Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
USERS' SCORE
Moderately Good
Based on 45 Reviews
7.8
Supplement Facts
Serving Size: 3 Vegetarian Capsules
Amount Per Serving
%DV
Magnesium (from 2,000 mg Magtein® magnesium L-threonate)
144 mg
34%
Top Medical Research Studies
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
Read More
Most Useful Reviews
9
Calming effect
133 people found this helpful
This is a fantastic medication prescribed by a renowned geneticist for my 5-year-old child with neurological disorders. It has a calming effect and enhances perseverance. The difference is noticeable once the medication runs out, proving its effectiveness compared to other magnesium types. No further experimentation is needed if it works well.
Read More
9
Significantly improved sleep
54 people found this helpful
This is the first magnesium I've bought from iHerb, and it’s proved effective for my entire family. Due to the ongoing war in Ukraine, we decided to take two capsules nightly to ensure our supplies lasted two months. Within days, my sleep improved remarkably, alleviating stress and enabling us to better handle the situation. A highly effective dietary supplement!
Read More
9
Less anxiety
36 people found this helpful
I started using the l-threonate form about a year ago while recovering from severe stress and post-traumatic stress disorder. This form has been remarkably effective. Transitioning from panic attacks to a more stable state has been incredible. When combined with lecithin and lithium, I've noticed a significant enhancement in my cognitive function. While magnesium glycinate is also beneficial, l-threonate has a distinct calming effect on my mind. Of all the variants tried, this one stood out, especially with its high dosage.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
- All Researches
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
9
We explored the potential of a new magnesium-aluminum layered double hydroxide combined with nano-ceria in treating rheumatoid arthritis (RA). This innovative therapy targets the unhealthy immune environment and the harmful buildup of hydrogen ions associated with RA. By neutralizing excess acidity, we observed improved immune responses, encouraging the body to heal damaged bones. This approach showed promising results in mice models, indicating it may be a viable future treatment for managing RA effectively.
Read More
9
Magnesium aids arthritis through immunity
We explored the effects of a high magnesium diet on rheumatoid arthritis using two mouse models. Our findings suggest that magnesium can significantly reduce arthritis severity and joint damage, while also promoting immune cell types that help combat inflammation.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Read More
9
Magnesium mitigates MS-related mood issues
We investigated the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression in multiple sclerosis (MS), a disease often accompanied by these mood disorders. Our findings indicated that MgH treatment significantly improved anxiety and depression-like behaviors in mice with experimental autoimmune encephalomyelitis (EAE).
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 45 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Calming effect
133 people found this helpful
This is a fantastic medication prescribed by a renowned geneticist for my 5-year-old child with neurological disorders. It has a calming effect and enhances perseverance. The difference is noticeable once the medication runs out, proving its effectiveness compared to other magnesium types. No further experimentation is needed if it works well.
Read More
9
Significantly improved sleep
54 people found this helpful
This is the first magnesium I've bought from iHerb, and it’s proved effective for my entire family. Due to the ongoing war in Ukraine, we decided to take two capsules nightly to ensure our supplies lasted two months. Within days, my sleep improved remarkably, alleviating stress and enabling us to better handle the situation. A highly effective dietary supplement!
Read More
9
Less anxiety
36 people found this helpful
I started using the l-threonate form about a year ago while recovering from severe stress and post-traumatic stress disorder. This form has been remarkably effective. Transitioning from panic attacks to a more stable state has been incredible. When combined with lecithin and lithium, I've noticed a significant enhancement in my cognitive function. While magnesium glycinate is also beneficial, l-threonate has a distinct calming effect on my mind. Of all the variants tried, this one stood out, especially with its high dosage.
Read More
9
Recovery from illness
23 people found this helpful
Suffering from Periodic Limb Movement Disorder, I combined high-intensity exercise with this supplement. Remarkably, my condition improved significantly when taken before bed. It leaves me feeling comfortably sleepy.
Read More
7.5
Significant sleep improvement
4 people found this helpful
My mother has a severe sleep disorder, and after taking magnesium threonate for three months, her sleep quality has greatly improved. I switched brands to this one upon hearing it was superior, and according to my mother, it does indeed work better.
Read More
Frequently Asked Questions
7.5
Perfect for magnesium deficiency
2 people found this helpful
I purchased this product upon my doctor's recommendation for my magnesium deficiency and sleep disorders. I felt its effects on the first day, resulting in sound sleep. The capsules are easy to swallow, odourless, and the convenient packaging makes it a quality product that has improved my sleep!
7.5
Boosted concentration
4 people found this helpful
Great product! A very high-quality brand. I took magnesium for memory and concentration, and the packaging lasted a month. The capsule size is average. After taking it, I've certainly noticed the benefits for my sleep and focus, but I think I need to continue the course for 3-4 months, so I will reorder.
9
ADHD management
3 people found this helpful
I ordered Neuro-Mag after learning it could help manage the evening crash from stimulant medications for ADHD. After taking it alongside L-Tyrosine for about two weeks, I've noticed significant improvements both during the day and as my medication starts to wear off in the late afternoon.
9
Significantly improved sleep
54 people found this helpful
This is the first magnesium I've bought from iHerb, and it’s proved effective for my entire family. Due to the ongoing war in Ukraine, we decided to take two capsules nightly to ensure our supplies lasted two months. Within days, my sleep improved remarkably, alleviating stress and enabling us to better handle the situation. A highly effective dietary supplement!
7.5
Significant sleep improvement
4 people found this helpful
My mother has a severe sleep disorder, and after taking magnesium threonate for three months, her sleep quality has greatly improved. I switched brands to this one upon hearing it was superior, and according to my mother, it does indeed work better.
9
Less anxiety
36 people found this helpful
I started using the l-threonate form about a year ago while recovering from severe stress and post-traumatic stress disorder. This form has been remarkably effective. Transitioning from panic attacks to a more stable state has been incredible. When combined with lecithin and lithium, I've noticed a significant enhancement in my cognitive function. While magnesium glycinate is also beneficial, l-threonate has a distinct calming effect on my mind. Of all the variants tried, this one stood out, especially with its high dosage.
6
Enhanced behaviour
132 people found this helpful
My 8-year-old child has been taking this at night, becoming calmer and more diligent with homework, which is completed more quickly and without stress. Initially, he found it hard to swallow the capsule, but now he can take it easily. I’m considering ordering it for myself as I've also been under mental stress at work and observe positive effects in him.
6
Noticeable sleep improvement
2 people found this helpful
As someone in my 50s, sleeping through the night has been challenging. I tried taking one capsule daily for a month, then paused for two weeks to assess my state. Although the difference isn’t huge, there is noticeable improvement in my sleep and overall calmness. I followed the same routine with my husband, who also reported a slight enhancement in his sleep and alertness. I have now reordered two bottles and intend to increase my intake to two capsules daily.
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
8
We explored the relationship between dietary magnesium intake and all-cause mortality in patients with rheumatoid arthritis (RA) using data from the NHANES database.
Analyzing nearly 3,000 RA patients, we found that those who consumed higher magnesium levels experienced an 11.12% lower risk of death.
This benefit was particularly notable in younger individuals under 65, females, and those with a lower body mass index.
This suggests that adequate magnesium intake could play a vital role in improving survival outcomes for RA patients.
Analyzing nearly 3,000 RA patients, we found that those who consumed higher magnesium levels experienced an 11.12% lower risk of death.
This benefit was particularly notable in younger individuals under 65, females, and those with a lower body mass index.
This suggests that adequate magnesium intake could play a vital role in improving survival outcomes for RA patients.
References
- Toaima DN, Abdel-Maksoud KS, Atef HM, Salah NY. Magnesium, fibrinolysis and clotting interplay among children and adolescents with type 1 diabetes mellitus; potential mediators of diabetic microangiopathy. Nutr Diabetes. 2025;15:13. doi:10.1038/s41387-025-00368-9
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. doi:10.3390/nu16234247
- Fu C, Huang L, Lian C, Yue J, Lin P, et al. Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood-brain barrier integrity in mice with neuromyelitis optica spectrum disorder. Brain Res. 2025;1846:149234. doi:10.1016/j.brainres.2024.149234
- Yan Y, Yao C, Zhang B, Yang Z, Xie J, et al. Olanzapine vs. magnesium valproate vs. lamotrigine in anti-N-methyl-D-aspartic acid receptor encephalitis: a retrospective study. BMC Neurol. 2024;24:331. doi:10.1186/s12883-024-03811-z
- Verlato A, Laragione T, Bin S, Kim RH, Salem F, et al. Revised version with tracked changes oral Magnesium reduces levels of pathogenic autoantibodies and skin disease in murine lupus. BMC Immunol. 2024;25:58. doi:10.1186/s12865-024-00650-y
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. doi:10.1186/s41043-024-00597-1
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. doi:10.1002/advs.202307094
- Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. doi:10.1186/s12889-023-16906-y
- Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. doi:10.1016/j.ebiom.2023.104603
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
