Overview

SCIENTIFIC SCORE
Questionable
Based on 23 Researches
6.6
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.8
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Magnesium [as magnesium oxide, citrate, succinate)
500 mg
119%

Top Medical Research Studies

9
Magnesium implantation improves heart recovery
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.

Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.

Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
8
Magnesium levels impact heart attack outcomes
We examined whether serum magnesium levels at admission could predict in-hospital outcomes for patients experiencing a heart attack.

In our study of 259 acute myocardial infarction patients, those with lower magnesium levels (below 1.82 mg/dl) faced significantly higher risks of complications, including arrhythmias and even death, compared to those with healthier levels.

Our findings suggest that maintaining adequate magnesium levels is essential for better health outcomes after a heart attack.
5
OCT and angiography show comparable effectiveness
We examined how two guidance methods—optical coherence tomography (OCT) and angiography—perform during magnesium bioresorbable scaffold (MBRS) implantation in patients recovering from a non-ST-elevation heart attack.

With 75 participants, our study revealed that both techniques resulted in comparable healing patterns after six months. Though OCT-guided intervention showed slightly better outcomes in certain technical measures, neither approach demonstrated a significant advantage in overall heart healing.

Thus, for NSTEMI patients, choosing between OCT and angiography for MBRS placement may depend on other factors, as both methods appear effective.

Most Useful Reviews

9
Reduces heart issues
6 people found this helpful
Life Extension's magnesium supplement is fantastic. It aids in recovery and alleviates stress due to deficiencies. It helps with heart health and lowers blood pressure, enhances energy production, and improves sleep. This supplement also has anti-inflammatory benefits, making it a vital part of my diet.
9
Improved energy
2 people found this helpful
Since starting this magnesium supplement, I feel more energetic and experience less pain overall, including in my heart. I will continue using this supplement and highly recommend it to others for heart health.
9
Pain reduction noted
1 people found this helpful
I bought this due to heart pain and noticed a 90% reduction in pain within two weeks. The quality is high, and it regulates sleep while also offering muscle and joint support. Magnesium is essential for our bodies.

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 23 Researches
6.6
  • All Researches
9
Magnesium implantation improves heart recovery
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.

Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.

Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
9
Magnesium scaffolds improve heart attack outcomes
We examined the performance of two types of bioresorbable scaffolds in patients experiencing acute coronary syndrome (ACS) - a common and serious manifestation of heart disease. Specifically, we compared the effectiveness of magnesium-based scaffolds, known as Magmaris, with the earlier polymer scaffolds called Absorb.

Our study included 193 patients using Magmaris and 160 patients using Absorb, all treated in similar clinical settings. Over the course of one year, we monitored their health outcomes, particularly focusing on serious issues like cardiac death, heart attacks, and instances of scaffold thrombosis.

Surprisingly, we found that patients with Magmaris had significantly better outcomes than those with Absorb. Specifically, the rates of primary complications and target lesion failures were notably lower with Magmaris. We noted a concerning trend with Absorb, where patients experienced a higher rate of scaffold thrombosis.

Overall, our findings suggest that magnesium-based scaffolds could provide a safer and more effective option for patients undergoing treatment for heart attacks compared to their polymer counterparts.
8
Magnesium enhances heart attack recovery
We explored an innovative approach to treating myocardial infarction (MI) by using a special composite hydrogel that incorporates magnesium-modified black phosphorus nanosheets. This treatment aims to address the significant changes in the heart's environment after a heart attack, which are usually detrimental to recovery.

The research involved creating a hydrogel scaffold that allows for the gradual release of these magnesium-enhanced nanosheets directly at the site of the infarct. This is particularly important because sustained release helps to manage oxidative stress and inflammation, both common issues following a heart attack.

We observed that the black phosphorus nanosheets have a high reactivity with reactive oxygen species (ROS), which helps reduce oxidative stress and inflammation in the heart. Additionally, the magnesium contributes to promoting blood vessel growth, or angiogenesis, which is crucial for long-term heart function after an MI.

Overall, the findings of this study suggest that the combination of these elements in the hydrogel can effectively block further damage from the heart attack and improve recovery outcomes, signaling a promising avenue for heart attack treatments in the future.
8
Magnesium improves heart recovery
In our investigation, we set out to understand how magnesium lithospermate B (MLB) can aid heart repair following a heart attack. We used a mouse model with surgically induced myocardial infarction (MI) and categorized the mice into five groups, including those treated with MLB and human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). By comparing different treatments, we evaluated the heart's recovery over four weeks through echocardiography and histochemical staining.

Our findings revealed that MLB significantly enhances the function of hiPSC-CMs, helping to repair the damaged heart muscle. This improvement happens by boosting the function of endothelial cells—important for blood vessel health—through a specific signaling pathway. Additionally, MLB decreases apoptosis, or cell death, in hiPSC-CMs by activating another pathway, which further supports heart recovery.

Overall, our work underscores the role of MLB in improving heart repair after a heart attack. While it was tested in tandem with hiPSC-CMs, which makes it an interesting combination for treatment strategies, it's clear that the integration of MLB can potentially enhance cardiac recovery mechanisms effectively.
8
Low magnesium indicates higher mortality
We explored how serum magnesium levels at the time of hospital admission affect the long-term health of patients experiencing a non-ST-elevation myocardial infarction (NSTEMI). In our analysis of data from over 4,500 patients, we focused on the differences between those with low serum magnesium levels—defined as below 1.9 mg/dL—and those with normal or higher levels.

Our findings indicate that patients with low magnesium levels were older, had more health complications like diabetes and hypertension, and faced a higher long-term risk of mortality. Specifically, we observed that 34% of patients with low magnesium levels died within four years, compared to 22% of those with adequate levels.

Importantly, even after adjusting for factors such as sex, existing health conditions, and interventions received during hospitalization, low serum magnesium levels still correlated with a significantly increased risk of death by 24%. While we revealed that low magnesium levels could be a concerning signal for NSTEMI patients, we did not assess the effects of magnesium treatment directly in this study.

Overall, this research brings to light the potential importance of monitoring magnesium levels in the clinical setting, highlighting how they may relate to long-term outcomes for heart attack patients.

User Reviews

USERS' SCORE
Moderately Good
Based on 13 Reviews
7.8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Reduces heart issues
6 people found this helpful
Life Extension's magnesium supplement is fantastic. It aids in recovery and alleviates stress due to deficiencies. It helps with heart health and lowers blood pressure, enhances energy production, and improves sleep. This supplement also has anti-inflammatory benefits, making it a vital part of my diet.
9
Improved energy
2 people found this helpful
Since starting this magnesium supplement, I feel more energetic and experience less pain overall, including in my heart. I will continue using this supplement and highly recommend it to others for heart health.
9
Pain reduction noted
1 people found this helpful
I bought this due to heart pain and noticed a 90% reduction in pain within two weeks. The quality is high, and it regulates sleep while also offering muscle and joint support. Magnesium is essential for our bodies.
7.5
Pain alleviated
8 people found this helpful
I was suffering from heart pain and constipation, but after the first use, both issues improved. The pain in my heart, back, and bones dissipated, and my sleep improved. I made the decision to buy this product after experiencing side effects from the Covid vaccine and finding recommendations for magnesium supplements.
6
Cramps relieved
1 people found this helpful
This product has been excellent for my heart health and has alleviated leg cramps. The capsules are of good size and easy to swallow. I’m very satisfied with the benefits, particularly for muscle health, as it also helps me sleep well at night.

Frequently Asked Questions

9
Pain reduction noted
1 people found this helpful
I bought this due to heart pain and noticed a 90% reduction in pain within two weeks. The quality is high, and it regulates sleep while also offering muscle and joint support. Magnesium is essential for our bodies.
7.5
Heart health improved
23 people found this helpful
The best magnesium on IHERB. A cardiologist discovered an issue with my heart. I had frequent tachycardia, even at rest, and cramps in my calves. This supplement significantly helped, and I felt results within a week. I prioritised chelated magnesium forms due to their higher bioavailability, and this product includes magnesium oxide, citrate, succinate, and lysylglycinate chelate.
7.5
Pain alleviated
8 people found this helpful
I was suffering from heart pain and constipation, but after the first use, both issues improved. The pain in my heart, back, and bones dissipated, and my sleep improved. I made the decision to buy this product after experiencing side effects from the Covid vaccine and finding recommendations for magnesium supplements.
7.5
Sleep improved
4 people found this helpful
This mineral offers excellent value! After using it for a month, I noticed a significant improvement in my sleep and energy levels. It helps with muscle cramps, insomnia, and supports heart health and hormone stability. The capsules are easy to swallow and tasteless; I recommend taking them before bedtime.
9
Improved energy
2 people found this helpful
Since starting this magnesium supplement, I feel more energetic and experience less pain overall, including in my heart. I will continue using this supplement and highly recommend it to others for heart health.
7.5
Calmed heart feelings
Decent magnesium. The body needs magnesium, which we obtain externally. I believe it’s wise to take magnesium at least once yearly, especially for those living in large cities and facing daily stress. Magnesium worked well for me, combined with biotin; it alleviated unpleasant sensations linked to heart attack and helped me feel calmer.
2
Sleep improvement
3 people found this helpful
Initially, after taking one capsule, I experienced strong heart palpitations at night, which was alarming, alongside diarrhoea. After pausing, I tried half a capsule, reducing the palpitations but doing little for my sleep. Although I eventually took a smaller dose, which improved my sleep, I do not recommend this supplement, as I remain uncertain about its overall benefit to my heart health.
8
Magnesium levels impact heart attack outcomes
We examined whether serum magnesium levels at admission could predict in-hospital outcomes for patients experiencing a heart attack.

In our study of 259 acute myocardial infarction patients, those with lower magnesium levels (below 1.82 mg/dl) faced significantly higher risks of complications, including arrhythmias and even death, compared to those with healthier levels.

Our findings suggest that maintaining adequate magnesium levels is essential for better health outcomes after a heart attack.
7
Magnesium levels impact kidney injury
We investigated how serum magnesium levels affect the risk of acute kidney injury (AKI) in patients who experienced ST segment elevation myocardial infarction (STEMI), a severe type of heart attack. In our study, we reviewed data from 1,219 patients, dividing them into two groups: those with hypomagnesemia (low magnesium levels) and those without. Hypomagnesemia was specifically defined as having a serum magnesium level of less than 0.75 mmol/L, a threshold that indicates deficiency.

Out of the participants, we found that 163 patients (about 13.4%) were hypomagnesemic, and alarmingly, 256 patients (21.0%) developed AKI during their hospital stay. The figures showed a significant disparity: AKI occurred in 31.9% of the hypomagnesemia group compared to 19.3% of those with normal magnesium levels, signaling a concerning association.

Our analysis indicated that hypomagnesemia is an independent risk factor for developing AKI, with a calculated odds ratio of 2.41. This suggests that patients with lower magnesium at admission face more than double the risk of experiencing kidney complications. These findings highlight the potential for magnesium interventions in heart attack recovery, suggesting that monitoring and managing magnesium levels could play a crucial role in improving patient outcomes and reducing the risk of kidney injury after a heart attack.
7
Magnesium levels and mortality link
We investigated how variations in serum magnesium levels might relate to in-hospital mortality for patients experiencing an acute myocardial infarction (AMI), commonly known as a heart attack. The research examined data from over 2,700 patients in intensive care, allowing us to analyze trends over time.

What we found was significant: elevated magnesium levels at ICU admission and changes in magnesium levels within the first 48 hours of ICU stay were associated with a higher risk of in-hospital mortality among these patients. In fact, 18.6% of the patients in our study did not survive their hospital stay.

This relationship remained consistent across different groups, regardless of age, gender, or health severity scores. It highlights the importance of closely monitoring magnesium levels during crucial treatment periods as it may provide insight that could help tailor treatments to improve patient outcomes.

However, we must note that while the study shows an association, it does not isolate the effects of magnesium treatment itself. This means we can't definitively say that magnesium treatment alone drastically alters mortality rates after a heart attack. Instead, the findings suggest magnesium monitoring is vital in intensive care settings.

References

  1. Demirtola Aİ, Mammadli A, Çiçek G. The Role of Magnesium Levels in the Progression of Contrast-Induced Nephropathy in Patients With STEMI Undergoing Primary PCI. Angiology. 2025. doi:10.1177/00033197251314629
  2. Jin Y, Lin Q, Wang D, Gong M, Huang W, et al. Hypomagnesemia is a Risk Factor for Acute Kidney Injury in Patients Admitted With ST-Segment Elevation Myocardial Infarction: A Retrospective Observational Study. J Ren Nutr. 2024. doi:10.1053/j.jrn.2024.12.006
  3. Naveen V, Rajesh Lenin R, Stanley LM, Kumar JS. Serum Magnesium Levels and QTc Interval Prolongation As Prognostic Markers in Acute Myocardial Infarction: A Randomized Controlled Study. Cureus. 2024;16:e66051. doi:10.7759/cureus.66051
  4. Zhuang J, Zhang Q, Wang H, Su PH, Chen PY. Association between short-term changes in serum magnesium and in-hospital mortality following acute myocardial infarction: a cohort study based on the MIMIC database. Magnes Res. 2024;37:45. doi:10.1684/mrh.2024.0517
  5. Zhang J, Sun D, Guo Y, Tong J, Liu Q, et al. Targeted delivery of black phosphorus nanosheets by ROS responsive complex hydrogel based on angiogenesis and antioxidant promotes myocardial infarction repair. J Nanobiotechnology. 2024;22:433. doi:10.1186/s12951-024-02685-0
  6. Wang B, Pan S, Nie C, Zou R, Liu J, et al. Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats. Sci Rep. 2024;14:10959. doi:10.1038/s41598-024-60609-2
  7. Fan C, Qin K, Iroegbu CD, Xiang K, Gong Y, et al. Magnesium lithospermate B enhances the potential of human-induced pluripotent stem cell-derived cardiomyocytes for myocardial repair. Chin Med J (Engl). 2024;137:1857. doi:10.1097/CM9.0000000000002867
  8. Segev A, Shechter M, Tsur AM, Belkin D, Cohen H, et al. Serum Magnesium Is Associated with Long-Term Survival of Non-ST-Elevation Myocardial Infarction Patients. Nutrients. 2023;15. doi:10.3390/nu15194299
  9. Włodarczak A, Rola P, Barycki M, Furtan Ł, Łanocha M, et al. Mid-term safety and efficacy of magnesium bioresorbable vascular scaffolds - magmaris in diabetic population. 2-Years outcome in acute coronary syndrome cohort. Diab Vasc Dis Res. 2023;20:14791641231188705. doi:10.1177/14791641231188705
  10. Sabah Z, Wani J, Deajim M, Al Zomia AS, Asiri A, et al. Serum Magnesium in Patients With Acute Myocardial Infarction and Its Effect on Cardiac Complications and Mortality in Myocardial Infarction Patients. Cureus. 2023;15:e38147. doi:10.7759/cureus.38147
  11. An P, Wan S, Luo Y, Luo J, Zhang X, et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2022;80:2269. doi:10.1016/j.jacc.2022.09.048
  12. Evers I, Cruijsen E, Kornaat I, Winkels RM, Busstra MC, et al. Dietary magnesium and risk of cardiovascular and all-cause mortality after myocardial infarction: A prospective analysis in the Alpha Omega Cohort. Front Cardiovasc Med. 2022;9:936772. doi:10.3389/fcvm.2022.936772
  13. Rola P, Włodarczak A, Łanocha M, Barycki M, Szudrowicz M, et al. Outcomes of the two generations of bioresorbable scaffolds (Magmaris vs. Absorb) in acute coronary syndrome in routine clinical practice. Cardiol J. 2022;30:870. doi:10.5603/CJ.a2022.0047
  14. Ortega-Paz L, Brugaletta S, Gomez-Lara J, Alfonso F, Cequier A, et al. Magnesium-based resorbable scaffold vs permanent metallic sirolimus-eluting stent in patients with ST-segment elevation myocardial infarction: 3-year results of the MAGSTEMI randomised controlled trial. EuroIntervention. 2022;18:e389. doi:10.4244/EIJ-D-21-00651
  15. Hasan MZ, Nahar K, Sharif JU, Paul SC, Thakur AK, et al. Serum Magnesium Level and It's Relation in Predicting Adverse In-Hospital Outcome in Patients with First Attack of Myocardial Infarction. Mymensingh Med J. 2023;32:65.
  16. Fallesen CO, Antonsen L, Maehara A, Noori M, Hougaard M, et al. Optical Coherence Tomography- Versus Angiography-Guided Magnesium Bioresorbable Scaffold Implantation in NSTEMI Patients. Cardiovasc Revasc Med. 2022;40:101. doi:10.1016/j.carrev.2021.12.003
  17. Włodarczak A, Łanocha M, Lesiak M, Benett J, Szudrowicz M, et al. Long-term clinical follow-up of the resorbable magnesium scaffolds in acute coronary syndrome patients. Kardiol Pol. 2021;79:827. doi:10.33963/KP.a2021.0035
  18. Açıkgöz E, Açıkgöz SK, Çiçek G. Serum magnesium concentration may predict no-reflow phenomenon in primary angioplasty for ST-elevation myocardial infarction. Magnes Res. 2020;33:123. doi:10.1684/mrh.2021.0477
  19. Shlezinger M, Amitai Y, Goldenberg I, Atar S, Shechter M. Acute myocardial infarction severity, complications, and mortality associated with lack of magnesium intake through consumption of desalinated seawater. Magnes Res. 2019;32:39. doi:10.1684/mrh.2019.0449
  20. Sabaté M, Alfonso F, Cequier A, Romaní S, Bordes P, et al. Magnesium-Based Resorbable Scaffold Versus Permanent Metallic Sirolimus-Eluting Stent in Patients With ST-Segment Elevation Myocardial Infarction: The MAGSTEMI Randomized Clinical Trial. Circulation. 2019;140:1904. doi:10.1161/CIRCULATIONAHA.119.043467
  21. Ielasi A, Cerrato E, Geraci S, Campo G, Garro N, et al. Sirolimus-Eluting Magnesium Resorbable Scaffold Implantation in Patients with Acute Myocardial Infarction. Cardiology. 2019;142:93. doi:10.1159/000499536
  22. Lee TM, Chang NC, Lin SZ. Effect of proton pump inhibitors on sympathetic hyperinnervation in infarcted rats: Role of magnesium. PLoS One. 2018;13:e0202979. doi:10.1371/journal.pone.0202979
  23. de Hemptinne Q, Picard F, Briki R, Awada A, Silance PG, et al. Drug-Eluting Resorbable Magnesium Scaffold Implantation in ST-Segment Elevation Myocardial Infarction: A Pilot Study. J Invasive Cardiol. 2018;30:202.
image