Quercetin reduces sinus inflammationQuercetin attenuates naso-sinusal inflammation and inflammatory response in lungs and brain on an experimental model of acute rhinosinusitis in rats.
Promising findings for treatment
This study explored how quercetin may help reduce inflammation associated with sinusitis using a rat model. We observed that introducing lipopolysaccharides (LPS) caused significant inflammation in nasal and sinus areas, as well as in the lungs and brain.
When we administered quercetin after the LPS treatment, it notably decreased inflammatory markers like TNF-α and IL-6. The results indicated reduced inflammation in nasal and lung tissues, showcasing quercetin's potential benefits. However, while there were encouraging findings, its effects on brain inflammation were more limited.
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Quercetin enhances mucus transportQuercetin increases cystic fibrosis transmembrane conductance regulator-mediated chloride transport and ciliary beat frequency: therapeutic implications for chronic rhinosinusitis.
High relevance for sinusitis treatment
We explored how quercetin might help sinusitis by boosting chloride secretion and improving ciliary beat frequency in cultured sinonasal cells. In our analysis, this compound showed notable ability to enhance these functions, suggesting it could promote better mucus clearance from the sinuses.
The study involved primary cultures of human and murine sinonasal epithelial cells and demonstrated quercetin's effectiveness in increasing chloride transport. This implies potential therapeutic benefits for individuals suffering from chronic rhinosinusitis.
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Quercetin reduces inflammation in sinusitisQuercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line.
Moderate relevance to sinusitis treatment.
We explored how quercetin affects sinusitis by examining its impact on human mast cells. Specifically, we focused on the expression of inflammatory cytokines after stimulating the cells.
Quercetin showed promise by reducing the gene expression and production of key inflammatory signals like TNF-alpha and IL-6. It did this by dampening the activation of NF-kappaB and p38 MAPK pathways, both crucial for inflammation.
This suggests that quercetin may be beneficial for managing conditions like sinusitis linked to mast cell activity.
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