Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.7
USERS' SCORE
Good
Based on 10 Reviews
8.1
Supplement Facts
Serving Size: 1 Vegetarian capsule
Amount Per Serving
%DV
Bio-Quercetin® Proprietary Blend providing 35% quercetin (10 mg) [from Japanese sophora concentrate flower bud)], 30% galactomannans (8 mg) [from fenugreek (seed)]
30 mg
**
Top Medical Research Studies
9
We explored how quercetin, a natural compound found in fruits and vegetables, can impact asthma symptoms. Using an ovalbumin-induced mouse model of asthma, we aimed to uncover whether quercetin can help inhibit a process known as ferroptosis, potentially offering a new therapeutic approach for asthma sufferers.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
Read More
9
Quercetin shows promise for asthma
We explored the impact of quercetin, a natural plant compound, on asthma by testing its anti-inflammatory and antioxidant properties in a controlled study with rats. Asthma was induced in the rats using a substance called ovalbumin, and they were divided into four groups: a control group, an asthma group treated with a saline solution, another asthma group treated with dexamethasone (a common asthma medication), and a group treated with quercetin.
After one week of daily injections of quercetin and dexamethasone, we noted significant changes in various biological markers. Quercetin appeared to lower the expression of several inflammatory factors linked to asthma, such as Gata-3 and TNF-α. It also positively influenced oxidative stress by reducing levels of malondialdehyde, a marker of cell damage, while boosting antioxidants in both the serum and lung tissue.
Our findings suggest that quercetin does more than just alleviate inflammatory responses; it also enhances the body's defenses against oxidative stress, particularly in the lungs. Overall, quercetin shows great potential as an effective treatment for asthma, helping to manage both inflammation and oxidative stress at the tissue level.
After one week of daily injections of quercetin and dexamethasone, we noted significant changes in various biological markers. Quercetin appeared to lower the expression of several inflammatory factors linked to asthma, such as Gata-3 and TNF-α. It also positively influenced oxidative stress by reducing levels of malondialdehyde, a marker of cell damage, while boosting antioxidants in both the serum and lung tissue.
Our findings suggest that quercetin does more than just alleviate inflammatory responses; it also enhances the body's defenses against oxidative stress, particularly in the lungs. Overall, quercetin shows great potential as an effective treatment for asthma, helping to manage both inflammation and oxidative stress at the tissue level.
Read More
9
We explored how quercetin, a natural compound, may help alleviate asthma symptoms. The focus was on its potential role regarding periostin, a protein linked to inflammatory responses in the lungs, and its interaction with the TGF-β1/Smad pathway, a key signaling system in asthma.
To gain insights, we constructed a model using mice sensitized to ovalbumin—an allergen that triggers asthma—and administered quercetin among other treatments. We carefully observed changes in inflammatory responses, airway remodeling, and hyperresponsiveness, using various tests and analyses to measure inflammation markers and proteins involved in airway fibrosis.
Our findings revealed that quercetin significantly reduced the levels of periostin and inhibited airway inflammation and fibrosis. It also showed a tendency to reduce airway hyperreactivity, suggesting that quercetin works through suppressing the TGF-β1/Smad signaling pathway.
Overall, our study supports quercetin as a promising candidate for asthma treatment, highlighting how it effectively targets specific pathways involved in the disease, offering a protective effect against its symptoms.
To gain insights, we constructed a model using mice sensitized to ovalbumin—an allergen that triggers asthma—and administered quercetin among other treatments. We carefully observed changes in inflammatory responses, airway remodeling, and hyperresponsiveness, using various tests and analyses to measure inflammation markers and proteins involved in airway fibrosis.
Our findings revealed that quercetin significantly reduced the levels of periostin and inhibited airway inflammation and fibrosis. It also showed a tendency to reduce airway hyperreactivity, suggesting that quercetin works through suppressing the TGF-β1/Smad signaling pathway.
Overall, our study supports quercetin as a promising candidate for asthma treatment, highlighting how it effectively targets specific pathways involved in the disease, offering a protective effect against its symptoms.
Read More
Most Useful Reviews
9
Alleviates asthma attacks
2 people found this helpful
Quercetin exhibits antihistamine and anti-inflammatory properties that aid in alleviating various allergies and asthma attacks effectively.
Read More
9
Eases allergy symptoms
Quercetin alleviates allergic manifestations including asthma and rhinitis, making it a reliable aid for my symptoms.
Read More
7.5
Effective for allergies
Quercetin is a natural flavonoid with antihistamine and anti-inflammatory effects, effective in relieving asthma attacks and allergic skin reactions.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.7
- All Researches
9
We explored how quercetin, a natural compound found in fruits and vegetables, can impact asthma symptoms. Using an ovalbumin-induced mouse model of asthma, we aimed to uncover whether quercetin can help inhibit a process known as ferroptosis, potentially offering a new therapeutic approach for asthma sufferers.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
Read More
9
We explored the potential of quercetin, a key component of Bushenyiqi decoction (BYD), in treating asthma. Through a combination of network pharmacology and experimental validation, we examined its effects on asthma symptoms and the underlying mechanisms behind them.
Our research highlighted that BYD significantly improves airway responsiveness and decreases inflammation in allergic asthma mice. We identified quercetin, along with other active ingredients in BYD, as critical players in targeting specific genes related to asthma, particularly interleukin 6 (IL-6), epidermal growth factor receptor (EGFR), and hypoxia-inducible factor 1 alpha (HIF1A).
The phosphatidylinositol-3-kinase/AKT signaling pathway also emerged as crucial in this process. Our findings suggest that quercetin contributes to reducing inflammation and respiratory symptoms in asthma by regulating these targets.
Overall, this investigation underscores the importance of quercetin as a valuable element of BYD in mitigating asthma-related inflammation, providing new insights into traditional Chinese medicine's effective strategies.
Our research highlighted that BYD significantly improves airway responsiveness and decreases inflammation in allergic asthma mice. We identified quercetin, along with other active ingredients in BYD, as critical players in targeting specific genes related to asthma, particularly interleukin 6 (IL-6), epidermal growth factor receptor (EGFR), and hypoxia-inducible factor 1 alpha (HIF1A).
The phosphatidylinositol-3-kinase/AKT signaling pathway also emerged as crucial in this process. Our findings suggest that quercetin contributes to reducing inflammation and respiratory symptoms in asthma by regulating these targets.
Overall, this investigation underscores the importance of quercetin as a valuable element of BYD in mitigating asthma-related inflammation, providing new insights into traditional Chinese medicine's effective strategies.
Read More
9
Quercetin reduces airway inflammation
We aimed to investigate the potential benefits of quercetin, a natural compound, in addressing airway hyperreactivity and inflammation in newborn rats exposed to high levels of oxygen. High oxygen environments often lead to lung injuries and increased airway sensitivity, mimicking some aspects of asthma.
To conduct this study, we divided young rats into groups exposed to either high oxygen or regular air for a week. Some of these groups received quercetin injections, while others did not. By measuring the contraction of tracheal smooth muscles in response to a specific chemical, we noted significant improvements in those treated with quercetin.
Specifically, quercetin reduced the excessive contraction observed in the high-oxygen groups and restored relaxation in the muscles, suggesting a protective effect. We also found that quercetin treatment lowered inflammation markers in the lungs, which is significant, given that inflammation often exacerbates asthma symptoms.
Overall, our findings indicate that quercetin could play a valuable role in managing airway hyperreactivity and associated inflammation, presenting a promising avenue for future therapies aimed at young patients with similar breathing issues.
To conduct this study, we divided young rats into groups exposed to either high oxygen or regular air for a week. Some of these groups received quercetin injections, while others did not. By measuring the contraction of tracheal smooth muscles in response to a specific chemical, we noted significant improvements in those treated with quercetin.
Specifically, quercetin reduced the excessive contraction observed in the high-oxygen groups and restored relaxation in the muscles, suggesting a protective effect. We also found that quercetin treatment lowered inflammation markers in the lungs, which is significant, given that inflammation often exacerbates asthma symptoms.
Overall, our findings indicate that quercetin could play a valuable role in managing airway hyperreactivity and associated inflammation, presenting a promising avenue for future therapies aimed at young patients with similar breathing issues.
Read More
9
Quercetin shows promise for asthma
We explored the impact of quercetin, a natural plant compound, on asthma by testing its anti-inflammatory and antioxidant properties in a controlled study with rats. Asthma was induced in the rats using a substance called ovalbumin, and they were divided into four groups: a control group, an asthma group treated with a saline solution, another asthma group treated with dexamethasone (a common asthma medication), and a group treated with quercetin.
After one week of daily injections of quercetin and dexamethasone, we noted significant changes in various biological markers. Quercetin appeared to lower the expression of several inflammatory factors linked to asthma, such as Gata-3 and TNF-α. It also positively influenced oxidative stress by reducing levels of malondialdehyde, a marker of cell damage, while boosting antioxidants in both the serum and lung tissue.
Our findings suggest that quercetin does more than just alleviate inflammatory responses; it also enhances the body's defenses against oxidative stress, particularly in the lungs. Overall, quercetin shows great potential as an effective treatment for asthma, helping to manage both inflammation and oxidative stress at the tissue level.
After one week of daily injections of quercetin and dexamethasone, we noted significant changes in various biological markers. Quercetin appeared to lower the expression of several inflammatory factors linked to asthma, such as Gata-3 and TNF-α. It also positively influenced oxidative stress by reducing levels of malondialdehyde, a marker of cell damage, while boosting antioxidants in both the serum and lung tissue.
Our findings suggest that quercetin does more than just alleviate inflammatory responses; it also enhances the body's defenses against oxidative stress, particularly in the lungs. Overall, quercetin shows great potential as an effective treatment for asthma, helping to manage both inflammation and oxidative stress at the tissue level.
Read More
9
We explored how quercetin, a natural compound, may help alleviate asthma symptoms. The focus was on its potential role regarding periostin, a protein linked to inflammatory responses in the lungs, and its interaction with the TGF-β1/Smad pathway, a key signaling system in asthma.
To gain insights, we constructed a model using mice sensitized to ovalbumin—an allergen that triggers asthma—and administered quercetin among other treatments. We carefully observed changes in inflammatory responses, airway remodeling, and hyperresponsiveness, using various tests and analyses to measure inflammation markers and proteins involved in airway fibrosis.
Our findings revealed that quercetin significantly reduced the levels of periostin and inhibited airway inflammation and fibrosis. It also showed a tendency to reduce airway hyperreactivity, suggesting that quercetin works through suppressing the TGF-β1/Smad signaling pathway.
Overall, our study supports quercetin as a promising candidate for asthma treatment, highlighting how it effectively targets specific pathways involved in the disease, offering a protective effect against its symptoms.
To gain insights, we constructed a model using mice sensitized to ovalbumin—an allergen that triggers asthma—and administered quercetin among other treatments. We carefully observed changes in inflammatory responses, airway remodeling, and hyperresponsiveness, using various tests and analyses to measure inflammation markers and proteins involved in airway fibrosis.
Our findings revealed that quercetin significantly reduced the levels of periostin and inhibited airway inflammation and fibrosis. It also showed a tendency to reduce airway hyperreactivity, suggesting that quercetin works through suppressing the TGF-β1/Smad signaling pathway.
Overall, our study supports quercetin as a promising candidate for asthma treatment, highlighting how it effectively targets specific pathways involved in the disease, offering a protective effect against its symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Alleviates asthma attacks
2 people found this helpful
Quercetin exhibits antihistamine and anti-inflammatory properties that aid in alleviating various allergies and asthma attacks effectively.
Read More
9
Eases allergy symptoms
Quercetin alleviates allergic manifestations including asthma and rhinitis, making it a reliable aid for my symptoms.
Read More
7.5
Effective for allergies
Quercetin is a natural flavonoid with antihistamine and anti-inflammatory effects, effective in relieving asthma attacks and allergic skin reactions.
Read More
7.5
Works well for asthma
Good quercetin! It helps with allergies and works effectively for asthma. We will continue taking it.
Read More
7.5
Excellent antioxidant
Wonderful! Quercetin is a natural flavonoid with antihistamine and anti-inflammatory effects, beneficial for alleviating allergies and asthma attacks. I take it to counteract allergy symptoms and appreciate its many other properties, acting as an excellent antioxidant.
Read More
Frequently Asked Questions
7.5
Reduces asthma symptoms
Quercetin effectively blocks histamine release, which is crucial for managing allergic reactions and improving asthma symptoms.
7.5
Works well for asthma
Good quercetin! It helps with allergies and works effectively for asthma. We will continue taking it.
9
Eases allergy symptoms
Quercetin alleviates allergic manifestations including asthma and rhinitis, making it a reliable aid for my symptoms.
7.5
Effective for allergies
Quercetin is a natural flavonoid with antihistamine and anti-inflammatory effects, effective in relieving asthma attacks and allergic skin reactions.
6
Supports nasal health
It assists a friend in managing asthma, prompting me to try it as well since I suffer from allergies. In conjunction with other supplements, it has reduced my nasal puffiness during heating season, leading to less frequent use of nasal spray.
9
Alleviates asthma attacks
2 people found this helpful
Quercetin exhibits antihistamine and anti-inflammatory properties that aid in alleviating various allergies and asthma attacks effectively.
7.5
Helps asthma attacks
7 people found this helpful
Taken in a complex for adults and children over 7 years old, according to my doctor’s prescription. Quercetin is a natural antioxidant from plants such as fruits and vegetables. It protects the body from free radicals, enhances cardiovascular health, and supports anti-inflammatory responses. Quercetin effectively combats allergies, asthma attacks, and skin problems. As histamine triggers allergy symptoms, quercetin helps reduce these effects with minimal side effects. I find these small capsules very effective, lasting for a month.
9
We explored how quercetin, a natural compound found in fruits and vegetables, can impact asthma symptoms. Using an ovalbumin-induced mouse model of asthma, we aimed to uncover whether quercetin can help inhibit a process known as ferroptosis, potentially offering a new therapeutic approach for asthma sufferers.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
8
Quercetin's potential in asthma treatment
Our investigation centered on how quercetin, a component of the Suhuang antitussive capsule—an herbal remedy used in traditional Chinese medicine—affects asthma. The Suhuang formula, known for its use in treating cough variant asthma, combines various herbs, creating a multi-ingredient treatment that poses challenges in isolating individual components.
Through our analysis using in vivo rat models, we observed significant interactions between quercetin and target genes associated with inflammation, specifically those active in the IL-17 signaling pathway. These interactions suggest that quercetin might help reduce lung inflammation when battling asthma symptoms.
We identified important compounds like quercetin and luteolin, revealing their potential therapeutic roles in this context. However, since quercetin is just one part of a larger herbal blend, the full extent of its isolated effects on asthma still requires further exploration. Overall, while the results are promising, they remind us of the complexities involved in understanding traditional herbal treatments and their specific mechanisms.
Through our analysis using in vivo rat models, we observed significant interactions between quercetin and target genes associated with inflammation, specifically those active in the IL-17 signaling pathway. These interactions suggest that quercetin might help reduce lung inflammation when battling asthma symptoms.
We identified important compounds like quercetin and luteolin, revealing their potential therapeutic roles in this context. However, since quercetin is just one part of a larger herbal blend, the full extent of its isolated effects on asthma still requires further exploration. Overall, while the results are promising, they remind us of the complexities involved in understanding traditional herbal treatments and their specific mechanisms.
9
We explored the potential of quercetin, a key component of Bushenyiqi decoction (BYD), in treating asthma. Through a combination of network pharmacology and experimental validation, we examined its effects on asthma symptoms and the underlying mechanisms behind them.
Our research highlighted that BYD significantly improves airway responsiveness and decreases inflammation in allergic asthma mice. We identified quercetin, along with other active ingredients in BYD, as critical players in targeting specific genes related to asthma, particularly interleukin 6 (IL-6), epidermal growth factor receptor (EGFR), and hypoxia-inducible factor 1 alpha (HIF1A).
The phosphatidylinositol-3-kinase/AKT signaling pathway also emerged as crucial in this process. Our findings suggest that quercetin contributes to reducing inflammation and respiratory symptoms in asthma by regulating these targets.
Overall, this investigation underscores the importance of quercetin as a valuable element of BYD in mitigating asthma-related inflammation, providing new insights into traditional Chinese medicine's effective strategies.
Our research highlighted that BYD significantly improves airway responsiveness and decreases inflammation in allergic asthma mice. We identified quercetin, along with other active ingredients in BYD, as critical players in targeting specific genes related to asthma, particularly interleukin 6 (IL-6), epidermal growth factor receptor (EGFR), and hypoxia-inducible factor 1 alpha (HIF1A).
The phosphatidylinositol-3-kinase/AKT signaling pathway also emerged as crucial in this process. Our findings suggest that quercetin contributes to reducing inflammation and respiratory symptoms in asthma by regulating these targets.
Overall, this investigation underscores the importance of quercetin as a valuable element of BYD in mitigating asthma-related inflammation, providing new insights into traditional Chinese medicine's effective strategies.
References
- Sun B, Cai F, Yu L, An R, Wei B, et al. Quercetin inhibits ferroptosis through the SIRT1/Nrf2/HO-1 signaling pathway and alleviates asthma disease. Transl Pediatr. 2024;13:1747. doi:10.21037/tp-24-193
- Wang Y, Sui Y, Yao J, Jiang H, Tian Q, et al. Herb-CMap: a multimodal fusion framework for deciphering the mechanisms of action in traditional Chinese medicine using Suhuang antitussive capsule as a case study. Brief Bioinform. 2024;25. doi:10.1093/bib/bbae362
- Qin Z, Chen Y, Liu N, Wang Y, Su L, et al. Mechanisms of Bushenyiqi decoction in the treatment of asthma: an investigation based on network pharmacology with experimental validation. Front Pharmacol. 2024;15:1361379. doi:10.3389/fphar.2024.1361379
- Kryeziu I, Reçica S, Thaçi Q, Kurshumliu F, Hadzi-Petrushev N, et al. Quercetin supplementation attenuates airway hyperreactivity and restores airway relaxation in rat pups exposed to hyperoxia. Exp Biol Med (Maywood). 2023;248:1492. doi:10.1177/15353702231199468
- Rajizadeh MA, Bejeshk MA, Doustimotlagh AH, Najafipour H, Eftekhari M, et al. The Alleviating Impacts of Quercetin on Inflammation and Oxidant-antioxidant Imbalance in Rats with Allergic Asthma. Iran J Allergy Asthma Immunol. 2023;22:138. doi:10.18502/ijaai.v22i2.12675
- Fang Y, Jin W, Guo Z, Hao J. Quercetin Alleviates Asthma-Induced Airway Inflammation and Remodeling through Downregulating Periostin via Blocking TGF-β1/Smad Pathway. Pharmacology. 2023;108:432. doi:10.1159/000530703
- Liu X, Yu Y, Wu Y, Luo A, Yang M, et al. A systematic pharmacology-based in vivo study to reveal the effective mechanism of Yupingfeng in asthma treatment. Phytomedicine. 2023;114:154783. doi:10.1016/j.phymed.2023.154783
- Wang Y, Wan R, Peng W, Zhao X, Bai W, et al. Quercetin alleviates ferroptosis accompanied by reducing M1 macrophage polarization during neutrophilic airway inflammation. Eur J Pharmacol. 2023;938:175407. doi:10.1016/j.ejphar.2022.175407
- Yang Y, Lai Q, Wang C, Zhou G. Protective Effects of Aqueous Extract against OVA-Induced Airway Hyperresponsiveness and Inflammation in Asthmatic Mice. Evid Based Complement Alternat Med. 2022;2022:7609785. doi:10.1155/2022/7609785
- Zhang BB, Zeng MN, Zhang QQ, Wang R, Jia JF, et al. [Mechanism of "Ephedrae Herba-Descurainiae Semen Lepidii Semen" combination in treatment of bronchial asthma based on network pharmacology and experimental verification]. Zhongguo Zhong Yao Za Zhi. 2022;47:4996. doi:10.19540/j.cnki.cjcmm.20220211.403
