Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.4
USERS' SCORE
Moderately Good
Based on 98 Reviews
7.8
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin C (from ascorbic acid, camu-camu berry extract)
30 mg
33%
Quercetin (as quercetin dihydrate)
250 mg
**
Optimized Food Blend[onion (bulb) (extracts), bitter orange bioflavonoids (peel and fruit), apple (fruit)
220 mg
**
Camu-camu extract (wildcrafted berry)
50 mg
**
Top Medical Research Studies
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
8
We explored how quercetin may help alleviate allergies by examining its impact on certain immune cells involved in allergic reactions. Using different types of mast cells, we observed that quercetin triggered the production of heme oxygenase-1 (HO-1), which plays a key role in this process.
Interestingly, when we inhibited HO-1, the protective effects of quercetin vanished, suggesting that the Nrf2-HO-1 pathway is crucial for its anti-allergic actions. Our findings strongly indicate that quercetin could be valuable in managing allergic responses.
Interestingly, when we inhibited HO-1, the protective effects of quercetin vanished, suggesting that the Nrf2-HO-1 pathway is crucial for its anti-allergic actions. Our findings strongly indicate that quercetin could be valuable in managing allergic responses.
9.5
We delved into the effects of quercetin on peanut-induced anaphylactic reactions using a rat model. The study involved sensitized Wistar rats divided into treatment and control groups. After four weeks of quercetin treatment, we observed a significant decrease in plasma histamine levels and anaphylactic responses.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Most Useful Reviews
7.5
Effective for allergies
88 people found this helpful
I recommend quercetin for its benefits in treating allergies and improving blood flow. This natural supplement has anti-inflammatory properties and can alleviate headaches caused by vessel spasms. It has significantly improved my overall well-being.
9
Alleviates seasonal allergies
69 people found this helpful
Quercetin has helped ease my seasonal allergies significantly. I began taking it a month before pollen season and found it to be much more effective than previous treatments. My symptoms are now much more manageable.
9
Significant symptom relief
31 people found this helpful
I began taking this on the recommendation of someone who said it could reduce my allergy symptoms. To my surprise, after three weeks of taking one pill in the morning, I haven’t needed Claritin, Allegra, or Zyrtec for a month. Living in Austin, my allergies to cedar and Bermuda grass are severe in spring and summer, but I’ve experienced no side effects, and my intestinal tract feels fine.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.4
- All Researches
9.5
We delved into the effects of quercetin on peanut-induced anaphylactic reactions using a rat model. The study involved sensitized Wistar rats divided into treatment and control groups. After four weeks of quercetin treatment, we observed a significant decrease in plasma histamine levels and anaphylactic responses.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
9
Quercetin shows promise in allergies
We delved into the potential of quercetin as a therapeutic option for treating allergic rhinitis, a common condition affecting roughly 40% of the global population. This study utilized various in-silico approaches, such as network pharmacology and molecular docking, to identify compounds from traditional medicinal plants and assess their effectiveness.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
9
We investigated how a specific leaf extract affects allergic inflammation in immune cell lines.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
9
Holo-BLG offers allergy protection
We investigated how the milk protein beta-lactoglobulin (BLG), particularly its holo form, could shield against pollen allergies. In our study, BALB/c mice received nasal pretreatments with holo-BLG containing quercetin-iron complexes before being exposed to birch pollen allergens.
We observed that this treatment led to lower levels of allergy-related antibodies and reduced inflammatory responses. Essentially, holo-BLG appeared to offer protection from allergic reactions not just specifically to itself but also to unrelated allergens, suggesting a potential role in enhancing immune response against various pollen allergens.
We observed that this treatment led to lower levels of allergy-related antibodies and reduced inflammatory responses. Essentially, holo-BLG appeared to offer protection from allergic reactions not just specifically to itself but also to unrelated allergens, suggesting a potential role in enhancing immune response against various pollen allergens.
User Reviews
USERS' SCORE
Moderately Good
Based on 98 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Effective for allergies
88 people found this helpful
I recommend quercetin for its benefits in treating allergies and improving blood flow. This natural supplement has anti-inflammatory properties and can alleviate headaches caused by vessel spasms. It has significantly improved my overall well-being.
9
Alleviates seasonal allergies
69 people found this helpful
Quercetin has helped ease my seasonal allergies significantly. I began taking it a month before pollen season and found it to be much more effective than previous treatments. My symptoms are now much more manageable.
9
Significant symptom relief
31 people found this helpful
I began taking this on the recommendation of someone who said it could reduce my allergy symptoms. To my surprise, after three weeks of taking one pill in the morning, I haven’t needed Claritin, Allegra, or Zyrtec for a month. Living in Austin, my allergies to cedar and Bermuda grass are severe in spring and summer, but I’ve experienced no side effects, and my intestinal tract feels fine.
9
Effective allergy relief
23 people found this helpful
This quercetin works excellently for my allergies. I've experienced a noticeable difference compared to other brands. Two capsules daily provide the relief I need without issues.
9
Helps during infections
13 people found this helpful
I’ve found quercetin beneficial against viral infections and allergies, drastically reducing the duration and severity of my colds. Its synergy with zinc enhances its effectiveness. I'm pleased with the outcomes for my family as well.
Frequently Asked Questions
9
Clears sinuses effectively
9 people found this helpful
This quercetin product is fantastic for alleviating my stuffy sinuses, working within 20 minutes. One tablet daily does the trick, with an extra one in the evening during severe allergies. I have tried many brands, but this one truly works!
9
Alleviates seasonal allergies
69 people found this helpful
Quercetin has helped ease my seasonal allergies significantly. I began taking it a month before pollen season and found it to be much more effective than previous treatments. My symptoms are now much more manageable.
9
Relieves rhinitis
7 people found this helpful
Initially sceptical if quercetin would help with allergies, I noticed relief from rhinitis after taking it. When I ran out, the symptoms returned, so I repurchased it, and my rhinitis improved again immediately.
7.5
Effective for allergies
88 people found this helpful
I recommend quercetin for its benefits in treating allergies and improving blood flow. This natural supplement has anti-inflammatory properties and can alleviate headaches caused by vessel spasms. It has significantly improved my overall well-being.
9
Helps during infections
13 people found this helpful
I’ve found quercetin beneficial against viral infections and allergies, drastically reducing the duration and severity of my colds. Its synergy with zinc enhances its effectiveness. I'm pleased with the outcomes for my family as well.
9
Effective for nose allergies
2 people found this helpful
Quercetin is a natural antihistamine that has improved my daughter's nose allergies. When she has a cold or nasal discomfort, adding vitamin C seems to help even more than medication.
7.5
Supports allergy immunity
4 people found this helpful
This intriguing combined preparation not only contains quercetin but also vitamin C and other beneficial extracts. Together, they boost immunity, combat viruses, and can replace antihistamines for seasonal allergies. The capsules last 1-2 months based on dosage and regimen.
9
Combined treatment
2 people found this helpful
Quercetin assists in combating seasonal allergies. I take two capsules daily, and it greatly alleviates nasal congestion and sneezing. It’s also included in treatments for illness during the pandemic.
9
Effective antihistamine
2 people found this helpful
I consistently take quercetin from Life Extension and appreciate its quality. It acts as an antihistamine and anti-inflammatory, relieving various allergies, asthma, and skin reactions. Adults and children over 14 should take one tablet daily with food, ideally for a month. It's recommended during flu and cold seasons.
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
9
Quercetin shows promise in allergies
We delved into the potential of quercetin as a therapeutic option for treating allergic rhinitis, a common condition affecting roughly 40% of the global population. This study utilized various in-silico approaches, such as network pharmacology and molecular docking, to identify compounds from traditional medicinal plants and assess their effectiveness.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
7
We investigated how quercetin works alongside fucoidan to help manage allergies, particularly type I hypersensitivity like hay fever. Our findings showed that when quercetin was taken together with fucoidan, even lower amounts could still provide significant anti-allergic effects.
Interestingly, taking just 50 μg of quercetin in combination with fucoidan produced similar benefits as higher doses alone. This suggests that the combination of these ingredients could lessen the need for larger fucoidan servings while still being effective.
It seems we’ve found a promising food combination that enhances allergy relief!
Interestingly, taking just 50 μg of quercetin in combination with fucoidan produced similar benefits as higher doses alone. This suggests that the combination of these ingredients could lessen the need for larger fucoidan servings while still being effective.
It seems we’ve found a promising food combination that enhances allergy relief!
9
We investigated how a specific leaf extract affects allergic inflammation in immune cell lines.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
8
We explored the effects of quercetin, a natural bioflavonoid found in foods like red wine and onions, on allergies and inflammation. This compound has antioxidant properties and works by inhibiting mast cell activity, which helps reduce the release of substances that trigger allergic reactions.
While quercetin shows promise as a natural therapy for allergies, its overall effectiveness is still being evaluated. It's considered safe and may be used alongside traditional treatments for better results.
While quercetin shows promise as a natural therapy for allergies, its overall effectiveness is still being evaluated. It's considered safe and may be used alongside traditional treatments for better results.
7
Quercetin shows potential for allergies
We explored the potential benefits of quercetin and other dietary components in managing allergic reactions. Research indicates that quercetin may play a role in reducing symptoms of allergic rhinitis by suppressing inflammatory mediators from mast cells, essential players in allergic responses.
Our analysis highlighted that while quercetin shows promise, it’s one of several dietary factors needing further investigation, especially due to concerns about how well our bodies can use these nutrients. Continued research on improving their bioavailability is crucial for maximizing their effects on allergies.
Our analysis highlighted that while quercetin shows promise, it’s one of several dietary factors needing further investigation, especially due to concerns about how well our bodies can use these nutrients. Continued research on improving their bioavailability is crucial for maximizing their effects on allergies.
References
- Islam KMT, Mahmud S. In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum chemistry and machine learning based QSAR approaches. Comput Biol Med. 2025;187:109754. 10.1016/j.compbiomed.2025.109754
- Bunddulam P, Nakamura M, Zorig A, Hinata Y, Takasugi M, et al. Effects of Leaf Extract on Allergic Inflammation in Immune Cell Lines. Prev Nutr Food Sci. 2025;30:68. 10.3746/pnf.2025.30.1.68
- Kaag S, Lorentz A. Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies?. Cells. 2023;12. 10.3390/cells12222602
- Mizuno M, Fujioka A, Bitani S, Minato KI, Sakakibara H. Anti-Allergic Activity of Fucoidan Can Be Enhanced by Coexistence with Quercetin. Int J Mol Sci. 2022;23. 10.3390/ijms232012163
- Yamada S, Shirai M, Inaba Y, Takara T. Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study. Eur Rev Med Pharmacol Sci. 2022;26:4331. 10.26355/eurrev_202206_29072
- Afify SM, Pali-Schöll I, Hufnagl K, Hofstetter G, El-Bassuoni MA, et al. Bovine Holo-Beta-Lactoglobulin Cross-Protects Against Pollen Allergies in an Innate Manner in BALB/c Mice: Potential Model for the Farm Effect. Front Immunol. 2021;12:611474. 10.3389/fimmu.2021.611474
- Ding Y, Che D, Li C, Cao J, Wang J, et al. Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCγ-IP3R related Ca fluctuations. Int Immunopharmacol. 2019;66:185. 10.1016/j.intimp.2018.11.025
- Carbone ML, Lulli D, Passarelli F, Pastore S. Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity. Int J Mol Sci. 2018;19. 10.3390/ijms19092652
- Takasugi M, Muta E, Yamada K, Arai H. A new method to evaluate anti-allergic effect of food component by measuring leukotriene B from a mouse mast cell line. Cytotechnology. 2018;70:177. 10.1007/s10616-017-0129-9
- Kim M, Lim SJ, Kang SW, Um BH, Nho CW. Aceriphyllum rossii extract and its active compounds, quercetin and kaempferol inhibit IgE-mediated mast cell activation and passive cutaneous anaphylaxis. J Agric Food Chem. 2014;62:3750. 10.1021/jf405486c
- Shishehbor F, Behroo L, Ghafouriyan Broujerdnia M, Namjoyan F, Latifi SM. Quercetin effectively quells peanut-induced anaphylactic reactions in the peanut sensitized rats. Iran J Allergy Asthma Immunol. 2010;9:27.
- Matsushima M, Takagi K, Ogawa M, Hirose E, Ota Y, et al. Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Inflamm Res. 2009;58:705. 10.1007/s00011-009-0039-1
- Cruz EA, Da-Silva SA, Muzitano MF, Silva PM, Costa SS, et al. Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock. Int Immunopharmacol. 2008;8:1616. 10.1016/j.intimp.2008.07.006
- Shaik YB, Castellani ML, Perrella A, Conti F, Salini V, et al. Role of quercetin (a natural herbal compound) in allergy and inflammation. J Biol Regul Homeost Agents. 2006;20:47.
- Rogerio AP, Kanashiro A, Fontanari C, da Silva EV, Lucisano-Valim YM, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007;56:402.
