We observed how n-acetyl-L-cysteine can impact the formation of cystine kidney stones. The study utilized crystallization experiments to mimic conditions similar to those in the kidneys. Cystine typically requires high supersaturation to crystallize, presenting a challenge since inhibitors, like n-acetyl-cysteine, tend to have reduced effects under such conditions.
Our findings highlighted that in the absence of crystallization inhibitors, crystallization begins within just 15 minutes. However, when n-acetyl-L-cysteine and other thiol agents like penicillamine and tiopronin were present, they completely blocked the crystallization process. Notably, n-acetyl-L-cysteine didn't just stop the formation of cystine crystals; it also altered their shape, which could play a vital role in how stones develop.
Moreover, we explored the structure of 30 cystine stones and found that they start from small crystals, continuously growing into larger structures depending on where they form in the kidney. The prevention of stone development hinges on keeping urinary cystine levels low, which n-acetyl-L-cysteine emerged as the most effective method among those tested. Increased hydration and physical activity further showed promise in helping remove cystine crystals and preventing stone formation.
Protects kidneys
Most Useful Review
This N-acetyl-L-cysteine (600 mg) from Life Extension is an effective antioxidant that protects my kidneys and liver from toxins. It also maintains respiratory health and supports the synthesis of intracellular glutathione, crucial for cellular processes. NAC is beneficial for both active and older individuals. I highly recommend this supplement.