Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Good
Based on 12 Reviews
8
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Folate [as (6S)-5-Methyltetrahydrofolate, Calcium salt]
1,700 mcg○
425%
Top Medical Research Studies
8
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Read More
9
We explored the potential benefits of folic acid in treating dangerous heart rhythm problems linked to TANGO2-deficiency disorder (TDD). By creating patient-derived heart cell models, we observed that high doses of folate significantly reduced these arrhythmias. Additionally, clinical studies indicated that taking multivitamins, particularly those rich in B complex, lowered the chance of heart crises in TDD patients. Together, these findings suggest that B vitamins, including folate, could be vital in managing severe heart complications associated with this rare genetic disorder.
Read More
8
We investigated whether folic acid treatment could help lower heart disease risk related to elevated homocysteine levels. The study highlighted that hyperhomocysteinemia is a significant independent risk factor for atherosclerosis, which can contribute to serious cardiovascular events. While folic acid, alongside other B vitamins, effectively reduces homocysteine levels, it does not appear to significantly improve heart disease outcomes on its own. Thus, while folic acid plays a role in managing homocysteine, its impact on preventing heart disease is less clear.
Read More
Most Useful Reviews
7.5
Supports cellular health
1 people found this helpful
Having researched dietary supplements, I can say that Optimized Folate 1700 mcg DFE is impressive. It’s highly bioavailable, helps with amino acid metabolism, and supports cardiovascular health by regulating homocysteine levels. I take one capsule daily with no side effects.
Read More
9
Great for heart health
Great Supplement for Heart Health.
Read More
9
Lowers homocysteine levels
This is a no-brainer! Folic acid has numerous benefits. I take it to manage my homocysteine levels, which have been associated with heart disease and strokes. Given my history, I believe taking folate is wise.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
- All Researches
9
Maternal folic acid reduces CHD risk
We explored how maternal folic acid supplementation relates to congenital heart disease (CHD) in children. Through a case-control study involving 595 children with CHD and 605 healthy controls, we found that mothers taking folic acid significantly reduced the risk of CHD and its subtypes. Notably, variations in the MTRR gene among offspring were linked to higher CHD risks, but maternal folic acid appeared to mitigate some of this risk. While results are promising, further research with larger samples is essential to fully understand these findings.
Read More
9
We explored the potential benefits of folic acid in treating dangerous heart rhythm problems linked to TANGO2-deficiency disorder (TDD). By creating patient-derived heart cell models, we observed that high doses of folate significantly reduced these arrhythmias. Additionally, clinical studies indicated that taking multivitamins, particularly those rich in B complex, lowered the chance of heart crises in TDD patients. Together, these findings suggest that B vitamins, including folate, could be vital in managing severe heart complications associated with this rare genetic disorder.
Read More
8
We investigated whether folic acid treatment could help lower heart disease risk related to elevated homocysteine levels. The study highlighted that hyperhomocysteinemia is a significant independent risk factor for atherosclerosis, which can contribute to serious cardiovascular events. While folic acid, alongside other B vitamins, effectively reduces homocysteine levels, it does not appear to significantly improve heart disease outcomes on its own. Thus, while folic acid plays a role in managing homocysteine, its impact on preventing heart disease is less clear.
Read More
8
We explored how folic acid affects patients with coronary heart disease (CHD) and hypertension, particularly considering the MTHFR C677T gene. The study included 540 patients who received either folic acid treatment alongside enalapril or standard care.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
Read More
8
We explored a new silk fibroin and hydroxypropyl cellulose hydrogel designed to improve heart repair after a myocardial infarction by using folic acid-modified extracellular vesicles (EVs). This method aims to overcome the challenge of EV retention in the heart.
Our findings suggest that the hydrogels not only support cell viability but also boost cell migration, contributing to tissue repair by reducing fibrosis and enhancing blood vessel growth in heart tissue. In essence, this innovative approach shows promise for advancing treatments for heart damage.
Our findings suggest that the hydrogels not only support cell viability but also boost cell migration, contributing to tissue repair by reducing fibrosis and enhancing blood vessel growth in heart tissue. In essence, this innovative approach shows promise for advancing treatments for heart damage.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Supports cellular health
1 people found this helpful
Having researched dietary supplements, I can say that Optimized Folate 1700 mcg DFE is impressive. It’s highly bioavailable, helps with amino acid metabolism, and supports cardiovascular health by regulating homocysteine levels. I take one capsule daily with no side effects.
Read More
9
Great for heart health
Great Supplement for Heart Health.
Read More
9
Lowers homocysteine levels
This is a no-brainer! Folic acid has numerous benefits. I take it to manage my homocysteine levels, which have been associated with heart disease and strokes. Given my history, I believe taking folate is wise.
Read More
7.5
Cognitive and heart benefits
I use this for heart and cognitive health. It certainly aids clarity. This form of folate, 5-MTHF, is more absorbable for those genetically predisposed to conversion issues. I'm pleased to have found such quality.
Read More
7.5
Improves folate levels
16 people found this helpful
On Iherb, there are many good folates, and this is one of them. I’m ordering a third package from different brands! It’s an ideal formula for folate for those planning a pregnancy, suffering from anaemia or elevated homocysteine levels, which is a marker of cardiovascular diseases! I recommend it!
Read More
Frequently Asked Questions
9
Reduces homocysteine levels
3 people found this helpful
My doctor recommended I take 5-MTHF due to my family's high homocysteine levels, linked to heart disease. After three days of taking it, I've been sleeping soundly.
7.5
Supports cellular health
1 people found this helpful
Having researched dietary supplements, I can say that Optimized Folate 1700 mcg DFE is impressive. It’s highly bioavailable, helps with amino acid metabolism, and supports cardiovascular health by regulating homocysteine levels. I take one capsule daily with no side effects.
7.5
Improves folate levels
16 people found this helpful
On Iherb, there are many good folates, and this is one of them. I’m ordering a third package from different brands! It’s an ideal formula for folate for those planning a pregnancy, suffering from anaemia or elevated homocysteine levels, which is a marker of cardiovascular diseases! I recommend it!
6
Prevents megaloblastic anaemia
7 people found this helpful
A lack of folic acid can lead to megaloblastic anaemia, altering blood structure and oxygen exchange. Symptoms include fatigue, concentration issues, migraine, heart palpitations, and breathlessness. I find this supplement very beneficial.
7.5
Boosted immunity
1 people found this helpful
Folic acid enhances immunity and supports heart health and blood circulation, providing energy and good activity levels. For optimal results, I recommend taking it with a B-complex supplement.
7.5
Cognitive and heart benefits
I use this for heart and cognitive health. It certainly aids clarity. This form of folate, 5-MTHF, is more absorbable for those genetically predisposed to conversion issues. I'm pleased to have found such quality.
7.5
Cardiovascular support
Folic acid effectively supports cardiovascular health by managing blood homocysteine levels, which can lead to heart disease. It is vital for nervous system function and neurotransmitter production, enhancing mood and cognitive abilities. It also plays a crucial role in pregnancy and the proper development of the fetus's nervous system.
9
Maternal folic acid reduces CHD risk
We explored how maternal folic acid supplementation relates to congenital heart disease (CHD) in children. Through a case-control study involving 595 children with CHD and 605 healthy controls, we found that mothers taking folic acid significantly reduced the risk of CHD and its subtypes. Notably, variations in the MTRR gene among offspring were linked to higher CHD risks, but maternal folic acid appeared to mitigate some of this risk. While results are promising, further research with larger samples is essential to fully understand these findings.
7
We investigated whether multivitamin and folic acid supplementation could lessen the risk of congenital heart disease (CHD) connected to high levels of indoor air pollutants. Our case-control study involved pregnant women from East China and utilized questionnaires, blood tests, and assessments of indoor air quality.
The results indicated that exposure to high indoor levels of total volatile organic compounds (TVOCs) could increase the risk of CHD. However, regular multivitamin use showed promise in protecting against these risks, suggesting a beneficial role for prenatal nutrition.
The results indicated that exposure to high indoor levels of total volatile organic compounds (TVOCs) could increase the risk of CHD. However, regular multivitamin use showed promise in protecting against these risks, suggesting a beneficial role for prenatal nutrition.
8
We investigated whether folic acid treatment could help lower heart disease risk related to elevated homocysteine levels. The study highlighted that hyperhomocysteinemia is a significant independent risk factor for atherosclerosis, which can contribute to serious cardiovascular events. While folic acid, alongside other B vitamins, effectively reduces homocysteine levels, it does not appear to significantly improve heart disease outcomes on its own. Thus, while folic acid plays a role in managing homocysteine, its impact on preventing heart disease is less clear.
8
We explored how folic acid affects patients with coronary heart disease (CHD) and hypertension, particularly considering the MTHFR C677T gene. The study included 540 patients who received either folic acid treatment alongside enalapril or standard care.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
References
- Ruan X, Shang W, Lu J, Li Z, Yang J, et al. Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study. Environ Health. 2024;23:110. 10.1186/s12940-024-01150-7
- Li L, Ou J, Chen Y, Chen Q, Luo M, et al. Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population. J Health Popul Nutr. 2024;43:220. 10.1186/s41043-024-00699-w
- Prasad K. Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment. Int J Angiol. 2024;33:262. 10.1055/s-0044-1788280
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. 10.14715/cmb/2024.70.9.20
- Ruan XR, Sun MT, Wei JH, Luo MJ, Liu HJ, et al. [Maternal gene polymorphisms and their interactions with periconceptional folic acid supplementation in relation to offspring ventricular septal defects]. Zhongguo Dang Dai Er Ke Za Zhi. 2024;26:899. 10.7499/j.issn.1008-8830.2403067
- Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, et al. Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024;9. 10.1172/jci.insight.171005
- Hua Y, He Z, Ni Y, Sun L, Wang R, et al. Silk fibroin and hydroxypropyl cellulose composite injectable hydrogel-containing extracellular vesicles for myocardial infarction repair. Biomed Phys Eng Express. 2024;10. 10.1088/2057-1976/ad40b2
- Liu L, Zhang X, Geng HR, Qiao YN, Gui YH, et al. High paternal homocysteine causes ventricular septal defects in mouse offspring. iScience. 2024;27:109447. 10.1016/j.isci.2024.109447
- Sobot T, Bajic Z, Skrbic R, Uletilovic S, Mandic-Kovacevic N, et al. Effect of folic acid on isoprenaline-induced myocardial injury in rats. Physiol Int. 2024;111:80. 10.1556/2060.2023.00291
- Bennett DA, Parish S, Millwood IY, Guo Y, Chen Y, et al. MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults. Int J Epidemiol. 2023;52:1862. 10.1093/ije/dyad147
- Chen L, Yang T, Wang T, Sun M, Qin J. Relationships between Maternal Folic Acid Supplementation and Gene Polymorphisms in Patients with Non-Chromosomal Congenital Heart Disease: A Hospital-Based Case-Control Study in China. Nutrients. 2023;15. 10.3390/nu15204478
- Ju DT, Huang RS, Tsai BC, Su YC, Chiu PL, et al. Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer's Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways. Neurotox Res. 2023;41:648. 10.1007/s12640-023-00666-z
- Dkhillon D, Samogulova A, Kolobov B. B Vitamins as Adjunctive Treatment for Chronic Heart Failure. Cardiovasc Hematol Disord Drug Targets. 2023;23:64. 10.2174/1871529X23666230719090419
- Webber DM, Li M, MacLeod SL, Tang X, Levy JW, et al. Gene-Folic Acid Interactions and Risk of Conotruncal Heart Defects: Results from the National Birth Defects Prevention Study. Genes (Basel). 2023;14. 10.3390/genes14010180
- Qu Y, Liu X, Lin S, Bloom MS, Wang X, et al. Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring. JAMA Netw Open. 2024;7:e2438747. 10.1001/jamanetworkopen.2024.38747
