' 
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Good
Based on 12 Reviews
8.6
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Folate [as (6S)-5-Methyltetrahydrofolate, Calcium salt]
1,700 mcg○
425%
Top Medical Research Studies
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Study directly links folate to heart health
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
8
Folate levels impact heart disease
Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring.
High relevance to heart disease
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Read More
9.5
Folate's role in heart protection
Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder.
Focus on folate for TDD
We explored the effects of folate, a form of vitamin B, on heart problems associated with TANGO2-deficiency disorder (TDD). This genetic condition can lead to dangerous heart rhythms that don’t respond well to standard treatments. To dive deeper into this issue, we established patient-derived heart cells, known as iPSC-CMs, to mimic the heart abnormalities seen in TDD.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
Read More
Most Useful Reviews
8.8
Supports cellular health
Having researched dietary supplements, I can say that Optimized Folate 1700 mcg DFE is impressive. It’s highly bioavailable, helps with amino acid metabolism, and supports cardiovascular health by regulating homocysteine levels. I take one capsule daily with no side effects.
Read More
9.5
Great for heart health
Great Supplement for Heart Health.
Read More
9.5
Lowers homocysteine levels
This is a no-brainer! Folic acid has numerous benefits. I take it to manage my homocysteine levels, which have been associated with heart disease and strokes. Given my history, I believe taking folate is wise.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
- All Researches
9.5
Folate's role in heart protection
Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder.
Focus on folate for TDD
We explored the effects of folate, a form of vitamin B, on heart problems associated with TANGO2-deficiency disorder (TDD). This genetic condition can lead to dangerous heart rhythms that don’t respond well to standard treatments. To dive deeper into this issue, we established patient-derived heart cells, known as iPSC-CMs, to mimic the heart abnormalities seen in TDD.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
Read More
9
Maternal folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Relevant findings support folic acid use.
We explored how maternal folic acid supplementation relates to congenital heart disease (CHD) in children. Through a case-control study involving 595 children with CHD and 605 healthy controls, we found that mothers taking folic acid significantly reduced the risk of CHD and its subtypes. Notably, variations in the MTRR gene among offspring were linked to higher CHD risks, but maternal folic acid appeared to mitigate some of this risk. While results are promising, further research with larger samples is essential to fully understand these findings.
Read More
9
Treating TANGO2 heart arrhythmias
Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder.
Highly relevant for cardiac care
We explored the potential benefits of folic acid in treating dangerous heart rhythm problems linked to TANGO2-deficiency disorder (TDD). By creating patient-derived heart cell models, we observed that high doses of folate significantly reduced these arrhythmias. Additionally, clinical studies indicated that taking multivitamins, particularly those rich in B complex, lowered the chance of heart crises in TDD patients. Together, these findings suggest that B vitamins, including folate, could be vital in managing severe heart complications associated with this rare genetic disorder.
Read More
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Study directly links folate to heart health
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
8
Folic acid's limited heart benefit
Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment.
Moderate relevance to heart disease
We investigated whether folic acid treatment could help lower heart disease risk related to elevated homocysteine levels. The study highlighted that hyperhomocysteinemia is a significant independent risk factor for atherosclerosis, which can contribute to serious cardiovascular events. While folic acid, alongside other B vitamins, effectively reduces homocysteine levels, it does not appear to significantly improve heart disease outcomes on its own. Thus, while folic acid plays a role in managing homocysteine, its impact on preventing heart disease is less clear.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Supports cellular health
Having researched dietary supplements, I can say that Optimized Folate 1700 mcg DFE is impressive. It’s highly bioavailable, helps with amino acid metabolism, and supports cardiovascular health by regulating homocysteine levels. I take one capsule daily with no side effects.
9.5
Great for heart health
Great Supplement for Heart Health.
9.5
Lowers homocysteine levels
This is a no-brainer! Folic acid has numerous benefits. I take it to manage my homocysteine levels, which have been associated with heart disease and strokes. Given my history, I believe taking folate is wise.
8.8
Cognitive and heart benefits
I use this for heart and cognitive health. It certainly aids clarity. This form of folate, 5-MTHF, is more absorbable for those genetically predisposed to conversion issues. I'm pleased to have found such quality.
8.8
Improves folate levels
On Iherb, there are many good folates, and this is one of them. I’m ordering a third package from different brands! It’s an ideal formula for folate for those planning a pregnancy, suffering from anaemia or elevated homocysteine levels, which is a marker of cardiovascular diseases! I recommend it!
Read More
