Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
125 mcg
625%
Vitamin K activity from:Vitamin K1 (as phytonadione)Vitamin K2 (as menaquinone-4)Vitamin K2 (as trans menaquinone-7)
2,100 mcg1,000 mcg1,000 mcg100 mcg
1,750%
Iodine [from Sea-Iodine™ Complex Blend (organic kelp and bladderwrack extracts, potassium iodide)]
1,000 mcg
667%
Top Medical Research Studies
We aimed to explore how vitamin D3 supplementation affects liver disease, specifically in patients with cirrhosis. In a thorough double-blind, randomized controlled trial involving 60 participants, we offered patients either a weekly dose of 50,000 IU of vitamin D or a placebo for 12 weeks. Our goal was to assess various health indicators, including serum vitamin D levels, blood glucose measures, and liver function tests.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
Read More
9
We explored the potential of vitamin D3 in mitigating liver disease associated with a high-fat diet. In our study, male mice were placed on a high-fat diet for 16 weeks while receiving regular vitamin D3 injections. This setup allowed us to effectively gauge the compound's impact on liver health.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
Read More
9
We explored how vitamin D3 impacts non-alcoholic fatty liver disease (NAFLD) and its influence on liver immune cells. In an exciting study, researchers set up an experiment using mice on a high-fat diet to create a model of NAFLD. The mice received 1,25-dihydroxyvitamin D, a potent form of vitamin D3, to see if it could counteract the detrimental effects of fatty liver condition.
The findings were promising. The treatment improved liver fat levels and enhanced lipid metabolism. It achieved this, in part, by reversing the polarization of inflammatory immune cells in the liver. Specifically, the vitamin D3 appeared to lower the presence of pro-inflammatory M1 macrophages, which are linked to greater liver fat accumulation. The research suggested that vitamin D3 works through specific pathways in the body, hinting at its potential as a helpful supplement for individuals struggling with liver fat issues.
Overall, this study highlights the therapeutic promise of 1,25(OH)D for improving liver health in the context of obesity-related conditions. While there’s more to uncover, the results offer hope for better management strategies for NAFLD in the future.
The findings were promising. The treatment improved liver fat levels and enhanced lipid metabolism. It achieved this, in part, by reversing the polarization of inflammatory immune cells in the liver. Specifically, the vitamin D3 appeared to lower the presence of pro-inflammatory M1 macrophages, which are linked to greater liver fat accumulation. The research suggested that vitamin D3 works through specific pathways in the body, hinting at its potential as a helpful supplement for individuals struggling with liver fat issues.
Overall, this study highlights the therapeutic promise of 1,25(OH)D for improving liver health in the context of obesity-related conditions. While there’s more to uncover, the results offer hope for better management strategies for NAFLD in the future.
Read More
Most Useful Reviews
9
Liver cleansing
1 people found this helpful
A standout product that ensures prices remain stable. The ingredients and quantities are ample, making it suitable for my age group. The packaging is adequate and the benefits are remarkable, serving as a crucial diet for body cleansing, effectively detoxifying. The composition is impressive, acting as a strong oxidiser for the liver, and it has no discernible taste. The quantity meets my needs, and I appreciate its consistent benefits—it's essential for maintaining my health.
Read More
7.5
Vitamin provision
A good product that includes vitamin K, essential for liver health and overall bodily wellness. I believe it is crucial to provide all necessary vitamins for optimal health. I recommend lowering the price for wider accessibility.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
- All Researches
We aimed to explore how vitamin D3 supplementation affects liver disease, specifically in patients with cirrhosis. In a thorough double-blind, randomized controlled trial involving 60 participants, we offered patients either a weekly dose of 50,000 IU of vitamin D or a placebo for 12 weeks. Our goal was to assess various health indicators, including serum vitamin D levels, blood glucose measures, and liver function tests.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
Read More
9
We explored the potential of vitamin D3 in mitigating liver disease associated with a high-fat diet. In our study, male mice were placed on a high-fat diet for 16 weeks while receiving regular vitamin D3 injections. This setup allowed us to effectively gauge the compound's impact on liver health.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
Read More
9
Calcitriol mitigates liver toxicity
We examined the potential of calcitriol, also known as vitamin D3, to protect the liver from damage caused by cisplatin, a commonly used chemotherapy drug. In this study, mice were split into groups to assess the effects of calcitriol alone, cisplatin alone, and the combination of both. Notably, calcitriol was given to some mice leading up to the administration of cisplatin.
Our observations showed that calcitriol significantly helped in reversing the liver damage induced by cisplatin. This was noticeable through improved liver and kidney function tests, as well as better histological results. Additionally, calcitriol appeared to reduce oxidative stress and inflammation in both the liver and kidneys while enhancing the expression of certain protective proteins.
We also noted that calcitriol played a role in lowering inflammation markers and promoting cell survival by downregulating harmful proteins. Interestingly, when calcitriol was given alongside cisplatin, the liver's resilience against cisplatin's toxic effects was markedly enhanced. Overall, our findings suggest that calcitriol may offer a protective strategy against liver damage caused by chemotherapy, primarily through its anti-inflammatory and antioxidant properties.
Our observations showed that calcitriol significantly helped in reversing the liver damage induced by cisplatin. This was noticeable through improved liver and kidney function tests, as well as better histological results. Additionally, calcitriol appeared to reduce oxidative stress and inflammation in both the liver and kidneys while enhancing the expression of certain protective proteins.
We also noted that calcitriol played a role in lowering inflammation markers and promoting cell survival by downregulating harmful proteins. Interestingly, when calcitriol was given alongside cisplatin, the liver's resilience against cisplatin's toxic effects was markedly enhanced. Overall, our findings suggest that calcitriol may offer a protective strategy against liver damage caused by chemotherapy, primarily through its anti-inflammatory and antioxidant properties.
Read More
9
We explored how vitamin D3 impacts non-alcoholic fatty liver disease (NAFLD) and its influence on liver immune cells. In an exciting study, researchers set up an experiment using mice on a high-fat diet to create a model of NAFLD. The mice received 1,25-dihydroxyvitamin D, a potent form of vitamin D3, to see if it could counteract the detrimental effects of fatty liver condition.
The findings were promising. The treatment improved liver fat levels and enhanced lipid metabolism. It achieved this, in part, by reversing the polarization of inflammatory immune cells in the liver. Specifically, the vitamin D3 appeared to lower the presence of pro-inflammatory M1 macrophages, which are linked to greater liver fat accumulation. The research suggested that vitamin D3 works through specific pathways in the body, hinting at its potential as a helpful supplement for individuals struggling with liver fat issues.
Overall, this study highlights the therapeutic promise of 1,25(OH)D for improving liver health in the context of obesity-related conditions. While there’s more to uncover, the results offer hope for better management strategies for NAFLD in the future.
The findings were promising. The treatment improved liver fat levels and enhanced lipid metabolism. It achieved this, in part, by reversing the polarization of inflammatory immune cells in the liver. Specifically, the vitamin D3 appeared to lower the presence of pro-inflammatory M1 macrophages, which are linked to greater liver fat accumulation. The research suggested that vitamin D3 works through specific pathways in the body, hinting at its potential as a helpful supplement for individuals struggling with liver fat issues.
Overall, this study highlights the therapeutic promise of 1,25(OH)D for improving liver health in the context of obesity-related conditions. While there’s more to uncover, the results offer hope for better management strategies for NAFLD in the future.
Read More
9
We set out to understand how vitamin D3 affects individuals with autoimmune hepatitis (AIH). Our retrospective cohort study gathered data from the vast TriNetX research network, focusing on patients diagnosed with AIH. Participants were categorized based on their vitamin D levels: sufficient, insufficient, and deficient.
Our analysis revealed some concerning findings. We observed that those with vitamin D deficiency had significantly higher odds of all-cause mortality compared to patients with normal levels. This translated to a 3.2 times increase in the likelihood of death. Additionally, vitamin D deficiency was linked to higher rates of hospitalization, critical care admissions, decompensated liver cirrhosis, acute liver failure, and even the need for liver transplants.
Quite simply, vitamin D deficiency appears to negatively influence the health outcomes of patients with AIH. Our research suggests that maintaining adequate vitamin D levels could be crucial for individuals suffering from this liver condition.
Our analysis revealed some concerning findings. We observed that those with vitamin D deficiency had significantly higher odds of all-cause mortality compared to patients with normal levels. This translated to a 3.2 times increase in the likelihood of death. Additionally, vitamin D deficiency was linked to higher rates of hospitalization, critical care admissions, decompensated liver cirrhosis, acute liver failure, and even the need for liver transplants.
Quite simply, vitamin D deficiency appears to negatively influence the health outcomes of patients with AIH. Our research suggests that maintaining adequate vitamin D levels could be crucial for individuals suffering from this liver condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Liver cleansing
1 people found this helpful
A standout product that ensures prices remain stable. The ingredients and quantities are ample, making it suitable for my age group. The packaging is adequate and the benefits are remarkable, serving as a crucial diet for body cleansing, effectively detoxifying. The composition is impressive, acting as a strong oxidiser for the liver, and it has no discernible taste. The quantity meets my needs, and I appreciate its consistent benefits—it's essential for maintaining my health.
Read More
7.5
Vitamin provision
A good product that includes vitamin K, essential for liver health and overall bodily wellness. I believe it is crucial to provide all necessary vitamins for optimal health. I recommend lowering the price for wider accessibility.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Derogar Kasmaei SR, Parastouei K, Hosseini Ahangar B, Saberifiroozi M, Taghdir M. Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial. BMJ Nutr Prev Health. 2024;7:e000938. 10.1136/bmjnph-2024-000938
- Liu N, Zhao P, Cao P, Hui J, Pan Y, et al. Vitamin D3/VDR alleviates double-stranded RNA virus -induced biliary epithelial cell damage by inhibiting autophagy. BMC Gastroenterol. 2025;25:44. 10.1186/s12876-025-03640-5
- Miao Y, Jiang Z, Song H, Zhang Y, Chen H, et al. Vitamin D supplementation alleviates high fat diet-induced metabolic associated fatty liver disease by inhibiting ferroptosis pathway. Eur J Nutr. 2024;64:50. 10.1007/s00394-024-03554-0
- Morsy MA, Abdel-Latif R, Ibrahim MF, Marey H, Abdel-Gaber SA. Calcitriol ameliorates cisplatin-induced hepatorenal toxicity via regulation of Nrf2-Mrp2/p38 MAPK signaling in mice. Int J Immunopathol Pharmacol. 2024;38:3946320241306276. 10.1177/03946320241306276
- Luo WJ, Dong XW, Ye H, Zhao QS, Zhang QB, et al. Vitamin D 1,25-Dihydroxyvitamin D reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization. World J Gastrointest Oncol. 2024;16:4685. 10.4251/wjgo.v16.i12.4685
- Kilani Y, Alsakarneh S, Madi MY, Mosquera DAG, Ferreira MN, et al. Autoimmune Hepatitis and Vitamin D Deficiency: A Nationwide Perspective. Aliment Pharmacol Ther. 2025;61:682. 10.1111/apt.18438
- Dai J, Song J, Chen X, Ding F, Ding Y, et al. 1,25(OH)D-treated mouse bone marrow-derived dendritic cells alleviate autoimmune hepatitis in mice by improving TFR/TFH imbalance. Immunopharmacol Immunotoxicol. 2025;47:59. 10.1080/08923973.2024.2435314
- Yaribeygi H, Ramezani M, Katsiki N, Mirmohammadkhani M, Tabaei NS. Efficacy of Adding Sitagliptin to Ongoing Metformin on Metabolic Profile, Triglyceride-Glucose Index, Vitamin D3, and Liver Tests in Patients Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease: A Double-Blind Randomized Clinical Trial. Curr Ther Res Clin Exp. 2024;101:100764. 10.1016/j.curtheres.2024.100764
- Farrash WF, Idris S, Elzubier ME, Khidir EBA, Aslam A, et al. Enhanced hepatoprotective effects of empagliflozin and vitamin D dual therapy against metabolic dysfunction-associated steatohepatitis in mice by boosted modulation of metabolic, oxidative stress, and inflammatory pathways. Int J Exp Pathol. 2024;105:219. 10.1111/iep.12519
- Dharshan SS, Ramamurthy K, Kaliraj S, Manikandan K, Chitra V, et al. Combined effects of vitamin D3 and dioxopiperidinamide derivative on lipid homeostasis, inflammatory pathways, and redox imbalance in non-alcoholic fatty liver disease in vivo zebrafish model. Biotechnol Appl Biochem. 2024. 10.1002/bab.2666
- Fogacci F, Giovannini M, Di Micoli V, Grandi E, Borghi C, et al. Effect of Supplementation of a Butyrate-Based Formula in Individuals with Liver Steatosis and Metabolic Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Nutrients. 2024;16. 10.3390/nu16152454
- Abdel-Hamid GR, Mostafa DM, Fathy RM, Lotfy DM, Osman S. Cytokine storm modulation using cholecalciferol and low dose gamma radiation in Escherichia coli infected mice. Cell Biochem Funct. 2024;42:e4026. 10.1002/cbf.4026
- Yang A, Chen Y, Gao Y, Lv Q, Li Y, et al. Vitamin D exacerbates steatosis while calcipotriol inhibits inflammation in non-alcoholic fatty liver disease in knockout mice: a comparative study of two forms of vitamin D. Food Funct. 2024;15:4614. 10.1039/d4fo00215f
- Lu Y, Chen H, Chen Y, Zhao L, Hou S. Accumulated LPS induced by colitis altered the activities of vitamin D-metabolizing hydroxylases and decreased the generation of 25-hydroxyvitamin D. Chem Biol Interact. 2024;395:110997. 10.1016/j.cbi.2024.110997
- Lee SB, Jin MH, Yoon JH. The contribution of vitamin D insufficiency to the onset of steatotic liver disease among individuals with metabolic dysfunction. Sci Rep. 2024;14:6714. 10.1038/s41598-024-57380-9
- Guo E, Yuan H, Li R, Yang J, Liu S, et al. Calcitriol ameliorates the progression of hepatic fibrosis through autophagy-related gene 16-like 1-mediated autophagy. Am J Med Sci. 2024;367:382. 10.1016/j.amjms.2024.02.010
