Last update
11/3/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Moderately Good
Based on 75 Reviews
7.7
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Magnesium [as magnesium oxide, citrate, succinate)
500 mg
119%
Top Medical Research Studies
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
7
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
Most Useful Reviews
7.5
No bone pain
490 people found this helpful
Working magnesium is excellent. I take one pill in the evening after discovering my magnesium levels were nearly zero. Despite being an emotional person, I've noticed no muscle pain or nerve issues during its use—it's clearly effective!
Read More
7.5
Improved bone health
421 people found this helpful
I appreciate the favourable packaging and cost of this magnesium supplement. After three months, I felt improvements: my bone pain and irritability diminished, and my sleep quality improved. This magnesium helped alleviate symptoms of deficiency without side effects.
Read More
7.5
No bone crunching
291 people found this helpful
I chose this magnesium after consulting my doctor. The capsules worked well, and after a week, the crunching in my bones stopped.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
- All Researches
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 75 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
No bone pain
490 people found this helpful
Working magnesium is excellent. I take one pill in the evening after discovering my magnesium levels were nearly zero. Despite being an emotional person, I've noticed no muscle pain or nerve issues during its use—it's clearly effective!
Read More
7.5
Improved bone health
421 people found this helpful
I appreciate the favourable packaging and cost of this magnesium supplement. After three months, I felt improvements: my bone pain and irritability diminished, and my sleep quality improved. This magnesium helped alleviate symptoms of deficiency without side effects.
Read More
7.5
No bone crunching
291 people found this helpful
I chose this magnesium after consulting my doctor. The capsules worked well, and after a week, the crunching in my bones stopped.
Read More
9
Reduced bone pain
44 people found this helpful
I experienced severe stomach pain during my pregnancy. After being advised to take magnesium, my spasms greatly reduced within three days, which helped alleviate my bone pain and improve my overall well-being.
Read More
9
Less back pain
17 people found this helpful
I began taking magnesium for my back pain. Within days, the discomfort lessened significantly, and it nearly disappeared with continued use. If I skip it, the pain returns.
Read More
Frequently Asked Questions
7.5
No bone crunching
291 people found this helpful
I chose this magnesium after consulting my doctor. The capsules worked well, and after a week, the crunching in my bones stopped.
9
Less back pain
17 people found this helpful
I began taking magnesium for my back pain. Within days, the discomfort lessened significantly, and it nearly disappeared with continued use. If I skip it, the pain returns.
7.5
Improved bone health
421 people found this helpful
I appreciate the favourable packaging and cost of this magnesium supplement. After three months, I felt improvements: my bone pain and irritability diminished, and my sleep quality improved. This magnesium helped alleviate symptoms of deficiency without side effects.
9
Improves bone pain
5 people found this helpful
After several months of using this magnesium supplement, I've noticed an improvement in my energy levels and vitality. My muscle cramps have decreased, and my sleep quality has increased significantly. The formula allows for optimal absorption, making it an essential part of my routine.
0
Severe stomach issues
2 people found this helpful
Unfortunately, this magnesium caused me severe stomach pain and diarrhoea after just four days of use; it was my only experience with it.
9
Reduced bone pain
44 people found this helpful
I experienced severe stomach pain during my pregnancy. After being advised to take magnesium, my spasms greatly reduced within three days, which helped alleviate my bone pain and improve my overall well-being.
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
References
- Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. 10.3389/fbioe.2023.1153969
- Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593.
- Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.
