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Life Extension Optimized Quercetin
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 6 Reviews
8.7
Supplement Facts
Serving Size:  1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin C (from ascorbic acid, camu-camu berry extract)
30 mg
33%
Quercetin (as quercetin dihydrate)
250 mg
**
Optimized Food Blend[onion (bulb) (extracts), bitter orange bioflavonoids (peel and fruit), apple (fruit)
220 mg
**
Camu-camu extract (wildcrafted berry)
50 mg
**

Top Medical Research Studies

9
Quercetin shows promise for lupus
Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway.
High relevance for lupus treatment
We explored how quercetin, a natural compound, may help alleviate symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Our study observed that quercetin reduced kidney damage and swelling in the lymph nodes of lupus-affected mice. It appeared to lower the number of certain T cells that drive the disease and promoted cell death in aged immune cells. By influencing key pathways, quercetin showed potential as a therapy for SLE, offering hope in tackling this complex condition.
Read More
9
Quercetin shows promise in arthritis
Metabolic effects of quercetin on inflammatory and autoimmune responses in rheumatoid arthritis are mediated through the inhibition of JAK1/STAT3/HIF-1α signaling.
Relevant therapeutic application explored
We explored the effects of quercetin, a flavonoid, on rheumatoid arthritis through a well-structured study involving collagen-induced arthritis models in rats. Quercetin was administered for four weeks, and various assessments were conducted to evaluate its impact on inflammation and joint health.

Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Read More
8
Quercetin protects diabetic kidney health
Quercetin prevents kidney against diabetes mellitus (type 1) in rats by inhibiting TGF-β/apelin gene expression.
High relevance for kidney treatment
We investigated how quercetin can help protect kidneys from damage caused by diabetes in rats. Our study involved forty male Wistar rats divided into different groups to compare the effects of quercetin treatment before and after diabetes was induced.

We found that quercetin significantly reduced kidney dysfunction symptoms and oxidative stress markers compared to untreated diabetic rats. This improvement linked to quercetin's ability to enhance antioxidant defenses and disrupt harmful signaling pathways. However, we observed that pretreatment with quercetin was more effective than post-treatment, suggesting timing matters in its effectiveness.
Read More

Most Useful Reviews

9.5
Beneficial for allergies
Excellent product! I’ve appreciated the quality of Quercetin from a trusted supplier. The medium-sized capsules are easy to swallow. I take it during spring when tree pollen triggers my allergies; thanks to this supplement, I experienced no allergic reactions last year. I also use it during colds and buy it regularly. I highly recommend it!
Read More
9.5
Stable lung condition
I have been taking it for two consecutive years to protect my respiratory system due to nodules in my lungs. My lung condition is now very good; the nodules remain stable, and I no longer experience significant symptoms. I will continue to take it to manage inflammation.
Read More
9.5
Product satisfaction
Прекрасно! The product was well packed, and I definitely noticed the effect! I will order more! Delivery was quick as well.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
  • All Researches
9
Quercetin shows promise for lupus
Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway.
High relevance for lupus treatment
We explored how quercetin, a natural compound, may help alleviate symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Our study observed that quercetin reduced kidney damage and swelling in the lymph nodes of lupus-affected mice. It appeared to lower the number of certain T cells that drive the disease and promoted cell death in aged immune cells. By influencing key pathways, quercetin showed potential as a therapy for SLE, offering hope in tackling this complex condition.
Read More
9
Quercetin shows promise in arthritis
Metabolic effects of quercetin on inflammatory and autoimmune responses in rheumatoid arthritis are mediated through the inhibition of JAK1/STAT3/HIF-1α signaling.
Relevant therapeutic application explored
We explored the effects of quercetin, a flavonoid, on rheumatoid arthritis through a well-structured study involving collagen-induced arthritis models in rats. Quercetin was administered for four weeks, and various assessments were conducted to evaluate its impact on inflammation and joint health.

Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Read More
9
Sendeng-4 alleviates rheumatoid arthritis
Exploring the mechanism of Sendeng-4 against rheumacid arthritis through integrated serum pharmacochemistry, transcriptomics, and network pharmacology.
High relevance for RA treatment
We explored how Sendeng-4, a traditional Mongolian medicine, can ease rheumatoid arthritis (RA). By using advanced methods to analyze its active components, we identified key phytochemicals and mapped their effects on biological pathways.

After testing on a rat model of RA, we observed that Sendeng-4 significantly reduces inflammation and arthritis symptoms, particularly through the PI3K-Akt signaling pathway. Overall, this study reveals Sendeng-4's potential benefits in treating RA and encourages further research into traditional remedies.
Read More
9
Quercetin liposomes aid diabetes therapy
Lipid nanoparticles of quercetin (QU-Lip) alleviated pancreatic microenvironment in diabetic male rats: The interplay between oxidative stress - unfolded protein response (UPR) - autophagy, and their regulatory miRNA.
High relevance for diabetes research
We observed that a new form of quercetin, delivered in lipid nanoparticles, can help alleviate diabetes symptoms in rats. This improved bioavailable quercetin significantly reduced blood glucose levels and lowered pancreatic oxidative stress and inflammation.

It also enhanced autophagy while reducing endoplasmic reticulum stress markers. However, when combined with an autophagy inhibitor, the positive effects disappeared, indicating the importance of autophagy in quercetin’s benefits. Overall, this study highlights the potential of quercetin liposomes in managing type 1 diabetes.
Read More
8
Quercetin shows promise for RA treatment
Active Ingredients and Potential Mechanism of Additive Sishen Decoction in Treating Rheumatoid Arthritis with Network Pharmacology and Molecular Dynamics Simulation and Experimental Verification.
Moderate relevance; needs further validation.
We examined the active components in the Additive Sishen Decoction (ASSD), a traditional Chinese medicine for rheumatoid arthritis (RA). Our findings revealed that key ingredients—quercetin, kaempferol, and luteolin—play a significant role in reducing inflammation through specific pathways.

These ingredients inhibit proinflammatory factors by affecting glucose metabolism in macrophages. We employed protein interaction networks and molecular simulations to clarify their mechanisms, showing that quercetin contributes significantly to ASSD’s therapeutic effects.

Overall, we established that quercetin can be a valuable aid in managing RA symptoms.
Read More

User Reviews

USERS' SCORE
Good
Based on 6 Reviews
8.7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9.5
Beneficial for allergies
Excellent product! I’ve appreciated the quality of Quercetin from a trusted supplier. The medium-sized capsules are easy to swallow. I take it during spring when tree pollen triggers my allergies; thanks to this supplement, I experienced no allergic reactions last year. I also use it during colds and buy it regularly. I highly recommend it!
Read More
9.5
Stable lung condition
I have been taking it for two consecutive years to protect my respiratory system due to nodules in my lungs. My lung condition is now very good; the nodules remain stable, and I no longer experience significant symptoms. I will continue to take it to manage inflammation.
9.5
Product satisfaction
Прекрасно! The product was well packed, and I definitely noticed the effect! I will order more! Delivery was quick as well.
8
Relieved allergy symptoms
Wonderful! This is my favourite antiviral remedy. Previously, I took vitamin C, zinc, and echinacea when I was ill, but now I find that Quercetin with zinc suffices. My father developed an allergy from his medication but couldn’t stop taking them. After starting Quercetin, his allergy symptoms have diminished. I also give it to my child when they feel unwell by mixing half a capsule with food or water.
Read More
9.5
Highly effective treatment
Excellent! Very effective. Would like to order more.
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