Last update
3/16/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Good
Based on 6 Reviews
8.2
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Folate [as (6S)-5-Methyltetrahydrofolate, Calcium salt]
1,700 mcg○
425%
Top Medical Research Studies
8
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Read More
8
Folate impacts heart health progression
We focused on whether folate and vitamin B12 levels influence the progression of carotid intima-media thickness (cIMT), an early sign of atherosclerosis. Our research covered over 4,200 participants in São Paulo over eight years.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
Read More
8
We explored the role of the MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension using folic acid along with enalapril treatment. Over 540 patients were divided into groups based on folic acid treatment and monitored for a year.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
Read More
Most Useful Reviews
8
Cardiovascular health support
1 people found this helpful
Life Extension's folic acid supplement is certified Non-GMO. It supports a well-functioning cardiovascular system and maintains normal homocysteine levels, which is crucial for cognitive function, especially in the elderly. Combining it with B12 enhances its effects.
Read More
7.5
Healthy homocysteine levels
1 people found this helpful
Maintaining normal homocysteine levels is vital for cardiovascular health. With my intake of 1,700 mcg of L-methylfolate, I ensure that my homocysteine remains within healthy limits.
Read More
9
Ample folate supply
The Optimised Folate, in a bottle of 100 vegetarian tablets, offers 1,700 mcg DFE of this essential B-vitamin, ensuring support for cardiovascular health and neurological function. This practical size is excellent for daily use.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
- All Researches
We investigated the link between maternal folic acid supplementation and the risk of congenital heart disease (CHD) in children, considering genetic factors too. In a hospital-based case-control study with 595 children diagnosed with CHD and 605 healthy children, we found that mothers who took folic acid reduced the risk of CHD in their children.
The data indicated a noteworthy interaction between maternal supplementation and certain genetic variants in the children, particularly one MTRR gene polymorphism. However, it's important to note that further research with larger samples is necessary to strengthen these findings.
The data indicated a noteworthy interaction between maternal supplementation and certain genetic variants in the children, particularly one MTRR gene polymorphism. However, it's important to note that further research with larger samples is necessary to strengthen these findings.
Read More
8
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Read More
8
Folate impacts heart health progression
We focused on whether folate and vitamin B12 levels influence the progression of carotid intima-media thickness (cIMT), an early sign of atherosclerosis. Our research covered over 4,200 participants in São Paulo over eight years.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
Read More
8
We explored the role of the MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension using folic acid along with enalapril treatment. Over 540 patients were divided into groups based on folic acid treatment and monitored for a year.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
Read More
8
We explored the relationship between folic acid levels and the outcomes of ischemic stroke in a study involving over 3,500 patients. Our findings indicated that higher folate levels were linked to a 29% reduced risk of death and serious disability after three months.
Conversely, high homocysteine levels correlated with a 52% increased risk of these adverse outcomes. Additionally, we found that part of folate's protective effect was mediated through homocysteine levels. This suggests that folic acid may play a crucial role in improving ischemic stroke prognosis.
Conversely, high homocysteine levels correlated with a 52% increased risk of these adverse outcomes. Additionally, we found that part of folate's protective effect was mediated through homocysteine levels. This suggests that folic acid may play a crucial role in improving ischemic stroke prognosis.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
8
Cardiovascular health support
1 people found this helpful
Life Extension's folic acid supplement is certified Non-GMO. It supports a well-functioning cardiovascular system and maintains normal homocysteine levels, which is crucial for cognitive function, especially in the elderly. Combining it with B12 enhances its effects.
Read More
7.5
Healthy homocysteine levels
1 people found this helpful
Maintaining normal homocysteine levels is vital for cardiovascular health. With my intake of 1,700 mcg of L-methylfolate, I ensure that my homocysteine remains within healthy limits.
Read More
9
Ample folate supply
The Optimised Folate, in a bottle of 100 vegetarian tablets, offers 1,700 mcg DFE of this essential B-vitamin, ensuring support for cardiovascular health and neurological function. This practical size is excellent for daily use.
Read More
7.5
Digestible folate form
I find this bioavailable form of folic acid beneficial. It helps regulate homocysteine levels and strengthens cardiovascular health, especially for pregnant women.
Read More
7.5
Supports pregnancy health
Folate supports pregnancy health, cardiovascular health, and maintains healthy homocysteine levels.
Read More
Frequently Asked Questions
8
Cardiovascular health support
1 people found this helpful
Life Extension's folic acid supplement is certified Non-GMO. It supports a well-functioning cardiovascular system and maintains normal homocysteine levels, which is crucial for cognitive function, especially in the elderly. Combining it with B12 enhances its effects.
7.5
Healthy homocysteine levels
1 people found this helpful
Maintaining normal homocysteine levels is vital for cardiovascular health. With my intake of 1,700 mcg of L-methylfolate, I ensure that my homocysteine remains within healthy limits.
7.5
Digestible folate form
I find this bioavailable form of folic acid beneficial. It helps regulate homocysteine levels and strengthens cardiovascular health, especially for pregnant women.
9
Ample folate supply
The Optimised Folate, in a bottle of 100 vegetarian tablets, offers 1,700 mcg DFE of this essential B-vitamin, ensuring support for cardiovascular health and neurological function. This practical size is excellent for daily use.
7.5
Promotes cognitive function
The Folate Optimised Formula promotes cardiovascular health and cognitive function with 1,700 mcg of folic acid, in the active form of 5-methylhydrofolate.
8
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
8
We explored the relationship between folic acid levels and the outcomes of ischemic stroke in a study involving over 3,500 patients. Our findings indicated that higher folate levels were linked to a 29% reduced risk of death and serious disability after three months.
Conversely, high homocysteine levels correlated with a 52% increased risk of these adverse outcomes. Additionally, we found that part of folate's protective effect was mediated through homocysteine levels. This suggests that folic acid may play a crucial role in improving ischemic stroke prognosis.
Conversely, high homocysteine levels correlated with a 52% increased risk of these adverse outcomes. Additionally, we found that part of folate's protective effect was mediated through homocysteine levels. This suggests that folic acid may play a crucial role in improving ischemic stroke prognosis.
8
We explored the role of the MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension using folic acid along with enalapril treatment. Over 540 patients were divided into groups based on folic acid treatment and monitored for a year.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
8
Folate impacts heart health progression
We focused on whether folate and vitamin B12 levels influence the progression of carotid intima-media thickness (cIMT), an early sign of atherosclerosis. Our research covered over 4,200 participants in São Paulo over eight years.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
References
- Liang Z, Fan F, Liu B, Li K, Chen H, et al. Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses. Nutrients. 2024;17. 10.3390/nu17010159
- Li L, Ou J, Chen Y, Chen Q, Luo M, et al. Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population. J Health Popul Nutr. 2024;43:220. 10.1186/s41043-024-00699-w
- Chen X, Bishai D. Revisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue. BMC Public Health. 2024;24:3540. 10.1186/s12889-024-21005-7
- Palchetti CZ, Gonçalves NG, Suemoto CK, Santos IS, Lotufo PA, et al. Serum folate levels, but not vitamin B12, are associated with slower progression in carotid intima-media thickness in a population exposed to mandatory folic acid fortification. Clin Nutr ESPEN. 2025;65:144. 10.1016/j.clnesp.2024.11.034
- Dong J, Li Z, Wang C, Zhang R, Li Y, et al. Dietary folate intake and all-cause mortality and cardiovascular mortality in American adults with non-alcoholic fatty liver disease: Data from NHANES 2003 to 2018. PLoS One. 2024;19:e0314148. 10.1371/journal.pone.0314148
- Kaushik A, Bhattacharjee D, Chaudhary V, Dahal S, Devi NK, et al. Hypertension and global DNA methylation: a population-based study in rural, Punjab, India. Sci Rep. 2024;14:25826. 10.1038/s41598-024-77437-z
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. 10.14715/cmb/2024.70.9.20
- Shi M, Zheng J, Liu Y, Mao X, Wu X, et al. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke. J Am Heart Assoc. 2024;13:e036527. 10.1161/JAHA.124.036527
- Liang X, Huang D, Bi Y, He Y, Mao T, et al. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study. J Hum Hypertens. 2024;38:844. 10.1038/s41371-024-00955-w
- Prasad K. Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment. Int J Angiol. 2024;33:262. 10.1055/s-0044-1788280
Data last updated:
