weeks of quercetin treatment, we observed a significant decrease in plasma histamine levels and anaphylactic responses.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Read More
Most Useful Reviews
9
Improves allergy symptoms
123 people found this helpful
Quercetin as an antioxidant is beneficial for covid and greatly improves symptoms of allergies. I switched from a regular form to this supposedly more bioavailable version for testing. The capsules contain smaller substances but claim a 50-fold better bioavailability.
Read More
7.5
Eases seasonal allergies
119 people found this helpful
Good quercetin; it helps me endure seasonal allergies more comfortably.
Read More
7.5
Solves allergy problems
12 people found this helpful
I’ve been taking Quercetin from various manufacturers for several years. It effectively addresses my seasonal allergies.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.4
- All Researches
9.5
We delved into the effects of quercetin on peanut-induced anaphylactic reactions using a rat model. The study involved sensitized Wistar rats divided into treatment and control groups. After four weeks of quercetin treatment, we observed a significant decrease in plasma histamine levels and anaphylactic responses.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Read More
9
Quercetin shows promise in allergies
We delved into the potential of quercetin as a therapeutic option for treating allergic rhinitis, a common condition affecting roughly 40% of the global population. This study utilized various in-silico approaches, such as network pharmacology and molecular docking, to identify compounds from traditional medicinal plants and assess their effectiveness.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Read More
9
We investigated how a specific leaf extract affects allergic inflammation in immune cell lines.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Read More
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Read More
9
Holo-BLG offers allergy protection
We investigated how the milk protein beta-lactoglobulin (BLG), particularly its holo form, could shield against pollen allergies. In our study, BALB/c mice received nasal pretreatments with holo-BLG containing quercetin-iron complexes before being exposed to birch pollen allergens.
We observed that this treatment led to lower levels of allergy-related antibodies and reduced inflammatory responses. Essentially, holo-BLG appeared to offer protection from allergic reactions not just specifically to itself but also to unrelated allergens, suggesting a potential role in enhancing immune response against various pollen allergens.
We observed that this treatment led to lower levels of allergy-related antibodies and reduced inflammatory responses. Essentially, holo-BLG appeared to offer protection from allergic reactions not just specifically to itself but also to unrelated allergens, suggesting a potential role in enhancing immune response against various pollen allergens.
Read More
User Reviews
USERS' SCORE
Good
Based on 60 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves allergy symptoms
123 people found this helpful
Quercetin as an antioxidant is beneficial for covid and greatly improves symptoms of allergies. I switched from a regular form to this supposedly more bioavailable version for testing. The capsules contain smaller substances but claim a 50-fold better bioavailability.
Read More
7.5
Eases seasonal allergies
119 people found this helpful
Good quercetin; it helps me endure seasonal allergies more comfortably.
Read More
7.5
Solves allergy problems
12 people found this helpful
I’ve been taking Quercetin from various manufacturers for several years. It effectively addresses my seasonal allergies.
Read More
9
Quick relief observed
11 people found this helpful
My allergies have been terrible this year. I decided to try quercetin again after previous experiences. This form seems to work well for me; within about 20 minutes of taking it, my runny nose cleared. The first dose made me a bit jittery, but that passed quickly. I take it twice daily, and I no longer wake up congested in the night. Any additional health benefits are a bonus.
Read More
10
Works miracles
9 people found this helpful
I absolutely love this quercetin! It cleared my seasonal allergies within two weeks. No more sneezing or itchy eyes. My dog, who had severe allergies unresponsive to diet changes or steroids, also improved dramatically after taking it.
Read More
Frequently Asked Questions
9
Quick relief
2 people found this helpful
This product really helped me with my flowering allergy. I felt significantly better by the second day of taking it—an impressive response right from the start!
10
Works miracles
9 people found this helpful
I absolutely love this quercetin! It cleared my seasonal allergies within two weeks. No more sneezing or itchy eyes. My dog, who had severe allergies unresponsive to diet changes or steroids, also improved dramatically after taking it.
9
Immediate relief
1 people found this helpful
Life Extension knows their supplements! My allergies have been terrible this year. I took quercetin before and decided to try it again. This form works well for me; about 20 minutes after taking it, my runny nose cleared. The first dose gave me some jitters, but these wore off quickly. I take this twice a day with my morning and bedtime meds, and I no longer wake up completely congested.
9
Severe allergy relief
1 people found this helpful
Excellent! This quercetin product has aided my severe allergies significantly. I followed a daily course for one month, taking one capsule each morning, and the price is reasonable.
9
Itchy eyes relief
4 people found this helpful
I suffer from allergic rhinitis, particularly with my cat allergy, which causes my eyes to be incredibly itchy. However, after taking this product, my itchy eyes subsided, and all other rhinitis symptoms disappeared.
9
Mast cell support
2 people found this helpful
Surprisingly effective for my allergies. If you experience mast cell dysfunction or histamine overload, this product is a tremendous help.
9
Powerful anti-allergenic
1 people found this helpful
Helps combat allergies effectively. In conjunction with bromelain, it boasts a strong anti-allergenic effect, alleviating symptoms from pollen, weeds, and even wool and pet dander. I am thoroughly pleased with the outcome and my purchase!
9
Significant allergy improvement
2 people found this helpful
Definitely more bioavailable than standard quercetin. I’ve tried several quercetin products without improvement for my severe allergies, but Life Extension's Bio-Quercetin has been a game changer. My skin is less reactive, rhinitis symptoms have improved, and I benefit more from zinc with this product. Another winner from Life Extension!
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
9
We investigated how a specific leaf extract affects allergic inflammation in immune cell lines.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
8
We explored the effects of quercetin, a natural bioflavonoid found in foods like red wine and onions, on allergies and inflammation. This compound has antioxidant properties and works by inhibiting mast cell activity, which helps reduce the release of substances that trigger allergic reactions.
While quercetin shows promise as a natural therapy for allergies, its overall effectiveness is still being evaluated. It's considered safe and may be used alongside traditional treatments for better results.
While quercetin shows promise as a natural therapy for allergies, its overall effectiveness is still being evaluated. It's considered safe and may be used alongside traditional treatments for better results.
7
Quercetin shows potential for allergies
We explored the potential benefits of quercetin and other dietary components in managing allergic reactions. Research indicates that quercetin may play a role in reducing symptoms of allergic rhinitis by suppressing inflammatory mediators from mast cells, essential players in allergic responses.
Our analysis highlighted that while quercetin shows promise, it’s one of several dietary factors needing further investigation, especially due to concerns about how well our bodies can use these nutrients. Continued research on improving their bioavailability is crucial for maximizing their effects on allergies.
Our analysis highlighted that while quercetin shows promise, it’s one of several dietary factors needing further investigation, especially due to concerns about how well our bodies can use these nutrients. Continued research on improving their bioavailability is crucial for maximizing their effects on allergies.
References
- Islam KMT, Mahmud S. In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum chemistry and machine learning based QSAR approaches. Comput Biol Med. 2025;187:109754. 10.1016/j.compbiomed.2025.109754
- Bunddulam P, Nakamura M, Zorig A, Hinata Y, Takasugi M, et al. Effects of Leaf Extract on Allergic Inflammation in Immune Cell Lines. Prev Nutr Food Sci. 2025;30:68. 10.3746/pnf.2025.30.1.68
- Kaag S, Lorentz A. Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies?. Cells. 2023;12. 10.3390/cells12222602
- Mizuno M, Fujioka A, Bitani S, Minato KI, Sakakibara H. Anti-Allergic Activity of Fucoidan Can Be Enhanced by Coexistence with Quercetin. Int J Mol Sci. 2022;23. 10.3390/ijms232012163
- Yamada S, Shirai M, Inaba Y, Takara T. Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study. Eur Rev Med Pharmacol Sci. 2022;26:4331. 10.26355/eurrev_202206_29072
- Afify SM, Pali-Schöll I, Hufnagl K, Hofstetter G, El-Bassuoni MA, et al. Bovine Holo-Beta-Lactoglobulin Cross-Protects Against Pollen Allergies in an Innate Manner in BALB/c Mice: Potential Model for the Farm Effect. Front Immunol. 2021;12:611474. 10.3389/fimmu.2021.611474
- Ding Y, Che D, Li C, Cao J, Wang J, et al. Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCγ-IP3R related Ca fluctuations. Int Immunopharmacol. 2019;66:185. 10.1016/j.intimp.2018.11.025
- Carbone ML, Lulli D, Passarelli F, Pastore S. Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity. Int J Mol Sci. 2018;19. 10.3390/ijms19092652
- Takasugi M, Muta E, Yamada K, Arai H. A new method to evaluate anti-allergic effect of food component by measuring leukotriene B from a mouse mast cell line. Cytotechnology. 2018;70:177. 10.1007/s10616-017-0129-9
- Kim M, Lim SJ, Kang SW, Um BH, Nho CW. Aceriphyllum rossii extract and its active compounds, quercetin and kaempferol inhibit IgE-mediated mast cell activation and passive cutaneous anaphylaxis. J Agric Food Chem. 2014;62:3750. 10.1021/jf405486c
- Shishehbor F, Behroo L, Ghafouriyan Broujerdnia M, Namjoyan F, Latifi SM. Quercetin effectively quells peanut-induced anaphylactic reactions in the peanut sensitized rats. Iran J Allergy Asthma Immunol. 2010;9:27.
- Matsushima M, Takagi K, Ogawa M, Hirose E, Ota Y, et al. Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Inflamm Res. 2009;58:705. 10.1007/s00011-009-0039-1
- Cruz EA, Da-Silva SA, Muzitano MF, Silva PM, Costa SS, et al. Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock. Int Immunopharmacol. 2008;8:1616. 10.1016/j.intimp.2008.07.006
- Shaik YB, Castellani ML, Perrella A, Conti F, Salini V, et al. Role of quercetin (a natural herbal compound) in allergy and inflammation. J Biol Regul Homeost Agents. 2006;20:47.
- Rogerio AP, Kanashiro A, Fontanari C, da Silva EV, Lucisano-Valim YM, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007;56:402.
