Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
USERS' SCORE
Moderately Good
Based on 47 Reviews
7.4
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Magnesium [as magnesium oxide, citrate, succinate)
500 mg
119%
Top Medical Research Studies
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
Most Useful Reviews
9
Emotional stability
215 people found this helpful
I noticed various forms of magnesium in this product, although the manufacturer did not specify their ratios. After a month, I've felt remarkably calmer, observing that the emotional reactions of others no longer affect me as they did before. However, it's essential to consult with a doctor before using it to ensure it's right for your autoimmune disorder.
9
Emotional regulation
36 people found this helpful
I've struggled to control my emotions recently, becoming aggressive unexpectedly. After starting magnesium, I felt a significant change; I stopped swearing entirely. Additionally, my legs no longer go numb after extended periods of sitting. I'm now ordering more for my husband as well.
9
Better sleep quality
11 people found this helpful
Perfect! I began taking magnesium after childbirth for nervous tension, and it worked wonders. I’ve taken it for almost three years, improving my sleep and calming my muscles. Other brands didn't help me, but this one remains the best.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
- All Researches
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
9
We explored the potential of a new magnesium-aluminum layered double hydroxide combined with nano-ceria in treating rheumatoid arthritis (RA). This innovative therapy targets the unhealthy immune environment and the harmful buildup of hydrogen ions associated with RA. By neutralizing excess acidity, we observed improved immune responses, encouraging the body to heal damaged bones. This approach showed promising results in mice models, indicating it may be a viable future treatment for managing RA effectively.
9
Magnesium aids arthritis through immunity
We explored the effects of a high magnesium diet on rheumatoid arthritis using two mouse models. Our findings suggest that magnesium can significantly reduce arthritis severity and joint damage, while also promoting immune cell types that help combat inflammation.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
9
Magnesium mitigates MS-related mood issues
We investigated the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression in multiple sclerosis (MS), a disease often accompanied by these mood disorders. Our findings indicated that MgH treatment significantly improved anxiety and depression-like behaviors in mice with experimental autoimmune encephalomyelitis (EAE).
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
User Reviews
USERS' SCORE
Moderately Good
Based on 47 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Emotional stability
215 people found this helpful
I noticed various forms of magnesium in this product, although the manufacturer did not specify their ratios. After a month, I've felt remarkably calmer, observing that the emotional reactions of others no longer affect me as they did before. However, it's essential to consult with a doctor before using it to ensure it's right for your autoimmune disorder.
9
Emotional regulation
36 people found this helpful
I've struggled to control my emotions recently, becoming aggressive unexpectedly. After starting magnesium, I felt a significant change; I stopped swearing entirely. Additionally, my legs no longer go numb after extended periods of sitting. I'm now ordering more for my husband as well.
9
Better sleep quality
11 people found this helpful
Perfect! I began taking magnesium after childbirth for nervous tension, and it worked wonders. I’ve taken it for almost three years, improving my sleep and calming my muscles. Other brands didn't help me, but this one remains the best.
9
Relieves muscle cramps
10 people found this helpful
This magnesium is the best I've tried. It relaxes my body and acts like a sleeping pill. Taken for constipation, it’s very effective. My leg cramps and muscle pain have eased, and I'm pleased with the results.
0
Prefer smaller dosage
8 people found this helpful
I ordered this for a friend, but I wouldn’t buy it for myself. I find 500mg of 95% oxide less useful as I prefer smaller, more digestible dosages.
Frequently Asked Questions
7.5
Calmer nerves
841 people found this helpful
The vitamins have a pleasant appearance and no taste, though they do have a smell. Their white shell is rather large, making them hard to swallow; it's better to drink plenty of water. After a month of use, I've noticed improvements in my autoimmune disorder. My husband has experienced similarly positive changes; we both feel calmer in stressful situations, with relaxed muscles and improved immune function.
9
Heart rhythm support
49 people found this helpful
I took MAGNEROT for heart rhythm disturbances upon my cardiologist's advice, but it wasn't entirely effective. Switching to this magnesium provided near-complete relief of my autoimmune disorder symptoms. My sleep improved, and I’ve been very pleased with the results.
0
Not beneficial
1 people found this helpful
I've encountered continual digestive issues with these capsules. The forms of magnesium used are not ideal for absorption, and I have not observed any improvement regarding my autoimmune disorder. Money wasted.
9
Emotional stability
215 people found this helpful
I noticed various forms of magnesium in this product, although the manufacturer did not specify their ratios. After a month, I've felt remarkably calmer, observing that the emotional reactions of others no longer affect me as they did before. However, it's essential to consult with a doctor before using it to ensure it's right for your autoimmune disorder.
9
Relieves muscle cramps
10 people found this helpful
This magnesium is the best I've tried. It relaxes my body and acts like a sleeping pill. Taken for constipation, it’s very effective. My leg cramps and muscle pain have eased, and I'm pleased with the results.
9
Emotional regulation
36 people found this helpful
I've struggled to control my emotions recently, becoming aggressive unexpectedly. After starting magnesium, I felt a significant change; I stopped swearing entirely. Additionally, my legs no longer go numb after extended periods of sitting. I'm now ordering more for my husband as well.
0
Digestive discomfort
1 people found this helpful
My husband and I took these capsules for a couple of weeks, but they upset our stomachs, causing gas and diarrhoea. I gave them another chance, but the same issues arose. I cannot recommend this product at all.
7.5
Supports autoimmune health
13 people found this helpful
A good working magnesium! I take it with vitamin B6 to alleviate painful nocturnal cramps and constipation. This magnesium has positively impacted my health for my autoimmune disorder, and I recommend it to everyone.
0
Poor absorption noted
1 people found this helpful
Unfortunately, I didn't check the composition before ordering. It seems to contain magnesium oxide, which is poorly absorbed and irritates the intestine. I regret this purchase as it does not benefit my autoimmune disorder.
0
Ineffective form
1 people found this helpful
Magnesium oxide is the least effective form for absorption. I don't understand its purpose; I mistakenly ordered it. I recommend other forms like citrate or glycinate.
9
Nerve health benefits
1 people found this helpful
An outstanding product for nerve health. It has significantly strengthened my nerves, leading to improvements in my bipolar disorder. I feel more at ease, and it has positive effects on my brain and overall organ health. I take two pills a day without side effects. Highly recommended.
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
8
We explored the relationship between dietary magnesium intake and all-cause mortality in patients with rheumatoid arthritis (RA) using data from the NHANES database.
Analyzing nearly 3,000 RA patients, we found that those who consumed higher magnesium levels experienced an 11.12% lower risk of death.
This benefit was particularly notable in younger individuals under 65, females, and those with a lower body mass index.
This suggests that adequate magnesium intake could play a vital role in improving survival outcomes for RA patients.
Analyzing nearly 3,000 RA patients, we found that those who consumed higher magnesium levels experienced an 11.12% lower risk of death.
This benefit was particularly notable in younger individuals under 65, females, and those with a lower body mass index.
This suggests that adequate magnesium intake could play a vital role in improving survival outcomes for RA patients.
References
- Toaima DN, Abdel-Maksoud KS, Atef HM, Salah NY. Magnesium, fibrinolysis and clotting interplay among children and adolescents with type 1 diabetes mellitus; potential mediators of diabetic microangiopathy. Nutr Diabetes. 2025;15:13. doi:10.1038/s41387-025-00368-9
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. doi:10.3390/nu16234247
- Fu C, Huang L, Lian C, Yue J, Lin P, et al. Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood-brain barrier integrity in mice with neuromyelitis optica spectrum disorder. Brain Res. 2025;1846:149234. doi:10.1016/j.brainres.2024.149234
- Yan Y, Yao C, Zhang B, Yang Z, Xie J, et al. Olanzapine vs. magnesium valproate vs. lamotrigine in anti-N-methyl-D-aspartic acid receptor encephalitis: a retrospective study. BMC Neurol. 2024;24:331. doi:10.1186/s12883-024-03811-z
- Verlato A, Laragione T, Bin S, Kim RH, Salem F, et al. Revised version with tracked changes oral Magnesium reduces levels of pathogenic autoantibodies and skin disease in murine lupus. BMC Immunol. 2024;25:58. doi:10.1186/s12865-024-00650-y
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. doi:10.1186/s41043-024-00597-1
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. doi:10.1002/advs.202307094
- Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. doi:10.1186/s12889-023-16906-y
- Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. doi:10.1016/j.ebiom.2023.104603
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
