Last update
3/14/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
USERS' SCORE
Moderately Good
Based on 1 Review
7.9
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Milk Thistle Phospholipid Proprietary BlendMilk thistle extract (fruit) [providing 480 mg silymarin, 180 mg silybin, 48 mg isosilybin A and isosilybin B], phospholipids
760 mg
**
SILIPHOS® phytosome milk thistle extract (fruit) [providing 47.52 mg silybin]
160 mg
**
Top Medical Research Studies
9
We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.
Read More
9
We explored the effects of silibinin on allergies by studying its impact on antibody production and T-cell responses in mice sensitized to ovalbumin. The mice received either no treatment or different doses of silibinin before being exposed to the allergen.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
Read More
8
Silybine shows potential against allergies
We observed the effects of silybine, a key component derived from Silybum marianum seeds, on allergic reactions in rats. The study revealed that silybine can lower blood pressure and inhibit the severe responses associated with anaphylactic shock.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
Read More
Most Useful Reviews
2
Product caused irritation
8 people found this helpful
While this Life Extension product is good quality, it caused my eyes to itch and become irritated. I have seasonal allergies, including to pollen, which may explain my reaction. I have used other milk thistle products without adverse effects. Although I was sensitive to this product, others may not have the same experience.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
- All Researches
9
We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.
Read More
9
We explored the effects of silibinin on allergies by studying its impact on antibody production and T-cell responses in mice sensitized to ovalbumin. The mice received either no treatment or different doses of silibinin before being exposed to the allergen.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
Read More
9
We explored how silymarin, a natural compound from milk thistle, impacts UV light-induced immune suppression and oxidative stress. Testing on mice showed that silymarin treatment significantly enhanced the skin's immune response, reducing harmful leukocyte infiltration and lowering levels of immunosuppressive cytokines.
Notably, silymarin also decreased the production of reactive oxygen species and nitric oxide linked to skin damage. Our findings suggest that silymarin could be a promising candidate for developing skincare products or sunscreens aimed at preventing skin cancer.
Notably, silymarin also decreased the production of reactive oxygen species and nitric oxide linked to skin damage. Our findings suggest that silymarin could be a promising candidate for developing skincare products or sunscreens aimed at preventing skin cancer.
Read More
8
Silybine shows potential against allergies
We observed the effects of silybine, a key component derived from Silybum marianum seeds, on allergic reactions in rats. The study revealed that silybine can lower blood pressure and inhibit the severe responses associated with anaphylactic shock.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 1 Review
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
2
Product caused irritation
8 people found this helpful
While this Life Extension product is good quality, it caused my eyes to itch and become irritated. I have seasonal allergies, including to pollen, which may explain my reaction. I have used other milk thistle products without adverse effects. Although I was sensitive to this product, others may not have the same experience.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Choi YH, Jin GY, Guo HS, Piao HM, Li Lc, et al. Silibinin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2012;427:450. 10.1016/j.bbrc.2012.07.112
- Kuo FH, Jan TR. Silibinin attenuates antigen-specific IgE production through the modulation of Th1/Th2 balance in ovalbumin-sensitized BALB/c mice. Phytomedicine. 2009;16:271. 10.1016/j.phymed.2008.07.006
- Katiyar SK. Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin. Int J Oncol. 2002;21:1213. PubMed
- Lecomte J. [General pharmacologic properties of silybine and silymarine in the rat]. Arch Int Pharmacodyn Ther. 1975;214:165. PubMed
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