Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.6
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin C (from ascorbic acid, camu-camu berry extract)
30 mg
33%
Quercetin (as quercetin dihydrate)
250 mg
**
Optimized Food Blend[onion (bulb) (extracts), bitter orange bioflavonoids (peel and fruit), apple (fruit)
220 mg
**
Camu-camu extract (wildcrafted berry)
50 mg
**
Top Medical Research Studies
8
We investigated the addition of quercetin to standard treatment in patients experiencing their first heart attack. In this multicenter study with 143 participants, quercetin was administered during the critical early hours of treatment.
The results showed a significant reduction in heart tissue damage compared to those who only received standard therapy. Specifically, fewer patients in the quercetin group experienced internal bleeding in the heart muscle.
While the initial findings are promising, additional studies are needed to confirm these benefits.
The results showed a significant reduction in heart tissue damage compared to those who only received standard therapy. Specifically, fewer patients in the quercetin group experienced internal bleeding in the heart muscle.
While the initial findings are promising, additional studies are needed to confirm these benefits.
8
We investigated how isoquercetin interacts with heart attack, using a rat model to uncover its protective effects. Our findings showed that isoquercetin reduced heart damage, inflammation, and cell death associated with myocardial infarction. It also improved certain enzyme levels and suppressed a key signaling pathway linked to heart stress. While promising, these results suggest isoquercetin may be beneficial for heart health, though further research in humans is needed to confirm its effectiveness.
9
Quercetin enhances heart recovery post-MI
We explored how quercetin, a common bioflavonoid found in fruits and vegetables, might impact recovery after a heart attack. In our study with mice, treating them with quercetin before inducing a heart attack led to better heart function and increased survival rates.
We noticed that quercetin helped reduce heart swelling and injury size, while also lowering inflammation. Notably, it encouraged a shift in immune cells to a more healing state. Overall, while quercetin shows promise, further research is needed to fully understand its potential in heart attack prevention and treatment.
We noticed that quercetin helped reduce heart swelling and injury size, while also lowering inflammation. Notably, it encouraged a shift in immune cells to a more healing state. Overall, while quercetin shows promise, further research is needed to fully understand its potential in heart attack prevention and treatment.
Most Useful Reviews
9
Promotes heart longevity
Quercetin supports heart health and longevity.
7.5
Improves general health
I opted for this quercetin for its numerous health advantages including antioxidant effects and support for heart and vascular health. Life Extension’s formula, enriched with rutin, enhances bioavailability. As a vegetarian, I appreciate that the capsules are easy to swallow. Since starting on Optimized Quercetin, I’ve noticed reduced inflammation, remarkable heart health improvement, and overall increased energy levels.
0
No noticeable effect
2 people found this helpful
After taking quercetin for two months on my cardiologist’s advice, I noticed no changes in my body whatsoever. My heart didn’t feel better, nor did my energy levels increase. There were no negative effects either.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
- All Researches
9
Quercetin enhances heart recovery post-MI
We explored how quercetin, a common bioflavonoid found in fruits and vegetables, might impact recovery after a heart attack. In our study with mice, treating them with quercetin before inducing a heart attack led to better heart function and increased survival rates.
We noticed that quercetin helped reduce heart swelling and injury size, while also lowering inflammation. Notably, it encouraged a shift in immune cells to a more healing state. Overall, while quercetin shows promise, further research is needed to fully understand its potential in heart attack prevention and treatment.
We noticed that quercetin helped reduce heart swelling and injury size, while also lowering inflammation. Notably, it encouraged a shift in immune cells to a more healing state. Overall, while quercetin shows promise, further research is needed to fully understand its potential in heart attack prevention and treatment.
9
We investigated how quercetin influences recovery after a heart attack. By inducing heart attacks in rats and treating them with quercetin, we found that it actively reduced harmful protein levels associated with heart damage.
Specifically, quercetin decreased the expression of circPAN3 and PTEN while boosting miR-221, which are important for cell survival. These changes suggest that quercetin may help protect heart tissue after a myocardial infarction, improving heart function.
Specifically, quercetin decreased the expression of circPAN3 and PTEN while boosting miR-221, which are important for cell survival. These changes suggest that quercetin may help protect heart tissue after a myocardial infarction, improving heart function.
9
We investigated how quercetin, combined with another drug, affects heart recovery after a heart attack in older female mice.
This study showed that using senolytics, specifically dasatinib and quercetin, helped improve heart function and repair by clearing out toxic, aged cells in the heart.
By eliminating these harmful cells, we enhanced heart performance and regeneration.
Overall, our findings suggest that targeting senescent cells could be a promising approach for improving heart health in aging females after a heart attack.
This study showed that using senolytics, specifically dasatinib and quercetin, helped improve heart function and repair by clearing out toxic, aged cells in the heart.
By eliminating these harmful cells, we enhanced heart performance and regeneration.
Overall, our findings suggest that targeting senescent cells could be a promising approach for improving heart health in aging females after a heart attack.
9
We explored the effects of hyperoside (Hyp), a compound from traditional Chinese medicine, on heart attacks in mice. In our study, we created a heart attack model and treated the mice with varying doses of Hyp for two weeks.
We observed significant improvements in heart function and reduced heart damage in the Hyp-treated groups compared to those without treatment. Hyp works partly by enhancing autophagy, which helps control inflammation related to heart injury.
Overall, our findings suggest that hyperoside may offer protective benefits for heart health.
We observed significant improvements in heart function and reduced heart damage in the Hyp-treated groups compared to those without treatment. Hyp works partly by enhancing autophagy, which helps control inflammation related to heart injury.
Overall, our findings suggest that hyperoside may offer protective benefits for heart health.
9
We explored whether quercetin can protect against heart attacks in rats through its influence on specific cellular pathways. The study involved different groups of rats, some receiving quercetin before inducing heart attacks. The results showed that quercetin reduced heart damage, improved heart function, and decreased harmful substances in the body.
However, it’s important to note that while quercetin had protective effects, its full impact on heart attack treatment remains unclear. Overall, quercetin appears beneficial by enhancing antioxidant defenses and influencing relevant signaling pathways.
However, it’s important to note that while quercetin had protective effects, its full impact on heart attack treatment remains unclear. Overall, quercetin appears beneficial by enhancing antioxidant defenses and influencing relevant signaling pathways.
User Reviews
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Promotes heart longevity
Quercetin supports heart health and longevity.
7.5
Improves general health
I opted for this quercetin for its numerous health advantages including antioxidant effects and support for heart and vascular health. Life Extension’s formula, enriched with rutin, enhances bioavailability. As a vegetarian, I appreciate that the capsules are easy to swallow. Since starting on Optimized Quercetin, I’ve noticed reduced inflammation, remarkable heart health improvement, and overall increased energy levels.
0
No noticeable effect
2 people found this helpful
After taking quercetin for two months on my cardiologist’s advice, I noticed no changes in my body whatsoever. My heart didn’t feel better, nor did my energy levels increase. There were no negative effects either.
7.5
Boosts immunity
1 people found this helpful
Life Extension Quercetin capsules genuinely enhance my immunity and overall well-being! As someone who values natural health, these capsules have exceeded my expectations. Quercetin is a robust antioxidant that promotes heart health, boosts immunity, and lowers inflammation. After regular use, I've experienced reduced allergy symptoms, increased energy, and stronger immunity. The packaging is user-friendly and practical.
7.5
Essential heart supplement
Great supplement. I will order more as its quality is excellent. It is irreplaceable for the heart.
Frequently Asked Questions
0
No noticeable effect
2 people found this helpful
After taking quercetin for two months on my cardiologist’s advice, I noticed no changes in my body whatsoever. My heart didn’t feel better, nor did my energy levels increase. There were no negative effects either.
7.5
Improves general health
I opted for this quercetin for its numerous health advantages including antioxidant effects and support for heart and vascular health. Life Extension’s formula, enriched with rutin, enhances bioavailability. As a vegetarian, I appreciate that the capsules are easy to swallow. Since starting on Optimized Quercetin, I’ve noticed reduced inflammation, remarkable heart health improvement, and overall increased energy levels.
7.5
Boosts immunity
1 people found this helpful
Life Extension Quercetin capsules genuinely enhance my immunity and overall well-being! As someone who values natural health, these capsules have exceeded my expectations. Quercetin is a robust antioxidant that promotes heart health, boosts immunity, and lowers inflammation. After regular use, I've experienced reduced allergy symptoms, increased energy, and stronger immunity. The packaging is user-friendly and practical.
8
We examined how quercetin could help reduce heart damage following a heart attack. In our study with Wistar rats, we administered quercetin before restoring blood flow after a simulated heart attack.
Our results showed that quercetin improved heart function significantly compared to the control group. It reduced harmful neutrophil activity, an important factor in heart injury. Post-MI treatment with quercetin seems promising for reducing heart damage and could offer an effective approach for treating reperfusion injury.
Our results showed that quercetin improved heart function significantly compared to the control group. It reduced harmful neutrophil activity, an important factor in heart injury. Post-MI treatment with quercetin seems promising for reducing heart damage and could offer an effective approach for treating reperfusion injury.
8
We investigated the addition of quercetin to standard treatment in patients experiencing their first heart attack. In this multicenter study with 143 participants, quercetin was administered during the critical early hours of treatment.
The results showed a significant reduction in heart tissue damage compared to those who only received standard therapy. Specifically, fewer patients in the quercetin group experienced internal bleeding in the heart muscle.
While the initial findings are promising, additional studies are needed to confirm these benefits.
The results showed a significant reduction in heart tissue damage compared to those who only received standard therapy. Specifically, fewer patients in the quercetin group experienced internal bleeding in the heart muscle.
While the initial findings are promising, additional studies are needed to confirm these benefits.
8
We aimed to understand how quercetin affects heart function and ischemia in patients with stable coronary heart disease (CHD). In our study, 85 CHD patients received quercetin alongside standard treatment, while a larger group continued standard therapy alone.
After two months, we noticed improvements in heart function for both groups, but the quercetin group showed significant benefits, especially in reducing episodes of myocardial ischemia and ventricular contractions. Our findings suggest quercetin has promising cardioprotective effects in CHD patients.
After two months, we noticed improvements in heart function for both groups, but the quercetin group showed significant benefits, especially in reducing episodes of myocardial ischemia and ventricular contractions. Our findings suggest quercetin has promising cardioprotective effects in CHD patients.
References
- Wang L, Lin S, Wei Q, Li T, Mo Q, et al. Preventive Administration of Quercetin Promotes Survival and Reduces Adverse Ventricular Remodeling after myocardial infarction through facilitating M2-like macrophage polarization. Int Immunopharmacol. 2025;151:114296. doi:10.1016/j.intimp.2025.114296
- Domingos AE, Breves CMDC, Boa LF, de Souza IIA, Maciel L, et al. Quercetin Reduces the Susceptibility to Cardiac Reperfusion Arrhythmias in Ovariectomized Rats. Mol Nutr Food Res. 2025;69:e202400284. doi:10.1002/mnfr.202400284
- Goshovska Y, Pashevin D, Goncharov S, Lapikova-Bryhinska T, Lisovyi O, et al. Quercetin is a potential therapy for post-infarction NETosis formation. Naunyn Schmiedebergs Arch Pharmacol. 2025;398:5705. doi:10.1007/s00210-024-03602-w
- Hu D, Li R, Li Y, Wang M, Wang L, et al. Inflammation-Targeted Nanomedicines Alleviate Oxidative Stress and Reprogram Macrophages Polarization for Myocardial Infarction Treatment. Adv Sci (Weinh). 2024;11:e2308910. doi:10.1002/advs.202308910
- Liu C, Huang J, Qiu J, Jiang H, Liang S, et al. Quercitrin improves cardiac remodeling following myocardial infarction by regulating macrophage polarization and metabolic reprogramming. Phytomedicine. 2024;127:155467. doi:10.1016/j.phymed.2024.155467
- Farazi MM, Rostamzadeh F, Jafarinejad-Farsangi S, Moazam Jazi M, Jafari E, et al. CircPAN3/miR-221/PTEN axis and apoptosis in myocardial Infarction: Quercetin's regulatory effects. Gene. 2024;909:148316. doi:10.1016/j.gene.2024.148316
- Kozhukhov S, Parkhomenko A, Lutay Y, Dovganych N. Impact of quercetin in patients with myocardial infarction. A multicenter, randomized, and open-label pilot study. Hellenic J Cardiol. 2024;76:68. doi:10.1016/j.hjc.2023.08.004
- Salerno N, Marino F, Scalise M, Salerno L, Molinaro C, et al. Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice. Mech Ageing Dev. 2022;208:111740. doi:10.1016/j.mad.2022.111740
- Chen L, Wu X, Wang W, Wang X, Ma J. Quercetin with lycopene modulates enzymic antioxidant genes pathway in isoproterenol cardiotoxicity in rats. Libyan J Med. 2021;16:1943924. doi:10.1080/19932820.2021.1943924
- Yang Y, Li J, Rao T, Fang Z, Zhang J. The role and mechanism of hyperoside against myocardial infarction in mice by regulating autophagy via NLRP1 inflammation pathway. J Ethnopharmacol. 2021;276:114187. doi:10.1016/j.jep.2021.114187
- Albadrani GM, Binmowyna MN, Bin-Jumah MN, El-Akabawy G, Aldera H, et al. Quercetin protects against experimentally-induced myocardial infarction in rats by an antioxidant potential and concomitant activation of signal transducer and activator of transcription 3. J Physiol Pharmacol. 2020;71. doi:10.26402/jpp.2020.6.11
- Liu CJ, Yao L, Hu YM, Zhao BT. Effect of Quercetin-Loaded Mesoporous Silica Nanoparticles on Myocardial Ischemia-Reperfusion Injury in Rats and Its Mechanism. Int J Nanomedicine. 2021;16:741. doi:10.2147/IJN.S277377
- Dehghani F, Sezavar Seyedi Jandaghi SH, Janani L, Sarebanhassanabadi M, Emamat H, et al. Effects of quercetin supplementation on inflammatory factors and quality of life in post-myocardial infarction patients: A double blind, placebo-controlled, randomized clinical trial. Phytother Res. 2021;35:2085. doi:10.1002/ptr.6955
- Ma C, Jiang Y, Zhang X, Chen X, Liu Z, et al. Isoquercetin ameliorates myocardial infarction through anti-inflammation and anti-apoptosis factor and regulating TLR4-NF-κB signal pathway. Mol Med Rep. 2018;17:6675. doi:10.3892/mmr.2018.8709
- Chekalina NI, Shut SV, Trybrat TA, Burmak YH, Petrov YY, et al. Effect of quercetin on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease. Wiad Lek. 2017;70:707.
- Kumar M, Kasala ER, Bodduluru LN, Kumar V, Lahkar M. Molecular and biochemical evidence on the protective effects of quercetin in isoproterenol-induced acute myocardial injury in rats. J Biochem Mol Toxicol. 2017;31:1. doi:10.1002/jbt.21832
