We explored a new approach to treat blood clots using piezoelectric selenene. This study introduced a unique design that combines selenene with platelet membranes, enhancing its ability to target thrombosis.
Under ultrasound, the selenene generates reactive oxygen species, effectively dissolving clots without the bleeding risks associated with traditional therapies.
In both lab and live animal tests, these selenium-based nanosheets demonstrated impressive results, outperforming a standard clinical drug. It's a promising step toward safer, more effective treatments for thrombosis.
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Ebselen delays blood clot formationAnti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expression.
Relevant to oxidative stress research
We explored the effects of ebselen, a selenium compound known for its antioxidant properties, on blood clot formation in rats. Our study demonstrated that ebselen significantly delayed thrombus formation in microvessels.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
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Selenium polymer reduces blood clotsMultifunctional Nitroso--acetylpenicillamine-Incorporated Medical-Grade Polymer with Selenium Interface for Biomedical Applications.
High relevance in medical devices
We explored the effectiveness of a new polymer infused with selenium in tackling blood clots and infections associated with medical devices. This SNAP-Se-1 composite works by releasing nitric oxide (NO), a natural defender against both issues. We found that it remarkably reduced platelet adhesion by 85.5% while also displaying antibacterial properties. Importantly, this innovative approach minimizes the need for traditional antibiotic treatments. Overall, while we see promising results in lab settings, further research is needed to confirm these benefits in real-world applications.
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Tocotrienols reduce blood clot formationTocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries.
Highly relevant for cardiovascular health
Our exploration focused on how tocotrienols, a form of vitamin E, influence blood clotting, especially in the context of risk factors like stroke. Using a canine model, we assessed the effects of tocotrienols on platelet aggregation and thrombus formation.
The findings revealed that tocotrienols significantly inhibited both platelet thrombus formation and collagen-induced platelet aggregation. We noticed that tocotrienols could be converted to tocopherols, which might add to their effectiveness. Overall, these results suggest tocotrienols could offer a therapeutic advantage in preventing serious cardiovascular events.
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Vitamin E may reduce blood clotsEffects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study.
High relevance to VTE treatment
We investigated whether vitamin E supplementation affects the risk of blood clots, specifically venous thromboembolism (VTE), in women. The Women's Health Study involved nearly 40,000 women who received either vitamin E or a placebo over more than ten years.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
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