Last update
4/5/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
USERS' SCORE
Good
Based on 8 Reviews
8.1
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Milk Thistle Phospholipid Proprietary BlendMilk thistle extract (fruit) [providing 480 mg silymarin, 180 mg silybin, 48 mg isosilybin A and isosilybin B], phospholipids
760 mg
**
SILIPHOS® phytosome milk thistle extract (fruit) [providing 47.52 mg silybin]
160 mg
**
Top Medical Research Studies
9
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows immunosuppressive effects
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
9
Silibinin shows promise in autoimmunity
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
Most Useful Reviews
9
Good detox support
1 people found this helpful
I'm ordering this for the second time, and both my husband and I find it suits us well. The quality is excellent, the tablet size is manageable, the ingredients are natural, and the taste is neutral. My liver feels rewarded with the benefits of this good detox supplement, particularly useful for bile stagnation. I plan to order this again as it is the most natural remedy for the liver.
Read More
9
Lightness regained
4 people found this helpful
After a month of taking this supplement, the heaviness in my right side has diminished, bringing me a sense of lightness. I intend to order more. Thank you!
Read More
8
Reduced symptoms
1 people found this helpful
I've been using Milk Thistle to support my liver health, recognising its active ingredient, silymarin, for its antioxidant and anti-inflammatory properties. I've noticed a significant reduction in symptoms linked to liver disorders, such as fatigue and indigestion. The pills are a manageable size, and I've had no adverse effects. Overall, I'm satisfied with the quality of this supplement.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
- All Researches
9
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows promise in autoimmunity
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
9
We analyzed how Silymarin affects the Pdx1 gene expression and insulin production in a model of diabetes following partial pancreatic removal. With 72 rats divided into groups, those treated with Silymarin showed significant increases in both Pdx1 and insulin levels compared to untreated rats.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Read More
9
Silibinin shows immunosuppressive effects
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
8
Silymarin shows promise for MS
We explored the impact of silymarin, a compound from milk thistle, on the immune system in patients with multiple sclerosis (MS). By isolating Th1 cells from both newly diagnosed and treatment-receiving patients, we assessed how silymarin affected cell activity at various doses and times.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Good detox support
1 people found this helpful
I'm ordering this for the second time, and both my husband and I find it suits us well. The quality is excellent, the tablet size is manageable, the ingredients are natural, and the taste is neutral. My liver feels rewarded with the benefits of this good detox supplement, particularly useful for bile stagnation. I plan to order this again as it is the most natural remedy for the liver.
Read More
9
Lightness regained
4 people found this helpful
After a month of taking this supplement, the heaviness in my right side has diminished, bringing me a sense of lightness. I intend to order more. Thank you!
Read More
8
Reduced symptoms
1 people found this helpful
I've been using Milk Thistle to support my liver health, recognising its active ingredient, silymarin, for its antioxidant and anti-inflammatory properties. I've noticed a significant reduction in symptoms linked to liver disorders, such as fatigue and indigestion. The pills are a manageable size, and I've had no adverse effects. Overall, I'm satisfied with the quality of this supplement.
Read More
7.5
Beneficial for family
1 people found this helpful
I've purchased this supplement for both myself and my dad multiple times. I take it as a precaution since my medications may impact liver function, while my dad was advised by his GP to use it and both of us find it beneficial. The product's quality is great! While the pills are on the larger side, they swallow easily and have no unpleasant taste.
Read More
7.5
Positive effects noted
1 people found this helpful
My first order from iHerb arrived promptly. I chose this product at random, and my liver responded well from the first capsule—it seemed to need this. After some time, I will provide an update on its effects, but I'm already noticing a positive response.
Read More
Frequently Asked Questions
9
Lightness regained
4 people found this helpful
After a month of taking this supplement, the heaviness in my right side has diminished, bringing me a sense of lightness. I intend to order more. Thank you!
7.5
Positive effect noted
Delivery is quick and the impact is noticeable immediately after consumption. I am pleased with the results and will certainly order again next time.
8
Reduced symptoms
1 people found this helpful
I've been using Milk Thistle to support my liver health, recognising its active ingredient, silymarin, for its antioxidant and anti-inflammatory properties. I've noticed a significant reduction in symptoms linked to liver disorders, such as fatigue and indigestion. The pills are a manageable size, and I've had no adverse effects. Overall, I'm satisfied with the quality of this supplement.
7.5
Positive effects noted
1 people found this helpful
My first order from iHerb arrived promptly. I chose this product at random, and my liver responded well from the first capsule—it seemed to need this. After some time, I will provide an update on its effects, but I'm already noticing a positive response.
9
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
7
Potential benefits but limited studies
We investigated how silymarin and its active ingredient, silibinin, can affect symptoms of rheumatoid arthritis (RA) and osteoarthritis (OA). Using a systematic review approach, we sifted through 437 studies, finally focusing on 21 relevant ones.
Our findings revealed that these compounds show impressive properties, such as reducing inflammation and pain and protecting joint health. However, we also noted that while the experimental evidence is promising, further clinical studies are crucial to confirm these benefits and guide effective treatment strategies.
Our findings revealed that these compounds show impressive properties, such as reducing inflammation and pain and protecting joint health. However, we also noted that while the experimental evidence is promising, further clinical studies are crucial to confirm these benefits and guide effective treatment strategies.
8
In our research, we examined the effects of silymarin (Livergol®) on rheumatoid arthritis (RA) in a small group of 44 stable patients. After 90 days of treatment, we noticed a significant decrease in the Disease Activity Score (DAS-28), which assesses inflammation levels. Specifically, patients reported improvement in their symptoms, suggesting potential anti-inflammatory benefits from silymarin due to its antioxidant properties. However, the exact ways it works remain unclear, highlighting the need for more extensive studies with cytokine measurement to unravel its mechanisms further.
7
We investigated how silymarin, sourced from milk thistle, affects activated T cells, which play a role in autoimmune disorders. The study examined the impact of various silymarin doses on cell cycle progression and a key signaling pathway in these immune cells.
Our findings revealed a notable G1 cell cycle arrest after treatment with a higher silymarin dose, showing its potential to inhibit T cell proliferation without causing cell death. Additionally, silymarin significantly suppressed mTOR activity in these cells.
While the study highlights promising immunomodulatory effects, the long-term significance for autoimmune treatment remains to be fully explored.
Our findings revealed a notable G1 cell cycle arrest after treatment with a higher silymarin dose, showing its potential to inhibit T cell proliferation without causing cell death. Additionally, silymarin significantly suppressed mTOR activity in these cells.
While the study highlights promising immunomodulatory effects, the long-term significance for autoimmune treatment remains to be fully explored.
References
- Ghahfarrokhi SH, Heidari-Soureshjani S, Sherwin CMT, Azadegan-Dehkordi Z. Efficacy and Mechanisms of , Silymarin, and Silibinin on Rheumatoid Arthritis and Osteoarthritis Symptoms: A Systematic Review. Curr Rheumatol Rev. 2024;20:414. 10.2174/0115733971266397231122080247
- Yang HL, Shi XW. Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation. Front Neurol. 2021;12:659678. 10.3389/fneur.2021.659678
- Ghiasian M, Nafisi H, Ranjbar A, Mohammadi Y, Ataei S. Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing-remitting multiple sclerosis: A clinical trial study. J Biochem Mol Toxicol. 2021;35:e22800. 10.1002/jbt.22800
- Navabi F, Shaygannejad V, Abbasirad F, Vaez E, Hosseininasab F, et al. Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-ß-Treated MS Patients. Inflammation. 2019;42:54. 10.1007/s10753-018-0872-x
- Dupuis ML, Conti F, Maselli A, Pagano MT, Ruggieri A, et al. The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis. Front Immunol. 2018;9:1903. 10.3389/fimmu.2018.01903
- Shavandi M, Moini A, Shakiba Y, Mashkorinia A, Dehghani M, et al. Silymarin (Livergol®) Decreases Disease Activity Score in Patients with Rheumatoid Arthritis: A Non-randomized Single-arm Clinical Trial. Iran J Allergy Asthma Immunol. 2017;16:99. PubMed
- Soto C, Raya L, Juárez J, Pérez J, González I. Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic β-cells in a pancreatectomy model. Phytomedicine. 2014;21:233. 10.1016/j.phymed.2013.09.008
- Gharagozloo M, Javid EN, Rezaei A, Mousavizadeh K. Silymarin inhibits cell cycle progression and mTOR activity in activated human T cells: therapeutic implications for autoimmune diseases. Basic Clin Pharmacol Toxicol. 2013;112:251. 10.1111/bcpt.12032
- Min K, Yoon WK, Kim SK, Kim BH. Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis. Arch Pharm Res. 2007;30:1265. PubMed
Data last updated:
