Last update
3/16/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9.5
USERS' SCORE
Good
Based on 2 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
N-acetyl-L-cysteine
600 mg
**
Top Medical Research Studies
9.5
In our exploration of new treatment options for diarrhea, we found that combining n-acetylcysteine (NAC) with rifaximin might improve outcomes for patients suffering from irritable bowel syndrome with diarrhea (IBS-D). The study involved a validated rat model, where we assessed the effects of various combinations of these treatments after inducing IBS-D with a specific toxin.
We observed that when rats were treated with rifaximin alone, their stool consistency and bacterial levels did not significantly improve compared to those that received a placebo. However, those treated with rifaximin combined with NAC showed marked improvements. Their stool consistency normalized, and the levels of harmful bacteria, including E. coli, were significantly reduced.
Furthermore, the combined treatment also led to a normalization of cytokine levels, which are molecules linked to inflammation and diarrhea. This suggests that NAC not only supports the action of rifaximin but may also enhance overall treatment effectiveness for IBS-D. Our findings highlight the promising potential of using NAC alongside rifaximin to better manage diarrhea symptoms in affected patients.
We observed that when rats were treated with rifaximin alone, their stool consistency and bacterial levels did not significantly improve compared to those that received a placebo. However, those treated with rifaximin combined with NAC showed marked improvements. Their stool consistency normalized, and the levels of harmful bacteria, including E. coli, were significantly reduced.
Furthermore, the combined treatment also led to a normalization of cytokine levels, which are molecules linked to inflammation and diarrhea. This suggests that NAC not only supports the action of rifaximin but may also enhance overall treatment effectiveness for IBS-D. Our findings highlight the promising potential of using NAC alongside rifaximin to better manage diarrhea symptoms in affected patients.
Read More
Most Useful Reviews
10
Intense diarrhea
3 people found this helpful
Diarrhoea! It gave me intense diarrhoea.
Read More
2
Loose stools
2 people found this helpful
Works, but gave me loose stools. This did what it was meant to do by clearing up all of my congestion. Unfortunately, it consistently caused me to have loose stools/diarrhoea from the first dose of a single pill. It wasn’t explosive, but just consistently loose, so I stopped taking it after a few days. I haven’t tried any other brands, so I can’t say if it’s this formulation or just what NAC does to me.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9.5
- All Researches
9.5
In our exploration of new treatment options for diarrhea, we found that combining n-acetylcysteine (NAC) with rifaximin might improve outcomes for patients suffering from irritable bowel syndrome with diarrhea (IBS-D). The study involved a validated rat model, where we assessed the effects of various combinations of these treatments after inducing IBS-D with a specific toxin.
We observed that when rats were treated with rifaximin alone, their stool consistency and bacterial levels did not significantly improve compared to those that received a placebo. However, those treated with rifaximin combined with NAC showed marked improvements. Their stool consistency normalized, and the levels of harmful bacteria, including E. coli, were significantly reduced.
Furthermore, the combined treatment also led to a normalization of cytokine levels, which are molecules linked to inflammation and diarrhea. This suggests that NAC not only supports the action of rifaximin but may also enhance overall treatment effectiveness for IBS-D. Our findings highlight the promising potential of using NAC alongside rifaximin to better manage diarrhea symptoms in affected patients.
We observed that when rats were treated with rifaximin alone, their stool consistency and bacterial levels did not significantly improve compared to those that received a placebo. However, those treated with rifaximin combined with NAC showed marked improvements. Their stool consistency normalized, and the levels of harmful bacteria, including E. coli, were significantly reduced.
Furthermore, the combined treatment also led to a normalization of cytokine levels, which are molecules linked to inflammation and diarrhea. This suggests that NAC not only supports the action of rifaximin but may also enhance overall treatment effectiveness for IBS-D. Our findings highlight the promising potential of using NAC alongside rifaximin to better manage diarrhea symptoms in affected patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
10
Intense diarrhea
3 people found this helpful
Diarrhoea! It gave me intense diarrhoea.
Read More
2
Loose stools
2 people found this helpful
Works, but gave me loose stools. This did what it was meant to do by clearing up all of my congestion. Unfortunately, it consistently caused me to have loose stools/diarrhoea from the first dose of a single pill. It wasn’t explosive, but just consistently loose, so I stopped taking it after a few days. I haven’t tried any other brands, so I can’t say if it’s this formulation or just what NAC does to me.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Leite G, Rezaie A, Morales W, Weitsman S, de Freitas Germano J, et al. Low dose rifaximin combined with N-acetylcysteine is superior to rifaximin alone in a rat model of IBS-D: a randomized trial. Sci Rep. 2024;14:18140. 10.1038/s41598-024-69162-4
Data last updated:
